khellin has been researched along with Scleroderma, Systemic in 47 studies
Khellin: A vasodilator that also has bronchodilatory action. It has been employed in the treatment of angina pectoris, in the treatment of asthma, and in conjunction with ultraviolet light A, has been tried in the treatment of vitiligo. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1024)
khellin : A furanochrome in which the basic tricyclic skeleton is substituted at positions 4 and 9 with methoxy groups and at position 7 with a methyl group. A major constituent of the plant Ammi visnaga it is a herbal folk medicine used for various illnesses, its main effect being as a vasodilator.
Scleroderma, Systemic: A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Skin fibrosis is a common pathological process characterized by fibroblast proliferation and excessive deposition of extracellular matrix." | 2.55 | MicroRNA-21 in Skin Fibrosis: Potential for Diagnosis and Treatment. ( Chen, T; Lei, Y; Li, Y; Lyu, L; Zhang, J; Zuo, R, 2017) |
| "Fibrosis is a common pathological state characterized by the excessive accumulation of extracellular matrix components, but the pathogenesis of the disease is still not clear." | 2.55 | MicroRNA-29: A Crucial Player in Fibrotic Disease. ( Deng, Z; He, L; He, Y; Lu, L; Shi, A; Shi, H; Yang, X, 2017) |
| "Skin fibrosis is a common pathological manifestation in systemic sclerosis (SSc), keloid, and localized scleroderma (LS) characterized by fibroblast activation and excessive extracellular matrix (ECM) deposition." | 1.91 | Enhancement of Zyxin Promotes Skin Fibrosis by Regulating FAK/PI3K/AKT and TGF-β Signaling Pathways via Integrins. ( Gong, Y; Huang, Y; Jiang, S; Lin, J; Liu, J; Liu, Q; Ma, Y; Pu, W; Shi, X; Tang, Y; Wang, J; Wu, W; Zhang, Y; Zhao, H, 2023) |
| "Skin fibrosis is a hallmark of a wide array of dermatological diseases which can greatly impact the patients' quality of life." | 1.72 | Increased Expression of Galectin-3 in Skin Fibrosis: Evidence from In Vitro and In Vivo Studies. ( Almudéver, P; Alonso-Carpio, M; Cortijo, J; Marín, S; Milara, J; Montero, P; Peiró, T; Ribera, P; Roger, I, 2022) |
| "Nodular scleroderma or keloidal morphea presenting in a linear distribution is even more uncommon." | 1.72 | Questions raised by a case of adult-onset linear nodular scleroderma. ( Hansen, CB; Jimenez, A; Marcelus, C; Sontheimer, RD; Zussman, J, 2022) |
| "Fibrosis is a major cause of human death and disability." | 1.34 | Does transformation of microvascular endothelial cells into myofibroblasts play a key role in the etiology and pathology of fibrotic disease? ( Karasek, MA, 2007) |
| "A 53-year-old woman with systemic sclerosis developed numerous cutaneous nodules, resembling keloids, on her anterior chest wall." | 1.32 | Keloidal scleroderma. ( Andrew, SM; Brammah, T; Griffiths, CE; Herrick, AL; Ling, TC, 2003) |
| "Two patients with progressive systemic sclerosis (PSS) developed keloidal-like nodules within areas of thickened skin." | 1.27 | Nodular (keloidal) scleroderma. ( Berger, TG; Butler, DF; James, WD; Tuffanelli, DL, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (44.68) | 18.7374 |
| 1990's | 5 (10.64) | 18.2507 |
| 2000's | 7 (14.89) | 29.6817 |
| 2010's | 8 (17.02) | 24.3611 |
| 2020's | 6 (12.77) | 2.80 |
| Authors | Studies |
|---|---|
| Peiró, T | 2 |
| Alonso-Carpio, M | 2 |
| Ribera, P | 2 |
| Almudéver, P | 2 |
| Roger, I | 2 |
| Montero, P | 2 |
