khellin has been researched along with Disease Models, Animal in 42 studies
Khellin: A vasodilator that also has bronchodilatory action. It has been employed in the treatment of angina pectoris, in the treatment of asthma, and in conjunction with ultraviolet light A, has been tried in the treatment of vitiligo. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1024)
khellin : A furanochrome in which the basic tricyclic skeleton is substituted at positions 4 and 9 with methoxy groups and at position 7 with a methyl group. A major constituent of the plant Ammi visnaga it is a herbal folk medicine used for various illnesses, its main effect being as a vasodilator.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, the effect of PDT mediated by the photosensitizer hematoporphyrin monomethyl ether (HMME) on keloids is not known well." | 7.96 | Hematoporphyrin monomethyl ether-mediated photodynamic therapy inhibits the growth of keloid graft by promoting fibroblast apoptosis and reducing vessel formation. ( Chen, X; Cui, X; Wu, X; Xu, P; Yang, S; Yao, X; Zhu, J; Zhu, W, 2020) |
| "Triamcinolone acetonide intralesional injections significantly increased apoptosis in keloids, represented by increased caspase 3 protein and TUNEL expressions, supporting that steroids suppress keloids in part owing to enhancement of apoptosis." | 7.91 | Triamcinolone Acetonide Suppresses Keloid Formation Through Enhancing Apoptosis in a Nude Mouse Model. ( Chen, AD; Chen, RF; Huang, YT; Kuo, YR; Lai, CS; Li, YT; Lin, SD, 2019) |
| "To create three-dimensional poly lactic-co-glycolic acid (PLGA) scaffolds containing autologous platelet-rich plasma (PRP) as an in vitro culture environment for keloid fibroblasts (KL), and to study their implantation into nude mice to mimic the process of keloid formation." | 7.88 | Three-dimensional poly lactic-co-glycolic acid scaffold containing autologous platelet-rich plasma supports keloid fibroblast growth and contributes to keloid formation in a nude mouse model. ( Chen, C; Li, F; Luo, S; Sun, Z; Wang, H; Xu, X; Zhu, G, 2018) |
| "We studied the inhibitory effects of tranilast, an anti-allergic drug, on the human keloid tissues implanted into the dorsal skin of athymic nude mice and on the growth of keloid fibroblast in vitro." | 7.68 | [Effect of tranilast, an anti-allergic drug, on the human keloid tissues]. ( Arai, N; Hamano, S; Ichikawa, K; Kikuchi, S; Momose, Y; Shibata, N; Sugimoto, C; Suzawa, H; Tazawa, S; Tsuchiya, O, 1992) |
| "Keloids are wounding-induced tumor-like human scars." | 5.43 | Keloid-derived, plasma/fibrin-based skin equivalents generate de novo dermal and epidermal pathology of keloid fibrosis in a mouse model. ( Benya, PD; Chiu, WC; Choi, A; Hsu, T; Kim, EW; Kulber, DA; Lee, YS; Sarkozy, H; Tuan, TL, 2016) |
| "Tacrolimus is an immunomodulator that could be useful in treating keloid." | 5.37 | Intradermal tacrolimus prevent scar hypertrophy in a rabbit ear model: a clinical, histological and spectroscopical analysis. ( Blondel, WC; Chassagne, JF; Gisquet, H; Guillemin, F; Latarche, C; Leroux, A; Liu, H; Merlin, JL; Peiffert, D, 2011) |
