khellin has been researched along with Anoxemia in 13 studies
Khellin: A vasodilator that also has bronchodilatory action. It has been employed in the treatment of angina pectoris, in the treatment of asthma, and in conjunction with ultraviolet light A, has been tried in the treatment of vitiligo. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1024)
khellin : A furanochrome in which the basic tricyclic skeleton is substituted at positions 4 and 9 with methoxy groups and at position 7 with a methyl group. A major constituent of the plant Ammi visnaga it is a herbal folk medicine used for various illnesses, its main effect being as a vasodilator.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Keloids are defined as overrepairing products that develop after skin lesions." | 3.01 | Role of HIF-1α in pathogenic mechanisms of keloids. ( Li, ZJ; Long, X; Qiu, ZK; Si, LB; Wang, XJ; Yu, NZ; Zhang, MZ; Zhang, WC, 2023) |
| "Keloids are the result of abnormal wound healing, and they differ from the normal skin of the patient in the level of blood perfusion and the degrees of inflammation, hypoxia, regeneration of vessels, and expression of sensory receptors." | 1.72 | Relative perfusion index: An objective, quantitative and noninvasive method for evaluating the severity of keloids. ( Li, S; Long, X; Wang, X; Zhang, M, 2022) |
| "Keloids are a common form of pathologic wound healing characterized by excessive production of extracellular matrix." | 1.37 | Unfolded protein response regulation in keloid cells. ( Butler, PD; Koong, AC; Longaker, MT; Ly, DP; Wang, Z; Yang, GP, 2011) |
| "Keloids are skin fibrotic conditions characterized by an excess accumulation of extracellular matrix (ECM) components secondary to trauma or surgical injuries." | 1.32 | Crosstalk of hypoxia-mediated signaling pathways in upregulating plasminogen activator inhibitor-1 expression in keloid fibroblasts. ( Ann, DK; Bertolami, CN; Chau, CH; Le, AD; Wu, Y; Zhang, Q, 2004) |
| "The blood supply to keloids is inadequate, and this persists." | 1.32 | Inadequate blood supply persists in keloids. ( Furuya, E; Oba, S; Ueda, K; Yasuda, Y, 2004) |
| "Histologically, keloids are composed of excessive collagen with an abnormally large number of partially or totally occluded microvessels." | 1.30 | Hypoxia upregulates VEGF production in keloid fibroblasts. ( Chau, D; Chin, G; Gittes, GK; Lee, T; Longaker, MT; Mehrara, BJ; Rowe, NM; Saadeh, PB; Steinbrech, DS, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 5 (38.46) | 2.80 |
| Authors | Studies |
|---|---|
| Li, S | 1 |
| Zhang, M | 1 |
| Long, X | 2 |
| Wang, X | 1 |
| Wang, Q | 3 |
| Yang, X | 3 |
| Ma, J | 1 |
| Xie, X | 1 |
| Sun, Y | 1 |
| Chang, X | 1 |
| Bi, H | 3 |
| Xue, H | 1 |
| Qin, Z | 3 |
| Qiu, ZK | 1 |
| Zhang, MZ | 1 |
| Zhang, WC | 1 |
| Li, ZJ | 1 |
| Si, LB | 1 |
| Yu, NZ | 1 |
| Wang, XJ | 1 |
| Wang, P | 2 |
| An, Y | 1 |
| Wang, J | 1 |
| Nie, F | 2 |
| Pan, B | 2 |
| Wulandari, E | 1 |
| Jusman, SW | 1 |
| Moenadjat, Y | 1 |
| Jusuf, AA | 1 |
| Sadikin, M | 1 |
| Butler, PD | 1 |
| Wang, Z | 1 |
| Ly, DP | 1 |
| Longaker, MT | 2 |
| Koong, AC | 1 |
| Yang, GP | 1 |
| Deschene, K | 1 |
| Céleste, C | 1 |
| Boerboom, D | 1 |
| Theoret, CL | 1 |
| Zhang, Q | 2 |
| Wu, Y | 1 |
| Chau, CH | 2 |
| Ann, DK | 2 |
| Bertolami, CN | 1 |
| Le, AD | 2 |
| Ueda, K | 1 |
| Yasuda, Y | 1 |
| Furuya, E | 1 |
| Oba, S | 1 |
| Clavijo, CA | 1 |
| Deng, HT | 1 |
| Kim, KJ | 1 |
| Qiu, Y | 1 |
| Steinbrech, DS | 1 |
| Mehrara, BJ | 1 |
| Chau, D | 1 |
| Rowe, NM | 1 |
| Chin, G | 1 |
| Lee, T | 1 |
| Saadeh, PB | 1 |
| Gittes, GK | 1 |
| Louw, L | 1 |
1 review available for khellin and Anoxemia
| Article | Year |
|---|---|
Role of HIF-1α in pathogenic mechanisms of keloids.
