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kinetin and Disease Models, Animal

kinetin has been researched along with Disease Models, Animal in 14 studies

Kinetin: A furanyl adenine found in PLANTS and FUNGI. It has plant growth regulation effects.
cytokinin : A phytohormone that promote cell division, or cytokinesis, in plant roots and shoots.
kinetin : A member of the class of 6-aminopurines that is adenine carrying a (furan-2-ylmethyl) substituent at the exocyclic amino group.

Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.

Research Excerpts

ExcerptRelevanceReference
"Olomoucine treatment did not significantly affect maximal infarct volume."5.62Differential effects of the cell cycle inhibitor, olomoucine, on functional recovery and on responses of peri-infarct microglia and astrocytes following photothrombotic stroke in rats. ( Djukic, ND; Jayaseelan, JSP; Muyderman, H; Sims, NR; Woodman, RJ; Yew, WP, 2021)
"Olomoucine treatment did not significantly affect maximal infarct volume."1.62Differential effects of the cell cycle inhibitor, olomoucine, on functional recovery and on responses of peri-infarct microglia and astrocytes following photothrombotic stroke in rats. ( Djukic, ND; Jayaseelan, JSP; Muyderman, H; Sims, NR; Woodman, RJ; Yew, WP, 2021)
"Astrogliosis occurs in a variety of neuropathological disorders and injuries, and excessive astrogliosis can be devastating to the recovery of neuronal function."1.34Inhibiting cell cycle progression reduces reactive astrogliosis initiated by scratch injury in vitro and by cerebral ischemia in vivo. ( Bu, B; Tian, D; Wang, W; Xie, M; Yu, Z; Zhang, L; Zhang, Q; Zhu, S; Zhu, Z, 2007)
"Olomoucine promotes the recovery of the locomotion function of the paralyzed hindlimbs, probably through microenvironmental improvement of axonal regeneration by inhibiting the glial scar formation and CSPG secretion as well as upregulating the GAP-43 expression."1.33[Effects of cyclin dependent protein kinase inhibitor olomoucine on the microenvironment of axonal regeneration after spinal cord injury: an experiment with rats]. ( Tian, DS; Wang, P; Wang, W; Xie, MJ; Xu, YL; Yu, ZY; Zhang, GB, 2006)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (64.29)29.6817
2010's3 (21.43)24.3611
2020's2 (14.29)2.80

Authors

AuthorsStudies
Abrams, RPM1
Yasgar, A1
Teramoto, T1
Lee, MH1
Dorjsuren, D1
Eastman, RT1
Malik, N1
Zakharov, AV1
Li, W1
Bachani, M1
Brimacombe, K1
Steiner, JP1
Hall, MD1
Balasubramanian, A1
Jadhav, A1
Padmanabhan, R1
Simeonov, A1
Nath, A1
Yew, WP1
Djukic, ND1
Jayaseelan, JSP1
Woodman, RJ1
Muyderman, H1
Sims, NR1
Orr, AL1
Rutaganira, FU1
de Roulet, D1
Huang, EJ1
Hertz, NT1
Shokat, KM1
Nakamura, K1
Ashraf, S1
Bell, S1
O'Leary, C1
Canning, P1
Micu, I1
Fernandez, JA1
O'Hare, M1
Barabas, P1
McCauley, H1
Brazil, DP1
Stitt, AW1
McGeown, JG1
Curtis, TM1
Morini, E1
Gao, D1
Montgomery, CM1
Salani, M1
Mazzasette, C1
Krussig, TA1
Swain, B1
Dietrich, P1
Narasimhan, J1
Gabbeta, V1
Dakka, A1
Hedrick, J1
Zhao, X1
Weetall, M1
Naryshkin, NA1
Wojtkiewicz, GG1
Ko, CP1
Talkowski, ME1
Dragatsis, I1
Slaugenhaupt, SA1
Zhang, M1
Li, J1
Chakrabarty, P1
Bu, B2
Vincent, I1
Tian, DS5
Wang, W6
Xu, YL1
Yu, ZY5
Xie, MJ5
Wang, P1
Zhang, GB1
Bu, BT2
Witte, OW2
Zhang, Q2
Wang, YH1
Chen, B1
Chen, C1
Zhu, Z1
Yu, Z1
Zhang, L2
Tian, D1
Zhu, S1
Xie, M1
Dong, Q1
Pan, DJ1
He, Y1
Redecker, C1
Bignante, EA1
Rodriguez Manzanares, PA1
Mlewski, EC1
Bertotto, ME1
Bussolino, DF1
Paglini, G1
Molina, VA1
Katchanov, J1
Harms, C1
Gertz, K1
Hauck, L1
Waeber, C1
Hirt, L1
Priller, J1
von Harsdorf, R1
Bruck, W1
Hortnagl, H1
Dirnagl, U1
Bhide, PG1
Endres, M1

