khellin has been researched along with Disease Exacerbation in 20 studies
Khellin: A vasodilator that also has bronchodilatory action. It has been employed in the treatment of angina pectoris, in the treatment of asthma, and in conjunction with ultraviolet light A, has been tried in the treatment of vitiligo. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1024)
khellin : A furanochrome in which the basic tricyclic skeleton is substituted at positions 4 and 9 with methoxy groups and at position 7 with a methyl group. A major constituent of the plant Ammi visnaga it is a herbal folk medicine used for various illnesses, its main effect being as a vasodilator.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to investigate the prevalences of hypertrophic scars and keloids in acne patients treated with oral isotretinoin." | 7.83 | Observational retrospective study evaluating the effects of oral isotretinoin in keloids and hypertrophic scars. ( Bagatin, E; Gonçalves, RG; Guadanhim, LR, 2016) |
| " Moreover, Diprotin A significantly suppressed proliferation and extracellular matrix secretion of CD26+ fibroblasts isolated from keloid tissues." | 3.85 | Expansion of CD26 positive fibroblast population promotes keloid progression. ( Bogari, M; Chai, G; Chen, W; Chen, X; Lin, L; Mar Aung, Z; Qu, M; Wang, X; Xin, Y; Zhang, Y; Zhu, M, 2017) |
| "The aim of this study was to investigate the prevalences of hypertrophic scars and keloids in acne patients treated with oral isotretinoin." | 3.83 | Observational retrospective study evaluating the effects of oral isotretinoin in keloids and hypertrophic scars. ( Bagatin, E; Gonçalves, RG; Guadanhim, LR, 2016) |
| "Keloid is troublesome for patients' skin appearance and mental health, although it is a benign tumor." | 1.62 | LncRNA HOXA11-AS Aggravates Keloid Progression by the Regulation of HOXA11-AS-miR-205-5p-FOXM1 Pathway. ( Gao, Y; Ma, Y; Su, X; Wang, Q, 2021) |
| "Keloid is a dermal tumor with high recurrence rate." | 1.51 | Connection between T regulatory cell enrichment and collagen deposition in keloid. ( Chen, Y; Fu, X; Jin, Q; Niu, F; Qiao, J, 2019) |
| "At present, keloids are classified as strongly inflammatory scars, while hypertrophic scars are considered to be mildly inflammatory scars." | 1.43 | Endothelial dysfunction may play a key role in keloid and hypertrophic scar pathogenesis - Keloids and hypertrophic scars may be vascular disorders. ( Akaishi, S; Ogawa, R, 2016) |
| "Keloid is a protruding hypertrophic fibrous formation of the dermis." | 1.40 | [Diagnosis and evolution of a keloid]. ( Hermanns-Lê, T; Nizet, JL; Piérard, GE; Piérard-Franchimont, C, 2014) |
| "Keloids are benign fibroproliferative dermal tumors of unknown etiology." | 1.36 | Association of HLA class I alleles with keloids in Chinese Han individuals. ( Cai, LQ; He, SM; Li, Y; Lu, WS; Quan, C; Wang, JF; Wang, ZX; Xiao, FL; Yang, S; Zhang, XJ, 2010) |