| " However, the effect of PDT mediated by the photosensitizer hematoporphyrin monomethyl ether (HMME) on keloids is not known well." | 3.96 | Hematoporphyrin monomethyl ether-mediated photodynamic therapy inhibits the growth of keloid graft by promoting fibroblast apoptosis and reducing vessel formation. ( Chen, X; Cui, X; Wu, X; Xu, P; Yang, S; Yao, X; Zhu, J; Zhu, W, 2020) |
| "Triamcinolone acetonide intralesional injections significantly increased apoptosis in keloids, represented by increased caspase 3 protein and TUNEL expressions, supporting that steroids suppress keloids in part owing to enhancement of apoptosis." | 3.91 | Triamcinolone Acetonide Suppresses Keloid Formation Through Enhancing Apoptosis in a Nude Mouse Model. ( Chen, AD; Chen, RF; Huang, YT; Kuo, YR; Lai, CS; Li, YT; Lin, SD, 2019) |
| "To create three-dimensional poly lactic-co-glycolic acid (PLGA) scaffolds containing autologous platelet-rich plasma (PRP) as an in vitro culture environment for keloid fibroblasts (KL), and to study their implantation into nude mice to mimic the process of keloid formation." | 3.88 | Three-dimensional poly lactic-co-glycolic acid scaffold containing autologous platelet-rich plasma supports keloid fibroblast growth and contributes to keloid formation in a nude mouse model. ( Chen, C; Li, F; Luo, S; Sun, Z; Wang, H; Xu, X; Zhu, G, 2018) |
| "We studied the inhibitory effects of tranilast, an anti-allergic drug, on the human keloid tissues implanted into the dorsal skin of athymic nude mice and on the growth of keloid fibroblast in vitro." | 3.68 | [Effect of tranilast, an anti-allergic drug, on the human keloid tissues]. ( Arai, N; Hamano, S; Ichikawa, K; Kikuchi, S; Momose, Y; Shibata, N; Sugimoto, C; Suzawa, H; Tazawa, S; Tsuchiya, O, 1992) |
| "Abnormal scars, such as hypertrophic scars and keloids, and cutaneous fibrosis that develops in diseases such as systemic sclerosis and graft-versus-host disease can be even more challenging for patients." | 2.66 | A Review of the Evidence for and against a Role for Mast Cells in Cutaneous Scarring and Fibrosis. ( Bayat, A; Ud-Din, S; Wilgus, TA, 2020) |
| "Skin fibrosis is a hallmark of a wide array of dermatological diseases which can greatly impact the patients' quality of life." | 1.72 | Increased Expression of Galectin-3 in Skin Fibrosis: Evidence from In Vitro and In Vivo Studies. ( Almudéver, P; Alonso-Carpio, M; Cortijo, J; Marín, S; Milara, J; Montero, P; Peiró, T; Ribera, P; Roger, I, 2022) |
| "The formation of hypertrophic scaring (HSc) is an abnormal wound-healing response." | 1.46 | A Comparison of Gene Expression of Decorin and MMP13 in Hypertrophic Scars Treated With Calcium Channel Blocker, Steroid, and Interferon: A Human-Scar-Carrying Animal Model Study. ( Chuang, SS; Hsiao, YC; Yang, JY; Yang, SY, 2017) |
| "Keloids are wounding-induced tumor-like human scars." | 1.43 | Keloid-derived, plasma/fibrin-based skin equivalents generate de novo dermal and epidermal pathology of keloid fibrosis in a mouse model. ( Benya, PD; Chiu, WC; Choi, A; Hsu, T; Kim, EW; Kulber, DA; Lee, YS; Sarkozy, H; Tuan, TL, 2016) |
