kinetin has been researched along with Dysautonomia, Familial in 13 studies
Kinetin: A furanyl adenine found in PLANTS and FUNGI. It has plant growth regulation effects.
cytokinin : A phytohormone that promote cell division, or cytokinesis, in plant roots and shoots.
kinetin : A member of the class of 6-aminopurines that is adenine carrying a (furan-2-ylmethyl) substituent at the exocyclic amino group.
Dysautonomia, Familial: An autosomal disorder of the peripheral and autonomic nervous systems limited to individuals of Ashkenazic Jewish descent. Clinical manifestations are present at birth and include diminished lacrimation, defective thermoregulation, orthostatic hypotension (HYPOTENSION, ORTHOSTATIC), fixed pupils, excessive SWEATING, loss of pain and temperature sensation, and absent reflexes. Pathologic features include reduced numbers of small diameter peripheral nerve fibers and autonomic ganglion neurons. (From Adams et al., Principles of Neurology, 6th ed, p1348; Nat Genet 1993;4(2):160-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pridopidine has an additive effect on IKAP levels when used in combination with kinetin or TSA, but not with PS; suggesting that PS and pridopidine influence IKBKAP levels through the same mechanism." | 1.51 | Combinatorial treatment increases IKAP levels in human cells generated from Familial Dysautonomia patients. ( Ast, G; Donyo, M; Yannai, S; Zonszain, J, 2019) |
| " In the highest dosing cohorts (23." | 1.35 | Kinetin in familial dysautonomia carriers: implications for a new therapeutic strategy targeting mRNA splicing. ( Axelrod, FB; Gold-von Simson, G; Goldberg, JD; Leyne, M; Mull, J; Rolnitzky, LM; Slaugenhaupt, SA; Voustianiouk, A, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 7 (53.85) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Morini, E | 3 |
| Chekuri, A | 1 |
| Logan, EM | 1 |
| Bolduc, JM | 1 |
| Kirchner, EG | 1 |
| Salani, M | 3 |
| Krauson, AJ | 1 |
| Narasimhan, J | 2 |
| Gabbeta, V | 2 |
| Grover, S | 1 |
| Dakka, A | 2 |
| Mollin, A | 1 |
| Jung, SP | 1 |
| Zhao, X | 2 |
| Zhang, N | 1 |
| Zhang, S | 1 |
| Arnold, M | 1 |
| Woll, MG | 1 |
| Naryshkin, NA | 2 |
| Weetall, M | 2 |
| Slaugenhaupt, SA | 7 |
| Urbina, F | 1 |
| Brenner, A | 1 |
| Shetty, R | 1 |
| Gallagher, CS | 1 |
| Law, EA | 1 |
| Sunshine, S | 1 |
| Finneran, DJ | 1 |
| Johnson, G | 1 |
| Minor, L | 1 |
| Yannai, S | 1 |
| Zonszain, J | 1 |
| Donyo, M | 1 |
| Ast, G | 1 |
| Gao, D | 1 |
| Montgomery, CM | 1 |
| Mazzasette, C | 1 |
| Krussig, TA | 1 |
| Swain, B | 1 |
| Dietrich, P | 1 |
| Hedrick, J | 1 |
| Wojtkiewicz, GG | 1 |
| Ko, CP | 1 |
| Talkowski, ME | 1 |
| Dragatsis, I | 1 |
| Lefler, S | 1 |
| Cohen, MA | 1 |
| Kantor, G | 1 |
| Cheishvili, D | 1 |
| Even, A | 1 |
| Birger, A | 1 |
| Turetsky, T | 1 |
| Gil, Y | 1 |
| Even-Ram, S | 1 |
| Aizenman, E | 1 |
| Bashir, N | 1 |
| Maayan, C | 1 |
| Razin, A | 1 |
| Reubinoff, BE | 1 |
| Weil, M | 1 |
| Gold-von Simson, G | 2 |
| Goldberg, JD | 1 |
| Rolnitzky, LM | 1 |
| Mull, J | 4 |
| Leyne, M | 4 |
| Voustianiouk, A | 1 |
| Axelrod, FB | 4 |
| Lee, G | 2 |
| Papapetrou, EP | 1 |
| Kim, H | 1 |
| Chambers, SM | 1 |
| Tomishima, MJ | 1 |
| Fasano, CA | 1 |
| Ganat, YM | 1 |
| Menon, J | 1 |
| Shimizu, F | 1 |
| Viale, A | 1 |
| Tabar, V | 1 |
| Sadelain, M | 1 |
| Studer, L | 2 |
| Liebes, L | 1 |
| Mendoza, S | 1 |
| Norcliffe-Kaufmann, L | 1 |
| Kaufmann, H | 1 |
| Boone, N | 1 |
| Bergon, A | 1 |
| Loriod, B | 1 |
| Devèze, A | 1 |
| Nguyen, C | 1 |
| Ibrahim, EC | 2 |
| Cuajungco, MP | 1 |
| Gill, SP | 1 |
| Hims, MM | 2 |
| Quintero, F | 1 |
| Gusella, JF | 2 |
| Luft, FC | 1 |
| Liu, L | 1 |
| Lazaro, C | 1 |
| Shetty, RS | 1 |
| Gill, S | 1 |
| Reed, R | 1 |
1 review available for kinetin and Dysautonomia, Familial
| Article | Year |
|---|---|
Better days are coming for Riley-Day patients.
