Page last updated: 2024-10-30

khellin and Cirrhosis

khellin has been researched along with Cirrhosis in 87 studies

Khellin: A vasodilator that also has bronchodilatory action. It has been employed in the treatment of angina pectoris, in the treatment of asthma, and in conjunction with ultraviolet light A, has been tried in the treatment of vitiligo. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1024)
khellin : A furanochrome in which the basic tricyclic skeleton is substituted at positions 4 and 9 with methoxy groups and at position 7 with a methyl group. A major constituent of the plant Ammi visnaga it is a herbal folk medicine used for various illnesses, its main effect being as a vasodilator.

Research Excerpts

ExcerptRelevanceReference
"Keloid fibroblasts were cultured and exposed to different concentrations of troglitazone in the presence of TGF-beta1."7.75Troglitazone suppresses transforming growth factor-beta1-induced collagen type I expression in keloid fibroblasts. ( Chen, XL; Gao, WY; Guo, SZ; Li, X; Li, ZJ; Ma, B; Yi, CG; Zhang, GY, 2009)
"Keloids are characterized by increased deposition of fibrous tissue in the skin and subcutaneous tissue following an abnormal wound healing process."5.62Halofuginone regulates keloid fibroblast fibrotic response to TGF-β induction. ( Chatelain, B; Dirand, Z; Humbert, P; Isidoro, C; Lihoreau, T; Marty, P; Rolin, G; Secomandi, E; Senez, C; Tissot, M, 2021)
"Keloid and hypertrophic scars are skin fibrosis-associated disorders that exhibit an uncontrollable proliferation of fibroblasts and their subsequent contribution to the excessive accumulation of extracellular matrix (ECM) in the dermis."5.62Ameliorating Fibrotic Phenotypes of Keloid Dermal Fibroblasts through an Epidermal Growth Factor-Mediated Extracellular Matrix Remodeling. ( Anggradita, LD; Bae, J; Hur, SS; Hwang, NS; Hwang, Y; Kim, H; Lee, SJ; Nam, SM, 2021)
"Paclitaxel (PTX) was an effective chemotherapeutic agent and has been reported to have anti-fibrotic effects, but the strong hydrophobicity brings a challenge for its clinical application."5.51Improving the anti-keloid outcomes through liposomes loading paclitaxel-cholesterol complexes. ( Chen, L; Gao, Z; Huang, W; Jin, M; Jin, Z; Wang, M; Wang, Q, 2019)
"Ginsenoside Rg3 (Rg3) has been reported to exert numerous antitumor effects, thus indicating that Rg3 may be a potential therapeutic agent that targets keloids."5.48Ginsenoside Rg3 inhibits keloid fibroblast proliferation, angiogenesis and collagen synthesis in vitro via the TGF‑β/Smad and ERK signaling pathways. ( Bian, W; Cheng, L; Jin, R; Tang, M; Wang, W; Zhang, L; Zhang, Y, 2018)
"Keloids are wounding-induced tumor-like human scars."5.43Keloid-derived, plasma/fibrin-based skin equivalents generate de novo dermal and epidermal pathology of keloid fibrosis in a mouse model. ( Benya, PD; Chiu, WC; Choi, A; Hsu, T; Kim, EW; Kulber, DA; Lee, YS; Sarkozy, H; Tuan, TL, 2016)
"Keloid fibroblasts were cultured and exposed to different concentrations of troglitazone in the presence of TGF-beta1."3.75Troglitazone suppresses transforming growth factor-beta1-induced collagen type I expression in keloid fibroblasts. ( Chen, XL; Gao, WY; Guo, SZ; Li, X; Li, ZJ; Ma, B; Yi, CG; Zhang, GY, 2009)
"Fibrosis is characterized by an excessive accumulation of collagen which contains increased levels of pyridinoline cross-links."3.72Increased formation of pyridinoline cross-links due to higher telopeptide lysyl hydroxylase levels is a general fibrotic phenomenon. ( Bank, RA; Boers, W; DeGroot, J; Huizinga, TW; Karel Ronday, H; Middelkoop, E; Ulrich, MM; van den Bogaerdt, AJ; van der Slot, AJ; Zuurmond, AM, 2004)
"Diseases such as uterine leiomyomata (fibroids and benign tumors of the uterus) and keloids (raised scars) may share common etiology."3.01Uterine leiomyomata and keloids fibrosis origins: a mini-review of fibroproliferative diseases. ( Edwards, TL; Hampton, G; Hellwege, JN; Kim, J; Velez Edwards, DR, 2023)
"Keloids and hypertrophic scars are pathological cutaneous scars."2.82Role of Inflammasomes in Keloids and Hypertrophic Scars-Lessons Learned from Chronic Diabetic Wounds and Skin Fibrosis. ( Huang, C; Ogawa, R, 2022)
"Scars are generated in mature skin as a result of the normal repair process, but the replacement of normal tissue with scar tissue can lead to biomechanical and functional deficiencies in the skin as well as psychological and social issues for patients that negatively affect quality of life."2.66A Review of the Evidence for and against a Role for Mast Cells in Cutaneous Scarring and Fibrosis. ( Bayat, A; Ud-Din, S; Wilgus, TA, 2020)
"Fibrosis is a common pathological state characterized by the excessive accumulation of extracellular matrix components, but the pathogenesis of the disease is still not clear."2.55MicroRNA-29: A Crucial Player in Fibrotic Disease. ( Deng, Z; He, L; He, Y; Lu, L; Shi, A; Shi, H; Yang, X, 2017)
"Skin fibrosis is a common pathological process characterized by fibroblast proliferation and excessive deposition of extracellular matrix."2.55MicroRNA-21 in Skin Fibrosis: Potential for Diagnosis and Treatment. ( Chen, T; Lei, Y; Li, Y; Lyu, L; Zhang, J; Zuo, R, 2017)
"The etiology of keloids is unknown but they occur after dermal injury in genetically susceptible individuals, and they cause both physical and psychological distress for the affected individuals."2.53Keloids: The paradigm of skin fibrosis - Pathomechanisms and treatment. ( Andrews, JP; Macarak, E; Marttala, J; Rosenbloom, J; Uitto, J, 2016)
"Organ fibrosis has been viewed as one of the major medical problems, which can lead to progressive dysfunction of the liver, lung, kidney, skin, heart, and eventually death of patients."2.48Organ fibrosis inhibited by blocking transforming growth factor-β signaling via peroxisome proliferator-activated receptor γ agonists. ( Cheng, NS; Deng, YL; Xiong, XZ, 2012)
"The medical subject headings ''scarring'' were combined with ''mechanisms''."2.48An overview of biological basis of pathologic scarring. ( Adeyemo, WL; Mofikoya, BO; Ugburo, AO, 2012)
"Fibroproliferative scars remain an ongoing clinical challenge."2.42Fibroproliferative scars. ( Garner, WL; Rahban, SR, 2003)
" Other elastin deficiencies may be due to excess elastolysis or gene dosage effects."2.39Regulation of elastin synthesis in pathological states. ( Davidson, JM; Giro, MG; Zang, MC; Zoia, O, 1995)
"Skin fibrosis is a common pathological manifestation in systemic sclerosis (SSc), keloid, and localized scleroderma (LS) characterized by fibroblast activation and excessive extracellular matrix (ECM) deposition."1.91Enhancement of Zyxin Promotes Skin Fibrosis by Regulating FAK/PI3K/AKT and TGF-β Signaling Pathways via Integrins. ( Gong, Y; Huang, Y; Jiang, S; Lin, J; Liu, J; Liu, Q; Ma, Y; Pu, W; Shi, X; Tang, Y; Wang, J; Wu, W; Zhang, Y; Zhao, H, 2023)
