khellin has been researched along with Scleroderma, Localized in 36 studies
Khellin: A vasodilator that also has bronchodilatory action. It has been employed in the treatment of angina pectoris, in the treatment of asthma, and in conjunction with ultraviolet light A, has been tried in the treatment of vitiligo. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1024)
khellin : A furanochrome in which the basic tricyclic skeleton is substituted at positions 4 and 9 with methoxy groups and at position 7 with a methyl group. A major constituent of the plant Ammi visnaga it is a herbal folk medicine used for various illnesses, its main effect being as a vasodilator.
Scleroderma, Localized: A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have previously reported that tranilast, an anti-allergic agent, specifically suppresses collagen synthesis in normal skin fibroblasts and to a greater extent in keloid fibroblasts." | 7.69 | Tranilast inhibits collagen synthesis in normal, scleroderma and keloid fibroblasts at a late passage culture but not at an early passage culture. ( Nishikawa, T; Tajima, S; Yamada, H, 1995) |
| "We have previously reported that tranilast, an anti-allergic agent, specifically suppresses collagen synthesis in normal skin fibroblasts and to a greater extent in keloid fibroblasts." | 3.69 | Tranilast inhibits collagen synthesis in normal, scleroderma and keloid fibroblasts at a late passage culture but not at an early passage culture. ( Nishikawa, T; Tajima, S; Yamada, H, 1995) |
| "Keloidal morphea is a rare variant of scleroderma, which often can be clinically confused with keloid or scar formation." | 2.66 | Morphea With Keloidal Features: A Case Report and Review of the Literature. ( Ahn, C; Akkurt, ZM; Ibarra, BS; Sangüeza, OP; Yu, D, 2020) |
| "Keloids are special type of skin lesions arising from sites of previous trauma." | 2.43 | [Therapeutic problems connected with keloid treatment--new treatment possibilities]. ( Brudnik, U; Podolec-Rubiś, M; Wojas-Pelc, A, 2006) |
| "Fibrosis is a common pathophysiological response of many tissues and organs subjected to chronic injury." | 1.72 | Skin fibrosis associated with keloid, scleroderma and Jorge Lobo's disease (lacaziosis): An immuno-histochemical study. ( Kanashiro-Galo, L; Mosser, DM; Pagliari, C; Quaresma, JAS; Silva, AMG; Sotto, MN; Tafuri, WL; Tomokane, TY, 2022) |
| "Nodular scleroderma or keloidal morphea presenting in a linear distribution is even more uncommon." | 1.72 | Questions raised by a case of adult-onset linear nodular scleroderma. ( Hansen, CB; Jimenez, A; Marcelus, C; Sontheimer, RD; Zussman, J, 2022) |
| "Tranilast was found to inhibit collagen synthesis in a dose-dependent manner to a maximum of 55% at 300 microM during 48 h of treatment; the synthesis of type I and type III collagens was equally affected." | 1.29 | Tranilast, a selective inhibitor of collagen synthesis in human skin fibroblasts. ( Murad, S; Nishikawa, T; Pinnell, SR; Tajima, S; Yamada, H, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (30.56) | 18.7374 |
