Page last updated: 2024-10-30

khellin and Melanoma

khellin has been researched along with Melanoma in 27 studies

Khellin: A vasodilator that also has bronchodilatory action. It has been employed in the treatment of angina pectoris, in the treatment of asthma, and in conjunction with ultraviolet light A, has been tried in the treatment of vitiligo. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1024)
khellin : A furanochrome in which the basic tricyclic skeleton is substituted at positions 4 and 9 with methoxy groups and at position 7 with a methyl group. A major constituent of the plant Ammi visnaga it is a herbal folk medicine used for various illnesses, its main effect being as a vasodilator.

Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)

Research Excerpts

ExcerptRelevanceReference
"The aim of this study was to test the effect of khellin and KUVA on proliferation and melanogenesis of normal human melanocytes and Mel-1 melanoma cells in vitro."7.72KUVA (khellin plus ultraviolet A) stimulates proliferation and melanogenesis in normal human melanocytes and melanoma cells in vitro. ( Carlie, G; Hulley, PA; Kidson, SH; Ntusi, NB, 2003)
"Visnagin was induced apoptosis due to the intracellular generation of reactive oxygen species (ROS) and showed an apoptotic effect against HT 144 cell lines by 25."5.51The anticancer activity of visnagin, isolated from Ammi visnaga L., against the human malignant melanoma cell lines, HT 144. ( Aydoğmuş-Öztürk, F; Beyazit, N; Choudhary, MI; Günaydın, K; Jahan, H, 2019)
"The aim of this study was to test the effect of khellin and KUVA on proliferation and melanogenesis of normal human melanocytes and Mel-1 melanoma cells in vitro."3.72KUVA (khellin plus ultraviolet A) stimulates proliferation and melanogenesis in normal human melanocytes and melanoma cells in vitro. ( Carlie, G; Hulley, PA; Kidson, SH; Ntusi, NB, 2003)
"Visnagin was induced apoptosis due to the intracellular generation of reactive oxygen species (ROS) and showed an apoptotic effect against HT 144 cell lines by 25."1.51The anticancer activity of visnagin, isolated from Ammi visnaga L., against the human malignant melanoma cell lines, HT 144. ( Aydoğmuş-Öztürk, F; Beyazit, N; Choudhary, MI; Günaydın, K; Jahan, H, 2019)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-199014 (51.85)18.7374
1990's2 (7.41)18.2507
2000's3 (11.11)29.6817
2010's6 (22.22)24.3611
2020's2 (7.41)2.80

Authors

AuthorsStudies
Aydoğmuş-Öztürk, F1
Jahan, H1
Beyazit, N1
Günaydın, K1
Choudhary, MI1
Carlie, G1
Ntusi, NB1
Hulley, PA1
Kidson, SH1
Dore, R1
McClelland, K1
Brady, A1
Reid, P1
Houghton, J1
Nakamura, Y1
Ishitsuka, Y1
Fujisawa, Y1
Konishi, R1
Maruyama, H1
Inoue, S1
Okiyama, N1
Watanabe, R1
Fujimoto, M1
Wadhwa, R1
Priyandoko, D1
Gao, R1
Widodo, N1
Nigam, N1
Li, L1
Ahn, HM1
Yun, CO1
Ando, N1
Mahe, C1
Kaul, SC1
Cicchi, R1
Sestini, S1
De Giorgi, V1
Massi, D1
Lotti, T1
Pavone, FS1
Lazarus, M1
Kaufman, H1
Liodaki, E1
Eirini, L1
Liodakis, E1
Emmanouil, L1
Papadopoulos, O1
Othonas, P1
Machens, HG1
Hans-Günther, M1
Papadopulos, NA1
Nikolaos, PA1
Zhang, X1
VILANOVA, X1
MATO, J1
JOHNSON, WC1
HELWIG, EB1
SCHULZ, MD1
WANG, CC1
Theopold, C1
Pritchard, S1
McGrouther, DA1
Bayat, A1
Pircher, FJ1
Anderson, B1
Cavanaugh, PJ1
Sharp, KW1
Thomas, JR1
Doyle, JA1
Parlette, HL1
Hendrix, JD1
Dompmartin, A1
Zabel, M1
Hiss, Y1
Shafir, R1
Gay, S1
Müller, PK1
Meigel, WN1
Kühn, K1
Morgan, JE1
Gilchrest, B1
Goldwyn, RM1
Smoller, BR1
McNutt, NS1
Hsu, A1
Ronnen, M1
Sokol, MS1
Huszar, M1
Kahana, M1
Schewach-Millet, M1
Morelli, JG1
Parrish, JA2
Walsh, J1
Morelli, J1
Conley, J1