"Fibrosis is a common pathophysiological response of many tissues and organs subjected to chronic injury."1.72Skin fibrosis associated with keloid, scleroderma and Jorge Lobo's disease (lacaziosis): An immuno-histochemical study. ( Kanashiro-Galo, L; Mosser, DM; Pagliari, C; Quaresma, JAS; Silva, AMG; Sotto, MN; Tafuri, WL; Tomokane, TY, 2022)
"Skin fibrosis is a hallmark of a wide array of dermatological diseases which can greatly impact the patients' quality of life."1.72Increased Expression of Galectin-3 in Skin Fibrosis: Evidence from In Vitro and In Vivo Studies. ( Almudéver, P; Alonso-Carpio, M; Cortijo, J; Marín, S; Milara, J; Montero, P; Peiró, T; Ribera, P; Roger, I, 2022)
"Keloids are a benign dermal fibrotic disorder with features similar to malignant tumors."1.72Single-Cell RNA-Sequencing Reveals Lineage-Specific Regulatory Changes of Fibroblasts and Vascular Endothelial Cells in Keloids. ( Chen, J; Chen, W; Li, Z; Liu, X; Long, X; Ma, B; Meng, T; Yu, N; Zeng, Q; Zhou, Z, 2022)
"Keloid specimens and grossly normal scars were excised, and local expression of CXCL12 was assayed."1.62Systemic Fibrocyte Levels and Keloid Expression of the Chemoattractant CXCL12 Are Upregulated Compared With Patients With Normal Scar. ( Burdick, MD; Campbell, CA; Strieter, RM, 2021)
"Keloid and hypertrophic scars are skin fibrosis-associated disorders that exhibit an uncontrollable proliferation of fibroblasts and their subsequent contribution to the excessive accumulation of extracellular matrix (ECM) in the dermis."1.62Ameliorating Fibrotic Phenotypes of Keloid Dermal Fibroblasts through an Epidermal Growth Factor-Mediated Extracellular Matrix Remodeling. ( Anggradita, LD; Bae, J; Hur, SS; Hwang, NS; Hwang, Y; Kim, H; Lee, SJ; Nam, SM, 2021)
"Keloids are characterized by increased deposition of fibrous tissue in the skin and subcutaneous tissue following an abnormal wound healing process."1.62Halofuginone regulates keloid fibroblast fibrotic response to TGF-β induction. ( Chatelain, B; Dirand, Z; Humbert, P; Isidoro, C; Lihoreau, T; Marty, P; Rolin, G; Secomandi, E; Senez, C; Tissot, M, 2021)
"A keloid is a type of pathological scar often caused by abnormal tissue repair after a skin injury and is more common in genetically susceptible individuals."1.62Downregulation of Epac Reduces Fibrosis and Induces Apoptosis Through Akt Signaling in Human Keloid Fibroblasts. ( Bao, X; Feng, Y; Liu, S; Lv, W; Ren, Y; Yi, Z; Zhang, Q, 2021)
"Keloid is a benign dermal tumor with excessive hyperplasia and deposition of collagen."1.56Overexpression of miR-133a-3p inhibits fibrosis and proliferation of keloid fibroblasts by regulating IRF5 to inhibit the TGF-β/Smad2 pathway. ( Huang, Y; Jiang, L; Lin, L; Liu, J; Wang, P; Wang, X; Wang, Y, 2020)
"Visnagin is a furanochromone and one of the main compounds of Ammi visnaga L."1.56Visnagin ameliorates myocardial ischemia/reperfusion injury through the promotion of autophagy and the inhibition of apoptosis. ( Feng, BB; Fu, HR; Li, XS; Pan, LH; Zhang, YH, 2020)
"Paclitaxel (PTX) was an effective chemotherapeutic agent and has been reported to have anti-fibrotic effects, but the strong hydrophobicity brings a challenge for its clinical application."1.51Improving the anti-keloid outcomes through liposomes loading paclitaxel-cholesterol complexes. ( Chen, L; Gao, Z; Huang, W; Jin, M; Jin, Z; Wang, M; Wang, Q, 2019)
"Ginsenoside Rg3 (Rg3) has been reported to exert numerous antitumor effects, thus indicating that Rg3 may be a potential therapeutic agent that targets keloids."1.48Ginsenoside Rg3 inhibits keloid fibroblast proliferation, angiogenesis and collagen synthesis in vitro via the TGF‑β/Smad and ERK signaling pathways. ( Bian, W; Cheng, L; Jin, R; Tang, M; Wang, W; Zhang, L; Zhang, Y, 2018)
"Keloids are wounding-induced tumor-like human scars."1.43Keloid-derived, plasma/fibrin-based skin equivalents generate de novo dermal and epidermal pathology of keloid fibrosis in a mouse model. ( Benya, PD; Chiu, WC; Choi, A; Hsu, T; Kim, EW; Kulber, DA; Lee, YS; Sarkozy, H; Tuan, TL, 2016)
"Polyfibromatosis is a rare fibrosing condition characterized by fibromatosis in different body areas and by keloid formation, and which can be associated with arthropathy and osteolysis."1.39Arthropathy, osteolysis, keloids, relapsing conjunctival pannus and gingival overgrowth: a variant of polyfibromatosis? ( Cinotti, E; Di Maria, E; Faravelli, F; Ferrero, G; Papadia, M; Paparo, F; Rongioletti, F; Traverso, C, 2013)
"This pathological scar formation is often associates with pain and malfunction of the organ."1.38Characterization of oral ulcer and pathological scar in nude mice model. ( Amiranashvili, I; Gogilashvili, Q; Imnadze, I; Sukhitashvili, N; Tabaghua, G, 2012)
"Keloids and hypertrophic scars are significant symptomatic clinical problems characterized by the excessive and abnormal deposition of collagen-based extracellular matrix (ECM) components."1.37Smad interacting protein 1 as a regulator of skin fibrosis in pathological scars. ( Bai, XZ; Cai, WX; Hu, DH; Liu, JQ; Shi, JH; Tang, CW; Wang, HT; Zhang, YG; Zhang, ZF; Zhao, ZT; Zhu, HY, 2011)
"Atypical fibroxanthoma (AFX) with prominent fibrosis, sclerosis and hyalinization, and near-total tumor regression is rare."1.36The histopathologic spectrum of regression in atypical fibroxanthoma. ( Calonje, JE; Robson, A; Stefanato, CM, 2010)
"Keloids are benign dermal tumors that form during wound healing in genetically susceptible individuals."1.36Epigenetically altered wound healing in keloid fibroblasts. ( Broquist, AH; Gayden, AE; Nanney, LB; Opalenik, SR; Raju, L; Russell, JD; Russell, SB; Trupin, KM; Williams, SM, 2010)
"Keloids are benign tumors of the dermis that form during a protracted wound healing process."1.35Gene profiling of keloid fibroblasts shows altered expression in multiple fibrosis-associated pathways. ( Boone, BE; Opalenik, SR; Russell, SB; Smith, JC; Williams, SM, 2008)
"Fibrosis is a major cause of human death and disability."1.34Does transformation of microvascular endothelial cells into myofibroblasts play a key role in the etiology and pathology of fibrotic disease? ( Karasek, MA, 2007)
"Keloid is a fibrotic skin disorder that results in an excessive deposition of extracellular matrix, which is associated with altered-expression of or -responses to TGF-beta in dermal fibroblasts."1.32IFN-gamma fails to antagonize fibrotic effect of TGF-beta on keloid-derived dermal fibroblasts. ( Hasegawa, T; Nakao, A; Ogawa, H; Sumiyoshi, K; Tsuboi, R, 2003)