| "The link between FOXO1 and scarring extends to patients, in particular keloid scars, where we see FOXO1 expression markedly increased in fibroblasts and inflammatory cells within the otherwise normal dermis." | 1.40 | Reduced FOXO1 expression accelerates skin wound healing and attenuates scarring. ( de Kerckhove, M; Hirano, A; Ikematsu, K; Kashiyama, K; Kawata, T; Kim, S; Komatsu, T; Martin, P; Mori, R; Okamoto, M; Park, S; Shimokawa, I; Tanaka, K, 2014) |
| "Keloids are thick fibrous scars that are refractory to treatment and unique to humans." | 1.38 | Deep and superficial keloid fibroblasts contribute differentially to tissue phenotype in a novel in vivo model of keloid scar. ( Boyce, ST; Glaser, K; Hahn, JM; McFarland, KL; Supp, DM, 2012) |
| "Oral ulcers are relatively common and these lesions cause strong pain and discomfort." | 1.38 | Characterization of oral ulcer and pathological scar in nude mice model. ( Amiranashvili, I; Gogilashvili, Q; Imnadze, I; Sukhitashvili, N; Tabaghua, G, 2012) |
| "Hyperoxaluria was induced in male Sprague-Dawley rats by giving 0." | 1.37 | Prevention of renal crystal deposition by an extract of Ammi visnaga L. and its constituents khellin and visnagin in hyperoxaluric rats. ( Butterweck, V; Chow, N; Khan, SR; Vanachayangkul, P, 2011) |
| "Tacrolimus is an immunomodulator that could be useful in treating keloid." | 1.37 | Intradermal tacrolimus prevent scar hypertrophy in a rabbit ear model: a clinical, histological and spectroscopical analysis. ( Blondel, WC; Chassagne, JF; Gisquet, H; Guillemin, F; Latarche, C; Leroux, A; Liu, H; Merlin, JL; Peiffert, D, 2011) |
| "Keloid is regarded as a fibroproliferative disorder with excessive accumulation of extracellular matrix." | 1.37 | Effect of heat shock protein 47 on collagen synthesis of keloid in vivo. ( Cen, Y; Chen, JJ; Duan, WQ; Jin, PS; Liu, Y; Wang, HS; Xu, XW; Zhao, S, 2011) |
| "Considering that hypertrophic scar and keloid are conditions characterized by abnormal cell proliferation and excessive collagen accumulation accompanied with itch and pain, these results suggest that tranilast is useful as a therapeutic drug for hypertrophic scars and keloids." | 1.28 | [Effect of tranilast, an anti-allergic drug, on carrageenin-induced granulation and capillary permeability in rats]. ( Hamano, S; Ichikawa, K; Kikuchi, S; Komatsu, H; Miyata, H; Suzawa, H; Tsuchiya, O; Yamada, K, 1992) |
| "Hypertrophic scars and keloids appear to be unique to humans since animals are not known to form these lesions." | 1.28 | Use of nude (athymic) mice for the study of hypertrophic scars and keloids: vascular continuity between mouse and implants. ( Kischer, CW; Pindur, J; Sheridan, D, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (7.14) | 18.7374 |
| 1990's | 3 (7.14) | 18.2507 |
| 2000's | 8 (19.05) | 29.6817 |
| 2010's | 20 (47.62) | 24.3611 |
| 2020's | 8 (19.05) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 2 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Pasari, LP | 1 |
| Khurana, A | 1 |
| Anchi, P | 1 |
| Aslam Saifi, M | 1 |
| Annaldas, S | 1 |
| Godugu, C | 1 |
| Vanachayangkul, P | 1 |
| Chow, N | 1 |
| Khan, SR | 1 |
| Butterweck, V | 1 |
| Yuan, R | 1 |
| Dai, X | 1 |
| Li, Y | 2 |
| Li, C | 1 |
| Liu, L | 1 |
| Peiró, T | 2 |
| Alonso-Carpio, M | 2 |