| 1990's | 7 (19.44) | 18.2507 |
| 2000's | 6 (16.67) | 29.6817 |
| 2010's | 6 (16.67) | 24.3611 |
| 2020's | 6 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Tafuri, WL | 1 |
| Tomokane, TY | 1 |
| Silva, AMG | 1 |
| Kanashiro-Galo, L | 1 |
| Mosser, DM | 1 |
| Quaresma, JAS | 1 |
| Pagliari, C | 1 |
| Sotto, MN | 1 |
| Marcelus, C | 1 |
| Jimenez, A | 1 |
| Zussman, J | 1 |
| Hansen, CB | 1 |
| Sontheimer, RD | 1 |
| Sanchez, NG | 1 |
| Rebollo Domínguez, N | 1 |
| Martínez Luna, E | 1 |
| Villaseñor Ovies, P | 1 |
| Yu, D | 1 |
| Ibarra, BS | 1 |
| Akkurt, ZM | 1 |
| Ahn, C | 1 |
| Sangüeza, OP | 1 |
| Castelli, E | 1 |
| Orlando, E | 1 |
| Pardo, N | 1 |
| Turdo, A | 1 |
| Pistone, G | 1 |
| Bongiorno, MR | 1 |
| Chattopadhyay, A | 1 |
| Sharma, SK | 1 |
| Mishra, D | 1 |
| Madakshira, MG | 1 |
| De, D | 1 |
| Jain, S | 1 |
| Salmon, NE | 1 |
| Roberts, N | 1 |
| Agnew, K | 1 |
| Ring, HC | 1 |
| Mogensen, M | 1 |
| Hussain, AA | 1 |
| Steadman, N | 1 |
| Banzhaf, C | 1 |
| Themstrup, L | 1 |
| Jemec, GB | 1 |
| Torchia, D | 1 |
| Schachner, LA | 1 |
| Elbendary, A | 1 |
| Valdebran, M | 1 |
| Parikh, K | 1 |
| Elston, DM | 1 |
| Chiu, HY | 1 |
| Tsai, TF | 1 |
| Arndt, S | 1 |
| Schmidt, J | 1 |
| Wacker, E | 1 |
| Karrer, S | 1 |
| Bosserhoff, AK | 1 |
| Barzilai, A | 1 |
| Lyakhovitsky, A | 1 |
| Horowitz, A | 1 |
| Trau, H | 1 |
| Labandeira, J | 2 |
| León-Mateos, A | 2 |
| Suárez-Peñaranda, JM | 2 |
| Garea, MT | 2 |
| Toribio, J | 2 |
| KORTING, GW | 1 |
| CABRE, J | 1 |
| LANDES, E | 1 |
| SCHIMPF, A | 1 |
| Cannick, L | 1 |
| Douglas, G | 1 |
| Crater, S | 1 |
| Silver, R | 1 |
| Rünger, TM | 1 |
| Quintanilla-Dieck, MJ | 1 |
| Bhawan, J | 1 |
| Brudnik, U | 1 |
| Podolec-Rubiś, M | 1 |
| Wojas-Pelc, A | 1 |
| Yamada, H | 2 |
| Tajima, S | 3 |
| Nishikawa, T | 2 |
| Murad, S | 1 |
| Pinnell, SR | 1 |
| Igarashi, A | 1 |
| Nashiro, K | 1 |
| Kikuchi, K | 2 |
| Sato, S | 1 |
| Ihn, H | 1 |
| Fujimoto, M | 2 |
| Grotendorst, GR | 1 |
| Takehara, K | 1 |
| Kubo, M | 1 |
| Tamaki, T | 1 |
| Tamaki, K | 1 |
| Varga, J | 1 |
| Kähäri, VM | 1 |
| Akagi, A | 1 |
| Ishibashi, A | 1 |
| Yamaguchi, N | 1 |
| Nagai, Y | 1 |
| Solomon, LM | 1 |
| Caputo, R | 1 |
| Davis, J | 1 |
| Evans, D | 1 |
| Greenberg, M | 1 |
| Hill, C | 1 |
| Keuer, E | 1 |
| Koya, D | 1 |
| Morgan, N | 1 |
| Pedvis-Leftick, A | 1 |
| Wick, G | 1 |
| Kraft, D | 1 |
| Kokoschka, EM | 1 |
| Timpl, R | 1 |
| Gay, S | 1 |
| Müller, PK | 1 |
| Meigel, WN | 1 |
| Kühn, K | 1 |
| Wozniak, KD | 2 |
| Braun, W | 2 |
| Berman, B | 1 |
| Duncan, MR | 1 |
| Young, EM | 1 |
| Barr, RJ | 1 |
| Akintewe, TA | 1 |
| Alabi, GO | 1 |
| Moynahan, EJ | 1 |
5 reviews available for khellin and Scleroderma, Localized
| Article | Year |
|---|---|
Morphea With Keloidal Features: A Case Report and Review of the Literature.
