knk-437 has been researched along with Multiple-Myeloma* in 2 studies
2 other study(ies) available for knk-437 and Multiple-Myeloma
| Article | Year |
|---|---|
Heat shock factor 1 is a potent therapeutic target for enhancing the efficacy of treatments for multiple myeloma with adverse prognosis.
Deregulated expression of heat shock proteins (HSPs) encoding genes is frequent in multiple myeloma. HSPs, which are molecular chaperones involved in protein homeostasis pathways, have emerged recently as promising therapeutic targets. Using human myeloma cell lines and primary myeloma cells belonging to various molecular groups, we tested the efficacy of HSP90, HSP70, and heat shock factor 1 (HSF1) inhibitors alone or associated with current antimyeloma drugs. We report here that KNK-437 (an inhibitor of HSF1) and bortezomib have additive effects on apoptosis induction in cells belonging to groups with bad prognosis. Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzhydryl Compounds; Blotting, Western; Bortezomib; Cell Line, Tumor; Cells, Cultured; DNA-Binding Proteins; Heat Shock Transcription Factors; Humans; Multiple Myeloma; Pyrrolidinones; Transcription Factors | 2015 |
Targeting heat shock protein 72 enhances Hsp90 inhibitor-induced apoptosis in myeloma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzhydryl Compounds; Benzoquinones; Blotting, Western; Cell Cycle; Cell Proliferation; Drug Synergism; HSP72 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Multiple Myeloma; Pyrrolidinones; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Transcription Factor CHOP; Tumor Cells, Cultured | 2010 |