| Ribera, P | 2 |
| Almudéver, P | 2 |
| Roger, I | 2 |
| Montero, P | 2 |
| Marín, S | 2 |
| Milara, J | 2 |
| Cortijo, J | 2 |
| Lee, AR | 1 |
| Lee, SY | 1 |
| Choi, JW | 1 |
| Um, IG | 1 |
| Na, HS | 1 |
| Lee, JH | 2 |
| Cho, ML | 1 |
| Cai, J | 1 |
| Zhou, Q | 1 |
| Wang, Z | 1 |
| Guo, R | 1 |
| Yang, R | 1 |
| Yang, X | 1 |
| Ahmad, N | 1 |
| Chen, Q | 1 |
| Hui, Q | 1 |
| Wang, X | 1 |
| Chen, AD | 1 |
| Chen, RF | 1 |
| Li, YT | 1 |
| Huang, YT | 1 |
| Lin, SD | 1 |
| Lai, CS | 1 |
| Kuo, YR | 1 |
| Cui, X | 1 |
| Zhu, J | 1 |
| Wu, X | 1 |
| Yang, S | 1 |
| Yao, X | 1 |
| Zhu, W | 1 |
| Xu, P | 1 |
| Chen, X | 1 |
| Tang, Z | 1 |
| Ding, J | 1 |
| Zhai, X | 1 |
| Jing, M | 1 |
| Guan, Z | 1 |
| Wilgus, TA | 1 |
| Ud-Din, S | 1 |
| Bayat, A | 1 |
| Choi, MH | 1 |
| Kim, J | 1 |
| Ha, JH | 1 |
| Park, JU | 1 |
| Chen, C | 1 |
| Wang, H | 2 |
| Zhu, G | 1 |
| Sun, Z | 1 |
| Xu, X | 1 |
| Li, F | 2 |
| Luo, S | 2 |
| Bao, B | 1 |
| Fu, K | 1 |
| Zhu, X | 1 |
| Li, X | 1 |
| Zheng, X | 1 |
| Fanous, A | 1 |
| Bezdjian, A | 1 |
| Caglar, D | 1 |
| Mlynarek, A | 1 |
| Fanous, N | 1 |
| Lenhart, SF | 1 |
| Daniel, SJ | 1 |
| Tunca, M | 1 |
| Gamsızkan, M | 1 |
| Yürekli, A | 1 |
| Alp Göksel, B | 1 |
| Fuat Çiçek, A | 1 |
| Çalışkan, E | 1 |
| Mori, R | 1 |
| Tanaka, K | 2 |
| de Kerckhove, M | 1 |
| Okamoto, M | 1 |
| Kashiyama, K | 1 |
| Kim, S | 1 |
| Kawata, T | 1 |
| Komatsu, T | 1 |
| Park, S | 1 |
| Ikematsu, K | 1 |
| Hirano, A | 1 |
| Martin, P | 1 |
| Shimokawa, I | 1 |
| Lee, YS | 1 |
| Hsu, T | 1 |
| Chiu, WC | 1 |
| Sarkozy, H | 1 |
| Kulber, DA | 1 |
| Choi, A | 1 |
| Kim, EW | 1 |
| Benya, PD | 1 |
| Tuan, TL | 1 |
| Shin, JU | 1 |
| Kim, SH | 1 |
| Kim, H | 1 |
| Noh, JY | 1 |
| Jin, S | 1 |
| Park, CO | 1 |
| Lee, WJ | 1 |
| Lee, DW | 1 |
| Lee, KH | 1 |
| Marttala, J | 1 |
| Andrews, JP | 1 |
| Rosenbloom, J | 1 |
| Uitto, J | 1 |
| Park, TH | 1 |
| Rah, DK | 1 |
| Chang, CH | 1 |
| Kim, SY | 1 |
| Yang, SY | 1 |
| Yang, JY | 1 |
| Hsiao, YC | 1 |
| Chuang, SS | 1 |
| Ogawa, R | 1 |
| Gisquet, H | 1 |
| Liu, H | 1 |
| Blondel, WC | 1 |
| Leroux, A | 1 |
| Latarche, C | 1 |
| Merlin, JL | 1 |
| Chassagne, JF | 1 |
| Peiffert, D | 1 |
| Guillemin, F | 1 |
| Chen, JJ | 2 |
| Jin, PS | 2 |
| Zhao, S | 1 |
| Cen, Y | 2 |
| Liu, Y | 2 |
| Xu, XW | 2 |
| Duan, WQ | 1 |
| Wang, HS | 1 |
| Supp, DM | 1 |
| Hahn, JM | 1 |
| Glaser, K | 1 |
| McFarland, KL | 1 |
| Boyce, ST | 1 |
| Sukhitashvili, N | 1 |
| Imnadze, I | 1 |
| Tabaghua, G | 1 |
| Gogilashvili, Q | 1 |
| Amiranashvili, I | 1 |
| Philandrianos, C | 1 |
| Gonnelli, D | 1 |
| Andrac-Meyer, L | 1 |
| Bruno, M | 1 |
| Magalon, G | 1 |
| Mordon, S | 1 |
| Yagi, Y | 1 |
| Muroga, E | 1 |
| Naitoh, M | 1 |
| Isogai, Z | 1 |
| Matsui, S | 1 |
| Ikehara, S | 1 |
| Suzuki, S | 1 |
| Miyachi, Y | 1 |
| Utani, A | 1 |
| Wang, HB | 1 |
| Luo, SK | 1 |
| Gao, JH | 2 |
| Liu, XX | 1 |
| Li, JJ | 1 |
| Wang, Y | 1 |
| Thielitz, A | 1 |
| Vetter, RW | 1 |
| Schultze, B | 1 |
| Wrenger, S | 1 |
| Simeoni, L | 1 |
| Ansorge, S | 1 |
| Neubert, K | 1 |
| Faust, J | 1 |
| Lindenlaub, P | 1 |
| Gollnick, HP | 1 |
| Reinhold, D | 1 |
| Lu, F | 1 |
| Blazek, J | 1 |
| Ottomann, C | 1 |