| "Severe cases of nuchal AM may precede acne keloidalis nuchae (AKN)." | 1.30 | Prevalence of acne keloidalis nuchae in football players. ( Gonin, R; Hanke, CW; Knable, AL, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 12 (60.00) | 24.3611 |
| 2020's | 5 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, Z | 1 |
| Gong, C | 1 |
| Wei, H | 1 |
| Luk, K | 1 |
| Fakhoury, J | 1 |
| Ozog, D | 1 |
| Chen, Y | 1 |
| Jin, Q | 1 |
| Fu, X | 1 |
| Qiao, J | 1 |
| Niu, F | 1 |
| Jin, J | 1 |
| Jia, ZH | 1 |
| Luo, XH | 1 |
| Zhai, HF | 1 |
| Zanoteli, E | 1 |
| Soares, PS | 1 |
| Silva, AMSD | 1 |
| Camelo, CG | 1 |
| Fonseca, ATQSM | 1 |
| Albuquerque, MAV | 1 |
| Moreno, CAM | 1 |
| Lopes Abath Neto, O | 1 |
| Novo Filho, GM | 1 |
| Kulikowski, LD | 1 |
| Reed, UC | 1 |
| Su, X | 1 |
| Ma, Y | 1 |
| Wang, Q | 1 |
| Gao, Y | 1 |
| Cabrera-Salom, C | 1 |
| González, LF | 1 |
| Rolón, M | 1 |
| Sánchez, BF | 1 |
| Xin, Y | 1 |
| Wang, X | 1 |
| Zhu, M | 1 |
| Qu, M | 1 |
| Bogari, M | 1 |
| Lin, L | 1 |
| Mar Aung, Z | 1 |
| Chen, W | 1 |
| Chen, X | 1 |
| Chai, G | 1 |
| Zhang, Y | 1 |
| Matsumoto, NM | 1 |
| Peng, WX | 1 |
| Aoki, M | 1 |
| Akaishi, S | 2 |
| Ohashi, R | 1 |
| Ogawa, R | 2 |
| Naito, Z | 1 |
| Hinojosa, JA | 1 |
| Pandya, AG | 1 |
| Ghazawi, FM | 1 |
| Zargham, R | 1 |
| Gilardino, MS | 1 |
| Sasseville, D | 1 |
| Jafarian, F | 1 |
| Piérard-Franchimont, C | 1 |
| Hermanns-Lê, T | 1 |
| Nizet, JL | 1 |
| Piérard, GE | 1 |
| Guadanhim, LR | 1 |
| Gonçalves, RG | 1 |
| Bagatin, E | 1 |
| Haurani, MJ | 1 |
| Foreman, K | 1 |
| Yang, JJ | 1 |
| Siddiqui, A | 1 |
| Tosa, M | 1 |
| Murakami, M | 1 |
| Ghazizadeh, M | 1 |
| Hyakusoku, H | 1 |
| Lu, WS | 1 |
| Cai, LQ | 1 |
| Wang, ZX | 1 |
| Li, Y | 1 |
| Wang, JF | 1 |
| Xiao, FL | 1 |
| Quan, C | 1 |
| He, SM | 1 |
| Yang, S | 1 |
| Zhang, XJ | 1 |
| Bond, JE | 1 |
| Bergeron, A | 1 |
| Thurlow, P | 1 |
| Selim, MA | 1 |
| Bowers, EV | 1 |
| Kuang, A | 1 |
| Levinson, H | 1 |
| Le, EN | 1 |
| Junkins-Hopkins, JM | 1 |
| Sherber, NS | 1 |
| Wigley, FM | 1 |
| Knable, AL | 1 |
| Hanke, CW | 1 |
| Gonin, R | 1 |
3 reviews available for khellin and Disease Exacerbation
| Article | Year |
|---|---|
Keloids on the ears.
Topics: Adult; Biopsy, Needle; Colombia; Cryosurgery; Disease Progression; Ear, External; Endemic Diseases; | 2017 |
The Importance of Patient Registries in Skin of Color.
Topics: Disease Progression; Humans; Keloid; Quality of Life; Registries; Skin Pigmentation; Vitiligo | 2017 |
Insights into the Pathophysiology of Hypertrophic Scars and Keloids: How Do They Differ?
Topics: Biopsy, Needle; Cicatrix, Hypertrophic; Collagen; Combined Modality Therapy; Diagnosis, Differential | 2018 |
17 other studies available for khellin and Disease Exacerbation
| Article | Year |
|---|---|
Long non-coding RNA H19 aggravates keloid progression by upregulating SMAD family member 5 expression via miR-196b-5p.
