khellin has been researched along with Progeria in 4 studies
Khellin: A vasodilator that also has bronchodilatory action. It has been employed in the treatment of angina pectoris, in the treatment of asthma, and in conjunction with ultraviolet light A, has been tried in the treatment of vitiligo. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1024)
khellin : A furanochrome in which the basic tricyclic skeleton is substituted at positions 4 and 9 with methoxy groups and at position 7 with a methyl group. A major constituent of the plant Ammi visnaga it is a herbal folk medicine used for various illnesses, its main effect being as a vasodilator.
Progeria: An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature graying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Other elastin deficiencies may be due to excess elastolysis or gene dosage effects." | 2.39 | Regulation of elastin synthesis in pathological states. ( Davidson, JM; Giro, MG; Zang, MC; Zoia, O, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zufferey, F | 1 |
| Hadj-Rabia, S | 1 |
| De Sandre-Giovannoli, A | 1 |
| Dufier, JL | 1 |
| Leheup, B | 1 |
| Schweitze, C | 1 |
| Bodemer, C | 1 |
| Cormier-Daire, V | 1 |
| Le Merrer, M | 1 |
| Davidson, JM | 1 |
| Zang, MC | 1 |
| Zoia, O | 1 |
| Giro, MG | 1 |
| Jimbow, K | 1 |
| Kobayashi, H | 1 |
| Ishii, M | 1 |
| Oyanagi, A | 1 |
| Ooshima, A | 1 |
| Lapiere, CH | 1 |
2 reviews available for khellin and Progeria
| Article | Year |
|---|---|
Regulation of elastin synthesis in pathological states.
Topics: Animals; Cutis Laxa; Elastin; Fibrosis; Humans; Keloid; Progeria | 1995 |
The molecular basis of connective tissue pathology.
Topics: Animals; Basement Membrane; Cattle; Collagen; Connective Tissue; Ehlers-Danlos Syndrome; Elastin; Ep | 1973 |
2 other studies available for khellin and Progeria
| Article | Year |
|---|---|
Acro-osteolysis, keloid like-lesions, distinctive facial features, and overgrowth: two newly recognized patients with premature aging syndrome, Penttinen type.
Topics: Acro-Osteolysis; Adolescent; Child; Collagen Type III; Face; Humans; Keloid; Lamin Type A; Limb Defo | 2013 |
Scar and keloidlike lesions in progeria. An electron-microscopic and immunohistochemical study.
Topics: Biopsy; Child, Preschool; Cicatrix; Female; Humans; Immunohistochemistry; Keloid; Microscopy, Electr | 1988 |