ketotifen and Urticaria studies

Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
ketotifen : An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.

Urticaria: A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.

Research Excerpts

Excerpt	Relevance	Reference
"Forty patients with urticaria, 13 with cholinergic urticaria, 22 with urticaria factitia, and 5 with both types of urticaria, were treated with ketotifen or placebo in a double-blind crossover study."	9.05	[Effect of ketotifen in urticaria factitia and urticaria cholinergica in a crossover double-blind trial]. ( Cap, JP; Czarnetzki, BM; Schwanitz, HJ, 1985)
"Eleven patients with primary acquired cold-induced urticaria were treated with ketotifen (1 mg b."	9.05	Effect of ketotifen treatment on cold-induced urticaria. ( Kobric, M; Rackham, A; St-Pierre, JP, 1985)
"The capacity for ketotifen to prevent mast-cell degranulation in vivo was studied in patients with physical urticarias."	7.67	Prevention of mast-cell degranulation by ketotifen in patients with physical urticarias. ( Baylor, MW; Bressler, RB; Huston, DP; Kaliner, M; Sowell, LK, 1986)
"21 patients suffering from chronic urticaria were treated with Ketotifen (2 X 1 mg/d) for 4 weeks."	7.67	[Ketotifen treatment of chronic urticaria. An open study of therapeutically difficult courses]. ( Lässig, W; Taube, KM; Wozniak, KD, 1985)
"Four patients suffering from cold urticaria were treated with ketotifen and oxatomide for one week each."	7.66	[Effect of ketotifen and oxatomide on histamine liberation due to exposure in cold urticaria]. ( Sauer, RR; Steigleder, GK, 1983)
"Ketotifen treatment provided significant relief of symptoms."	6.70	Levothyroxine versus ketotifen in the treatment of patients with chronic urticaria and thyroid autoimmunity. ( Akar, A; Calişkaner, Z; Karaayvaz, M; Ozangüç, N; Oztürk, S; Turan, M, 2002)
"Both of them showed good results in the treatment of cold urticaria with mild side effects."	6.68	Cold urticaria in Thai children: comparison between cyproheptadine and ketotifen in the treatment. ( Tuchinda, M; Vichyanond, P; Visitsunthorn, N, 1995)
"Forty patients with urticaria, 13 with cholinergic urticaria, 22 with urticaria factitia, and 5 with both types of urticaria, were treated with ketotifen or placebo in a double-blind crossover study."	5.05	[Effect of ketotifen in urticaria factitia and urticaria cholinergica in a crossover double-blind trial]. ( Cap, JP; Czarnetzki, BM; Schwanitz, HJ, 1985)
"Eleven patients with primary acquired cold-induced urticaria were treated with ketotifen (1 mg b."	5.05	Effect of ketotifen treatment on cold-induced urticaria. ( Kobric, M; Rackham, A; St-Pierre, JP, 1985)
"The capacity for ketotifen to prevent mast-cell degranulation in vivo was studied in patients with physical urticarias."	3.67	Prevention of mast-cell degranulation by ketotifen in patients with physical urticarias. ( Baylor, MW; Bressler, RB; Huston, DP; Kaliner, M; Sowell, LK, 1986)
"21 patients suffering from chronic urticaria were treated with Ketotifen (2 X 1 mg/d) for 4 weeks."	3.67	[Ketotifen treatment of chronic urticaria. An open study of therapeutically difficult courses]. ( Lässig, W; Taube, KM; Wozniak, KD, 1985)
"Four patients suffering from cold urticaria were treated with ketotifen and oxatomide for one week each."	3.66	[Effect of ketotifen and oxatomide on histamine liberation due to exposure in cold urticaria]. ( Sauer, RR; Steigleder, GK, 1983)
"Ketotifen treatment provided significant relief of symptoms."	2.70	Levothyroxine versus ketotifen in the treatment of patients with chronic urticaria and thyroid autoimmunity. ( Akar, A; Calişkaner, Z; Karaayvaz, M; Ozangüç, N; Oztürk, S; Turan, M, 2002)
"Both of them showed good results in the treatment of cold urticaria with mild side effects."	2.68	Cold urticaria in Thai children: comparison between cyproheptadine and ketotifen in the treatment. ( Tuchinda, M; Vichyanond, P; Visitsunthorn, N, 1995)

