kojic acid has been researched along with B16 Melanoma in 39 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " The two hydroxydaidzeins reduced melanin synthesis comparably to treatment with kojic acid, a proven whitening agent, in B16 melanoma cells." | 3.78 | Effects of ortho-dihydroxyisoflavone derivatives from Korean fermented soybean paste on melanogenesis in B16 melanoma cells and human skin equivalents. ( Bae, JH; Goh, MJ; Kim, DH; Kim, HK; Na, YJ; Park, JS, 2012) |
| " It also inhibited melanin production by B16 melanoma cell line and normal human melanocytes more efficiently than kojic acid." | 3.77 | Dimeric cinnamoylamide derivatives as inhibitors of melanogenesis. ( Criton, M; Le Mellay-Hamon, V, 2011) |
| "SF inhibited melanin synthesis in B16 melanoma cells via down-regulation of MITF and tyrosinase expression, which provides a rationale for future utilization of SF." | 1.62 | Quantitative proteomic analysis uncovers inhibition of melanin synthesis by silk fibroin via MITF/tyrosinase axis in B16 melanoma cells. ( Duan, T; Hong, M; Huang, H; Lu, Z; Wang, Y; Xiao, X; Zheng, J; Zhou, H; Zhou, Y, 2021) |
| "Kojic acid (KA) is a naturally occurring fungal metabolite that is utilized as a skin-lightener and antibrowning agent owing to its potent tyrosinase inhibition activity." | 1.46 | Biodegradable Kojic Acid-Based Polymers: Controlled Delivery of Bioactives for Melanogenesis Inhibition. ( Faig, JJ; Joseph, LB; Moretti, A; Nova, MJ; Smith, K; Uhrich, KE; Zhang, Y, 2017) |
| "Flavokawain analogs were synthesized through a Claisen-Schmidt condensation of their corresponding acetophenones and benzaldehydes and were evaluated in terms of their tyrosinase inhibitory and anti-melanogenesis activities." | 1.42 | Flavokawains B and C, melanogenesis inhibitors, isolated from the root of Piper methysticum and synthesis of analogs. ( Choi, J; Hong, YD; Jeong, HJ; Ko, J; Lee, CS; Lee, JH; Lee, S; Park, JS; Shin, SS; Yoon, KD, 2015) |
| "Treatment with glycine (1-16 mM) for 72 h inhibited alpha-melanocyte stimulating hormone (alpha-MSH)-induced melanogenesis in a concentration-dependent manner without any effects on cell proliferation in B16F0 melanoma cells." | 1.34 | Glycine inhibits melanogenesis in vitro and causes hypopigmentation in vivo. ( Ishii, F; Ishikawa, M; Kawase, I, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.56) | 18.2507 |
| 2000's | 10 (25.64) | 29.6817 |
| 2010's | 27 (69.23) | 24.3611 |
| 2020's | 1 (2.56) | 2.80 |
| Authors | Studies |
|---|---|
| Yamazaki, Y | 1 |
| Kawano, Y | 1 |
| Yamanaka, A | 1 |
