knk-437 and Mouth-Neoplasms

knk-437 has been researched along with Mouth-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for knk-437 and Mouth-Neoplasms

Article	Year
Effects of KNK437 on heat-induced methylation of histone H3 in human oral squamous cell carcinoma cells. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 2006, Volume: 22, Issue:8 Methylation of H3 at lysine 4 (H3 Lys4) may be correlated with active gene trascription, whereas methylation of H3 at lysine 9 (H3 Lys9) may be linked to gene repression in murine cells and Schizosaccharomyces pombe.. Using Western blot analysis, heat-induced changes were studied in two human oral cancer cell lines, HSC4 (thermoresistant cells) and KB (thermosensitive cells). Histone H3 changes were studied; in particular for H3-Lys4 and H3-Lys9 methylation combined with KNK437.. Heating of HSC4 cells at 45 degrees C for 20 min and KB cells for 3 min gradually increased H3-Lys4 and H3-Lys9 methylation. Treatment of both cells with 100 microM KNK437 before or after heat-treatment inhibited methylation of H3-Lys4, while methylation of H3 Lys9 remained unaffected. Use of KNK437 either before or after heat treatment inhibited the expression of HSP70.. The findings suggest that heat-induced methylation of histone H3 may be correlated with the induction of HSPs by heating. Topics: Benzhydryl Compounds; Cell Line, Tumor; Heat-Shock Proteins; Histones; Humans; Hyperthermia, Induced; KB Cells; Methylation; Mouth Neoplasms; Neoplasms, Squamous Cell; Pyrrolidinones	2006

Article

Year

Effects of KNK437 on heat-induced methylation of histone H3 in human oral squamous cell carcinoma cells.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 2006, Volume: 22, Issue:8

Methylation of H3 at lysine 4 (H3 Lys4) may be correlated with active gene trascription, whereas methylation of H3 at lysine 9 (H3 Lys9) may be linked to gene repression in murine cells and Schizosaccharomyces pombe.. Using Western blot analysis, heat-induced changes were studied in two human oral cancer cell lines, HSC4 (thermoresistant cells) and KB (thermosensitive cells). Histone H3 changes were studied; in particular for H3-Lys4 and H3-Lys9 methylation combined with KNK437.. Heating of HSC4 cells at 45 degrees C for 20 min and KB cells for 3 min gradually increased H3-Lys4 and H3-Lys9 methylation. Treatment of both cells with 100 microM KNK437 before or after heat-treatment inhibited methylation of H3-Lys4, while methylation of H3 Lys9 remained unaffected. Use of KNK437 either before or after heat treatment inhibited the expression of HSP70.. The findings suggest that heat-induced methylation of histone H3 may be correlated with the induction of HSPs by heating.

Topics: Benzhydryl Compounds; Cell Line, Tumor; Heat-Shock Proteins; Histones; Humans; Hyperthermia, Induced; KB Cells; Methylation; Mouth Neoplasms; Neoplasms, Squamous Cell; Pyrrolidinones

2006