kojic acid has been researched along with Melanoma in 22 studies
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mannich bases of kojic acid derivatives may be promising therapeutic agents, since some have more potent effects on melanoma cells than previously FDA-approved drugs for the treatment of malignant melanoma." | 7.88 | Synthesis and Cytotoxic Evaluation of Kojic Acid Derivatives with Inhibitory Activity on Melanogenesis in Human Melanoma Cells. ( Aytemir, MD; Ercan, A; Karakaya, G; Oncul, S, 2018) |
| "Although the toxicogenomics of kojic acid treated A375 human malignant melanoma cells has been elucidated, the proteomics of cellular response is still poorly understood." | 7.74 | Proteomics analysis of kojic acid treated A375 human malignant melanoma cells. ( Chen, ST; Cheng, SL; Huang-Liu, R; Kao, SH; Liao, HH; Nawarak, J; Sinchaikul, S, 2008) |
| "the sesamol- and kojic-treated SK-MEL2 cells." | 5.40 | Application of FTIR microspectroscopy for characterization of biomolecular changes in human melanoma cells treated by sesamol and kojic acid. ( Barusrux, S; Srisayam, M; Tanthanuch, W; Thumanu, K; Weerapreeyakul, N, 2014) |
| "Kojic acid is a natural product and normally used as a food additive and preservative, a skin-whitening agent in cosmetics, a plant growth regulator and a chemical intermediate." | 5.33 | Toxicogenomics of kojic acid on gene expression profiling of a375 human malignant melanoma cells. ( Chen, ST; Cheng, SL; Huang Liu, R; Sheu, JN; Sinchaikul, S; Tsay, GJ, 2006) |
| "Mannich bases of kojic acid derivatives may be promising therapeutic agents, since some have more potent effects on melanoma cells than previously FDA-approved drugs for the treatment of malignant melanoma." | 3.88 | Synthesis and Cytotoxic Evaluation of Kojic Acid Derivatives with Inhibitory Activity on Melanogenesis in Human Melanoma Cells. ( Aytemir, MD; Ercan, A; Karakaya, G; Oncul, S, 2018) |
| "the sesamol- and kojic-treated SK-MEL2 cells." | 1.40 | Application of FTIR microspectroscopy for characterization of biomolecular changes in human melanoma cells treated by sesamol and kojic acid. ( Barusrux, S; Srisayam, M; Tanthanuch, W; Thumanu, K; Weerapreeyakul, N, 2014) |
| "Kojic acid is a natural product and normally used as a food additive and preservative, a skin-whitening agent in cosmetics, a plant growth regulator and a chemical intermediate." | 1.33 | Toxicogenomics of kojic acid on gene expression profiling of a375 human malignant melanoma cells. ( Chen, ST; Cheng, SL; Huang Liu, R; Sheu, JN; Sinchaikul, S; Tsay, GJ, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (9.09) | 18.2507 |
| 2000's | 5 (22.73) | 29.6817 |
| 2010's | 11 (50.00) | 24.3611 |
| 2020's | 4 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Criton, M | 1 |
| Le Mellay-Hamon, V | 1 |
| Yamazaki, Y | 1 |
| Kawano, Y | 1 |
| Yamanaka, A | 1 |
| Maruyama, S | 1 |
| Nam, JH | 1 |
| Nam, DY | 1 |
| Lee, DU | 1 |
| Ferro, S | 1 |
| De Luca, L | 1 |
| Germanò, MP | 1 |
| Buemi, MR | 1 |
| Ielo, L | 1 |
| Certo, G | 1 |
| Kanteev, M | 1 |
| Fishman, A | 1 |
| Rapisarda, A | 1 |
| Gitto, R | 1 |
| Ullah, S | 1 |
| Kang, D | 1 |
| Lee, S | 1 |
| Ikram, M | 1 |
| Park, C | 1 |
| Park, Y | 1 |
| Yoon, S | 1 |
