kojic acid has been researched along with Hyperpigmentation in 22 studies
Hyperpigmentation: Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Kojic acid and arbutin-loaded thermosensitive gel spray can prove to be a promising strategy to treat hyperpigmentation." | 3.96 | Novel user-friendly night care spray to manage skin darkening. ( Prabhu, D; Ravikumar, P, 2020) |
| " In the past several years, kojic acid has gained popularity as a skincare ingredient to treat hyperpigmentation and melasma." | 3.96 | Kojic Acid for Melasma: Popular Ingredient in Skincare Products. ( Saedi, N; Wang, JV; Zachary, CM, 2020) |
| " In this study we provide conclusive evidence of the inhibition mechanism of two well studied tyrosinase inhibitors, KA (kojic acid) and HQ (hydroquinone), which are extensively used in hyperpigmentation treatment." | 3.83 | The unravelling of the complex pattern of tyrosinase inhibition. ( Adir, N; Deri, B; Fishman, A; Goldfeder, M; Guallar, V; Kanteev, M; Lecina, D, 2016) |
| " The two hydroxydaidzeins reduced melanin synthesis comparably to treatment with kojic acid, a proven whitening agent, in B16 melanoma cells." | 3.78 | Effects of ortho-dihydroxyisoflavone derivatives from Korean fermented soybean paste on melanogenesis in B16 melanoma cells and human skin equivalents. ( Bae, JH; Goh, MJ; Kim, DH; Kim, HK; Na, YJ; Park, JS, 2012) |
| " It also inhibited melanin production by B16 melanoma cell line and normal human melanocytes more efficiently than kojic acid." | 3.77 | Dimeric cinnamoylamide derivatives as inhibitors of melanogenesis. ( Criton, M; Le Mellay-Hamon, V, 2011) |
| "The first-line treatment for hyperpigmentation involves topical formulations of conventional agents such as hydroquinone, kojic acid, and glycolic acid followed by oral formulations of therapeutic agents such as tranexamic acid, melatonin, and cysteamine hydrochloride." | 2.72 | Management of hyperpigmentation: Current treatments and emerging therapies. ( Nautiyal, A; Wairkar, S, 2021) |
| "Kojic acid (KA) is a natural metabolite produced by fungi that has the ability to inhibit tyrosinase activity in synthesis of melanin." | 2.61 | Kojic acid applications in cosmetic and pharmaceutical preparations. ( Eslamifar, M; Khezri, K; Saeedi, M, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (13.64) | 18.2507 |
| 2000's | 3 (13.64) | 29.6817 |
| 2010's | 11 (50.00) | 24.3611 |
| 2020's | 5 (22.73) | 2.80 |
| Authors | Studies |
|---|---|
| Ghani, U | 1 |
| Ullah, N | 1 |
| Tanveer, N | 1 |
| Khan, HMS | 1 |
| Akhtar, N | 1 |
| Prabhu, D | 1 |
| Ravikumar, P | 1 |
| Khezri, K | 2 |
| Saeedi, M | 2 |
| Morteza-Semnani, K | 1 |
| Akbari, J | 1 |
| Rostamkalaei, SS | 1 |
| Zachary, CM | 1 |
| Wang, JV | 1 |
| Saedi, N | 1 |
| Nautiyal, A | 1 |
| Wairkar, S | 1 |
| Eslamifar, M | 1 |
| Desai, S | 1 |
| Ayres, E | 1 |
| Bak, H | 1 |
| Manco, M | 1 |
| Lynch, S | 1 |
| Raab, S | 1 |
| Du, A | 1 |
| Green, D | 1 |
| Skobowiat, C | 1 |
| Wangari-Talbot, J | 1 |
| Zheng, Q | 1 |
| Shokeen, D | 1 |
| Deri, B | 1 |
| Kanteev, M | 1 |
| Goldfeder, M | 1 |
| Lecina, D | 1 |
| Guallar, V | 1 |
| Adir, N | 1 |
| Fishman, A | 1 |
| Abdel-Halim, OB | 1 |
| Marzouk, AM | 1 |
| Mothana, R | 1 |
| Awadh, N | 1 |
| Kai, H | 1 |
| Baba, M | 1 |
| Okuyama, T | 1 |
| García-Gavín, J | 1 |
| González-Vilas, D | 1 |
| Fernández-Redondo, V | 1 |
| Toribio, J | 1 |
| Criton, M | 1 |
| Le Mellay-Hamon, V | 1 |
| Cha, SH | 1 |
| Ko, SC | 1 |
| Kim, D | 1 |
| Jeon, YJ | 1 |
| Leyden, JJ | 1 |
| Shergill, B | 1 |
| Micali, G | 1 |
| Downie, J | 1 |
| Wallo, W | 1 |
| Goh, MJ | 1 |
| Park, JS | 1 |
| Bae, JH | 1 |
| Kim, DH | 1 |
| Kim, HK | 1 |
| Na, YJ | 1 |
| Kolbe, L | 1 |
| Mann, T | 1 |
| Gerwat, W | 1 |
| Batzer, J | 1 |
| Ahlheit, S | 1 |
| Scherner, C | 1 |
| Wenck, H | 1 |
| Stäb, F | 1 |
| Kong, YH | 1 |
| Jo, YO | 1 |
| Cho, CW | 1 |
| Son, D | 1 |
| Park, S | 1 |
| Rho, J | 1 |
| Choi, SY | 1 |
| Ellis, DA | 2 |
| Tan, AK | 2 |
| Ellis, CS | 1 |
| Serra-Baldrich, E | 1 |
| Tribó, MJ | 1 |
| Camarasa, JG | 1 |
5 reviews available for kojic acid and Hyperpigmentation
| Article | Year |
|---|---|
Management of hyperpigmentation: Current treatments and emerging therapies.