Research

Studies (87)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (6.90)18.2507
2000's13 (14.94)29.6817
2010's39 (44.83)24.3611
2020's29 (33.33)2.80

Authors

AuthorsStudies
Fu, HR1
Li, XS1
Zhang, YH1
Feng, BB1
Pan, LH1
Hua, Z1
Wei, P1
Dong, X2
Jin, X1
Li, Y3
Li, M1
Qu, C1
Tang, Z1
Zhou, Z2
Yu, Z1
Wang, X2
Xin, L1
Shi, T1
Hermenean, A1
Oatis, D1
Herman, H1
Ciceu, A1
D'Amico, G1
Trotta, MC1
Huang, C1
Ogawa, R2
Tafuri, WL1
Tomokane, TY1
Silva, AMG1
Kanashiro-Galo, L1
Mosser, DM1
Quaresma, JAS1
Pagliari, C1
Sotto, MN1
Cohen, AJ3
Nikbakht, N3
Uitto, J7
Peiró, T2
Alonso-Carpio, M2
Ribera, P2
Almudéver, P2
Roger, I2
Montero, P2
Marín, S2
Milara, J2
Cortijo, J2
Kidzeru, EB1
Lebeko, M1
Sharma, JR1
Nkengazong, L1
Adeola, HA1
Ndlovu, H1
P Khumalo, N1
Bayat, A6
Dolivo, DM1
Sun, LS1
Rodrigues, AE1
Galiano, RD2
Mustoe, TA2
Hong, SJ2
Huang, Y2
Zhao, H1
Zhang, Y2
Tang, Y1
Shi, X1
Jiang, S1
Pu, W1
Liu, J3
Ma, Y1
Lin, J2
Wu, W1
Gong, Y1
Wang, J1
Liu, Q1
Hampton, G1
Kim, J1
Edwards, TL1
Hellwege, JN1
Velez Edwards, DR1
Faour, S1
Farahat, M1
Aijaz, A1
Jeschke, MG2
Wood, FM1
Middelkoop, E2
Teot, L1
Gauglitz, GG1
Jeon, YR1
Roh, H2
Jung, JH1
Ahn, HM3
Lee, JH2
Yun, CO4
Lee, WJ4
Wang, Y1
Lin, L1
Wang, P1
Jiang, L1
Uchiyama, M1
Harada, K1
Tobita, R1
Irisawa, R1
Tsuboi, R2
Darmawan, CC1
Montenegro, SE1
Jo, G1
Kusumaningrum, N1
Lee, SH1
Chung, JH1
Mun, JH1
Liu, P1
Hu, Y1
Xia, L1
DU, M1
Hu, Z1
Russo, B1
Brembilla, NC1
Chizzolini, C1
Lv, W1
Liu, S1
Zhang, Q2
Yi, Z1
Bao, X1
Feng, Y1
Ren, Y1
Jeon, HB1
Roh, TS1
Wilgus, TA1
Ud-Din, S1
Marty, P1
Chatelain, B1
Lihoreau, T1
Tissot, M1
Dirand, Z1
Humbert, P1
Senez, C1
Secomandi, E1
Isidoro, C1
Rolin, G1
Kim, H1
Anggradita, LD1
Lee, SJ1
Hur, SS1
Bae, J1
Hwang, NS1
Nam, SM1
Hwang, Y1
Norouzi-Barough, L1
Liu, X1
Chen, W1
Zeng, Q1
Ma, B2
Li, Z1
Meng, T1
Chen, J1
Yu, N1
Long, X1
Campbell, CA1
Burdick, MD1
Strieter, RM1
Li, X4
Zhai, Y1
Xi, B1
Ma, W1
Zhang, J3
Ma, X1
Miao, Y1
Zhao, Y1
Ning, W1
Zhou, H1
Yang, C1
Lei, Y1
Lyu, L1
Zuo, R1
Chen, T1
Na, Y1
Wadhwa, R1
Hong, J1
Ren, J1
Su, L1
Cheng, S1
Zhou, J1
Ye, X1
Dong, Y1
Sun, S1
Qi, F1
Liu, Z2
Pleat, J1
Zhai, H1
Zhu, N1
Tang, M1
Bian, W1
Cheng, L1
Zhang, L2
Jin, R1
Wang, W1
Song, CL1
Yao, M1
Coentro, JQ1
Pugliese, E1
Hanley, G1
Raghunath, M1
Zeugolis, DI1
Ho, JD1
Chung, HJ2
Ms Barron, A1
Ho, DA1
Sahni, D1
Browning, JL1
Bhawan, J1
Han, B1
Fan, J1
Liu, L1
Tian, J1
Gan, C1
Yang, Z1
Jiao, H1
Zhang, T1
Zhang, H1
Shook, BA1
Wasko, RR1
Rivera-Gonzalez, GC1
Salazar-Gatzimas, E1
López-Giráldez, F1
Dash, BC1
Muñoz-Rojas, AR1
Aultman, KD1
Zwick, RK1
Lei, V1
Arbiser, JL1
Miller-Jensen, K1
Clark, DA1
Hsia, HC1
Horsley, V1
Chen, Z1
Wang, H1
Huguier, V1
Giot, JP1
Simonneau, M1
Levillain, P1
Charreau, S1
Garcia, M1
Jégou, JF1
Bodet, C1
Morel, F1
Lecron, JC1
Favot, L1
Wang, M1
Chen, L1
Huang, W1
Jin, M1
Wang, Q1
Gao, Z1
Jin, Z1
Cinotti, E1
Ferrero, G1
Paparo, F1
Papadia, M1
Faravelli, F1
Rongioletti, F1
Traverso, C1
Di Maria, E1
Theoret, CL1
Olutoye, OO1
Parnell, LK1
Hicks, J1
Zhang, GY3
Wu, LC1
Dai, T1
Chen, SY1
Wang, AY2
Lin, K1
Lin, DM1
Yang, JQ1
Cheng, B1
Gao, WY3
Li, ZJ2
Zhang, C1
Ma, S1
Wen, H1
Lee, YS1
Hsu, T1
Chiu, WC1
Sarkozy, H1
Kulber, DA1
Choi, A1
Kim, EW1
Benya, PD1
Tuan, TL1
Marttala, J2
Andrews, JP2
Rosenbloom, J2
Macarak, E1
Jumper, N1
Hodgkinson, T1
Arscott, G1
Har-Shai, Y1
Paus, R1
Zhao, J1
Zhong, A1
Friedrich, EE1
Jia, S1
Xie, P1
Zhao, B1
Guan, H1
Liu, JQ2
Zheng, Z1
Zhou, Q1
Su, LL1
Hu, DH2
Deng, Z1
He, Y1
Yang, X1
Shi, H1
Shi, A1
Lu, L1
He, L1
Steplewski, A1
Chung, KY1
Fertala, A1
Lopes, LB1
Furnish, EJ1
Komalavilas, P1
Flynn, CR1
Ashby, P1
Hansen, A1
Ly, DP1
Yang, GP1
Longaker, MT1
Panitch, A1
Brophy, CM1
Yi, CG1
Chen, XL1
Guo, SZ1
Gragnani, A1
Warde, M1
Furtado, F1
Ferreira, LM1
Stefanato, CM1
Robson, A1
Calonje, JE1
Valand, K1
McLoughlin, PM1
Russell, SB2
Russell, JD1
Trupin, KM1
Gayden, AE1
Opalenik, SR2
Nanney, LB1
Broquist, AH1
Raju, L1
Williams, SM2
Kronenberg, D1
Bruns, BC1
Moali, C1
Vadon-Le Goff, S1
Sterchi, EE1
Traupe, H1
Böhm, M1
Hulmes, DJ1
Stöcker, W1
Becker-Pauly, C1
McCarty, SM1
Syed, F1
Zhang, ZF1
Zhang, YG1
Shi, JH1
Zhao, ZT1
Wang, HT1
Bai, XZ1
Cai, WX1
Zhu, HY1
Tang, CW1
Pistorio, AL1
Ehrlich, HP1
Yu, Q1
Cheng, T1
Liao, T1
Nie, CL1
Zheng, X1
Xie, XG1
Albers, AE1
Kim, YO1
Choi, IK1
Rah, DK1
Mofikoya, BO1
Adeyemo, WL1
Ugburo, AO1
Sukhitashvili, N1
Imnadze, I1
Tabaghua, G1
Gogilashvili, Q1
Amiranashvili, I1
Jin, SE1
Kim, CK1
Kim, YB1
Deng, YL1
Xiong, XZ1
Cheng, NS1
Canady, J1
Arndt, S1
Karrer, S1
Bosserhoff, AK1
Rahban, SR1
Garner, WL1
Hasegawa, T1
Nakao, A1
Sumiyoshi, K1
Ogawa, H1
Barzilai, A1
Lyakhovitsky, A1
Horowitz, A1
Trau, H1
Labandeira, J2
León-Mateos, A2
Suárez-Peñaranda, JM2
Garea, MT2
Toribio, J2
Le, AD1
Wu, Y1
Messadi, DV1
Akhondzadeh, A1
Nguyen, AL1
Aghaloo, TL1
Kelly, AP1
Bertolami, CN1
van der Slot, AJ1
Zuurmond, AM1
van den Bogaerdt, AJ1
Ulrich, MM1
Boers, W1
Karel Ronday, H1
DeGroot, J1
Huizinga, TW1
Bank, RA1
Karasek, MA1
Thielitz, A1
Vetter, RW1
Schultze, B1
Wrenger, S1
Simeoni, L1
Ansorge, S1
Neubert, K1
Faust, J1
Lindenlaub, P1
Gollnick, HP1
Reinhold, D1
Smith, JC1
Boone, BE1
Davidson, JM1
Zang, MC1
Zoia, O1
Giro, MG1
Igarashi, A1
Nashiro, K1
Kikuchi, K1
Sato, S1
Ihn, H1
Fujimoto, M1
Grotendorst, GR1
Takehara, K1
Varga, J1
Kähäri, VM1
Burkhart, CG1
Burkhart, CN1
Higgins, PJ1
Slack, JK1
Diegelmann, RF1
Staiano-Coico, L1
Sollberg, S1
Peltonen, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of a Filming Formulation of Hydrogen Peroxide and Hyaluronic Acid (BMG0703) in Promoting the Healing of Post-extraction Sites, Compared to Placebo and 0.2% Chlorhexidine. A Randomised Controlled Clinical Trial.[NCT04438434]Phase 357 participants (Anticipated)Interventional2020-06-30Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