Topics: Cell Movement; Cell Nucleus; Cell Proliferation; Cell Survival; Cells, Cultured; Cytoplasm; Disease | 2022 |
Nonresponse and Progression of Diffuse Keloids to Dupilumab Therapy.
Topics: Adolescent; Antibodies, Monoclonal, Humanized; Cytokines; Dermatitis, Atopic; Disease Progression; F | 2022 |
Connection between T regulatory cell enrichment and collagen deposition in keloid.
Topics: Adult; Case-Control Studies; Cell Proliferation; Cells, Cultured; Cicatrix, Hypertrophic; Collagen; | 2019 |
Long non-coding RNA HOXA11-AS accelerates the progression of keloid formation via miR-124-3p/TGFβR1 axis.
Topics: Adult; Apoptosis; Base Sequence; Disease Progression; Down-Regulation; Female; Fibroblasts; Humans; | 2020 |
Clinical features of collagen VI-related dystrophies: A large Brazilian cohort.
Topics: Adolescent; Adult; Age of Onset; Brazil; Child; Cohort Studies; Collagen Type VI; Contracture; Disea | 2020 |
LncRNA HOXA11-AS Aggravates Keloid Progression by the Regulation of HOXA11-AS-miR-205-5p-FOXM1 Pathway.
Topics: Adult; Disease Progression; Female; Forkhead Box Protein M1; Gene Expression Regulation; Humans; Kel | 2021 |
Expansion of CD26 positive fibroblast population promotes keloid progression.
Topics: Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Cytokines; Dipeptidyl Peptidase 4 | 2017 |
Histological analysis of hyalinised keloidal collagen formation in earlobe keloids over time: collagen hyalinisation starts in the perivascular area.
Topics: Adolescent; Adult; Collagen; Cross-Sectional Studies; Disease Progression; Ear, External; Female; Hu | 2017 |
[Diagnosis and evolution of a keloid].
Topics: Disease Progression; Humans; Keloid; Male; Young Adult | 2014 |
Observational retrospective study evaluating the effects of oral isotretinoin in keloids and hypertrophic scars.
Topics: Acne Vulgaris; Administration, Oral; Adolescent; Adult; Case-Control Studies; Cicatrix, Hypertrophic | 2016 |
Endothelial dysfunction may play a key role in keloid and hypertrophic scar pathogenesis - Keloids and hypertrophic scars may be vascular disorders.
Topics: Adrenal Cortex Hormones; Burns; Cell Movement; Cicatrix, Hypertrophic; Disease Progression; Endothel | 2016 |
5-Fluorouracil treatment of problematic scars.
Topics: Adult; Antimetabolites; Cicatrix, Hypertrophic; Disease Progression; Female; Fluorouracil; Follow-Up | 2009 |
Chronologic change of the maximum dimension of Bacillus Calmette-Guerin-induced keloids.
Topics: Adolescent; Adult; Age of Onset; BCG Vaccine; Child; Disease Progression; Female; Humans; Keloid; Ma | 2009 |
Association of HLA class I alleles with keloids in Chinese Han individuals.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; China; Disease Progression; DNA Mutational Analysi | 2010 |
Angiotensin-II mediates nonmuscle myosin II activation and expression and contributes to human keloid disease progression.
Topics: Adolescent; Adult; Angiotensin II; Cell Movement; Cell Proliferation; Dermis; Disease Progression; F | 2011 |
Nodular/keloidal scleroderma: acquired collagenous nodules in systemic sclerosis.
Topics: Aged; Collagen; Disease Progression; Female; Humans; Keloid; Middle Aged; Scleroderma, Diffuse; Scle | 2012 |
Prevalence of acne keloidalis nuchae in football players.
Topics: Acne Keloid; Acne Vulgaris; Adolescent; Adult; Age Factors; Analysis of Variance; Black People; Conf | 1997 |