kn-93 and Colonic-Neoplasms

kn-93 has been researched along with Colonic-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for kn-93 and Colonic-Neoplasms

ArticleYear
Activation of Ca2+/calmodulin-dependent protein kinase II is involved in hyperosmotic induction of the human taurine transporter.
    FEBS letters, 2004, Jul-02, Volume: 569, Issue:1-3

    We investigated the signaling pathways participating in hyperosmotic regulation of the human taurine transporter (TAUT) by using specific inhibitors of various intracellular signaling molecules. Among them, the specific inhibitor of calcium/calmodulin-dependent protein kinase II (Ca(2+)/CaM kinase II) completely repressed the hyperosmotic regulation of TAUT. The osmosensitive upregulation of TAUT was also significantly inhibited by calmodulin antagonists and calcium-chelators. The increased expression level of TAUT mRNA by hypertonicity was repressed by the specific Ca(2+)/CaM kinase II inhibitor. The activated form of Ca(2+)/CaM kinase II protein could only be detected in Caco-2 cells under hypertonic conditions.

    Topics: Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cell Line, Tumor; Colonic Neoplasms; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Kinetics; Membrane Glycoproteins; Membrane Transport Proteins; Osmolar Concentration; Pyridines; RNA, Messenger; Sulfonamides

2004