| Marín, S | 2 |
| Milara, J | 2 |
| Cortijo, J | 2 |
| Marcelus, C | 1 |
| Jimenez, A | 1 |
| Zussman, J | 1 |
| Hansen, CB | 1 |
| Sontheimer, RD | 1 |
| Huang, Y | 1 |
| Zhao, H | 1 |
| Zhang, Y | 1 |
| Tang, Y | 1 |
| Shi, X | 1 |
| Jiang, S | 1 |
| Pu, W | 1 |
| Liu, J | 1 |
| Ma, Y | 1 |
| Lin, J | 2 |
| Wu, W | 1 |
| Gong, Y | 1 |
| Wang, J | 1 |
| Liu, Q | 1 |
| Sanchez, NG | 1 |
| Rebollo Domínguez, N | 1 |
| Martínez Luna, E | 1 |
| Villaseñor Ovies, P | 1 |
| Russo, B | 1 |
| Brembilla, NC | 1 |
| Chizzolini, C | 1 |
| Deng, CC | 1 |
| Hu, YF | 1 |
| Zhu, DH | 1 |
| Cheng, Q | 1 |
| Gu, JJ | 1 |
| Feng, QL | 1 |
| Zhang, LX | 1 |
| Xu, YP | 1 |
| Wang, D | 1 |
| Rong, Z | 1 |
| Yang, B | 1 |
| Li, Y | 1 |
| Zhang, J | 1 |
| Lei, Y | 1 |
| Lyu, L | 1 |
| Zuo, R | 1 |
| Chen, T | 1 |
| Babalola, O | 1 |
| Mamalis, A | 1 |
| Lev-Tov, H | 1 |
| Jagdeo, J | 1 |
| Ring, HC | 1 |
| Mogensen, M | 1 |
| Hussain, AA | 1 |
| Steadman, N | 1 |
| Banzhaf, C | 1 |
| Themstrup, L | 1 |
| Jemec, GB | 1 |
| Goyal, A | 1 |
| Linskey, KR | 1 |
| Kay, J | 1 |
| Duncan, LM | 1 |
| Nazarian, RM | 1 |
| Deng, Z | 1 |
| He, Y | 1 |
| Yang, X | 1 |
| Shi, H | 1 |
| Shi, A | 1 |
| Lu, L | 1 |
| He, L | 1 |
| Wriston, CC | 1 |
| Rubin, AI | 1 |
| Elenitsas, R | 1 |
| Crawford, GH | 1 |
| McCarty, SM | 1 |
| Syed, F | 1 |
| Bayat, A | 1 |
| Heath, CR | 1 |
| David, JN | 1 |
| Taylor, SC | 1 |
| Canady, J | 1 |
| Arndt, S | 1 |
| Karrer, S | 1 |
| Bosserhoff, AK | 1 |
| Ling, TC | 1 |
| Herrick, AL | 1 |
| Andrew, SM | 1 |
| Brammah, T | 1 |
| Griffiths, CE | 1 |
| Labandeira, J | 2 |
| León-Mateos, A | 2 |
| Suárez-Peñaranda, JM | 2 |
| Garea, MT | 2 |
| Toribio, J | 2 |
| KORTING, GW | 2 |
| CABRE, J | 1 |
| LANDES, E | 1 |
| JOHNSON, WC | 1 |
| HELWIG, EB | 1 |
| VIGLIOGLIA, PA | 1 |
| RASMUSSEN, DM | 1 |
| WAKIM, KG | 1 |
| WINKELMANN, RK | 1 |
| Fujimoto, M | 1 |
| Hamaguchi, Y | 1 |
| Yazawa, N | 1 |
| Komura, K | 1 |
| Takehara, K | 1 |
| Sato, S | 1 |
| Karasek, MA | 1 |
| James, WD | 1 |
| Berger, TG | 1 |
| Butler, DF | 1 |
| Tuffanelli, DL | 1 |
| Dimitrova, J | 1 |
| Molcho, L | 1 |
| Rueva, C | 1 |
| Pramatarov, K | 1 |
| Mizutani, H | 1 |
| Taniguchi, H | 1 |
| Sakakura, T | 1 |
| Shimizu, M | 1 |
| Duncan, MR | 2 |
| Hasan, A | 1 |
| Berman, B | 2 |
| Akagi, A | 1 |
| Tajima, S | 1 |
| Ishibashi, A | 1 |
| Yamaguchi, N | 1 |
| Nagai, Y | 1 |
| Sogabe, Y | 1 |
| Akimoto, S | 1 |
| Abe, M | 1 |
| Ishikawa, O | 1 |
| Takagi, Y | 1 |
| Imokawa, G | 1 |
| el-Amin, AM | 1 |
| Solomon, LM | 1 |
| Caputo, R | 1 |
| Davis, J | 1 |
| Evans, D | 1 |
| Greenberg, M | 1 |
| Hill, C | 1 |
| Keuer, E | 1 |
| Koya, D | 1 |
| Morgan, N | 1 |
| Pedvis-Leftick, A | 1 |
| Wick, G | 1 |
| Kraft, D | 1 |
| Kokoschka, EM | 1 |
| Timpl, R | 1 |
| Wozniak, KD | 2 |
| Braun, W | 2 |
| Perez-Wilson, J | 1 |
| Pujol, RM | 1 |
| Alejo, M | 1 |
| Geli, C | 1 |
| de Moragas, JM | 1 |
| Oikarinen, A | 1 |
| Oikarinen, H | 1 |
| Meeker, CA | 1 |
| Tan, EM | 1 |
| Uitto, J | 1 |
| Young, EM | 1 |
| Barr, RJ | 1 |
| Studnitsin, AA | 1 |
| Nikitina, MN | 1 |
| Lashmanova, AP | 1 |
| Nikitina, LV | 1 |
| Lachner, H | 1 |
| Engel, MF | 2 |
| Weitgasser, H | 1 |
| Schmid, AH | 1 |
| Groel, JT | 1 |
6 reviews available for khellin and Scleroderma, Systemic
| Article | Year |
|---|---|
Interplay Between Keratinocytes and Fibroblasts: A Systematic Review Providing a New Angle for Understanding Skin Fibrotic Disorders.