| Maruyama, S | 1 |
| Matsuda, H | 3 |
| Nakashima, S | 3 |
| Oda, Y | 3 |
| Nakamura, S | 3 |
| Yoshikawa, M | 3 |
| Thanigaimalai, P | 3 |
| Lee, KC | 3 |
| Bang, SC | 1 |
| Lee, JH | 2 |
| Yun, CY | 1 |
| Roh, E | 3 |
| Hwang, BY | 1 |
| Kim, Y | 4 |
| Jung, SH | 3 |
| Xu, F | 1 |
| Choi, J | 2 |
| Bae, SJ | 3 |
| Ha, YM | 5 |
| No, JK | 1 |
| Lee, EK | 2 |
| Lee, JS | 1 |
| Song, S | 2 |
| Lee, H | 3 |
| Suh, H | 2 |
| Yu, BP | 1 |
| Chung, HY | 7 |
| Park, JY | 3 |
| Park, YJ | 2 |
| Park, D | 2 |
| Choi, YJ | 1 |
| Kim, JM | 1 |
| Han, YK | 1 |
| Kim, JA | 2 |
| Lee, JY | 1 |
| Moon, HR | 6 |
| Sharma, VK | 2 |
| Joo, C | 1 |
| Cho, WJ | 1 |
| Bandgar, BP | 1 |
| Adsul, LK | 1 |
| Chavan, HV | 1 |
| Shringare, SN | 1 |
| Korbad, BL | 1 |
| Jalde, SS | 1 |
| Lonikar, SV | 1 |
| Nile, SH | 1 |
| Shirfule, AL | 1 |
| Oode, C | 1 |
| Shimada, W | 1 |
| Izutsu, Y | 1 |
| Yokota, M | 1 |
| Iwadate, T | 1 |
| Nihei, K | 1 |
| Jeong, HJ | 1 |
| Lee, CS | 1 |
| Hong, YD | 1 |
| Shin, SS | 1 |
| Park, JS | 2 |
| Lee, S | 2 |
| Yoon, KD | 1 |
| Ko, J | 1 |
| Liu, J | 1 |
| Onishi, K | 1 |
| Kawabata, M | 1 |
| Miki, H | 1 |
| Himuro, Y | 1 |
| Wang, Y | 1 |
| Duan, T | 1 |
| Hong, M | 2 |
| Zhou, Y | 1 |
| Huang, H | 1 |
| Xiao, X | 1 |
| Zheng, J | 2 |
| Zhou, H | 1 |
| Lu, Z | 1 |
| Chen, YM | 1 |
| Su, WC | 1 |
| Li, C | 1 |
| Shi, Y | 1 |
| Chen, QX | 1 |
| Tang, DL | 1 |
| Chen, SM | 1 |
| Wang, Q | 1 |
| Bang, E | 1 |
| Noh, SG | 1 |
| Ha, S | 1 |
| Jung, HJ | 1 |
| Kim, DH | 4 |
| Lee, AK | 1 |
| Hyun, MK | 1 |
| Kang, D | 1 |
| Park, C | 1 |
| Ai, N | 1 |
| Welsh, WJ | 1 |
| Santhanam, U | 1 |
| Hu, H | 1 |
| Lyga, J | 1 |
| Park, MH | 1 |
| Kim, SJ | 2 |
| Jeong, HO | 1 |
| Moon, KM | 1 |
| Son, S | 2 |
| Kim, HR | 1 |
| Kim, MJ | 1 |
| Yun, HY | 2 |
| Chun, P | 4 |
| Je, NK | 1 |
| Yokozawa, T | 2 |
| Ullah, S | 1 |
| Kim, YJ | 2 |
| Yoo, JW | 1 |
| Jung, Y | 1 |
| Maack, A | 1 |
| Pegard, A | 1 |
| Chen, MJ | 1 |
| Hung, CC | 2 |
| Chen, YR | 1 |
| Lai, ST | 1 |
| Chan, CF | 1 |
| Reddy, TL | 1 |
| Garikapati, KR | 1 |
| Reddy, SG | 1 |
| Reddy, BV | 1 |
| Yadav, JS | 1 |
| Bhadra, U | 1 |
| Bhadra, MP | 1 |
| Faig, JJ | 1 |
| Moretti, A | 1 |
| Joseph, LB | 1 |
| Zhang, Y | 1 |
| Nova, MJ | 1 |
| Smith, K | 1 |
| Uhrich, KE | 1 |
| Nesterov, A | 1 |
| Zhao, J | 1 |
| Minter, D | 1 |
| Hertel, C | 1 |
| Ma, W | 1 |
| Abeysinghe, P | 1 |
| Jia, Q | 1 |
| Kai, H | 1 |
| Baba, M | 1 |
| Okuyama, T | 1 |
| Zhang, X | 1 |
| Hu, X | 1 |
| Hou, A | 1 |
| Wang, H | 1 |
| An, SM | 1 |
| Koh, JS | 1 |
| Boo, YC | 1 |
| Miyake, M | 1 |
| Yamamoto, S | 1 |