| Chun, P | 1 |
| Moon, HR | 1 |
| Santi, MD | 1 |
| Peralta, MA | 1 |
| Puiatti, M | 1 |
| Cabrera, JL | 1 |
| Ortega, MG | 1 |
| Nazir, Y | 1 |
| Saeed, A | 1 |
| Rafiq, M | 1 |
| Afzal, S | 1 |
| Ali, A | 1 |
| Latif, M | 1 |
| Zuegg, J | 1 |
| Hussein, WM | 1 |
| Fercher, C | 1 |
| Barnard, RT | 1 |
| Cooper, MA | 1 |
| Blaskovich, MAT | 1 |
| Ashraf, Z | 1 |
| Ziora, ZM | 1 |
| Roulier, B | 1 |
| Pérès, B | 1 |
| Haudecoeur, R | 1 |
| Vanjare, BD | 1 |
| Choi, NG | 1 |
| Mahajan, PG | 1 |
| Raza, H | 2 |
| Hassan, M | 2 |
| Han, Y | 1 |
| Yu, SM | 1 |
| Kim, SJ | 2 |
| Seo, SY | 2 |
| Lee, KH | 1 |
| Cardoso, R | 1 |
| Valente, R | 1 |
| Souza da Costa, CH | 1 |
| da S Gonçalves Vianez, JL | 1 |
| Santana da Costa, K | 1 |
| de Molfetta, FA | 1 |
| Nahum Alves, C | 1 |
| Abbas, Q | 1 |
| Phull, AR | 1 |
| Karakaya, G | 1 |
| Ercan, A | 1 |
| Oncul, S | 1 |
| Aytemir, MD | 1 |
| Peng, M | 1 |
| Wang, Y | 1 |
| Fu, Q | 1 |
| Sun, F | 1 |
| Na, N | 1 |
| Ouyang, J | 1 |
| Micillo, R | 1 |
| Sirés-Campos, J | 1 |
| García-Borrón, JC | 1 |
| Panzella, L | 1 |
| Napolitano, A | 1 |
| Olivares, C | 1 |
| Srisayam, M | 1 |
| Weerapreeyakul, N | 1 |
| Barusrux, S | 1 |
| Tanthanuch, W | 1 |
| Thumanu, K | 1 |
| Nawarak, J | 1 |
| Huang-Liu, R | 1 |
| Kao, SH | 1 |
| Liao, HH | 1 |
| Sinchaikul, S | 2 |
| Chen, ST | 2 |
| Cheng, SL | 2 |
| Li, X | 1 |
| Guo, L | 1 |
| Sun, Y | 1 |
| Zhou, J | 1 |
| Gu, Y | 1 |
| Li, Y | 1 |
| Miyake, M | 1 |
| Yamamoto, S | 1 |
| Sano, O | 1 |
| Fujii, M | 1 |
| Kohno, K | 1 |
| Ushio, S | 1 |
| Iwaki, K | 1 |
| Fukuda, S | 1 |
| Kim, DH | 1 |
| Hwang, JS | 1 |
| Baek, HS | 1 |
| Kim, KJ | 1 |
| Lee, BG | 1 |
| Chang, I | 1 |
| Kang, HH | 1 |
| Lee, OS | 1 |
| Huang Liu, R | 1 |
| Sheu, JN | 1 |
| Tsay, GJ | 1 |
| Kobayashi, R | 1 |
| Takisada, M | 1 |
| Suzuki, T | 1 |
| Kirimura, K | 1 |
| Usami, S | 1 |
| Mishima, Y | 1 |
2 reviews available for kojic acid and Melanoma
| Article | Year |
|---|---|
Advances in the Design of Genuine Human Tyrosinase Inhibitors for Targeting Melanogenesis and Related Pigmentations.
Topics: Agaricales; Amino Acid Sequence; Biological Factors; Drug Delivery Systems; Drug Design; Enzyme Inhi | 2020 |
A post melanosomal era: control of melanogenesis and melanoma growth.
Topics: Adolescent; Animals; Boron; Boron Compounds; Cricetinae; Fatty Acids, Unsaturated; Gene Expression R | 1992 |
20 other studies available for kojic acid and Melanoma
| Article | Year |
|---|---|
Analogues of N-hydroxy-N'-phenylthiourea and N-hydroxy-N'-phenylurea as inhibitors of tyrosinase and melanin formation.
Topics: Agaricales; Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; Inhibitory Concentration 50 | 2008 |
N-[(Dihydroxyphenyl)acyl]serotonins as potent inhibitors of tyrosinase from mouse and human melanoma cells.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Enz | 2009 |
Valencene from the Rhizomes of Cyperus rotundus Inhibits Skin Photoaging-Related Ion Channels and UV-Induced Melanogenesis in B16F10 Melanoma Cells.
Topics: Animals; Cyperus; Melanins; Melanoma; Mice; Molecular Structure; Republic of Korea; Rhizome; Sesquit | 2016 |
Chemical exploration of 4-(4-fluorobenzyl)piperidine fragment for the development of new tyrosinase inhibitors.