Topics: Alternative Splicing; Dysautonomia, Familial; Humans; Kinetin | 2007 |
12 other studies available for kinetin and Dysautonomia, Familial
| Article | Year |
|---|---|
Development of an oral treatment that rescues gait ataxia and retinal degeneration in a phenotypic mouse model of familial dysautonomia.
Topics: Administration, Oral; Animals; Dysautonomia, Familial; Gait Ataxia; Kinetin; Mice; Neurodegenerative | 2023 |
Development of a Screening Platform to Identify Small Molecules That Modify ELP1 Pre-mRNA Splicing in Familial Dysautonomia.
Topics: Cell Line; Cytokinins; Drug Evaluation, Preclinical; Dysautonomia, Familial; Exons; HEK293 Cells; Hu | 2019 |
Combinatorial treatment increases IKAP levels in human cells generated from Familial Dysautonomia patients.
Topics: Brain-Derived Neurotrophic Factor; Carrier Proteins; Cells, Cultured; Dose-Response Relationship, Dr | 2019 |
ELP1 Splicing Correction Reverses Proprioceptive Sensory Loss in Familial Dysautonomia.
Topics: Alleles; Animals; Behavior, Animal; Cell Line; Crosses, Genetic; Disease Models, Animal; Dysautonomi | 2019 |
Familial Dysautonomia (FD) Human Embryonic Stem Cell Derived PNS Neurons Reveal that Synaptic Vesicular and Neuronal Transport Genes Are Directly or Indirectly Affected by IKBKAP Downregulation.
Topics: Biological Transport; Carrier Proteins; Cell Differentiation; Down-Regulation; Dysautonomia, Familia | 2015 |
Kinetin in familial dysautonomia carriers: implications for a new therapeutic strategy targeting mRNA splicing.
Topics: Adult; Alternative Splicing; Carrier Proteins; Dose-Response Relationship, Drug; Dysautonomia, Famil | 2009 |
Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs.
Topics: Adolescent; Alternative Splicing; Animals; Carrier Proteins; Cell Dedifferentiation; Cell Differenti | 2009 |
Modelling familial dysautonomia in human induced pluripotent stem cells.
Topics: Biomedical Research; Cell Culture Techniques; Cell Line; Dysautonomia, Familial; Genetic Therapy; Hu | 2011 |
Kinetin improves IKBKAP mRNA splicing in patients with familial dysautonomia.
Topics: Administration, Oral; Adult; Analysis of Variance; Area Under Curve; Carrier Proteins; Dysautonomia, | 2011 |
Genome-wide analysis of familial dysautonomia and kinetin target genes with patient olfactory ecto-mesenchymal stem cells.
Topics: Adolescent; Carrier Proteins; Cell Differentiation; Cells, Cultured; Child; Dysautonomia, Familial; | 2012 |
Rescue of a human mRNA splicing defect by the plant cytokinin kinetin.
Topics: Adenine; Alternative Splicing; Carrier Proteins; Cells, Cultured; Cytokinins; Dysautonomia, Familial | 2004 |
Therapeutic potential and mechanism of kinetin as a treatment for the human splicing disease familial dysautonomia.
Topics: Carrier Proteins; Cell Line, Tumor; Dysautonomia, Familial; Exons; Humans; Kinetin; Neurofibromatose | 2007 |