Reviews

8 reviews available for khellin and Melanoma

ArticleYear
Dark Skin Representation in Mobile Applications for Dermatology Education: A Scoping Review.
    Skinmed, 2023, Volume: 21, Issue:4

    Topics: Dermatology; Humans; Keloid; Melanoma; Mobile Applications; Skin Neoplasms; Skin Pigmentation

2023
An association between corticosteroid use and melanoma recurrence: a case report and review of the literature.
    Medical oncology (Northwood, London, England), 2012, Volume: 29, Issue:3

    Topics: Adrenal Cortex Hormones; Aged; Carcinoma in Situ; Carcinoma, Basal Cell; Humans; Keloid; Male; Melan

2012
PET scanning in plastic and reconstructive surgery.
    Annals of nuclear medicine, 2012, Volume: 26, Issue:2

    Topics: Breast Neoplasms; Diabetic Foot; Female; Fluorodeoxyglucose F18; Head and Neck Neoplasms; Humans; Ke

2012
Genome-wide association study of skin complex diseases.
    Journal of dermatological science, 2012, Volume: 66, Issue:2

    Topics: Alopecia; Carcinoma, Basal Cell; Dermatitis, Atopic; Female; Genetic Predisposition to Disease; Geno

2012
The therapeutic uses of topical vitamin A acid.
    Journal of the American Academy of Dermatology, 1981, Volume: 4, Issue:5

    Topics: Acne Vulgaris; Animals; Callosities; Cocarcinogenesis; Fox-Fordyce Disease; Humans; Ichthyosis; Kelo

1981
Cutaneous and cartilaginous lesions of the auricle.
    Facial plastic surgery : FPS, 1995, Volume: 11, Issue:4

    Topics: Carcinoma in Situ; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cysts; Ear Cartilage; Ear Diseas

1995
Skin pigmentation. Current concepts and relevance to plastic surgery.
    Plastic and reconstructive surgery, 1975, Volume: 56, Issue:6

    Topics: Adolescent; Adult; Dermabrasion; Female; Ficusin; Humans; Keloid; Male; Melanins; Melanocyte-Stimula

1975
Lasers in dermatology: a selective historical review.
    Photo-dermatology, 1985, Volume: 2, Issue:5

    Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Dermatology; Humans; Keloid; Laser Therapy; Melanom

1985

Other Studies

19 other studies available for khellin and Melanoma

ArticleYear
The anticancer activity of visnagin, isolated from Ammi visnaga L., against the human malignant melanoma cell lines, HT 144.
    Molecular biology reports, 2019, Volume: 46, Issue:2

    Topics: Ammi; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chromones; Furans; Hum

2019
KUVA (khellin plus ultraviolet A) stimulates proliferation and melanogenesis in normal human melanocytes and melanoma cells in vitro.
    The British journal of dermatology, 2003, Volume: 149, Issue:4

    Topics: Blotting, Northern; Blotting, Western; Cell Division; Cell Line, Tumor; Cells, Cultured; Fibroblasts

2003
Keloidal atypical fibroxanthoma of the scalp.
    BMJ case reports, 2023, Nov-16, Volume: 16, Issue:11

    Topics: Aged; Biomarkers, Tumor; Carcinoma, Squamous Cell; Diagnosis, Differential; Humans; Keloid; Melanoma

2023
Pelvic reactive lymphadenopathy mimicking lymph node metastasis of heel malignant melanoma.
    European journal of dermatology : EJD, 2018, Dec-01, Volume: 28, Issue:6

    Topics: Diagnosis, Differential; Heel; Humans; Keloid; Lymphadenopathy; Lymphatic Metastasis; Male; Melanoma

2018
Stress chaperone mortalin regulates human melanogenesis.
    Cell stress & chaperones, 2016, Volume: 21, Issue:4

    Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Diglycerides; HSP70 Heat-Shock Proteins; Humans; Hy