Topics: Agaricales; Binding, Competitive; Enzyme Inhibitors; Inhibitory Concentration 50; Kinetics; Melanoma | 2017 |
Synthesis of cinnamic amide derivatives and their anti-melanogenic effect in α-MSH-stimulated B16F10 melanoma cells.
Topics: Agaricales; Amides; Antineoplastic Agents; Cell Proliferation; Cell Survival; Cinnamates; Dose-Respo | 2019 |
Melanogenic inhibitory effects of Triangularin in B16F0 melanoma cells, in vitro and molecular docking studies.
Topics: Humans; Melanoma; Molecular Docking Simulation | 2019 |
Hydroxyl substituted benzoic acid/cinnamic acid derivatives: Tyrosinase inhibitory kinetics, anti-melanogenic activity and molecular docking studies.
Topics: Benzoic Acid; Cinnamates; Humans; Melanoma; Molecular Docking Simulation; Structure-Activity Relatio | 2020 |
Novel 1,3,4-oxadiazole compounds inhibit the tyrosinase and melanin level: Synthesis, in-vitro, and in-silico studies.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Humans; Melanins; Melanoma; Models, Molecula | 2021 |
Analysis of Kojic Acid Derivatives as Competitive Inhibitors of Tyrosinase: A Molecular Modeling Approach.
Topics: Catalytic Domain; Enzyme Inhibitors; Humans; Levodopa; Melanins; Melanocytes; Melanoma; Molecular Do | 2021 |
Acetazolamide Inhibits the Level of Tyrosinase and Melanin: An Enzyme Kinetic, In Vitro, In Vivo, and In Silico Studies.
Topics: Acetazolamide; Agaricales; Animals; Cell Line, Tumor; Cell Survival; Computer Simulation; Enzyme Inh | 2017 |
Synthesis and Cytotoxic Evaluation of Kojic Acid Derivatives with Inhibitory Activity on Melanogenesis in Human Melanoma Cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Mannich Bases; Me | 2018 |
Melanosome-Targeting Near-Infrared Fluorescent Probe with Large Stokes Shift for in Situ Quantification of Tyrosinase Activity and Assessing Drug Effects on Differently Invasive Melanoma Cells.
Topics: Ficusin; Fluorescent Dyes; Humans; Infrared Rays; Melanoma; Melanosomes; Monophenol Monooxygenase; N | 2018 |
Conjugation with Dihydrolipoic Acid Imparts Caffeic Acid Ester Potent Inhibitory Effect on Dopa Oxidase Activity of Human Tyrosinase.
Topics: Agaricales; Caffeic Acids; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Enzyme | 2018 |
Application of FTIR microspectroscopy for characterization of biomolecular changes in human melanoma cells treated by sesamol and kojic acid.
Topics: Benzodioxoles; Cell Line, Tumor; Cell Survival; Humans; Melanoma; Phenols; Principal Component Analy | 2014 |
Proteomics analysis of kojic acid treated A375 human malignant melanoma cells.
Topics: Base Sequence; Blotting, Western; Cell Line, Tumor; DNA Primers; Electrophoresis, Gel, Two-Dimension | 2008 |
Baicalein inhibits melanogenesis through activation of the ERK signaling pathway.
Topics: Animals; Cell Death; Cell Line, Tumor; Cell Survival; Down-Regulation; Enzyme Activation; Extracellu | 2010 |
Inhibitory effects of 2-amino-3H-phenoxazin-3-one on the melanogenesis of murine B16 melanoma cell line.
Topics: Agaricales; Animals; Cell Line, Tumor; Indoles; Melanins; Melanoma; Melanoma, Experimental; Mice; Mi | 2010 |
Development of 5-[(3-aminopropyl)phosphinooxy]-2-(hydroxymethyl)-4H-pyran-4-one as a novel whitening agent.
Topics: Animals; Dermatologic Agents; Female; Guinea Pigs; Humans; Melanins; Melanocytes; Melanoma; Mice; Py | 2003 |
Toxicogenomics of kojic acid on gene expression profiling of a375 human malignant melanoma cells.
Topics: Antioxidants; Cell Line, Tumor; Cell Survival; Computational Biology; Gene Amplification; Gene Expre | 2006 |
Neoagarobiose as a novel moisturizer with whitening effect.
Topics: Animals; Arbutin; Disaccharides; Melanoma; Mice; Pyrones; Skin Care; Tumor Cells, Cultured; Wettabil | 1997 |