ketotifen has been researched along with Stomach Ulcer in 4 studies
Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
ketotifen : An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.
Stomach Ulcer: Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
| Excerpt | Relevance | Reference |
|---|---|---|
| " This research first proposed that alterations of mast cell histamine release, gastric acid back-diffusion and mucosal microvascular permeability are important in modulating gastric ulcer and hemorrhage in Salmonella typhi-infected rats." | 3.72 | Role of histamine and acid back-diffusion in modulation of gastric microvascular permeability and hemorrhagic ulcers in Salmonella typhimurium-infected rats. ( Hung, CR; Wang, PS, 2004) |
| "Pretreatment with ketotifen, a mast cell stabilizer (1 mg/kg) protected rat gastric mucosa from the amplified injury induced by capsaicin and ethanol." | 1.29 | Ketotifen and nitroxides decrease capsaicin-augmented ethanol-induced gastric damage in rats. ( Eliakim, R; Karmeli, F; Okon, E; Rachmilewitz, D, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hung, CR | 3 |
| Wang, PS | 1 |
| Karmeli, F | 1 |
| Eliakim, R | 1 |
| Okon, E | 1 |
| Rachmilewitz, D | 1 |
4 other studies available for ketotifen and Stomach Ulcer
| Article | Year |
|---|---|
Role of histamine and acid back-diffusion in modulation of gastric microvascular permeability and hemorrhagic ulcers in Salmonella typhimurium-infected rats.
Topics: Amine Oxidase (Copper-Containing); Animals; Capillary Permeability; Diphenhydramine; Disease Models, | 2004 |
Ketotifen and nitroxides decrease capsaicin-augmented ethanol-induced gastric damage in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Capsaicin; Cyclic N-Oxides; Ethanol; Free Radical Scavengers; | 1995 |
Importance of histamine, glutathione and oxyradicals in modulating gastric haemorrhagic ulcer in septic rats.
Topics: Amine Oxidase (Copper-Containing); Animals; Dose-Response Relationship, Drug; Free Radical Scavenger | 2000 |
Role of histamine in aggravation of gastric acid back-diffusion and vascular permeability in septic rats.
Topics: Amine Oxidase (Copper-Containing); Animals; Bacterial Infections; Capillary Permeability; Diffusion; | 2001 |