| Muehlberger, T | 1 |
| Polo, M | 1 |
| Kim, YJ | 1 |
| Kucukcelebi, A | 1 |
| Hayward, PG | 1 |
| Ko, F | 1 |
| Robson, MC | 1 |
| Suzawa, H | 2 |
| Kikuchi, S | 2 |
| Ichikawa, K | 2 |
| Arai, N | 1 |
| Tazawa, S | 1 |
| Tsuchiya, O | 2 |
| Momose, Y | 1 |
| Shibata, N | 1 |
| Sugimoto, C | 1 |
| Hamano, S | 2 |
| Yamada, K | 1 |
| Komatsu, H | 1 |
| Miyata, H | 1 |
| Kischer, CW | 2 |
| Sheridan, D | 1 |
| Pindur, J | 1 |
| Estrem, SA | 1 |
| Domayer, M | 1 |
| Bardach, J | 1 |
| Cram, AE | 1 |
| Shetlar, MR | 1 |
| Shetlar, CL | 1 |
| Hendricks, L | 1 |
2 reviews available for khellin and Disease Models, Animal
| Article | Year |
|---|---|
A Review of the Evidence for and against a Role for Mast Cells in Cutaneous Scarring and Fibrosis.
Topics: Animals; Biomarkers; Cell Communication; Cicatrix; Cicatrix, Hypertrophic; Disease Models, Animal; D | 2020 |
Keloids: Animal models and pathologic equivalents to study tissue fibrosis.
Topics: Animals; Cicatrix, Hypertrophic; Disease Models, Animal; Fibroblasts; Fibrosis; Humans; Keloid; Mice | 2016 |
40 other studies available for khellin and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Visnagin attenuates acute pancreatitis via Nrf2/NFκB pathway and abrogates associated multiple organ dysfunction.
Topics: Acute Disease; Ammi; Amylases; Animals; Anti-Inflammatory Agents; Ceruletide; Disease Models, Animal | 2019 |
Prevention of renal crystal deposition by an extract of Ammi visnaga L. and its constituents khellin and visnagin in hyperoxaluric rats.
Topics: Administration, Oral; Ammi; Animals; Calcium Oxalate; Disease Models, Animal; Hyperoxaluria; Khellin | 2011 |
Exosomes from miR-29a-modified adipose-derived mesenchymal stem cells reduce excessive scar formation by inhibiting TGF-β2/Smad3 signaling.
Topics: Animals; Cell Line; Cicatrix, Hypertrophic; Disease Models, Animal; Down-Regulation; Exosomes; Fibro | 2021 |
Increased Expression of Galectin-3 in Skin Fibrosis: Evidence from In Vitro and In Vivo Studies.
Topics: Animals; Disease Models, Animal; Fibroblasts; Fibrosis; Galectin 3; Humans; Keloid; Mice; Quality of | 2022 |
Increased Expression of Galectin-3 in Skin Fibrosis: Evidence from In Vitro and In Vivo Studies.
Topics: Animals; Disease Models, Animal; Fibroblasts; Fibrosis; Galectin 3; Humans; Keloid; Mice; Quality of | 2022 |
Increased Expression of Galectin-3 in Skin Fibrosis: Evidence from In Vitro and In Vivo Studies.
Topics: Animals; Disease Models, Animal; Fibroblasts; Fibrosis; Galectin 3; Humans; Keloid; Mice; Quality of | 2022 |
Increased Expression of Galectin-3 in Skin Fibrosis: Evidence from In Vitro and In Vivo Studies.
Topics: Animals; Disease Models, Animal; Fibroblasts; Fibrosis; Galectin 3; Humans; Keloid; Mice; Quality of | 2022 |
Establishment of a humanized mouse model of keloid diseases following the migration of patient immune cells to the lesion: Patient-derived keloid xenograft (PDKX) model.
Topics: Animals; Disease Models, Animal; Fibroblasts; Heterografts; Humans; Keloid; Mice; Mice, Inbred NOD; | 2023 |
Comparative Analysis of KGF-2 and bFGF in Prevention of Excessive Wound Healing and Scar Formation in a Corneal Alkali Burn Model.
