kiss1-protein--human and Starvation

kiss1-protein--human has been researched along with Starvation* in 2 studies

Other Studies

2 other study(ies) available for kiss1-protein--human and Starvation

Article	Year
AgRP to Kiss1 neuron signaling links nutritional state and fertility. Proceedings of the National Academy of Sciences of the United States of America, 2017, 02-28, Volume: 114, Issue:9 Mammalian reproductive function depends upon a neuroendocrine circuit that evokes the pulsatile release of gonadotropin hormones (luteinizing hormone and follicle-stimulating hormone) from the pituitary. This reproductive circuit is sensitive to metabolic perturbations. When challenged with starvation, insufficient energy reserves attenuate gonadotropin release, leading to infertility. The reproductive neuroendocrine circuit is well established, composed of two populations of kisspeptin-expressing neurons (located in the anteroventral periventricular hypothalamus, Kiss1 Topics: Agouti-Related Protein; Animals; Circadian Clocks; Clozapine; Estrous Cycle; Female; Fertility; Gene Expression Regulation; Gonadotropin-Releasing Hormone; Hypothalamus; Kisspeptins; Leptin; Luteinizing Hormone; Male; Mice; Mice, Transgenic; Neurons; Optogenetics; Reproduction; Signal Transduction; Starvation; Stereotaxic Techniques	2017
FGF21 contributes to neuroendocrine control of female reproduction. Nature medicine, 2013, Volume: 19, Issue:9 Preventing reproduction during nutritional deprivation is an adaptive process that is conserved and essential for the survival of species. In mammals, the mechanisms that inhibit fertility during starvation are complex and incompletely understood. Here we show that exposure of female mice to fibroblast growth factor 21 (FGF21), a fasting-induced hepatokine, mimics infertility secondary to starvation. Mechanistically, FGF21 acts on the suprachiasmatic nucleus (SCN) in the hypothalamus to suppress the vasopressin-kisspeptin signaling cascade, thereby inhibiting the proestrus surge in luteinizing hormone. Mice lacking the FGF21 co-receptor, β-Klotho, in the SCN are refractory to the inhibitory effect of FGF21 on female fertility. Thus, FGF21 defines an important liver-neuroendocrine axis that modulates female reproduction in response to nutritional challenge. Topics: Animals; Energy Metabolism; Female; Fibroblast Growth Factors; Hypothalamus; Infertility, Female; Kisspeptins; Klotho Proteins; Luteinizing Hormone; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Proestrus; Reproduction; Signal Transduction; Starvation; Suprachiasmatic Nucleus; Vasopressins	2013

Article

Year

AgRP to Kiss1 neuron signaling links nutritional state and fertility.

Proceedings of the National Academy of Sciences of the United States of America, 2017, 02-28, Volume: 114, Issue:9

Mammalian reproductive function depends upon a neuroendocrine circuit that evokes the pulsatile release of gonadotropin hormones (luteinizing hormone and follicle-stimulating hormone) from the pituitary. This reproductive circuit is sensitive to metabolic perturbations. When challenged with starvation, insufficient energy reserves attenuate gonadotropin release, leading to infertility. The reproductive neuroendocrine circuit is well established, composed of two populations of kisspeptin-expressing neurons (located in the anteroventral periventricular hypothalamus, Kiss1

Topics: Agouti-Related Protein; Animals; Circadian Clocks; Clozapine; Estrous Cycle; Female; Fertility; Gene Expression Regulation; Gonadotropin-Releasing Hormone; Hypothalamus; Kisspeptins; Leptin; Luteinizing Hormone; Male; Mice; Mice, Transgenic; Neurons; Optogenetics; Reproduction; Signal Transduction; Starvation; Stereotaxic Techniques

2017

FGF21 contributes to neuroendocrine control of female reproduction.

Nature medicine, 2013, Volume: 19, Issue:9

Preventing reproduction during nutritional deprivation is an adaptive process that is conserved and essential for the survival of species. In mammals, the mechanisms that inhibit fertility during starvation are complex and incompletely understood. Here we show that exposure of female mice to fibroblast growth factor 21 (FGF21), a fasting-induced hepatokine, mimics infertility secondary to starvation. Mechanistically, FGF21 acts on the suprachiasmatic nucleus (SCN) in the hypothalamus to suppress the vasopressin-kisspeptin signaling cascade, thereby inhibiting the proestrus surge in luteinizing hormone. Mice lacking the FGF21 co-receptor, β-Klotho, in the SCN are refractory to the inhibitory effect of FGF21 on female fertility. Thus, FGF21 defines an important liver-neuroendocrine axis that modulates female reproduction in response to nutritional challenge.

Topics: Animals; Energy Metabolism; Female; Fibroblast Growth Factors; Hypothalamus; Infertility, Female; Kisspeptins; Klotho Proteins; Luteinizing Hormone; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Proestrus; Reproduction; Signal Transduction; Starvation; Suprachiasmatic Nucleus; Vasopressins

2013