Topics: Collagen; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Keloid; Signal Transduction | 2023 |
12 other studies available for khellin and Anoxemia
| Article | Year |
|---|---|
Relative perfusion index: An objective, quantitative and noninvasive method for evaluating the severity of keloids.
Topics: Cross-Sectional Studies; Humans; Hypoxia; Interleukin-17; Keloid; Pain; Perfusion Index; Pruritus; S | 2022 |
PI3K/AKT pathway promotes keloid fibroblasts proliferation by enhancing glycolysis under hypoxia.
Topics: Cell Proliferation; Fibroblasts; Glucose; Glycolysis; Humans; Hypoxia; Hypoxia-Inducible Factor 1, a | 2023 |
Targeting the Glycolytic Enzyme PGK1 to Inhibit the Warburg Effect: A New Strategy for Keloid Therapy.
Topics: Cell Proliferation; Fibroblasts; Glucose Transporter Type 1; Glycolysis; Humans; Hypoxia; Keloid; La | 2023 |
Altered glucose metabolism and cell function in keloid fibroblasts under hypoxia.
Topics: Animals; Cell Hypoxia; Fibroblasts; Glucose; Glycolysis; Hypoxia; Keloid; Phosphatidylinositol 3-Kin | 2021 |
Expressions of Collagen I and III in Hypoxic Keloid Tissue.
Topics: Collagen Type I; Collagen Type III; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immu | 2016 |
Unfolded protein response regulation in keloid cells.
Topics: DNA-Binding Proteins; Extracellular Matrix; Fibroblasts; Humans; Hypoxia; Keloid; Regulatory Factor | 2011 |
Hypoxia regulates the expression of extracellular matrix associated proteins in equine dermal fibroblasts via HIF1.
Topics: Animals; Apoptosis; Cell Proliferation; Cell Survival; Extracellular Matrix; Fibroblasts; Horses; Hu | 2012 |
Crosstalk of hypoxia-mediated signaling pathways in upregulating plasminogen activator inhibitor-1 expression in keloid fibroblasts.
Topics: Blotting, Northern; Blotting, Western; DNA-Binding Proteins; Enzyme Inhibitors; Fibroblasts; Gene Ex | 2004 |
Inadequate blood supply persists in keloids.
Topics: Adenosine Triphosphate; Biopsy, Needle; Cicatrix, Hypertrophic; Female; Humans; Hypoxia; Immunohisto | 2004 |
Etk/Bmx mediates expression of stress-induced adaptive genes VEGF, PAI-1, and iNOS via multiple signaling cascades in different cell systems.
Topics: Animals; Blotting, Northern; Blotting, Western; Cell Line; Enzyme Activation; Enzyme Inhibitors; Gen | 2005 |
Hypoxia upregulates VEGF production in keloid fibroblasts.
Topics: Endothelial Growth Factors; Extracellular Matrix; Humans; Hypoxia; Keloid; Lymphokines; Up-Regulatio | 1999 |
Keloids in rural black South Africans. Part 3: a lipid model for the prevention and treatment of keloid formations.
Topics: Apoptosis; Arachidonic Acid; Biopsy; Black People; Case-Control Studies; Cell Division; Cholesterol | 2000 |