| Sano, O | 1 |
| Fujii, M | 1 |
| Kohno, K | 1 |
| Ushio, S | 1 |
| Iwaki, K | 1 |
| Fukuda, S | 1 |
| Criton, M | 1 |
| Le Mellay-Hamon, V | 1 |
| Wang, YW | 1 |
| Jou, CH | 1 |
| Yang, MC | 1 |
| Goh, MJ | 1 |
| Bae, JH | 1 |
| Kim, HK | 1 |
| Na, YJ | 1 |
| Lajis, AF | 1 |
| Hamid, M | 1 |
| Ariff, AB | 1 |
| Song, YM | 1 |
| Ha, TK | 2 |
| Park, NH | 1 |
| Ohguchi, K | 1 |
| Tanaka, T | 1 |
| Iliya, I | 1 |
| Ito, T | 1 |
| Iinuma, M | 1 |
| Matsumoto, K | 1 |
| Akao, Y | 1 |
| Nozawa, Y | 1 |
| Chung, SW | 1 |
| Ishikawa, M | 1 |
| Kawase, I | 1 |
| Ishii, F | 1 |
| Kim, YM | 1 |
| Yun, J | 1 |
| Lee, CK | 1 |
| Min, KR | 1 |
| Mishima, Y | 1 |
1 review available for kojic acid and B16 Melanoma
| Article | Year |
|---|---|
A post melanosomal era: control of melanogenesis and melanoma growth.
Topics: Adolescent; Animals; Boron; Boron Compounds; Cricetinae; Fatty Acids, Unsaturated; Gene Expression R | 1992 |
38 other studies available for kojic acid and B16 Melanoma
| Article | Year |
|---|---|
N-[(Dihydroxyphenyl)acyl]serotonins as potent inhibitors of tyrosinase from mouse and human melanoma cells.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Enz | 2009 |
Melanogenesis inhibitors from the rhizomes of Alpinia officinarum in B16 melanoma cells.
Topics: Alpinia; Animals; Antineoplastic Agents; Enzyme Inhibitors; Flavonoids; Kaempferols; Melanoma, Exper | 2009 |
Evaluation of 3,4-dihydroquinazoline-2(1H)-thiones as inhibitors of alpha-MSH-induced melanin production in melanoma B16 cells.
Topics: alpha-MSH; Animals; Cell Line, Tumor; Drug Evaluation, Preclinical; Magnetic Resonance Spectroscopy; | 2010 |
Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells.
Topics: Agaricales; Animals; Antineoplastic Agents; Brassicaceae; Cell Proliferation; Cell Survival; Drug Sc | 2010 |
A newly synthesized, potent tyrosinase inhibitor: 5-(6-hydroxy-2-naphthyl)-1,2,3-benzenetriol.
Topics: Agaricales; Animals; Enzyme Inhibitors; Kinetics; Melanins; Melanoma, Experimental; Mice; Monophenol | 2010 |
Synthesis and biological activity of hydroxy substituted phenyl-benzo[d]thiazole analogues for antityrosinase activity in B16 cells.
Topics: Agaricales; Animals; Benzothiazoles; Binding Sites; Catalytic Domain; Cell Line, Tumor; Computer Sim | 2011 |
Ketonethiosemicarbazones: structure-activity relationships for their melanogenesis inhibition.
Topics: Animals; Cell Line, Tumor; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Ke | 2011 |
Structural requirement of phenylthiourea analogs for their inhibitory activity of melanogenesis and tyrosinase.
