khellin has been researched along with Sensitivity and Specificity in 26 studies
Khellin: A vasodilator that also has bronchodilatory action. It has been employed in the treatment of angina pectoris, in the treatment of asthma, and in conjunction with ultraviolet light A, has been tried in the treatment of vitiligo. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1024)
khellin : A furanochrome in which the basic tricyclic skeleton is substituted at positions 4 and 9 with methoxy groups and at position 7 with a methyl group. A major constituent of the plant Ammi visnaga it is a herbal folk medicine used for various illnesses, its main effect being as a vasodilator.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the clinical response of keloidal and hypertrophic scars after treatment with intralesional corticosteroid alone or combined with 5-fluorouracil (5-FU), 5-FU alone, and the 585-nm flashlamp-pumped pulsed-dye laser (PDL)." | 9.10 | Treatment response of keloidal and hypertrophic sternotomy scars: comparison among intralesional corticosteroid, 5-fluorouracil, and 585-nm flashlamp-pumped pulsed-dye laser treatments. ( Fitzpatrick, RE; Manuskiatti, W, 2002) |
| "This clinical study determines the effectiveness of verapamil hydrochloride on the prevention and treatment of keloids." | 9.10 | Prevention and treatment of keloids with intralesional verapamil. ( Baroni, A; Brongo, S; D'Andrea, F; Ferraro, G, 2002) |
| "Preliminary clinical trials suggest a superior effect when steroids and 5-fluorouracil are injected together for the intralesional therapy of keloids." | 7.79 | A study of the combination of triamcinolone and 5-fluorouracil in modulating keloid fibroblasts in vitro. ( Burd, A; Cai, YJ; Huang, L; Leung, BC; Lung, I, 2013) |
| "Sphingosine (Sph) is a metabolite product of ceramide that has some different biochemical properties." | 5.32 | Sphingosine may have cytotoxic effects via apoptosis on the growth of keloid fibroblasts. ( Chang, SE; Choi, JH; Kim, KJ; Lim, YJ; Moon, KC; Ro, KH; Sung, KJ, 2004) |
| "To compare the clinical response of keloidal and hypertrophic scars after treatment with intralesional corticosteroid alone or combined with 5-fluorouracil (5-FU), 5-FU alone, and the 585-nm flashlamp-pumped pulsed-dye laser (PDL)." | 5.10 | Treatment response of keloidal and hypertrophic sternotomy scars: comparison among intralesional corticosteroid, 5-fluorouracil, and 585-nm flashlamp-pumped pulsed-dye laser treatments. ( Fitzpatrick, RE; Manuskiatti, W, 2002) |
| "This clinical study determines the effectiveness of verapamil hydrochloride on the prevention and treatment of keloids." | 5.10 | Prevention and treatment of keloids with intralesional verapamil. ( Baroni, A; Brongo, S; D'Andrea, F; Ferraro, G, 2002) |
| "Preliminary clinical trials suggest a superior effect when steroids and 5-fluorouracil are injected together for the intralesional therapy of keloids." | 3.79 | A study of the combination of triamcinolone and 5-fluorouracil in modulating keloid fibroblasts in vitro. ( Burd, A; Cai, YJ; Huang, L; Leung, BC; Lung, I, 2013) |
| "Keloids are fibroproliferative disorders characterized by high recurrence rates, with few factors known to influence the same." | 1.62 | Does Keloid Histology Influence Recurrence? ( Agak, GW; Anzala, O; Nangole, FW; Ogeng'o, J; Ouyang, K; Zuriel, D, 2021) |