24 reviews available for khellin and Cirrhosis

ArticleYear
Galectin 1-A Key Player between Tissue Repair and Fibrosis.
    International journal of molecular sciences, 2022, May-16, Volume: 23, Issue:10

    Topics: Fibrosis; Galectin 1; Humans; Keloid; Phosphatidylinositol 3-Kinases; Wound Healing

2022
Role of Inflammasomes in Keloids and Hypertrophic Scars-Lessons Learned from Chronic Diabetic Wounds and Skin Fibrosis.
    International journal of molecular sciences, 2022, Jun-19, Volume: 23, Issue:12

    Topics: Cicatrix, Hypertrophic; Diabetes Mellitus; Endothelial Cells; Fibrosis; Humans; Inflammasomes; Infla

2022
Keloid Disorder: Genetic Basis, Gene Expression Profiles, and Immunological Modulation of the Fibrotic Processes in the Skin.
    Cold Spring Harbor perspectives in biology, 2023, 07-05, Volume: 15, Issue:7

    Topics: Cell Proliferation; Collagen; Fibronectins; Fibrosis; Humans; Keloid; Skin; Transcriptome

2023
Keloid Disorder: Genetic Basis, Gene Expression Profiles, and Immunological Modulation of the Fibrotic Processes in the Skin.
    Cold Spring Harbor perspectives in biology, 2023, 07-05, Volume: 15, Issue:7

    Topics: Cell Proliferation; Collagen; Fibronectins; Fibrosis; Humans; Keloid; Skin; Transcriptome

2023
Keloid Disorder: Genetic Basis, Gene Expression Profiles, and Immunological Modulation of the Fibrotic Processes in the Skin.
    Cold Spring Harbor perspectives in biology, 2023, 07-05, Volume: 15, Issue:7

    Topics: Cell Proliferation; Collagen; Fibronectins; Fibrosis; Humans; Keloid; Skin; Transcriptome

2023
Keloid Disorder: Genetic Basis, Gene Expression Profiles, and Immunological Modulation of the Fibrotic Processes in the Skin.
    Cold Spring Harbor perspectives in biology, 2023, 07-05, Volume: 15, Issue:7

    Topics: Cell Proliferation; Collagen; Fibronectins; Fibrosis; Humans; Keloid; Skin; Transcriptome

2023
Keloid Disorder: Genetic Basis, Gene Expression Profiles, and Immunological Modulation of the Fibrotic Processes in the Skin.
    Cold Spring Harbor perspectives in biology, 2023, 07-05, Volume: 15, Issue:7

    Topics: Cell Proliferation; Collagen; Fibronectins; Fibrosis; Humans; Keloid; Skin; Transcriptome

2023
Keloid Disorder: Genetic Basis, Gene Expression Profiles, and Immunological Modulation of the Fibrotic Processes in the Skin.
    Cold Spring Harbor perspectives in biology, 2023, 07-05, Volume: 15, Issue:7

    Topics: Cell Proliferation; Collagen; Fibronectins; Fibrosis; Humans; Keloid; Skin; Transcriptome

2023
Keloid Disorder: Genetic Basis, Gene Expression Profiles, and Immunological Modulation of the Fibrotic Processes in the Skin.
    Cold Spring Harbor perspectives in biology, 2023, 07-05, Volume: 15, Issue:7

    Topics: Cell Proliferation; Collagen; Fibronectins; Fibrosis; Humans; Keloid; Skin; Transcriptome

2023
Keloid Disorder: Genetic Basis, Gene Expression Profiles, and Immunological Modulation of the Fibrotic Processes in the Skin.
    Cold Spring Harbor perspectives in biology, 2023, 07-05, Volume: 15, Issue:7

    Topics: Cell Proliferation; Collagen; Fibronectins; Fibrosis; Humans; Keloid; Skin; Transcriptome

