kn-62 and Zika-Virus-Infection

kn-62 has been researched along with Zika-Virus-Infection* in 1 studies

Other Studies

1 other study(ies) available for kn-62 and Zika-Virus-Infection

Article	Year
Benzenesulfonamide Derivatives as Calcium/Calmodulin-Dependent Protein Kinase Inhibitors and Antiviral Agents against Dengue and Zika Virus Infections. Journal of medicinal chemistry, 2020, 02-13, Volume: 63, Issue:3 Emerging and resurging mosquito-borne flaviviruses are an important public health challenge. The increased prevalence of dengue virus (DENV) infection has had a significant socioeconomic impact on epidemic countries. The recent outbreak of Zika virus (ZIKV) has created an international public health emergency because ZIKV infection has been linked to congenital defects and Guillain-Barré syndrome. To develop potentially prophylactic antiviral drugs for combating these acute infectious diseases, we have targeted the host calcium/calmodulin-dependent kinase II (CaMKII) for inhibition. By using CaMKII structure-guided inhibitor design, we generated four families of benzenesulfonamide (BSA) derivatives for SAR analysis. Among these substances, Topics: Animals; Antiviral Agents; Catalytic Domain; Dengue; Dengue Virus; Drug Design; Humans; Mice; Molecular Docking Simulation; Molecular Structure; Protein Binding; Protein Kinase Inhibitors; Proteins; Structure-Activity Relationship; Sulfonamides; Zika Virus; Zika Virus Infection	2020

Article

Year

Benzenesulfonamide Derivatives as Calcium/Calmodulin-Dependent Protein Kinase Inhibitors and Antiviral Agents against Dengue and Zika Virus Infections.

Journal of medicinal chemistry, 2020, 02-13, Volume: 63, Issue:3

Emerging and resurging mosquito-borne flaviviruses are an important public health challenge. The increased prevalence of dengue virus (DENV) infection has had a significant socioeconomic impact on epidemic countries. The recent outbreak of Zika virus (ZIKV) has created an international public health emergency because ZIKV infection has been linked to congenital defects and Guillain-Barré syndrome. To develop potentially prophylactic antiviral drugs for combating these acute infectious diseases, we have targeted the host calcium/calmodulin-dependent kinase II (CaMKII) for inhibition. By using CaMKII structure-guided inhibitor design, we generated four families of benzenesulfonamide (BSA) derivatives for SAR analysis. Among these substances,

Topics: Animals; Antiviral Agents; Catalytic Domain; Dengue; Dengue Virus; Drug Design; Humans; Mice; Molecular Docking Simulation; Molecular Structure; Protein Binding; Protein Kinase Inhibitors; Proteins; Structure-Activity Relationship; Sulfonamides; Zika Virus; Zika Virus Infection

2020