Topics: Agaricales; Animals; Catalytic Domain; Cell Line, Tumor; Enzyme Inhibitors; Humans; Melanins; Melano | 2011 |
Synthesis, biological evaluation, and molecular docking of N-{3-[3-(9-methyl-9H-carbazol-3-yl)-acryloyl]-phenyl}-benzamide/amide derivatives as xanthine oxidase and tyrosinase inhibitors.
Topics: Animals; Benzamides; Carbazoles; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; | 2012 |
Synthesis of dihydroresveratrol glycosides and evaluation of their activity against melanogenesis in B16F0 melanoma cells.
Topics: Animals; Cell Line, Tumor; Drug Screening Assays, Antitumor; Glycosides; Magnetic Resonance Spectros | 2014 |
Flavokawains B and C, melanogenesis inhibitors, isolated from the root of Piper methysticum and synthesis of analogs.
Topics: Animals; Flavonoids; Humans; Kava; Melanins; Melanoma, Experimental; Mice; Structure-Activity Relati | 2015 |
Inhibitors of melanogenesis in B16 melanoma 4A5 cells from flower buds of Lawsonia inermis (Henna).
Topics: Animals; Antifibrinolytic Agents; Cell Line, Tumor; Cell Proliferation; Flavonoids; Flowers; Humans; | 2015 |
Quantitative proteomic analysis uncovers inhibition of melanin synthesis by silk fibroin via MITF/tyrosinase axis in B16 melanoma cells.
Topics: Animals; Fibroins; Melanins; Melanoma, Experimental; Mice; Microphthalmia-Associated Transcription F | 2021 |
Anti-melanogenesis of novel kojic acid derivatives in B16F10 cells and zebrafish.
Topics: Agaricales; Animals; Cell Shape; Melanins; Melanoma, Experimental; Mice; Microphthalmia-Associated T | 2019 |
Evaluation of the Novel Synthetic Tyrosinase Inhibitor (
Topics: Agaricales; Animals; Cell Survival; Chromans; Computer Simulation; Drug Design; Enzyme Inhibitors; I | 2018 |
Novel virtual screening approach for the discovery of human tyrosinase inhibitors.
Topics: Agaricales; Algorithms; Animals; Cell Line, Tumor; Drug Discovery; Enzyme Inhibitors; Fungal Protein | 2014 |
Inhibition of melanogenesis by 2-[4-(5-chlorobenzo[d]thiazol-2-yl)phenoxy]-2-methylpropanoic acid (MHY908).
Topics: Agaricales; Animals; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Melanins; M | 2015 |
Design, synthesis, and anti-melanogenic effects of (E)-2-benzoyl-3-(substituted phenyl)acrylonitriles.
Topics: Acrylonitrile; Agaricales; Animals; Binding Sites; Cell Line, Tumor; Dose-Response Relationship, Dru | 2015 |
Populus nigra (Salicaceae) absolute rich in phenolic acids, phenylpropanoïds and flavonoids as a new potent tyrosinase inhibitor.
Topics: Agaricales; Animals; Flavonoids; Humans; Hydroxybenzoates; Melanins; Melanocytes; Melanoma, Experime | 2016 |
Novel synthetic kojic acid-methimazole derivatives inhibit mushroom tyrosinase and melanogenesis.
Topics: Agaricales; Animals; Biphenyl Compounds; Chick Embryo; Enzyme Inhibitors; Melanins; Melanoma, Experi | 2016 |
Simultaneous delivery of Paclitaxel and Bcl-2 siRNA via pH-Sensitive liposomal nanocarrier for the synergistic treatment of melanoma.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Drug Compounding; Drug Deli | 2016 |
Biodegradable Kojic Acid-Based Polymers: Controlled Delivery of Bioactives for Melanogenesis Inhibition.
Topics: Animals; Biocompatible Materials; Cell Survival; Drug Delivery Systems; Melanins; Melanoma, Experime | 2017 |
1-(2,4-dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylphenyl)propane, a novel tyrosinase inhibitor with strong depigmenting effects.