2023
Keloid Disorder: Genetic Basis, Gene Expression Profiles, and Immunological Modulation of the Fibrotic Processes in the Skin.
    Cold Spring Harbor perspectives in biology, 2023, 07-05, Volume: 15, Issue:7

    Topics: Cell Proliferation; Collagen; Fibronectins; Fibrosis; Humans; Keloid; Skin; Transcriptome

2023
Immune cells and associated molecular markers in dermal fibrosis with focus on raised cutaneous scars.
    Experimental dermatology, 2023, Volume: 32, Issue:5

    Topics: Cicatrix, Hypertrophic; Cytokines; Extracellular Matrix; Fibroblasts; Fibrosis; Humans; Keloid

2023
Epidermal Potentiation of Dermal Fibrosis: Lessons from Occlusion and Mucosal Healing.
    The American journal of pathology, 2023, Volume: 193, Issue:5

    Topics: Cicatrix, Hypertrophic; Epidermis; Fibrosis; Humans; Keloid; Skin; Wound Healing

2023
Uterine leiomyomata and keloids fibrosis origins: a mini-review of fibroproliferative diseases.
    American journal of physiology. Cell physiology, 2023, 10-01, Volume: 325, Issue:4

    Topics: Female; Fibrosis; Humans; Keloid; Leiomyoma; Uterus

2023
Fibrosis in burns: an overview of mechanisms and therapies.
    American journal of physiology. Cell physiology, 2023, 12-01, Volume: 325, Issue:6

    Topics: Burns; Fibrosis; Humans; Keloid; Quality of Life; Skin

2023
Scars.
    Nature reviews. Disease primers, 2023, Nov-16, Volume: 9, Issue:1

    Topics: Cicatrix, Hypertrophic; Fibrosis; Humans; Keloid; Skin; Wound Healing

2023
Interplay Between Keratinocytes and Fibroblasts: A Systematic Review Providing a New Angle for Understanding Skin Fibrotic Disorders.
    Frontiers in immunology, 2020, Volume: 11

    Topics: Animals; Cicatrix, Hypertrophic; Fibroblasts; Fibrosis; Humans; Keloid; Keratinocytes; Scleroderma,

2020
A Review of the Evidence for and against a Role for Mast Cells in Cutaneous Scarring and Fibrosis.
    International journal of molecular sciences, 2020, Dec-18, Volume: 21, Issue:24

    Topics: Animals; Biomarkers; Cell Communication; Cicatrix; Cicatrix, Hypertrophic; Disease Models, Animal; D

2020
Validation strategies for identifying drug targets in dermal fibrotic disorders.
    Drug discovery today, 2021, Volume: 26, Issue:10

    Topics: Animals; Drug Development; Drug Discovery; Fibrosis; Humans; Keloid; Molecular Targeted Therapy; Ski

2021
MicroRNA-21 in Skin Fibrosis: Potential for Diagnosis and Treatment.
    Molecular diagnosis & therapy, 2017, Volume: 21, Issue:6

    Topics: Cicatrix, Hypertrophic; Fibrosis; Gene Expression Regulation; Humans; Keloid; MicroRNAs; Molecular T

2017
[Advances in the research of relationship between CD26 and hypertrophic scar and keloid].
    Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns, 2018, Jan-20, Volume: 34, Issue:1

    Topics: Cicatrix, Hypertrophic; Dipeptidyl Peptidase 4; Fibrosis; Humans; Keloid

2018
Current and upcoming therapies to modulate skin scarring and fibrosis.
    Advanced drug delivery reviews, 2019, Volume: 146

    Topics: Animals; Cicatrix, Hypertrophic; Fibrosis; Humans; Inflammation; Keloid; Skin Diseases

2019
Keloids: Animal models and pathologic equivalents to study tissue fibrosis.
    Matrix biology : journal of the International Society for Matrix Biology, 2016, Volume: 51

    Topics: Animals; Cicatrix, Hypertrophic; Disease Models, Animal; Fibroblasts; Fibrosis; Humans; Keloid; Mice

2016
Keloids: The paradigm of skin fibrosis - Pathomechanisms and treatment.
    Matrix biology : journal of the International Society for Matrix Biology, 2016, Volume: 51

    Topics: Collagen; Extracellular Matrix; Fibroblasts; Fibrosis; Humans; Keloid; Skin; Steroids; Wound Healing

2016
MicroRNA-29: A Crucial Player in Fibrotic Disease.
    Molecular diagnosis & therapy, 2017, Volume: 21, Issue:3

    Topics: Fibrosis; Gene Expression Regulation; Humans; Keloid; Kidney; Liver Cirrhosis; MicroRNAs; Myocardium

2017
Influence of the human leukocyte antigen complex on the development of cutaneous fibrosis: an immunogenetic perspective.
    Acta dermato-venereologica, 2010, Volume: 90, Issue:6

    Topics: Cicatrix, Hypertrophic; Connective Tissue Diseases; Evidence-Based Medicine; Fibrosis; HLA Antigens;

2010
An overview of biological basis of pathologic scarring.
    The Nigerian postgraduate medical journal, 2012, Volume: 19, Issue:1

    Topics: Cicatrix; Cytokines; Fibrosis; Humans; Inflammation; Keloid; Skin; Skin Physiological Phenomena; Tra

2012
Organ fibrosis inhibited by blocking transforming growth factor-β signaling via peroxisome proliferator-activated receptor γ agonists.
    Hepatobiliary & pancreatic diseases international : HBPD INT, 2012, Volume: 11, Issue:5

    Topics: Epithelial-Mesenchymal Transition; Fibrosis; Humans; Keloid; Kidney; Liver Cirrhosis; Myocardium; PP

2012
Fibroproliferative scars.
    Clinics in plastic surgery, 2003, Volume: 30, Issue:1

    Topics: Cicatrix; Cicatrix, Hypertrophic; Fibrosis; Humans; Keloid; Wound Healing

2003
Elevated vascular endothelial growth factor in keloids: relevance to tissue fibrosis.
    Cells, tissues, organs, 2004, Volume: 176, Issue:1-3

    Topics: DNA-Binding Proteins; Endothelial Cells; Extracellular Matrix; Fibroblasts; Fibrosis; Humans; Hypoxi

2004
Regulation of elastin synthesis in pathological states.
    Ciba Foundation symposium, 1995, Volume: 192

    Topics: Animals; Cutis Laxa; Elastin; Fibrosis; Humans; Keloid; Progeria

1995
Eosinophilia-myalgia syndrome, eosinophilic fasciitis, and related fibrosing disorders.
    Current opinion in rheumatology, 1997, Volume: 9, Issue:6

    Topics: Colonic Diseases; Eosinophilia; Eosinophilia-Myalgia Syndrome; Fasciitis; Fibrosis; Humans; Keloid;

1997

Other Studies

63 other studies available for khellin and Cirrhosis

ArticleYear
Visnagin ameliorates myocardial ischemia/reperfusion injury through the promotion of autophagy and the inhibition of apoptosis.
    European journal of histochemistry : EJH, 2020, Sep-07, Volume: 64, Issue:s2

    Topics: Animals; Apoptosis; Autophagy; Cardiotonic Agents; Fibrosis; Khellin; Male; Myocardial Reperfusion I