Topics: Alkalies; Animals; Burns, Chemical; Cell Movement; Cell Proliferation; Cells, Cultured; Cornea; Corn | 2019 |
Triamcinolone Acetonide Suppresses Keloid Formation Through Enhancing Apoptosis in a Nude Mouse Model.
Topics: Animals; Apoptosis; Disease Models, Animal; In Situ Nick-End Labeling; Injections, Intralesional; Ke | 2019 |
Hematoporphyrin monomethyl ether-mediated photodynamic therapy inhibits the growth of keloid graft by promoting fibroblast apoptosis and reducing vessel formation.
Topics: Adult; Animals; Apoptosis; Cell Proliferation; Cell Survival; Disease Models, Animal; Female; Fibrob | 2020 |
MicroRNA-21 may be involved in the therapeutic effects of Galla chinensis ointment on keloid.
Topics: Animals; Biomarkers; Disease Models, Animal; Drugs, Chinese Herbal; Female; Fibroblasts; Humans; Imm | 2020 |
A selective small-molecule inhibitor of c-Met suppresses keloid fibroblast growth in vitro and in a mouse model.
Topics: Animals; Cell Line; Cell Proliferation; Disease Models, Animal; Fibroblasts; Humans; Keloid; Male; M | 2021 |
Three-dimensional poly lactic-co-glycolic acid scaffold containing autologous platelet-rich plasma supports keloid fibroblast growth and contributes to keloid formation in a nude mouse model.
Topics: Adult; Animals; Cells, Cultured; Collagen; Disease Models, Animal; Female; Fibroblasts; Genetic Vect | 2018 |
[ESTABLISHING AN ANIMAL MODEL OF DEFECATION RECONSTRUCTION AFTER SPINAL CORD INJURY IN RATS BY MECHANICAL POLISHING METHOD].
Topics: Animals; Cauda Equina; Defecation; Disease Models, Animal; Epidermis; Female; Humans; Immunohistoche | 2016 |
Treatment of Keloid Scars with Botulinum Toxin Type A versus Triamcinolone in an Athymic Nude Mouse Model.
Topics: Acetylcholine Release Inhibitors; Adult; Animals; Botulinum Toxins, Type A; Disease Models, Animal; | 2019 |
Cryosurgery to remove perichondrium for the rabbit ear hypertrophic scar model: a simplified method.
Topics: Animals; Cicatrix, Hypertrophic; Cryosurgery; Disease Models, Animal; Keloid; Rabbits; Wound Healing | 2019 |
Reduced FOXO1 expression accelerates skin wound healing and attenuates scarring.
Topics: Animals; Blotting, Western; Cicatrix; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; For | 2014 |
Keloid-derived, plasma/fibrin-based skin equivalents generate de novo dermal and epidermal pathology of keloid fibrosis in a mouse model.
Topics: Animals; Cells, Cultured; Collagen Type I; Dermis; Disease Models, Animal; Epidermal Cells; Fibrin; | 2016 |
TSLP Is a Potential Initiator of Collagen Synthesis and an Activator of CXCR4/SDF-1 Axis in Keloid Pathogenesis.
Topics: Animals; Blotting, Western; Cells, Cultured; Chemokine CXCL12; Collagen; Cytokines; Disease Models, | 2016 |
Establishment of Patient-Derived Keloid Xenograft Model.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Fibroblasts; Heterografts; Humans; Keloid; Male; M | 2016 |
A Comparison of Gene Expression of Decorin and MMP13 in Hypertrophic Scars Treated With Calcium Channel Blocker, Steroid, and Interferon: A Human-Scar-Carrying Animal Model Study.
Topics: Adolescent; Adult; Animals; Burns; Calcium Channel Blockers; Child; Child, Preschool; Cicatrix; Cica | 2017 |
Keloid and hypertrophic scarring may result from a mechanoreceptor or mechanosensitive nociceptor disorder.
Topics: Animals; Cicatrix, Hypertrophic; Disease Models, Animal; Humans; Keloid; Mechanoreceptors; Models, T | 2008 |
Intradermal tacrolimus prevent scar hypertrophy in a rabbit ear model: a clinical, histological and spectroscopical analysis.