Topics: Animals; Cicatrix, Hypertrophic; Fibroblasts; Fibrosis; Humans; Keloid; Keratinocytes; Scleroderma, | 2020 |
MicroRNA-21 in Skin Fibrosis: Potential for Diagnosis and Treatment.
Topics: Cicatrix, Hypertrophic; Fibrosis; Gene Expression Regulation; Humans; Keloid; MicroRNAs; Molecular T | 2017 |
The role of microRNAs in skin fibrosis.
Topics: Cell Differentiation; Cell Proliferation; Humans; Keloid; MicroRNAs; Oligonucleotides; Scleroderma, | 2013 |
MicroRNA-29: A Crucial Player in Fibrotic Disease.
Topics: Fibrosis; Gene Expression Regulation; Humans; Keloid; Kidney; Liver Cirrhosis; MicroRNAs; Myocardium | 2017 |
Influence of the human leukocyte antigen complex on the development of cutaneous fibrosis: an immunogenetic perspective.
Topics: Cicatrix, Hypertrophic; Connective Tissue Diseases; Evidence-Based Medicine; Fibrosis; HLA Antigens; | 2010 |
Sclerosing dermatoses.
Topics: Diagnosis, Differential; Eosinophilia; Fasciitis; Humans; Keloid; Lichen Planus; Radiodermatitis; Sc | 1985 |
3 trials available for khellin and Scleroderma, Systemic
| Article | Year |
|---|---|
[Initial results of high-dosage hyaluromidase long-term therapy ("Hylase" Dessau) in dermatology].
Topics: Clinical Trials as Topic; Humans; Hyaluronoglucosaminidase; Keloid; Scleroderma, Localized; Sclerode | 1972 |
Dimethyl sulfoxide (DMSO) in clinical dermatology.
Topics: Amyloidosis; Cicatrix; Clinical Trials as Topic; Dimethyl Sulfoxide; Eczema; Female; Humans; Keloid; | 1966 |
Dimethyl sulfoxide as a vehicle for corticosteroids. A comparison with the occlusive dressing technique.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Dermatitis, Atopic; Dermatitis, Contact; Eczema; F | 1968 |
38 other studies available for khellin and Scleroderma, Systemic
| Article | Year |
|---|---|
Increased Expression of Galectin-3 in Skin Fibrosis: Evidence from In Vitro and In Vivo Studies.
Topics: Animals; Disease Models, Animal; Fibroblasts; Fibrosis; Galectin 3; Humans; Keloid; Mice; Quality of | 2022 |
Increased Expression of Galectin-3 in Skin Fibrosis: Evidence from In Vitro and In Vivo Studies.
Topics: Animals; Disease Models, Animal; Fibroblasts; Fibrosis; Galectin 3; Humans; Keloid; Mice; Quality of | 2022 |
Increased Expression of Galectin-3 in Skin Fibrosis: Evidence from In Vitro and In Vivo Studies.
Topics: Animals; Disease Models, Animal; Fibroblasts; Fibrosis; Galectin 3; Humans; Keloid; Mice; Quality of | 2022 |
Increased Expression of Galectin-3 in Skin Fibrosis: Evidence from In Vitro and In Vivo Studies.