Topics: Agaricales; Animals; Antioxidants; Cell Line; Dermatologic Agents; Enzyme Inhibitors; Kinetics; Lili | 2008 |
Inhibitory effect of Cucumis sativus on melanin production in melanoma B16 cells by downregulation of tyrosinase expression.
Topics: Animals; Antioxidants; Cucumis sativus; Hyperpigmentation; Melanins; Melanoma, Experimental; Mice; M | 2008 |
Inhibitory effect of 2,4,2',4'-tetrahydroxy-3-(3-methyl-2-butenyl)-chalcone on tyrosinase activity and melanin biosynthesis.
Topics: alpha-MSH; Animals; Antioxidants; Cell Line, Tumor; Cell Survival; Chalcone; Dopamine Agents; Dose-R | 2009 |
p-coumaric acid not only inhibits human tyrosinase activity in vitro but also melanogenesis in cells exposed to UVB.
Topics: Agaricales; Animals; Arbutin; Cells, Cultured; Coumaric Acids; Dihydroxyphenylalanine; Epidermal Cel | 2010 |
Inhibitory effects of 2-amino-3H-phenoxazin-3-one on the melanogenesis of murine B16 melanoma cell line.
Topics: Agaricales; Animals; Cell Line, Tumor; Indoles; Melanins; Melanoma; Melanoma, Experimental; Mice; Mi | 2010 |
Dimeric cinnamoylamide derivatives as inhibitors of melanogenesis.
Topics: Animals; Cell Line; Cell Line, Tumor; Coumaric Acids; Dermatologic Agents; Dimerization; Ethylenedia | 2011 |
Cellular fusion and whitening effect of a chitosan derivative coated liposome.
Topics: Animals; Antioxidants; Cell Fusion; Cell Line, Tumor; Cell Proliferation; Chitin; Cholesterol; Fibro | 2012 |
Effects of ortho-dihydroxyisoflavone derivatives from Korean fermented soybean paste on melanogenesis in B16 melanoma cells and human skin equivalents.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Proliferation; Cell Survival; Enzyme Activation; Fe | 2012 |
Depigmenting effect of Kojic acid esters in hyperpigmented B16F1 melanoma cells.
Topics: Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; Esters; Melanins; Melanoma, Experimenta | 2012 |
Design, synthesis, and evaluation of (E)-N-substituted benzylidene-aniline derivatives as tyrosinase inhibitors.
Topics: Agaricales; alpha-MSH; Aniline Compounds; Animals; Antineoplastic Agents; Benzylidene Compounds; Cat | 2012 |
A novel synthesized tyrosinase inhibitor: (E)-2-((2,4-dihydroxyphenyl)diazenyl)phenyl 4-methylbenzenesulfonate as an azo-resveratrol analog.
Topics: Animals; Azo Compounds; Benzenesulfonates; Cell Line, Tumor; Cell Survival; Dose-Response Relationsh | 2013 |
Gnetol as a potent tyrosinase inhibitor from genus Gnetum.
Topics: Animals; Gnetum; Inhibitory Concentration 50; Melanins; Melanoma, Experimental; Mice; Peptides; Pyro | 2003 |
4-(6-Hydroxy-2-naphthyl)-1,3-bezendiol: a potent, new tyrosinase inhibitor.
Topics: Agaricales; Animals; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydroquinon | 2007 |
Piceatannol inhibits melanogenesis by its antioxidative actions.
Topics: Animals; Antioxidants; Cell Line, Tumor; Dose-Response Relationship, Drug; Down-Regulation; Glutathi | 2007 |
Glycine inhibits melanogenesis in vitro and causes hypopigmentation in vivo.
Topics: alpha-MSH; Amino Acids; Animals; Antioxidants; Cell Line, Tumor; Dose-Response Relationship, Drug; F | 2007 |
Oxyresveratrol and hydroxystilbene compounds. Inhibitory effect on tyrosinase and mechanism of action.
Topics: Agaricales; Animals; Antioxidants; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Kinet | 2002 |