2020
Letter to the Editor: Comment on Jeon HB, et al. Metformin Inhibits Transforming Growth Factor β-Induced Fibrogenic Response of Human Dermal Fibroblasts and Suppresses Fibrosis in Keloid Spheroids ( Ann Plast Surg . 2021;86:406-411).
    Annals of plastic surgery, 2022, 09-01, Volume: 89, Issue:3

    Topics: Cells, Cultured; Fibroblasts; Fibrosis; Humans; Keloid; Metformin; Transforming Growth Factor beta;

2022
Letter to the Editor: Comment on Jeon HB, et al. Metformin Inhibits Transforming Growth Factor β-Induced Fibrogenic Response of Human Dermal Fibroblasts and Suppresses Fibrosis in Keloid Spheroids ( Ann Plast Surg . 2021;86:406-411).
    Annals of plastic surgery, 2022, 09-01, Volume: 89, Issue:3

    Topics: Cells, Cultured; Fibroblasts; Fibrosis; Humans; Keloid; Metformin; Transforming Growth Factor beta;

2022
The Polygenic Map of Keloid Fibroblasts Reveals Fibrosis-Associated Gene Alterations in Inflammation and Immune Responses.
    Frontiers in immunology, 2021, Volume: 12

    Topics: Computational Biology; Disease Susceptibility; Fibroblasts; Fibrosis; Gene Expression Profiling; Gen

2021
Skin fibrosis associated with keloid, scleroderma and Jorge Lobo's disease (lacaziosis): An immuno-histochemical study.
    International journal of experimental pathology, 2022, Volume: 103, Issue:6

    Topics: Endothelial Cells; Fibroblasts; Fibrosis; Forkhead Transcription Factors; Humans; Keloid; Ki-67 Anti

2022
Increased Expression of Galectin-3 in Skin Fibrosis: Evidence from In Vitro and In Vivo Studies.
    International journal of molecular sciences, 2022, Dec-05, Volume: 23, Issue:23

    Topics: Animals; Disease Models, Animal; Fibroblasts; Fibrosis; Galectin 3; Humans; Keloid; Mice; Quality of

2022
Increased Expression of Galectin-3 in Skin Fibrosis: Evidence from In Vitro and In Vivo Studies.
    International journal of molecular sciences, 2022, Dec-05, Volume: 23, Issue:23

    Topics: Animals; Disease Models, Animal; Fibroblasts; Fibrosis; Galectin 3; Humans; Keloid; Mice; Quality of

2022
Increased Expression of Galectin-3 in Skin Fibrosis: Evidence from In Vitro and In Vivo Studies.
    International journal of molecular sciences, 2022, Dec-05, Volume: 23, Issue:23

    Topics: Animals; Disease Models, Animal; Fibroblasts; Fibrosis; Galectin 3; Humans; Keloid; Mice; Quality of

2022
Increased Expression of Galectin-3 in Skin Fibrosis: Evidence from In Vitro and In Vivo Studies.
    International journal of molecular sciences, 2022, Dec-05, Volume: 23, Issue:23

    Topics: Animals; Disease Models, Animal; Fibroblasts; Fibrosis; Galectin 3; Humans; Keloid; Mice; Quality of

2022
Enhancement of Zyxin Promotes Skin Fibrosis by Regulating FAK/PI3K/AKT and TGF-β Signaling Pathways via Integrins.
    International journal of biological sciences, 2023, Volume: 19, Issue:8

    Topics: Animals; Fibroblasts; Fibrosis; Humans; Integrins; Keloid; Mice; Phosphatidylinositol 3-Kinases; Pro

2023
Antifibrotic Effects of High-Mobility Group Box 1 Protein Inhibitor (Glycyrrhizin) on Keloid Fibroblasts and Keloid Spheroids through Reduction of Autophagy and Induction of Apoptosis.
    International journal of molecular sciences, 2019, Aug-24, Volume: 20, Issue:17

    Topics: Apoptosis; Autophagy; Biomarkers; Cell Survival; Collagen; Extracellular Matrix; Fibroblasts; Fibros

2019
Overexpression of miR-133a-3p inhibits fibrosis and proliferation of keloid fibroblasts by regulating IRF5 to inhibit the TGF-β/Smad2 pathway.
    Molecular and cellular probes, 2020, Volume: 52

    Topics: Adolescent; Adult; Apoptosis; Base Sequence; Biomarkers; Cell Proliferation; Cell Survival; Extracel

2020
Histopathologic and dermoscopic features of 42 cases of folliculitis decalvans: A case series.
    Journal of the American Academy of Dermatology, 2021, Volume: 85, Issue:5

    Topics: Alopecia; Fibrosis; Folliculitis; Humans; Keloid; Retrospective Studies

2021
Adiponectin-Based Peptide (ADP355) Inhibits Transforming Growth Factor-β1-Induced Fibrosis in Keloids.
    International journal of molecular sciences, 2020, Apr-18, Volume: 21, Issue:8

    Topics: Adiponectin; AMP-Activated Protein Kinase Kinases; Animals; Cell Survival; Cells, Cultured; Cicatrix

2020
miR-4417 suppresses keloid fibrosis growth by inhibiting CyclinD1.
    Journal of biosciences, 2020, Volume: 45

    Topics: Apoptosis; Cell Movement; Cell Proliferation; Cells, Cultured; Cyclin D1; Down-Regulation; Fibroblas

2020
Downregulation of Epac Reduces Fibrosis and Induces Apoptosis Through Akt Signaling in Human Keloid Fibroblasts.
    The Journal of surgical research, 2021, Volume: 257

    Topics: Apoptosis; Cells, Cultured; Dermis; Down-Regulation; Fibroblasts; Fibrosis; Guanine Nucleotide Excha

2021
Metformin Inhibits Transforming Growth Factor β-Induced Fibrogenic Response of Human Dermal Fibroblasts and Suppresses Fibrosis in Keloid Spheroids.
    Annals of plastic surgery, 2021, 04-01, Volume: 86, Issue:4

    Topics: Cells, Cultured; Fibroblasts; Fibrosis; Humans; Keloid; Metformin; Transforming Growth Factor beta;

2021
Halofuginone regulates keloid fibroblast fibrotic response to TGF-β induction.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 135

    Topics: Actins; Adult; Cell Movement; Cell Proliferation; Cells, Cultured; Collagen Type I; Extracellular Ma

2021
Ameliorating Fibrotic Phenotypes of Keloid Dermal Fibroblasts through an Epidermal Growth Factor-Mediated Extracellular Matrix Remodeling.
    International journal of molecular sciences, 2021, Feb-23, Volume: 22, Issue:4

    Topics: Adult; Cell Movement; Cells, Cultured; Cicatrix, Hypertrophic; Elastic Modulus; Enzymes; Epidermal G

2021
Single-Cell RNA-Sequencing Reveals Lineage-Specific Regulatory Changes of Fibroblasts and Vascular Endothelial Cells in Keloids.
    The Journal of investigative dermatology, 2022, Volume: 142, Issue:1

    Topics: Adult; Carcinogenesis; Cell Differentiation; Cell Lineage; Cells, Cultured; Endothelial Cells; Ephri

2022
Systemic Fibrocyte Levels and Keloid Expression of the Chemoattractant CXCL12 Are Upregulated Compared With Patients With Normal Scar.
    Annals of plastic surgery, 2021, 08-01, Volume: 87, Issue:2

    Topics: Cell Differentiation; Chemokine CXCL12; Chemotactic Factors; Cicatrix; Fibroblasts; Fibrosis; Humans