Timeframe	Studies, this research(%)	All Research%
pre-1990	18 (64.29)	18.7374
1990's	7 (25.00)	18.2507
2000's	2 (7.14)	29.6817
2010's	1 (3.57)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Sokol, KC	1
Amar, NK	1
Starkey, J	1
Grant, JA	2
Karaayvaz, M	1
Calişkaner, Z	1
Turan, M	1
Akar, A	1
Oztürk, S	1
Ozangüç, N	1
Frezzolini, A	1
De Pità, O	1
Cassano, N	2
D'Argento, V	2
Ferranti, G	1
Filotico, R	1
Vena, GA	2
Mikuni, I	1
Sauer, RR	1
Steigleder, GK	1
Haustein, UF	2
Kirchhof, B	1
Sokolova, TS	1
Reviakina, VA	1
Partsalis, EM	1
Botvin'eva, VV	1
Zakhidov, IuV	1
Camarasa, JG	1
Moragas, JM	1
Saihan, EM	1
Visitsunthorn, N	1
Tuchinda, M	1
Vichyanond, P	1
Egan, CA	1
Rallis, TM	1
Mijailović, BB	1
Karadaglić, DM	1
Ninković, MP	1
Mladenović, TM	1
Zecević, RD	1
Pavlović, MD	1
Taşkapan, O	1
Harmanyeri, Y	1
Mastrolonardo, M	1
Bourrain, JL	1
Béani, JC	1
Czarnetzki, BM	2
Huston, DP	1
Bressler, RB	1
Kaliner, M	1
Sowell, LK	1
Baylor, MW	1
Edge, JA	1
Osborne, JP	1
Wagner, W	1
Kamide, R	1
Niimura, M	1
Ueda, H	1
Imamura, S	1
Yamamoto, S	1
Yoshida, H	1
Kukita, A	1
McClean, SP	1
Arreaza, EE	1
Lett-Brown, MA	1
Lipets, ME	1
Lopatko, VN	1
Guillot, B	1
Meynadier, J	1
Sergeev, IuV	1
Potekaev, NS	1
Cap, JP	1
Schwanitz, HJ	1
St-Pierre, JP	1
Kobric, M	1
Rackham, A	1
Taube, KM	1
Wozniak, KD	1
Lässig, W	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Ketotifen as a Treatment for Vascular Leakage During Dengue Fever (KETODEN)[NCT02673840]			Phase 4	110 participants (Anticipated)	Interventional	2015-03-31	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Eye itching in ophthalmology and its treatment. The Tokai journal of experimental and clinical medicine, 1984, Volume: 9, Issue:5-6 Topics: Conjunctiva; Cromolyn Sodium; Dermatitis; Eczema; Edema; Emotions; Eye; Histamine; Histamine H1 Anta	1984
[Urticaria and Quincke's edema: etiology, diagnosis, treatment]. La Revue du praticien, 1999, Nov-15, Volume: 49, Issue:18 Topics: Adolescent; Adrenal Cortex Hormones; Adult; Angioedema; Antipruritics; Child; Child, Preschool; Crom	1999

Article	Year
Levothyroxine versus ketotifen in the treatment of patients with chronic urticaria and thyroid autoimmunity. The Journal of dermatological treatment, 2002, Volume: 13, Issue:4 Topics: Adult; Anti-Allergic Agents; Autoantibodies; Chronic Disease; Female; Humans; Iodide Peroxidase; Ket	2002
Evaluation of inflammatory parameters in physical urticarias and effects of an anti-inflammatory/antiallergic treatment. International journal of dermatology, 2002, Volume: 41, Issue:7 Topics: Adolescent; Adult; Anti-Allergic Agents; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion Mole	2002
Cold urticaria in Thai children: comparison between cyproheptadine and ketotifen in the treatment. Asian Pacific journal of allergy and immunology, 1995, Volume: 13, Issue:1 Topics: Anti-Allergic Agents; Child; Child, Preschool; Cold Temperature; Cross-Over Studies; Cyproheptadine;	1995
Sequential therapy with nimesulide and ketotifen in delayed pressure urticaria. Acta dermato-venereologica, 1998, Volume: 78, Issue:4 Topics: Administration, Oral; Adult; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Doub	1998
Clinical evaluation of ketotifen for chronic urticaria: multicenter double-blind comparative study with clemastine. Annals of allergy, 1989, Volume: 62, Issue:4 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Chronic Disease; Clemastine; Clinical Trials as T	1989
[Effect of ketotifen in urticaria factitia and urticaria cholinergica in a crossover double-blind trial]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1985, Volume: 36, Issue:9 Topics: Clinical Trials as Topic; Double-Blind Method; Humans; Ketotifen; Urticaria	1985
Effect of ketotifen treatment on cold-induced urticaria. Annals of allergy, 1985, Volume: 55, Issue:6 Topics: Adolescent; Adult; Child; Clinical Trials as Topic; Cold Temperature; Double-Blind Method; Female; H	1985