Topics: Animals; Disease Models, Animal; Fibroblasts; Fibrosis; Galectin 3; Humans; Keloid; Mice; Quality of | 2022 |
Questions raised by a case of adult-onset linear nodular scleroderma.
Topics: Adult; Female; Humans; Hydroxychloroquine; Keloid; Scleroderma, Localized; Scleroderma, Systemic; Sk | 2022 |
Enhancement of Zyxin Promotes Skin Fibrosis by Regulating FAK/PI3K/AKT and TGF-β Signaling Pathways via Integrins.
Topics: Animals; Fibroblasts; Fibrosis; Humans; Integrins; Keloid; Mice; Phosphatidylinositol 3-Kinases; Pro | 2023 |
Nodular (keloidal) scleroderma.
Topics: Humans; Keloid; Scleroderma, Localized; Scleroderma, Systemic | 2023 |
Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases.
Topics: Cell Adhesion Molecules; Collagen; Extracellular Matrix; Fibroblasts; Gene Expression Regulation; Ge | 2021 |
Imaging of collagen deposition disorders using optical coherence tomography.
Topics: Adult; Cicatrix, Hypertrophic; Collagen; Humans; Keloid; Lichen Sclerosus et Atrophicus; Middle Aged | 2015 |
Differential Expression of Hedgehog and Snail in Cutaneous Fibrosing Disorders: Implications for Targeted Inhibition.
Topics: beta Catenin; Cicatrix; Cicatrix, Hypertrophic; Glycogen Synthase Kinase 3 beta; Hedgehog Proteins; | 2016 |
Nodular scleroderma: a report of 2 cases.
Topics: Adult; Anti-Inflammatory Agents; Arthralgia; Female; Humans; Keloid; Male; Middle Aged; Pericarditis | 2008 |
Nodular scleroderma presenting as multiple spontaneous keloidal scars.
Topics: Adolescent; Cicatrix, Hypertrophic; Female; Humans; Keloid; Scleroderma, Systemic | 2012 |
Increased KGF expression promotes fibroblast activation in a double paracrine manner resulting in cutaneous fibrosis.
Topics: Cell Communication; Cell Movement; Cell Proliferation; Cells, Cultured; Collagen Type I; Fibroblast | 2013 |
Keloidal scleroderma.
Topics: Administration, Topical; Anti-Inflammatory Agents; Beclomethasone; Calcitriol; Dermatologic Agents; | 2003 |
What is nodular-keloidal scleroderma?
Topics: Fibrosis; Humans; Keloid; Scleroderma, Localized; Scleroderma, Systemic; Skin | 2003 |
Polymorphic fibrosing reaction mimicking keloidal scleroderma but without associated classic scleroderma.
Topics: Adult; Female; Fibrosis; Humans; Hyperpigmentation; Keloid; Scleroderma, Localized; Scleroderma, Sys | 2003 |
[Keloid-like scleroderma, with remarks on phase variation of certain sclerodermic diseases].
Topics: Basidiomycota; Fibroma; Humans; Keloid; Scleroderma, Localized; Scleroderma, Systemic | 1954 |
[A contribution to nodular scleroderma (keloid-like scleroderma Unna)].
Topics: Humans; Keloid; Medical Records; Scleroderma, Localized; Scleroderma, Systemic | 1960 |
HISTOCHEMISTRY OF THE ACID MUCOPOLYSACCHARIDES OF SKIN IN NORMAL AND IN CERTAIN PATHOLOGIC CONDITIONS.
Topics: Adenocarcinoma, Mucinous; Calcinosis; Classification; Coloring Agents; Glycosaminoglycans; Histocyto | 1963 |
[INTRALESIONAL EFFECTS OF BETAMETHASONE WITH SPECIAL REFERENCE TO ITS HISTOPATHOLOGIC STUDY].
Topics: Acne Vulgaris; Betamethasone; Humans; Injections; Keloid; Leprosy; Lichen Planus; Lupus Erythematosu | 1963 |
ISOTONIC AND ISOMETRIC THERMAL CONTRACTION OF HUMAN DERMIS. 3. SCLERODERMA AND CICATRIZING LESIONS.
Topics: Cicatrix; Dermatologic Agents; Dermis; Hot Temperature; Humans; Isometric Contraction; Keloid; Physi | 1964 |
Autoantibodies to a collagen-specific molecular chaperone, heat-shock protein 47, in systemic sclerosis.
Topics: Adolescent; Adult; Aged; Animals; Autoantibodies; Child; Dermatomyositis; Female; Heat-Shock Protein | 2004 |
Does transformation of microvascular endothelial cells into myofibroblasts play a key role in the etiology and pathology of fibrotic disease?
