kn-62 and Lymphoma

kn-62 has been researched along with Lymphoma* in 1 studies

Other Studies

1 other study(ies) available for kn-62 and Lymphoma

Article	Year
Targeting P2X₇ receptor inhibits the metastasis of murine P388D1 lymphoid neoplasm cells to lymph nodes. Cell biology international, 2010, Volume: 34, Issue:12 The P2X₇R (P2X₇ receptor) is an ATP-gated cation channel expressed in normal cells that participates in both cell proliferation and apoptosis. Here, we have confirmed P2X₇R expression on murine P388D1 lymphoid neoplasm cells. In addition, ATP-stimulated P2X₇R expression was found to trigger increased intracellular calcium flux. Furthermore, silencing with short hairpin RNA and blocking with P2X₇R antibody significantly reduced the metastasis of P388D1 cells to lymph nodes. These results indicate that inhibition of the expression and function of P2X₇R attenuates the metastatic ability of murine lymphoid neoplasm cell line P388D1, which represents a new potential target for anti-metastatic therapy. Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line, Tumor; Lymph Nodes; Lymphatic Metastasis; Lymphocytes; Lymphoma; Mice; Mice, Inbred DBA; Molecular Targeted Therapy; Neoplasm Transplantation; Purinergic P2X Receptor Antagonists; Receptors, Purinergic P2X7; RNA, Small Interfering	2010

Article

Year

Targeting P2X₇ receptor inhibits the metastasis of murine P388D1 lymphoid neoplasm cells to lymph nodes.

Cell biology international, 2010, Volume: 34, Issue:12

The P2X₇R (P2X₇ receptor) is an ATP-gated cation channel expressed in normal cells that participates in both cell proliferation and apoptosis. Here, we have confirmed P2X₇R expression on murine P388D1 lymphoid neoplasm cells. In addition, ATP-stimulated P2X₇R expression was found to trigger increased intracellular calcium flux. Furthermore, silencing with short hairpin RNA and blocking with P2X₇R antibody significantly reduced the metastasis of P388D1 cells to lymph nodes. These results indicate that inhibition of the expression and function of P2X₇R attenuates the metastatic ability of murine lymphoid neoplasm cell line P388D1, which represents a new potential target for anti-metastatic therapy.

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line, Tumor; Lymph Nodes; Lymphatic Metastasis; Lymphocytes; Lymphoma; Mice; Mice, Inbred DBA; Molecular Targeted Therapy; Neoplasm Transplantation; Purinergic P2X Receptor Antagonists; Receptors, Purinergic P2X7; RNA, Small Interfering

2010