kiss1-protein--human and Acute-Kidney-Injury

Kisspeptin is biologically active peptide encoded by the KISS1 gene that is structurally found in the kidney tubule, collecting duct and vein smooth muscle cells.. We aimed to investigate the role of kisspeptin in kidney function and renal pathophysiology in experimental kidney ischemia/reperfusion (I/R) injury.. Male Spraque-Dawley rats were divided into control and I/R groups (n=8). Both kidney vessels of I/R group rats were clamped and subjected to ischemia for 60 minutes and reperfusion for 48 hours. After the reperfusion period blood samples and kidney tissue were collected under anesthesia.. Levels of urea, creatinine (.. The present study has shown that the levels of kisspeptin change in kidney damage and thus the kisspeptin may play a role in the regulation of renal function and in the pathophysiology of acute kidney injury.

Topics: Acute Kidney Injury; Aldosterone; Angiotensin II; Animals; Arginine; Cell Adhesion Molecules; Creatinine; Glutathione; Glutathione Disulfide; Kidney; Kisspeptins; Male; Malondialdehyde; Nitric Oxide; Rats; Rats, Sprague-Dawley; Reperfusion Injury