Other Studies

14 other studies available for kinetin and Disease Models, Animal

ArticleYear
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49

    Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr

2020
Differential effects of the cell cycle inhibitor, olomoucine, on functional recovery and on responses of peri-infarct microglia and astrocytes following photothrombotic stroke in rats.
    Journal of neuroinflammation, 2021, Jul-31, Volume: 18, Issue:1

    Topics: Animals; Astrocytes; Cell Cycle; Disease Models, Animal; Gliosis; Kinetin; Male; Microglia; Motor Co

2021
Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease.
    Neurochemistry international, 2017, Volume: 109

    Topics: Administration, Oral; alpha-Synuclein; Animals; Cells, Cultured; Disease Models, Animal; Drug Admini

2017
CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularization.
    JCI insight, 2019, 03-21, Volume: 4, Issue:6

    Topics: Angiogenesis Inducing Agents; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Surv

2019
ELP1 Splicing Correction Reverses Proprioceptive Sensory Loss in Familial Dysautonomia.
    American journal of human genetics, 2019, 04-04, Volume: 104, Issue:4

    Topics: Alleles; Animals; Behavior, Animal; Cell Line; Crosses, Genetic; Disease Models, Animal; Dysautonomi

2019
Cyclin-dependent kinase inhibitors attenuate protein hyperphosphorylation, cytoskeletal lesion formation, and motor defects in Niemann-Pick Type C mice.
    The American journal of pathology, 2004, Volume: 165, Issue:3

    Topics: Animals; Apoptosis; Cyclin-Dependent Kinases; Cytoskeleton; Disease Models, Animal; Enzyme Inhibitor

2004
[Effects of cyclin dependent protein kinase inhibitor olomoucine on the microenvironment of axonal regeneration after spinal cord injury: an experiment with rats].
    Zhonghua yi xue za zhi, 2006, Apr-04, Volume: 86, Issue:13

    Topics: Animals; Axons; Blotting, Western; Cyclin-Dependent Kinases; Cyclins; Disease Models, Animal; Enzyme

2006
Suppression of astroglial scar formation and enhanced axonal regeneration associated with functional recovery in a spinal cord injury rat model by the cell cycle inhibitor olomoucine.
    Journal of neuroscience research, 2006, Volume: 84, Issue:5

    Topics: Analysis of Variance; Animals; Astrocytes; Behavior, Animal; Blotting, Western; Cell Count; Cell Cyc

2006
Cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats.
    Brain research, 2007, Mar-02, Volume: 1135, Issue:1

    Topics: Analysis of Variance; Animals; Brain Edema; CD11b Antigen; Cell Cycle; Cell Death; Cell Proliferatio

2007
Inhibiting cell cycle progression reduces reactive astrogliosis initiated by scratch injury in vitro and by cerebral ischemia in vivo.
    Glia, 2007, Apr-01, Volume: 55, Issue:5

    Topics: Analysis of Variance; Animals; Astrocytes; Brain Injuries; Brain Ischemia; Cell Cycle; Cell Death; C

2007
Attenuation of astrogliosis by suppressing of microglial proliferation with the cell cycle inhibitor olomoucine in rat spinal cord injury model.
    Brain research, 2007, Jun-18, Volume: 1154

    Topics: Analysis of Variance; Animals; CD11b Antigen; Cell Proliferation; Disease Models, Animal; Enzyme Inh

2007
Rat focal cerebral ischemia induced astrocyte proliferation and delayed neuronal death are attenuated by cyclin-dependent kinase inhibition.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2008, Volume: 15, Issue:3

    Topics: Animals; Astrocytes; Brain Ischemia; Cell Death; Cell Proliferation; Disease Models, Animal; Drug In

2008
Involvement of septal Cdk5 in the emergence of excessive anxiety induced by stress.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2008, Volume: 18, Issue:8

    Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Cyclin-Dependent Kinase 5; Disease Models,

2008
Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal cell death.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Jul-15, Volume: 21, Issue:14

    Topics: Animals; Brain Ischemia; Bromodeoxyuridine; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cel

2001