Topics: Adult; Antibodies, Antinuclear; Biopsy; Diagnosis, Differential; Erythema; Female; Humans; Hyperpigm | 2020 |
Nodular scleroderma: case report and literature review.
Topics: Adult; Hip Joint; Humans; Keloid; Male; Osteoarthritis; Scleroderma, Localized | 2003 |
[Therapeutic problems connected with keloid treatment--new treatment possibilities].
Topics: Cicatrix, Hypertrophic; Dermatologic Agents; Fibroblasts; Humans; Keloid; Mitomycin; Scleroderma, Lo | 2006 |
Eosinophilia-myalgia syndrome, eosinophilic fasciitis, and related fibrosing disorders.
Topics: Colonic Diseases; Eosinophilia; Eosinophilia-Myalgia Syndrome; Fasciitis; Fibrosis; Humans; Keloid; | 1997 |
Sclerosing dermatoses.
Topics: Diagnosis, Differential; Eosinophilia; Fasciitis; Humans; Keloid; Lichen Planus; Radiodermatitis; Sc | 1985 |
1 trial available for khellin and Scleroderma, Localized
| Article | Year |
|---|---|
[Initial results of high-dosage hyaluromidase long-term therapy ("Hylase" Dessau) in dermatology].
Topics: Clinical Trials as Topic; Humans; Hyaluronoglucosaminidase; Keloid; Scleroderma, Localized; Sclerode | 1972 |
30 other studies available for khellin and Scleroderma, Localized
| Article | Year |
|---|---|
Skin fibrosis associated with keloid, scleroderma and Jorge Lobo's disease (lacaziosis): An immuno-histochemical study.
Topics: Endothelial Cells; Fibroblasts; Fibrosis; Forkhead Transcription Factors; Humans; Keloid; Ki-67 Anti | 2022 |
Questions raised by a case of adult-onset linear nodular scleroderma.
Topics: Adult; Female; Humans; Hydroxychloroquine; Keloid; Scleroderma, Localized; Scleroderma, Systemic; Sk | 2022 |
Nodular (keloidal) scleroderma.
Topics: Humans; Keloid; Scleroderma, Localized; Scleroderma, Systemic | 2023 |
Nodular morphea keloidal type: A rare case with paradigmatic histopathology significantly accompanied by a flawless surgical scar.
Topics: Breast Neoplasms; Female; Humans; Keloid; Middle Aged; Scleroderma, Localized | 2021 |
Keloidal Morphea: Clinical Picture.
Topics: Diagnosis, Differential; Humans; Keloid; Scleroderma, Localized | 2020 |
Keloid-like morphoea.
Topics: Child; Female; Humans; Hyperpigmentation; Keloid; Scleroderma, Localized | 2014 |
Imaging of collagen deposition disorders using optical coherence tomography.
Topics: Adult; Cicatrix, Hypertrophic; Collagen; Humans; Keloid; Lichen Sclerosus et Atrophicus; Middle Aged | 2015 |
Superimposed segmental morphea with keloidal features.
Topics: Adolescent; Female; Humans; Keloid; Scleroderma, Localized; Ultraviolet Therapy | 2015 |
Polarized Microscopy in Lesions With Altered Dermal Collagen.
Topics: Biomarkers, Tumor; Biopsy; Dermatofibrosarcoma; Diagnosis, Differential; Fibrillar Collagens; Histio | 2016 |
Images in clinical medicine. Keloidal morphea.
Topics: Adult; Diagnosis, Differential; Female; Humans; Keloid; Scleroderma, Localized; Skin | 2011 |
Fussel-15, a new player in wound healing, is deregulated in keloid and localized scleroderma.
Topics: Actins; Biological Assay; Cell Adhesion; Cell Line; Cell Movement; Cell Proliferation; Co-Repressor | 2011 |
Keloid-like scleroderma.
Topics: Actins; Elastic Tissue; Female; Fibroblasts; Fibrosis; Humans; Immunohistochemistry; Keloid; Middle | 2003 |
What is nodular-keloidal scleroderma?
