kn-93 has been researched along with Cardiotoxicity* in 1 studies
1 other study(ies) available for kn-93 and Cardiotoxicity
| Article | Year |
|---|---|
Thioridazine Induces Cardiotoxicity via Reactive Oxygen Species-Mediated hERG Channel Deficiency and L-Type Calcium Channel Activation.
Thioridazine (THIO) is a phenothiazine derivative that is mainly used for the treatment of psychotic disorders. However, cardiac arrhythmias especially QT interval prolongation associated with the application of this compound have received serious attention after its introduction into clinical practice, and the mechanisms underlying the cardiotoxicity induced by THIO have not been well defined. The present study was aimed at exploring the long-term effects of THIO on the hERG and L-type calcium channels, both of which are relevant to the development of QT prolongation. The hERG current ( Topics: Action Potentials; Animals; Benzylamines; Calcium; Calcium Channels, L-Type; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cardiotoxicity; Endoplasmic Reticulum Stress; Ether-A-Go-Go Potassium Channels; Heart Ventricles; HEK293 Cells; HSP70 Heat-Shock Proteins; Humans; Induced Pluripotent Stem Cells; Male; Mice; Myocytes, Cardiac; Proteasome Endopeptidase Complex; Rats; Reactive Oxygen Species; Sulfonamides; Thioridazine; Ubiquitination | 2020 |