Topics: Animals; Cicatrix, Hypertrophic; Dermoscopy; Disease Models, Animal; Ear, External; Female; Hypertro | 2011 |
Effect of heat shock protein 47 on collagen synthesis of keloid in vivo.
Topics: Adolescent; Adult; Animals; Blotting, Western; Collagen; Disease Models, Animal; Female; Fibroblasts | 2011 |
Deep and superficial keloid fibroblasts contribute differentially to tissue phenotype in a novel in vivo model of keloid scar.
Topics: Adolescent; Animals; Cells, Cultured; Child; Collagen Type I; Collagen Type I, alpha 1 Chain; Diseas | 2012 |
Characterization of oral ulcer and pathological scar in nude mice model.
Topics: Animals; Cicatrix; Disease Models, Animal; Fibrosis; Humans; Hydrochloric Acid; Immunohistochemistry | 2012 |
[Establishment of a keloid model by transplanting human keloid onto the backs of nude mice].
Topics: Animals; Disease Models, Animal; Female; Humans; Keloid; Mice; Mice, Nude; Transplantation, Heterolo | 2014 |
An ex vivo model employing keloid-derived cell-seeded collagen sponges for therapy development.
Topics: Adult; Animals; Chondroitin ABC Lyase; Disease Models, Animal; Extracellular Matrix; Female; Fibrobl | 2013 |
[The research of assembling animal models of keloid employing the method of tissue engineering].
Topics: Adult; Animals; Cells, Cultured; Disease Models, Animal; Female; Fibroblasts; Humans; Keloid; Lactic | 2005 |
[Construction of animal models of keloid by tissue engineering].
Topics: Animals; Cells, Cultured; Disease Models, Animal; Female; Fibroblasts; Humans; Keloid; Mice; Mice, I | 2005 |
[Experimental gene therapy of keloid in vivo using recombinant adenovirus coding for Fas gene with steroid hormone].
Topics: Adenoviridae; Animals; Disease Models, Animal; fas Receptor; Genetic Therapy; Genetic Vectors; Hormo | 2007 |
[Replication of pathological scar in nude mice].
Topics: Animals; Cicatrix, Hypertrophic; Disease Models, Animal; Keloid; Mice; Mice, Inbred BALB C; Mice, Nu | 2007 |
Inhibitors of dipeptidyl peptidase IV-like activity mediate antifibrotic effects in normal and keloid-derived skin fibroblasts.
Topics: Actins; Animals; Collagen Type I; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Diseas | 2008 |
[Experimental gene therapy of keloid in vivo using recombinant adenovirus carrying Fas gene].
Topics: Adenoviridae; Animals; Disease Models, Animal; fas Receptor; Female; Genetic Therapy; Genetic Vector | 2007 |
[Pharmacological therapy of keloids in an athymic mouse model].
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Colchicine; Data Interpretation, Stati | 2008 |
An in vivo model of human proliferative scar.
Topics: Animals; Cell Count; Cicatrix, Hypertrophic; Dermatologic Surgical Procedures; Disease Models, Anima | 1998 |
[Effect of tranilast, an anti-allergic drug, on the human keloid tissues].
Topics: Animals; Cell Division; Cells, Cultured; Collagen; Disease Models, Animal; Extracellular Matrix; Fib | 1992 |
[Effect of tranilast, an anti-allergic drug, on carrageenin-induced granulation and capillary permeability in rats].
Topics: Adult; Animals; Capillary Permeability; Carrageenan; Cicatrix; Disease Models, Animal; Dose-Response | 1992 |
Use of nude (athymic) mice for the study of hypertrophic scars and keloids: vascular continuity between mouse and implants.
Topics: Anastomosis, Surgical; Animals; Cicatrix; Dermatologic Surgical Procedures; Disease Models, Animal; | 1989 |
Implantation of human keloid into athymic mice.
Topics: Adult; Animals; Cells, Cultured; Disease Models, Animal; Female; Fibroblasts; Humans; Keloid; Male; | 1987 |
The use of athymic nude mice for the study of human keloids.
Topics: Animals; Disease Models, Animal; Glycosaminoglycans; Humans; Keloid; Mice; Mice, Nude | 1985 |