kopsinine and Cough
kopsinine has been researched along with Cough* in 1 studies
Other Studies
1 other study(ies) available for kopsinine and Cough
| Article | Year |
|---|---|
Antitussive indole alkaloids from Kopsia hainanensis.
Three new indole alkaloids, named kopsihainins A-C (1-3), and two known compounds, kopsinine (4) and methyl demethoxycarbonylchanofruticosinate (5), were isolated from the stems of Kopsia hainanensis. Their structures were determined using extensive spectroscopic methods. The two main constituents 4 and 5 exhibited significant antitussive activity in a citric acid induced guinea pig cough model. The antitussive effect of 4 was demonstrated to interact with the δ-opioid receptor. This is the first report of antitussive effects of aspidofractinine type and chanofruticosinate type alkaloids. Topics: Animals; Antitussive Agents; Apocynaceae; Citric Acid; Cough; Guinea Pigs; Indole Alkaloids; Molecular Structure; Plant Extracts; Plant Stems | 2011 |