Topics: Fibrosis; Humans; Keloid; Scleroderma, Localized; Scleroderma, Systemic; Skin | 2003 |
Polymorphic fibrosing reaction mimicking keloidal scleroderma but without associated classic scleroderma.
Topics: Adult; Female; Fibrosis; Humans; Hyperpigmentation; Keloid; Scleroderma, Localized; Scleroderma, Sys | 2003 |
[Keloid-like scleroderma, with remarks on phase variation of certain sclerodermic diseases].
Topics: Basidiomycota; Fibroma; Humans; Keloid; Scleroderma, Localized; Scleroderma, Systemic | 1954 |
[A contribution to nodular scleroderma (keloid-like scleroderma Unna)].
Topics: Humans; Keloid; Medical Records; Scleroderma, Localized; Scleroderma, Systemic | 1960 |
[PRIMARY BLASTOMATOUS RETICULOSIS OF THE SKIN SIMULATING MORPHEA)].
Topics: Humans; Keloid; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Neoplasms; Sarcoma; Scalp; S | 1965 |
Role of cathepsin K in the turnover of the dermal extracellular matrix during scar formation.
Topics: Cathepsin K; Cathepsins; Cells, Cultured; Cicatrix; Cytoplasm; Dermis; Endosomes; Extracellular Matr | 2007 |
Tranilast, a selective inhibitor of collagen synthesis in human skin fibroblasts.
Topics: Adolescent; Adult; Aged; Cells, Cultured; Collagen; Female; Fibroblasts; Histamine H1 Antagonists; H | 1994 |
Tranilast inhibits collagen synthesis in normal, scleroderma and keloid fibroblasts at a late passage culture but not at an early passage culture.
Topics: Cells, Cultured; Cellular Senescence; Collagen; Fibroblasts; Humans; Keloid; ortho-Aminobenzoates; S | 1995 |
Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders.
Topics: Adolescent; Adult; Child; Connective Tissue Growth Factor; Fibrosis; Gene Expression; Growth Substan | 1996 |
Keloidlike morphea.
Topics: Female; Humans; Keloid; Middle Aged; Neck; Scleroderma, Localized | 1997 |
Expression of type XVI collagen in human skin fibroblasts: enhanced expression in fibrotic skin diseases.
Topics: Adolescent; Adult; Collagen; Female; Fibroblasts; Fluorescent Antibody Technique; Humans; Keloid; Ma | 1999 |
Miscellaneous dermatoses.
Topics: Acanthosis Nigricans; Adolescent; Athletic Injuries; Dermatomycoses; Female; Granuloma; Humans; Icht | 1978 |
The diagnostic application of specific anti-procollagen sera. I. Analysis of skin biopsies.
Topics: Adolescent; Adult; Aged; Humans; Immune Sera; Keloid; Lichen Planus; Lupus Erythematosus, Discoid; L | 1976 |
[The polymorphism of collagen. New viewpoints on the structure and function of connective tissue].
Topics: Age Factors; Amino Acid Sequence; Antibodies; Aorta; Cartilage; Chemical Phenomena; Chemistry; Colla | 1976 |
[Treatment with hyaluronidase in dermatology].
Topics: Humans; Hyaluronoglucosaminidase; Keloid; Male; Penile Induration; Scleroderma, Localized; Scleroder | 1975 |
Pentoxifylline inhibits the proliferation of human fibroblasts derived from keloid, scleroderma and morphoea skin and their production of collagen, glycosaminoglycans and fibronectin.
Topics: Cell Division; Collagen; Depression, Chemical; Fibroblasts; Fibronectins; Glycosaminoglycans; Humans | 1990 |
Scleroderma presenting with multiple keloids.
Topics: Adolescent; Female; Humans; Keloid; Scleroderma, Localized | 1985 |
Penicillamine in the treatment of morphoea and keloid in children.
Topics: Child; Female; Humans; Keloid; Male; Penicillamine; Scleroderma, Localized | 1974 |