2021
Pinocembrin Ameliorates Skin Fibrosis via Inhibiting TGF-β1 Signaling Pathway.
    Biomolecules, 2021, 08-19, Volume: 11, Issue:8

    Topics: Animals; Animals, Newborn; Cell Movement; Cell Proliferation; Female; Fibroblasts; Fibrosis; Flavano

2021
Mortalin deficiency suppresses fibrosis and induces apoptosis in keloid spheroids.
    Scientific reports, 2017, 10-11, Volume: 7, Issue:1

    Topics: Adenoviridae; Apoptosis; Cell Nucleus; Collagen Type I; Collagen Type III; Elastin; ErbB Receptors;

2017
Human adipose tissue-derived stem cells inhibit the activity of keloid fibroblasts and fibrosis in a keloid model by paracrine signaling.
    Burns : journal of the International Society for Burn Injuries, 2018, Volume: 44, Issue:2

    Topics: Adipose Tissue; Adolescent; Adult; Apoptosis; Cell Movement; Cell Proliferation; Coculture Technique

2018
Ginsenoside Rg3 inhibits keloid fibroblast proliferation, angiogenesis and collagen synthesis in vitro via the TGF‑β/Smad and ERK signaling pathways.
    International journal of molecular medicine, 2018, Volume: 41, Issue:3

    Topics: Adult; Apoptosis; Cell Movement; Cell Proliferation; Collagen; Extracellular Matrix; Female; Fibrobl

2018
Extensive CD34-to-CD90 Fibroblast Transition Defines Regions of Cutaneous Reparative, Hypertrophic, and Keloidal Scarring.
    The American Journal of dermatopathology, 2019, Volume: 41, Issue:1

    Topics: Actins; Antigens, CD34; Biomarkers; Cicatrix, Hypertrophic; Collagen Type I; Fibroblasts; Fibrosis;

2019
Adipose-derived mesenchymal stem cells treatments for fibroblasts of fibrotic scar via downregulating TGF-β1 and Notch-1 expression enhanced by photobiomodulation therapy.
    Lasers in medical science, 2019, Volume: 34, Issue:1

    Topics: Actins; Adipose Tissue; Animals; Apoptosis; Cell Movement; Cell Proliferation; Cicatrix, Hypertrophi

2019
Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair.
    Science (New York, N.Y.), 2018, 11-23, Volume: 362, Issue:6417

    Topics: Adipocytes; Animals; Cell Proliferation; Extracellular Matrix; Fibrosis; Integrin beta1; Keloid; Lec

2018
In vitro analysis of the role of tumor necrosis factor‑stimulated gene‑6 in keloid.
    Molecular medicine reports, 2019, Volume: 19, Issue:2

    Topics: Adolescent; Adult; Apoptosis; Cell Adhesion Molecules; Cell Cycle Checkpoints; Cell Proliferation; C

2019
Oncostatin M exerts a protective effect against excessive scarring by counteracting the inductive effect of TGFβ1 on fibrosis markers.
    Scientific reports, 2019, 02-14, Volume: 9, Issue:1

    Topics: Adult; Biomarkers; Case-Control Studies; Cicatrix, Hypertrophic; Female; Fibroblasts; Fibrosis; Foll

2019
Improving the anti-keloid outcomes through liposomes loading paclitaxel-cholesterol complexes.
    International journal of nanomedicine, 2019, Volume: 14

    Topics: Animals; Apoptosis; Cell Cycle; Cell Proliferation; Cell Survival; Cells, Cultured; Cholesterol; Col

2019
Arthropathy, osteolysis, keloids, relapsing conjunctival pannus and gingival overgrowth: a variant of polyfibromatosis?
    American journal of medical genetics. Part A, 2013, Volume: 161A, Issue:6

    Topics: Abnormalities, Multiple; Arthrography; Cleft Palate; Comparative Genomic Hybridization; Conjunctival

2013
Equine exuberant granulation tissue and human keloids: a comparative histopathologic study.
    Veterinary surgery : VS, 2013, Volume: 42, Issue:7

    Topics: Animals; Cicatrix, Hypertrophic; Dermis; Epidermis; Fibrosis; Gene Expression Regulation; Horse Dise

2013
NADPH oxidase-2 is a key regulator of human dermal fibroblasts: a potential therapeutic strategy for the treatment of skin fibrosis.
    Experimental dermatology, 2014, Volume: 23, Issue:9

    Topics: Cells, Cultured; Collagen; Enzyme Inhibitors; Fibroblasts; Fibrosis; Gene Knockdown Techniques; Huma

2014
Mast cell chymase in keloid induces profibrotic response via transforming growth factor-β1/Smad activation in keloid fibroblasts.
    International journal of clinical and experimental pathology, 2014, Volume: 7, Issue:7

    Topics: Adult; Blotting, Western; Chymases; Enzyme-Linked Immunosorbent Assay; Female; Fibroblasts; Fibrosis

2014
Keloid-derived, plasma/fibrin-based skin equivalents generate de novo dermal and epidermal pathology of keloid fibrosis in a mouse model.
    Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 2016, Volume: 24, Issue:2

    Topics: Animals; Cells, Cultured; Collagen Type I; Dermis; Disease Models, Animal; Epidermal Cells; Fibrin;

2016
The Aldo-Keto Reductase AKR1B10 Is Up-Regulated in Keloid Epidermis, Implicating Retinoic Acid Pathway Dysregulation in the Pathogenesis of Keloid Disease.
    The Journal of investigative dermatology, 2016, Volume: 136, Issue:7

    Topics: Aldehyde Reductase; Aldo-Keto Reductases; Culture Media, Conditioned; Epidermis; Fibroblasts; Fibros

2016
S100A12 Induced in the Epidermis by Reduced Hydration Activates Dermal Fibroblasts and Causes Dermal Fibrosis.
    The Journal of investigative dermatology, 2017, Volume: 137, Issue:3

    Topics: Animals; Cell Culture Techniques; Cell Line, Tumor; Cicatrix, Hypertrophic; Coculture Techniques; Cu

2017
Hypoxia drives the transition of human dermal fibroblasts to a myofibroblast-like phenotype via the TGF-β1/Smad3 pathway.
    International journal of molecular medicine, 2017, Volume: 39, Issue:1

    Topics: Adult; Cell Hypoxia; Dermis; Fibrosis; Fluorescent Antibody Technique; Humans; Hypoxia-Inducible Fac

2017
Collagen fibril formation. A new target to limit fibrosis.
    The Journal of biological chemistry, 2008, Sep-19, Volume: 283, Issue:38

    Topics: Animals; Antibodies, Monoclonal; Bone Morphogenetic Protein 1; Bone Morphogenetic Proteins; Collagen

2008
Cell permeant peptide analogues of the small heat shock protein, HSP20, reduce TGF-beta1-induced CTGF expression in keloid fibroblasts.
    The Journal of investigative dermatology, 2009, Volume: 129, Issue:3

    Topics: 14-3-3 Proteins; Animals; Collagen Type I; Connective Tissue Growth Factor; Cricetinae; Endothelins;

2009
Troglitazone suppresses transforming growth factor-beta1-induced collagen type I expression in keloid fibroblasts.
    The British journal of dermatology, 2009, Volume: 160, Issue:4

    Topics: Adolescent; Adult; Blotting, Western; Chromans; Collagen Type I; Female; Fibroblasts; Fibrosis; Huma

2009
Topical tamoxifen therapy in hypertrophic scars or keloids in burns.
    Archives of dermatological research, 2010, Volume: 302, Issue:1