Topics: Glycolates; Humans; Hydroquinones; Hyperpigmentation; Pyrones; Skin | 2021 |
Kojic acid applications in cosmetic and pharmaceutical preparations.
Topics: Animals; Antifungal Agents; Antioxidants; Cosmetics; Free Radical Scavengers; Humans; Hyperpigmentat | 2019 |
Postinflammatory hyperpigmentation in patients with skin of color.
Topics: Chemexfoliation; Dermatitis; Dermatologic Agents; Dicarboxylic Acids; Drug Combinations; Ethanol; Gl | 2016 |
Natural options for the management of hyperpigmentation.
Topics: Administration, Topical; Arbutin; Cosmetics; Glycyrrhiza; Humans; Hyperpigmentation; Plant Extracts; | 2011 |
Superficial micropeels: glycolic acid and alpha-hydroxy acid with kojic acid.
Topics: Chemexfoliation; Clinical Protocols; Dermatologic Surgical Procedures; Glycolates; Humans; Hydroxy A | 1995 |
2 trials available for kojic acid and Hyperpigmentation
| Article | Year |
|---|---|
Effect of a Tranexamic Acid, Kojic Acid, and Niacinamide Containing Serum on Facial Dyschromia: A Clinical Evaluation
Topics: Administration, Cutaneous; Adult; Dermatologic Agents; Facial Dermatoses; Female; Humans; Hyperpigme | 2019 |
4-n-butylresorcinol, a highly effective tyrosinase inhibitor for the topical treatment of hyperpigmentation.
Topics: Administration, Topical; Aged; Arbutin; Female; Humans; Hydroquinones; Hyperpigmentation; Melanins; | 2013 |
15 other studies available for kojic acid and Hyperpigmentation
| Article | Year |
|---|---|
New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site.
Topics: Animals; Azoles; Bacterial Proteins; Catalytic Domain; Catechol Oxidase; Copper; Drug Design; Enzyme | 2010 |
Whitening effect of kojic acid dipalmitate loaded nanosized ethosomal gel for the treatment of hyperpigmentation: In vitro and in vivo characterization.
Topics: Administration, Cutaneous; Humans; Hyperpigmentation; Monophenol Monooxygenase; Skin; Skin Absorptio | 2022 |
Novel user-friendly night care spray to manage skin darkening.
Topics: Animals; Arbutin; Chick Embryo; Chorioallantoic Membrane; Cosmeceuticals; Drug Compounding; Drug Lib | 2020 |
An emerging technology in lipid research for targeting hydrophilic drugs to the skin in the treatment of hyperpigmentation disorders: kojic acid-solid lipid nanoparticles.
Topics: Animals; Drug Carriers; Drug Liberation; Humans; Hydrophobic and Hydrophilic Interactions; Hyperpigm | 2020 |
Kojic Acid for Melasma: Popular Ingredient in Skincare Products.
Topics: Dermatologic Agents; Facial Dermatoses; Humans; Hyperpigmentation; Melanosis; Nonprescription Drugs; | 2020 |
The unravelling of the complex pattern of tyrosinase inhibition.
Topics: Bacillus megaterium; Enzyme Inhibitors; Hydroquinones; Hyperpigmentation; Kinetics; Melanins; Monoph | 2016 |
A new tyrosinase inhibitor from Crinum yemense as potential treatment for hyperpigmentation.
Topics: Agaricus; Aldehydes; Crinum; Enzyme Inhibitors; Hyperpigmentation; Levodopa; Magnetic Resonance Spec | 2008 |
Inhibitory effect of Cucumis sativus on melanin production in melanoma B16 cells by downregulation of tyrosinase expression.
Topics: Animals; Antioxidants; Cucumis sativus; Hyperpigmentation; Melanins; Melanoma, Experimental; Mice; M | 2008 |
Pigmented contact dermatitis due to kojic acid. A paradoxical side effect of a skin lightener.
Topics: Cosmetics; Dermatitis, Contact; Female; Humans; Hyperpigmentation; Middle Aged; Pyrones; Skin Pigmen | 2010 |
Dimeric cinnamoylamide derivatives as inhibitors of melanogenesis.
Topics: Animals; Cell Line; Cell Line, Tumor; Coumaric Acids; Dermatologic Agents; Dimerization; Ethylenedia | 2011 |
Screening of marine algae for potential tyrosinase inhibitor: those inhibitors reduced tyrosinase activity and melanin synthesis in zebrafish.
Topics: Animals; Bleaching Agents; Cell Line; Drug Evaluation, Preclinical; Enzyme Inhibitors; Hyperpigmenta | 2011 |
Effects of ortho-dihydroxyisoflavone derivatives from Korean fermented soybean paste on melanogenesis in B16 melanoma cells and human skin equivalents.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Proliferation; Cell Survival; Enzyme Activation; Fe | 2012 |
Inhibitory effects of cinnamic acid on melanin biosynthesis in skin.
Topics: Animals; Antioxidants; Blotting, Western; Cell Survival; Cinnamates; Guinea Pigs; Hyperpigmentation; | 2008 |
How we do it: management of facial hyperpigmentation.
Topics: Chemexfoliation; Face; Humans; Hyperpigmentation; Laser Therapy; Pyrones | 1997 |
Allergic contact dermatitis from kojic acid.
Topics: Adult; Dermatitis, Allergic Contact; Female; Humans; Hyperpigmentation; Ointments; Patch Tests; Pyro | 1998 |