Topics: Cell Differentiation; Endothelium, Vascular; Fibroblasts; Fibrosis; Humans; Keloid; Microcirculation | 2007 |
Nodular (keloidal) scleroderma.
Topics: Adolescent; Adult; Biopsy; Female; Humans; Keloid; Male; Scleroderma, Systemic; Skin | 1984 |
[Nodular scleroderma].
Topics: Diagnosis, Differential; Humans; Keloid; Male; Middle Aged; Scleroderma, Systemic | 1980 |
Nodular scleroderma: focally increased tenascin expression differing from that in the surrounding scleroderma skin.
Topics: Adult; Biopsy; Cell Adhesion Molecules, Neuronal; Diagnosis, Differential; Extracellular Matrix Prot | 1995 |
Oncostatin M stimulates collagen and glycosaminoglycan production by cultured normal dermal fibroblasts: insensitivity of sclerodermal and keloidal fibroblasts.
Topics: Adult; Aged; Blotting, Western; Cells, Cultured; Collagen; Female; Fibroblasts; Glycosaminoglycans; | 1995 |
Expression of type XVI collagen in human skin fibroblasts: enhanced expression in fibrotic skin diseases.
Topics: Adolescent; Adult; Collagen; Female; Fibroblasts; Fluorescent Antibody Technique; Humans; Keloid; Ma | 1999 |
Functions of the stratum corneum in systemic sclerosis as distinct from hypertrophic scar and keloid functions.
Topics: Adult; Aged; Arm; Cicatrix, Hypertrophic; Epidermis; Female; Galvanic Skin Response; Humans; Keloid; | 2002 |
Peculiarities in dermatology.
Topics: Adult; Child; Diagnosis, Differential; Female; Humans; Ichthyosis; Infant; Keloid; Leprosy; Male; Sc | 1978 |
Miscellaneous dermatoses.
Topics: Acanthosis Nigricans; Adolescent; Athletic Injuries; Dermatomycoses; Female; Granuloma; Humans; Icht | 1978 |
The diagnostic application of specific anti-procollagen sera. I. Analysis of skin biopsies.
Topics: Adolescent; Adult; Aged; Humans; Immune Sera; Keloid; Lichen Planus; Lupus Erythematosus, Discoid; L | 1976 |
[Treatment with hyaluronidase in dermatology].
Topics: Humans; Hyaluronoglucosaminidase; Keloid; Male; Penile Induration; Scleroderma, Localized; Scleroder | 1975 |
Nodular (keloidal) scleroderma.
Topics: Adult; Female; Humans; Keloid; Scleroderma, Systemic; Skin | 1992 |
Pentoxifylline inhibits the proliferation of human fibroblasts derived from keloid, scleroderma and morphoea skin and their production of collagen, glycosaminoglycans and fibronectin.
Topics: Cell Division; Collagen; Depression, Chemical; Fibroblasts; Fibronectins; Glycosaminoglycans; Humans | 1990 |
Glucocorticoid receptors in cultured human skin fibroblasts: evidence for down-regulation of receptor by glucocorticoid hormone.
Topics: Cells, Cultured; Dexamethasone; Diabetes Mellitus; Fibroblasts; Humans; In Vitro Techniques; Keloid; | 1987 |
[Treatment of dermatoses in children with synalar-forte, synalar-gel and metosyn].
Topics: Acetates; Adolescent; Child; Child, Preschool; Drug Evaluation; Eczema; Fluocinolone Acetonide; Gran | 1974 |
[Malabsorptive scleroderma].
Topics: Adult; Autopsy; Biopsy; Celiac Disease; Diagnosis, Differential; Diarrhea; Digestive System; Female; | 1972 |
Indications and contraindications for the use of DMSO in clinical dermatology.
Topics: Amyloidosis; Animals; Anura; Dimethyl Sulfoxide; Dogs; Eczema; Humans; Keloid; Keratosis; Lichen Pla | 1967 |
[Dermatological experience with dimethyl sulfoxide (DMSO)].
Topics: Dimethyl Sulfoxide; Dupuytren Contracture; Female; Fibroma; Granuloma; Herpes Zoster; Humans; Keloid | 1967 |
[Local treatment of skin diseases with Volon A tincture].
Topics: Alopecia Areata; Benzalkonium Compounds; Dermatologic Agents; Eczema; Humans; Keloid; Lichen Planus; | 1967 |