| "Keloids are pathologic scars afflicting a large segment of our population and for which there is no definitive therapy." | 1.35 | Use of organotypic coculture to study keloid biology. ( Butler, PD; Longaker, MT; Ly, DP; Yang, GP, 2008) |
| "Sphingosine (Sph) is a metabolite product of ceramide that has some different biochemical properties." | 1.32 | Sphingosine may have cytotoxic effects via apoptosis on the growth of keloid fibroblasts. ( Chang, SE; Choi, JH; Kim, KJ; Lim, YJ; Moon, KC; Ro, KH; Sung, KJ, 2004) |
| "The blood supply to keloids is inadequate, and this persists." | 1.32 | Inadequate blood supply persists in keloids. ( Furuya, E; Oba, S; Ueda, K; Yasuda, Y, 2004) |
| "Khellin and visnagin were detected and analyzed with a spectrophotometer set at 250 nm." | 1.28 | Improved high-performance liquid chromatographic determination of khellin and visnagin in Ammi visnaga fruits and pharmaceutical formulations. ( el-Domiaty, MM, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (7.69) | 18.2507 |
| 2000's | 13 (50.00) | 29.6817 |
| 2010's | 10 (38.46) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Hadad, GM | 1 |
| Badr, JM | 1 |
| El-Nahriry, K | 1 |
| Hassanean, HA | 1 |
| Mawatari, K | 1 |
| Mashiko, S | 1 |
| Watanabe, M | 1 |
| Nakagomi, K | 1 |
| El-Gogary, S | 1 |
| Grabner, G | 1 |
| Günaydin, K | 1 |
| Erim, FB | 1 |
| el-Domiaty, MM | 1 |
| Nangole, FW | 1 |
| Ouyang, K | 1 |
| Anzala, O | 1 |
| Ogeng'o, J | 1 |
| Agak, GW | 1 |
| Zuriel, D | 1 |
| Huang, L | 1 |
| Cai, YJ | 1 |
| Lung, I | 1 |
| Leung, BC | 1 |
| Burd, A | 1 |
| Haubner, F | 1 |
| Leyh, M | 1 |
| Ohmann, E | 1 |
| Sadick, H | 1 |
| Gassner, HG | 1 |
| Theocharidis, G | 1 |
| Drymoussi, Z | 1 |
| Kao, AP | 1 |
| Barber, AH | 1 |
| Lee, DA | 1 |
| Braun, KM | 1 |
| Connelly, JT | 1 |
| Verhiel, SH | 1 |
| Piatkowski de Grzymala, AA | 1 |
| Van den Kerckhove, E | 1 |
| Colla, C | 1 |
| van der Hulst, RR | 1 |
| Balci, DD | 1 |
| Inandi, T | 1 |
| Dogramaci, CA | 1 |
| Celik, E | 1 |
| Akaishi, S | 1 |
| Akimoto, M | 1 |
| Hyakusoku, H | 2 |
| Ogawa, R | 2 |
| Hollywood, KA | 1 |
| Maatje, M | 1 |
| Shadi, IT | 1 |
| Henderson, A | 1 |
| McGrouther, DA | 1 |
| Goodacre, R | 1 |
| Bayat, A | 1 |
| Muzaffar, SJ | 1 |
| Pollock, JC | 1 |
| Southern, SJ | 1 |
| Kurokawa, N | 1 |
| Ueda, K | 2 |
| Tsuji, M | 1 |
| Chen, J | 1 |
| Zhuo, S | 1 |
| Jiang, X | 1 |
| Zhu, X | 1 |
| Zheng, L | 1 |
| Xie, S | 1 |
| Lin, B | 1 |
| Zeng, H | 1 |
| Manuskiatti, W | 1 |
| Fitzpatrick, RE | 1 |
| Chang, SE | 1 |
| Kim, KJ | 1 |
| Ro, KH | 1 |
| Lim, YJ | 1 |
| Choi, JH | 1 |
| Moon, KC | 1 |
| Sung, KJ | 1 |
| Yasuda, Y | 1 |
| Furuya, E | 1 |
| Oba, S | 1 |
| Lu, F | 1 |
| Gao, J | 1 |
| Ou, C | 1 |
| Butler, PD | 1 |
| Ly, DP | 1 |
| Longaker, MT | 1 |
| Yang, GP | 1 |
| Dobrev, H | 1 |
| Kuwahara, RT | 1 |
| Rasberry, RD | 1 |
| D'Andrea, F | 1 |
| Brongo, S | 1 |
| Ferraro, G | 1 |
| Baroni, A | 1 |
| Liu, W | 1 |
| Cai, Z | 1 |
| Wang, D | 1 |
| Wu, X | 1 |
| Cui, L | 1 |
| Shang, Q | 1 |
| Qian, Y | 1 |
| Cao, Y | 1 |
| Tsao, SS | 1 |
| Dover, JS | 1 |
| Arndt, KA | 1 |
