khellactone and Carcinoma

khellactone has been researched along with Carcinoma* in 1 studies

Other Studies

1 other study(ies) available for khellactone and Carcinoma

Article	Year
Isolation of coumarins and ferulate from the roots of Angelica purpuraefolia and the antitumor activity of khellactone. Phytotherapy research : PTR, 2007, Volume: 21, Issue:5 A new coumarin, hydroxylomatin (1), was isolated from the CHCl(3)-soluble fraction of the roots of Angelica purpuraefolia, along with one ferulate (2) and three other known coumarins (3-5) including khellactone (3). The structure of hydroxylomatin (1) was determined to be 3'beta,5'-dihydroxy-3',4'-dihydroseselin (1) by spectroscopic means including 2D-NMR. The modified Mosher's method was used to determine the chiral center at C-1 of compound 2. Khellactone (3) is a major compound of the roots of A. purpuraefolia. This study also examined the antitumor activity of khellactone (3) using a LLC mouse lung carcinoma in the BDF-1 mice and a NCI-H460 human lung carcinoma in a human tumor xenograft model in nude mice. This compound (3) inhibited LLC tumor growth with a T/C (mean value of treated group/mean value of control group) value of 12.9% at a dose of 5 mg/kg and 33.2% at a dose of 10 mg/kg, respectively, in a dose-dependent manner. In addition, it suppressed the growth of NCI-H460 tumor cells, accounting for 81.4% at a dose of 10 mg/kg in nude mice. Topics: Angelica; Animals; Antineoplastic Agents, Phytogenic; Carcinoma; Coumaric Acids; Coumarins; Female; Humans; Lung Neoplasms; Mice; Mice, Nude; Plant Roots; Pyrans; Xenograft Model Antitumor Assays	2007

Article

Year

Isolation of coumarins and ferulate from the roots of Angelica purpuraefolia and the antitumor activity of khellactone.

Phytotherapy research : PTR, 2007, Volume: 21, Issue:5

A new coumarin, hydroxylomatin (1), was isolated from the CHCl(3)-soluble fraction of the roots of Angelica purpuraefolia, along with one ferulate (2) and three other known coumarins (3-5) including khellactone (3). The structure of hydroxylomatin (1) was determined to be 3'beta,5'-dihydroxy-3',4'-dihydroseselin (1) by spectroscopic means including 2D-NMR. The modified Mosher's method was used to determine the chiral center at C-1 of compound 2. Khellactone (3) is a major compound of the roots of A. purpuraefolia. This study also examined the antitumor activity of khellactone (3) using a LLC mouse lung carcinoma in the BDF-1 mice and a NCI-H460 human lung carcinoma in a human tumor xenograft model in nude mice. This compound (3) inhibited LLC tumor growth with a T/C (mean value of treated group/mean value of control group) value of 12.9% at a dose of 5 mg/kg and 33.2% at a dose of 10 mg/kg, respectively, in a dose-dependent manner. In addition, it suppressed the growth of NCI-H460 tumor cells, accounting for 81.4% at a dose of 10 mg/kg in nude mice.

Topics: Angelica; Animals; Antineoplastic Agents, Phytogenic; Carcinoma; Coumaric Acids; Coumarins; Female; Humans; Lung Neoplasms; Mice; Mice, Nude; Plant Roots; Pyrans; Xenograft Model Antitumor Assays

2007