ketotifen and Urticaria

Research Excerpts

Research

Studies (28)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Ketotifen in the management of chronic urticaria: resurrection of an old drug. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2013, Volume: 111, Issue:6 Topics: Anti-Allergic Agents; Chronic Disease; Humans; Ketotifen; Urticaria	2013
[Effect of ketotifen and oxatomide on histamine liberation due to exposure in cold urticaria]. Zeitschrift fur Hautkrankheiten, 1983, Dec-15, Volume: 58, Issue:24 Topics: Adult; Cold Temperature; Female; Histamine H1 Antagonists; Histamine Release; Humans; Ketotifen; Mal	1983
[Treatment of acquired cold urticaria with ketotifen]. Dermatologische Monatschrift, 1984, Volume: 170, Issue:8 Topics: Adult; Cold Temperature; Female; Humans; Ketotifen; Male; Middle Aged; Urticaria	1984
[Clinical study of the preventive action of ketotifen in children with allergic diseases]. Pediatriia, 1983, Issue:6 Topics: Asthma; Child; Child, Preschool; Dermatitis, Atopic; Eczema; Humans; Hypersensitivity; Infant; Ketot	1983
[Chronic urticaria. Treatment with ketotifen]. Medicina cutanea ibero-latino-americana, 1982, Volume: 10, Issue:5 Topics: Administration, Oral; Adolescent; Adult; Aged; Child; Chronic Disease; Female; Humans; Ketotifen; Ma	1982
Ketotifen and terbutaline in urticaria. The British journal of dermatology, 1981, Volume: 104, Issue:2 Topics: Adult; Aged; Drug Therapy, Combination; Female; Humans; Ketotifen; Male; Middle Aged; Piperidines; T	1981
Treatment of chronic urticaria with ketotifen. Archives of dermatology, 1997, Volume: 133, Issue:2 Topics: Adult; Chronic Disease; Female; Histamine H1 Antagonists; Humans; Ketotifen; Urticaria	1997
Bullous delayed pressure urticaria; pressure testing may produce a systemic reaction. The British journal of dermatology, 1997, Volume: 136, Issue:3 Topics: Adult; Antipruritics; Drug Therapy, Combination; Histamine H2 Antagonists; Humans; Ketotifen; Leukoc	1997
Ketotifen and chronic urticaria. Archives of dermatology, 1998, Volume: 134, Issue:2 Topics: Anti-Allergic Agents; Antipruritics; Autoimmune Diseases; Child; Chronic Disease; Histamine H1 Antag	1998
Ketotifen in cholinergic urticaria. The Journal of allergy and clinical immunology, 1990, Volume: 86, Issue:1 Topics: Humans; Ketotifen; Receptors, Cholinergic; Urticaria	1990
Prevention of mast-cell degranulation by ketotifen in patients with physical urticarias. Annals of internal medicine, 1986, Volume: 104, Issue:4 Topics: Adult; Cold Temperature; Cytoplasmic Granules; Female; Histamine; Histamine Release; Humans; Ketotif	1986
Terbutaline and ketotifen in cold urticaria in a child. Journal of the Royal Society of Medicine, 1989, Volume: 82, Issue:7 Topics: Child; Cold Temperature; Female; Histamine Release; Humans; Ketotifen; Terbutaline; Urticaria	1989
[Ketotifen inhibits urticaria and tumor progression in neurofibromatosis]. Dermatologische Monatschrift, 1989, Volume: 175, Issue:9 Topics: Administration, Oral; Humans; Ketotifen; Neurofibromatosis 1; Skin Neoplasms; Urticaria	1989
Exercise-induced allergic syndromes on the increase. Cleveland Clinic journal of medicine, 1989, Volume: 56, Issue:7 Topics: Adolescent; Adult; Albuterol; Anaphylaxis; Asthma; Asthma, Exercise-Induced; Beclomethasone; Exercis	1989
Refractory cholinergic urticaria successfully treated with ketotifen. The Journal of allergy and clinical immunology, 1989, Volume: 83, Issue:4 Topics: Adolescent; Adult; Child; Cold Temperature; Exercise; Female; Histamine; Hot Temperature; Humans; Ke	1989
[The use of zaditen in the combined treatment of allergic skin diseases in children]. Vestnik dermatologii i venerologii, 1989, Issue:7 Topics: Adolescent; Child; Child, Preschool; Chronic Disease; Combined Modality Therapy; Dermatitis, Atopic;	1989
[Treatment of chronic urticaria with ketotifen]. Allergie et immunologie, 1986, Volume: 18, Issue:7 Topics: Adolescent; Adult; Aged; Child; Chronic Disease; Female; Histamine H1 Antagonists; Humans; Ketotifen	1986
[Clinical effectiveness and prospects for using zaditen (ketotifen) in the therapy of allergic dermatoses]. Vestnik dermatologii i venerologii, 1987, Issue:4 Topics: Adolescent; Adult; Aged; Chronic Disease; Dermatitis, Atopic; Drug Evaluation; Eczema; Female; Human	1987
[Ketotifen treatment of chronic urticaria. An open study of therapeutically difficult courses]. Zeitschrift fur Hautkrankheiten, 1985, Dec-01, Volume: 60, Issue:23 Topics: Adolescent; Adult; Child; Chronic Disease; Female; Humans; Ketotifen; Male; Middle Aged; Urticaria	1985