kme-4 and Asthma
kme-4 has been researched along with Asthma* in 1 studies
Other Studies
1 other study(ies) available for kme-4 and Asthma
| Article | Year |
|---|---|
Studies on hindered phenols and analogues. 2. 1,3-Benzoxathioles having SRS-A inhibiting activity.
A series of hindered phenolic 1,3-benzoxathioles (7a-l) were prepared and investigated for biological properties. Many compounds had LPO-lowering, antisuperoxide inhibiting, SRS-A inhibiting, and 5-lipoxygenase inhibiting activities. Among them, 5-hydroxy-4,6,7-trimethyl-2-propyl-1,3-benzoxathiole (7d) and 3-(5-hydroxy-4,6,7-trimethyl-1,3-benzoxathiol-2-yl)propanol (7j) were most potent in SRS-A inhibiting and 5-lipoxygenase inhibiting activities, respectively, and were selected for further development as candidate drugs for the treatment of asthma. Topics: Animals; Asthma; Benzoxazoles; Chemical Phenomena; Chemistry; Guinea Pigs; Lipid Peroxidation; Lipoxygenase Inhibitors; Mice; Mice, Inbred C57BL; SRS-A; Structure-Activity Relationship | 1990 |