    Topics: Administration, Topical; Burns; Cell Differentiation; Cell Line; Cell Proliferation; Cicatrix, Hyper

2010
The histopathologic spectrum of regression in atypical fibroxanthoma.
    Journal of cutaneous pathology, 2010, Volume: 37, Issue:3

    Topics: Aged; Aged, 80 and over; Cheek; Female; Fibrosis; Head and Neck Neoplasms; Histiocytoma, Benign Fibr

2010
Encapsuloma: a case report.
    The British journal of oral & maxillofacial surgery, 2010, Volume: 48, Issue:8

    Topics: Aged; Arthroplasty, Replacement; Facial Neuralgia; Female; Fibrosis; Follow-Up Studies; Granuloma, F

2010
Epigenetically altered wound healing in keloid fibroblasts.
    The Journal of investigative dermatology, 2010, Volume: 130, Issue:10

    Topics: Acetylation; Azacitidine; Black or African American; Cell Division; Cells, Cultured; Culture Media;

2010
Processing of procollagen III by meprins: new players in extracellular matrix assembly?
    The Journal of investigative dermatology, 2010, Volume: 130, Issue:12

    Topics: Bone Morphogenetic Protein 1; Cells, Cultured; Collagen Type III; Dermis; Extracellular Matrix Prote

2010
Smad interacting protein 1 as a regulator of skin fibrosis in pathological scars.
    Burns : journal of the International Society for Burn Injuries, 2011, Volume: 37, Issue:4

    Topics: Adolescent; Adult; Aged; Child; Cicatrix; Collagen; Collagen Type I; Down-Regulation; Female; Fibrob

2011
Modulatory effects of connexin-43 expression on gap junction intercellular communications with mast cells and fibroblasts.
    Journal of cellular biochemistry, 2011, Volume: 112, Issue:5

    Topics: Actins; Animals; Cell Culture Techniques; Connexin 43; Fibroblasts; Fibrosis; Gap Junctions; Gene Ex

2011
Role of caveolin-1 in the pathogenesis of tissue fibrosis by keloid-derived fibroblasts in vitro.
    The British journal of dermatology, 2011, Volume: 164, Issue:3

    Topics: Blotting, Western; Caveolin 1; Cell Survival; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Fi

2011
Adenovirus-relaxin gene therapy for keloids: implication for reversing pathological fibrosis.
    The British journal of dermatology, 2011, Volume: 165, Issue:3

    Topics: Adenoviridae; Adult; Collagen Type I; Collagen Type III; Enzyme-Linked Immunosorbent Assay; Female;

2011
Characterization of oral ulcer and pathological scar in nude mice model.
    Georgian medical news, 2012, Issue:205

    Topics: Animals; Cicatrix; Disease Models, Animal; Fibrosis; Humans; Hydrochloric Acid; Immunohistochemistry

2012
Cellular delivery of cationic lipid nanoparticle-based SMAD3 antisense oligonucleotides for the inhibition of collagen production in keloid fibroblasts.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2012, Volume: 82, Issue:1

    Topics: Cells, Cultured; Collagen Type I; Drug Stability; Drug Storage; Fibroblasts; Fibrosis; Humans; Keloi

2012
Increased KGF expression promotes fibroblast activation in a double paracrine manner resulting in cutaneous fibrosis.
    The Journal of investigative dermatology, 2013, Volume: 133, Issue:3

    Topics: Cell Communication; Cell Movement; Cell Proliferation; Cells, Cultured; Collagen Type I; Fibroblast

2013
IFN-gamma fails to antagonize fibrotic effect of TGF-beta on keloid-derived dermal fibroblasts.
    Journal of dermatological science, 2003, Volume: 32, Issue:1

    Topics: Actins; Blotting, Western; Case-Control Studies; Cells, Cultured; Collagen; Collagen Type I; Fibrobl

2003
Keloid-like scleroderma.
    The American Journal of dermatopathology, 2003, Volume: 25, Issue:4

    Topics: Actins; Elastic Tissue; Female; Fibroblasts; Fibrosis; Humans; Immunohistochemistry; Keloid; Middle

2003
What is nodular-keloidal scleroderma?
    Dermatology (Basel, Switzerland), 2003, Volume: 207, Issue:2

    Topics: Fibrosis; Humans; Keloid; Scleroderma, Localized; Scleroderma, Systemic; Skin

2003
Polymorphic fibrosing reaction mimicking keloidal scleroderma but without associated classic scleroderma.
    Dermatology (Basel, Switzerland), 2003, Volume: 207, Issue:2

    Topics: Adult; Female; Fibrosis; Humans; Hyperpigmentation; Keloid; Scleroderma, Localized; Scleroderma, Sys

2003
Increased formation of pyridinoline cross-links due to higher telopeptide lysyl hydroxylase levels is a general fibrotic phenomenon.
    Matrix biology : journal of the International Society for Matrix Biology, 2004, Volume: 23, Issue:4

    Topics: Amino Acids; Cells, Cultured; Cicatrix, Hypertrophic; Dupuytren Contracture; Fascia; Fibrosis; Hand;

2004
Does transformation of microvascular endothelial cells into myofibroblasts play a key role in the etiology and pathology of fibrotic disease?
    Medical hypotheses, 2007, Volume: 68, Issue:3

    Topics: Cell Differentiation; Endothelium, Vascular; Fibroblasts; Fibrosis; Humans; Keloid; Microcirculation

2007
Inhibitors of dipeptidyl peptidase IV-like activity mediate antifibrotic effects in normal and keloid-derived skin fibroblasts.
    The Journal of investigative dermatology, 2008, Volume: 128, Issue:4

    Topics: Actins; Animals; Collagen Type I; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Diseas

2008
Gene profiling of keloid fibroblasts shows altered expression in multiple fibrosis-associated pathways.
    The Journal of investigative dermatology, 2008, Volume: 128, Issue:5

    Topics: Cells, Cultured; Dermis; Fibroblasts; Fibrosis; Gene Expression Profiling; Humans; Keloid; Oligonucl

2008
Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders.
    The Journal of investigative dermatology, 1996, Volume: 106, Issue:4

    Topics: Adolescent; Adult; Child; Connective Tissue Growth Factor; Fibrosis; Gene Expression; Growth Substan

1996
Acne keloidalis is lichen simplex chronicus with fibrotic keloidal scarring.
    Journal of the American Academy of Dermatology, 1998, Volume: 39, Issue:4 Pt 1

    Topics: Acne Keloid; Diagnosis, Differential; Fibrosis; Humans; Keloid; Neck; Neurodermatitis

1998
Differential regulation of PAI-1 gene expression in human fibroblasts predisposed to a fibrotic phenotype.
    Experimental cell research, 1999, May-01, Volume: 248, Issue:2

    Topics: Adult; Cell Adhesion; Cells, Cultured; Dermis; Female; Fibroblasts; Fibrosis; Gene Expression Regula

1999
Combined use of in situ hybridization and unlabeled antibody peroxidase anti-peroxidase methods: simultaneous detection of type I procollagen mRNAs and factor VIII-related antigen epitopes in keloid tissue.
    Laboratory investigation; a journal of technical methods and pathology, 1991, Volume: 64, Issue:1

    Topics: DNA; Epitopes; Factor VIII; Fibrosis; Gene Expression; Humans; Immunoenzyme Techniques; Keloid; Nucl

1991