| Kaminer, MS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Role of 5-Fluorouracil in Post-Operative Scar Formation Following Direct Brow Ptosis Repair[NCT03219580] | Phase 3 | 50 participants (Anticipated) | Interventional | 2017-05-20 | Enrolling by invitation | ||
| The Application of Preoperative Silicone Ointment and Its Effect on Wound Healing[NCT05461157] | 60 participants (Anticipated) | Interventional | 2022-11-14 | Enrolling by invitation | |||
| Effect of Pulse Width of a 595-nm Flashlamp-pumped Pulsed-dye Laser on the Treatment Response of Keloidal and Hypertrophic Sternotomy Scars[NCT00142441] | 19 participants | Interventional | 2003-06-30 | Completed | |||
| 6 Month Double-Blind Randomized Placebo-Controlled Trial to Evaluate the Safety and Efficacy of Small Particle Hyaluronic Acid to Treat Acne Scars Located on the Cheeks and Forehead[NCT02955381] | 26 participants (Actual) | Interventional | 2017-03-28 | Terminated (stopped due to Liquidation of Research Department) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for khellin and Sensitivity and Specificity
| Article | Year |
|---|---|
Scar management: keloid, hypertrophic, atrophic, and acne scars.
Topics: Acne Keloid; Cicatrix; Cicatrix, Hypertrophic; Dermabrasion; Dermatologic Agents; Esthetics; Female; | 2002 |
2 trials available for khellin and Sensitivity and Specificity
| Article | Year |
|---|---|
Treatment response of keloidal and hypertrophic sternotomy scars: comparison among intralesional corticosteroid, 5-fluorouracil, and 585-nm flashlamp-pumped pulsed-dye laser treatments.
Topics: Adrenal Cortex Hormones; Adult; Aged; Biopsy, Needle; Cicatrix, Hypertrophic; Drug Therapy, Combinat | 2002 |
Prevention and treatment of keloids with intralesional verapamil.
Topics: Administration, Topical; Adult; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Inject | 2002 |
23 other studies available for khellin and Sensitivity and Specificity
| Article | Year |
|---|---|
Validated HPLC and HPTLC methods for simultaneous determination of colchicine and khellin in pharmaceutical formulations.
Topics: Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Colchicine; Khellin; Linear Models | 2013 |
Fluorometric determination of khellin in human urine and serum by high-performance liquid chromatography using postcolumn photoirradiation.
Topics: Calibration; Chromatography, High Pressure Liquid; Fluorescence; Fluorometry; Humans; Khellin; Sensi | 2003 |
Ultraviolet photoionization of the photosensitizers khellin and visnagin in aqueous solution and in micelles: one-photon ionization is a minor process.
Topics: Free Radicals; Khellin; Lasers; Micelles; Molecular Structure; Photochemistry; Photons; Photosensiti | 2006 |
Determination of khellin and visnagin in Ammi visnaga fruits by capillary electrophoresis.
Topics: Ammi; Electrophoresis, Capillary; Khellin; Sensitivity and Specificity | 2002 |
Improved high-performance liquid chromatographic determination of khellin and visnagin in Ammi visnaga fruits and pharmaceutical formulations.
Topics: Calibration; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Fruit; Khellin; Plants | 1992 |
Does Keloid Histology Influence Recurrence?
Topics: Adolescent; Adult; Aged; Connective Tissue Cells; Female; Fibroblasts; Humans; Keloid; Longitudinal | 2021 |
A study of the combination of triamcinolone and 5-fluorouracil in modulating keloid fibroblasts in vitro.