2016
Nonlinear laser imaging of skin lesions.
    Journal of biophotonics, 2008, Volume: 1, Issue:1

    Topics: Adult; Aged; Carcinoma, Basal Cell; Female; Humans; Keloid; Lasers; Male; Melanoma; Microscopy, Conf

2008
[Melanoma treated at the initial site with formation of a keloid scar, with residual lymph node metastases].
    Actas dermo-sifiliograficas, 1952, Volume: 43, Issue:9

    Topics: Cicatrix; Humans; Keloid; Lymph Nodes; Lymphatic Metastasis; Melanoma

1952
HISTOCHEMISTRY OF THE ACID MUCOPOLYSACCHARIDES OF SKIN IN NORMAL AND IN CERTAIN PATHOLOGIC CONDITIONS.
    American journal of clinical pathology, 1963, Volume: 40

    Topics: Adenocarcinoma, Mucinous; Calcinosis; Classification; Coloring Agents; Glycosaminoglycans; Histocyto

1963
RADIOTHERAPY OF LESIONS OF THE LIDS.
    International ophthalmology clinics, 1964, Volume: 4

    Topics: Conjunctiva; Conjunctivitis; Cornea; Eyelashes; Eyelids; Humans; Keloid; Lens, Crystalline; Lymphoma

1964
Keloid scar harbouring malignant blue naevus emphasises the need for excision biopsy and routine histology.
    Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 2009, Volume: 62, Issue:1

    Topics: Aged; Diagnosis, Differential; Ear Neoplasms; Ear, External; Humans; Keloid; Male; Melanoma; Nevus,

2009
Experiences with a solid state detector for surface counting of phosphorus-32.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1967, Volume: 8, Issue:6

    Topics: Ciliary Body; Eye Neoplasms; Humans; Keloid; Melanoma; Neoplasm Metastasis; Phosphorus Isotopes; Rad

1967
[Nodules of the external ear].
    Annales de dermatologie et de venereologie, 1999, Volume: 126, Issue:3

    Topics: Angiolymphoid Hyperplasia with Eosinophilia; Calcinosis; Carcinoma, Basal Cell; Carcinoma, Squamous

1999
[Scar keloids, eruptive xanthomas, mollusca contagiosa, juvenile melanoma, circumscript pretibial myxedema].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1978, Volume: 29, Issue:8

    Topics: Adolescent; Adult; Aged; Female; Humans; Keloid; Melanoma; Middle Aged; Molluscum Contagiosum; Myxed

1978
"Pseudomelanoma" in a keloid.
    The Journal of dermatologic surgery and oncology, 1978, Volume: 4, Issue:12

    Topics: Adult; Diagnosis, Differential; Female; Humans; Keloid; Melanoma; Nevus, Pigmented; Recurrence; Skin

1978
[The polymorphism of collagen. New viewpoints on the structure and function of connective tissue].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1976, Volume: 27, Issue:5

    Topics: Age Factors; Amino Acid Sequence; Antibodies; Aorta; Cartilage; Chemical Phenomena; Chemistry; Colla

1976
HMB-45 recognizes stimulated melanocytes.
    Journal of cutaneous pathology, 1989, Volume: 16, Issue:2

    Topics: Antibodies, Monoclonal; Antigens; Binding Sites, Antibody; Cicatrix; Cytoplasm; Ecchymosis; Fibroma;

1989
Pseudomelanoma following treatment with surgical excision and intralesional triamcinolone acetonide to prevent keloid formation.
    International journal of dermatology, 1986, Volume: 25, Issue:8

    Topics: Adult; Female; Humans; Keloid; Melanoma; Neoplasm Recurrence, Local; Nevus, Pigmented; Skin Neoplasm

1986
Laser-tissue interactions and their clinical applications.
    Current problems in dermatology, 1986, Volume: 15

    Topics: Forecasting; Hematoporphyrin Photoradiation; Humans; Keloid; Laser Therapy; Melanoma; Nevus, Pigment

1986
Irradiation as an etiologic factor in the development of melanoma.
    Archives of otolaryngology (Chicago, Ill. : 1960), 1970, Volume: 92, Issue:6

    Topics: Adult; Aged; Burns; Carcinoma, Squamous Cell; Facial Neoplasms; Female; Head and Neck Neoplasms; Hum

1970