Topics: Analysis of Variance; Apoptosis; Blotting, Western; Cell Cycle; Cell Death; Cell Proliferation; Cell | 2013 |
Effects of botulinum toxin A on patient-specific keloid fibroblasts in vitro.
Topics: Adolescent; Adult; Botulinum Toxins, Type A; Cell Proliferation; Cells, Cultured; Cytokines; Enzyme- | 2014 |
Type VI Collagen Regulates Dermal Matrix Assembly and Fibroblast Motility.
Topics: Animals; Cell Movement; Cells, Cultured; Collagen Type VI; Epidermal Cells; Epidermis; Extracellular | 2016 |
Three-dimensional imaging for volume measurement of hypertrophic and keloid scars, reliability of a previously validated simplified technique in clinical setting.
Topics: Adolescent; Adult; Aged; Child; Cicatrix, Hypertrophic; Equipment Design; Equipment Failure Analysis | 2016 |
DLQI scores in patients with keloids and hypertrophic scars: a prospective case control study.
Topics: Adult; Case-Control Studies; Cicatrix, Hypertrophic; Female; Humans; Keloid; Male; Prospective Studi | 2009 |
The tensile reduction effects of silicone gel sheeting.
Topics: Administration, Topical; Cicatrix, Hypertrophic; Finite Element Analysis; Humans; Keloid; Materials | 2010 |
Phenotypic profiling of keloid scars using FT-IR microspectroscopy reveals a unique spectral signature.
Topics: Adult; Feasibility Studies; Female; Humans; Image Processing, Computer-Assisted; Keloid; Male; Middl | 2010 |
Vitamin E--an aid to wound healing?
Topics: Administration, Topical; Antioxidants; Female; Humans; Keloid; Male; Postoperative Care; Sensitivity | 2011 |
Study of microvascular structure in keloid and hypertrophic scars: density of microvessels and the efficacy of three-dimensional vascular imaging.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Capillaries; Child; Cicatrix, Hypertrophic; Cohort Studi | 2010 |
Multiphoton microscopy study of the morphological and quantity changes of collagen and elastic fiber components in keloid disease.
Topics: Adult; Cells, Cultured; Collagen; Elastic Tissue; Equipment Design; Equipment Failure Analysis; Fema | 2011 |
Sphingosine may have cytotoxic effects via apoptosis on the growth of keloid fibroblasts.
Topics: Apoptosis; Biopsy, Needle; Case-Control Studies; Cell Division; Cell Survival; Cells, Cultured; Cera | 2004 |
Inadequate blood supply persists in keloids.
Topics: Adenosine Triphosphate; Biopsy, Needle; Cicatrix, Hypertrophic; Female; Humans; Hypoxia; Immunohisto | 2004 |
Fas-mediated apoptotic signal transduction in keloid and hypertrophic scar.
Topics: Adolescent; Adult; Apoptosis; Cells, Cultured; Ceramides; Cicatrix, Hypertrophic; Fas Ligand Protein | 2007 |
Use of organotypic coculture to study keloid biology.
Topics: Cells, Cultured; Coculture Techniques; Fibroblasts; Humans; Immunohistochemistry; Keloid; Keratinocy | 2008 |
Non-invasive monitoring of the mechanical properties of keloids during cryosurgery.
Topics: Adult; Cryosurgery; Follow-Up Studies; Humans; Keloid; Male; Minimally Invasive Surgical Procedures; | 1999 |
Perpendicular suture method for earlobe keloids.
Topics: Ear, External; Female; Humans; Keloid; Male; Sensitivity and Specificity; Surgical Procedures, Opera | 2000 |
Blocking transforming growth factor-beta receptor signaling down-regulates transforming growth factor-beta1 autoproduction in keloid fibroblasts.
Topics: Activin Receptors, Type I; Cells, Cultured; Down-Regulation; Fibroblasts; Gene Expression; Humans; K | 2002 |