ketotifen has been researched along with Sclerosis, Systemic in 3 studies
Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
ketotifen : An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Oral treatment with ketotifen, an inhibitor of mast cell degranulation, at a dose comparable to that recommended for man, was associated with a decrease in both mast cell degranulation and in skin fibrosis, suggesting the potential for its use in human scleroderma." | 7.68 | Ketotifen prevents skin fibrosis in the tight skin mouse. ( Harley, R; LeRoy, EC; Walker, M, 1990) |
| " Oral treatment with ketotifen, an inhibitor of mast cell degranulation, at a dose comparable to that recommended for man, was associated with a decrease in both mast cell degranulation and in skin fibrosis, suggesting the potential for its use in human scleroderma." | 3.68 | Ketotifen prevents skin fibrosis in the tight skin mouse. ( Harley, R; LeRoy, EC; Walker, M, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gruber, BL | 2 |
| Kaufman, LD | 2 |
| Walker, M | 1 |
| Harley, R | 1 |
| LeRoy, EC | 1 |
1 trial available for ketotifen and Sclerosis, Systemic
| Article | Year |
|---|---|
A double-blind randomized controlled trial of ketotifen versus placebo in early diffuse scleroderma.
Topics: Adult; Double-Blind Method; Drug Evaluation; Female; Humans; Intradermal Tests; Ketotifen; Male; Mas | 1991 |
2 other studies available for ketotifen and Sclerosis, Systemic
| Article | Year |
|---|---|
Ketotifen prevents skin fibrosis in the tight skin mouse.
Topics: Animals; Disease Models, Animal; Fibrosis; Ketotifen; Mast Cells; Mice; Mice, Inbred C57BL; Sclerode | 1990 |
Ketotifen-induced remission in progressive early diffuse scleroderma: evidence for the role of mast cells in disease pathogenesis.
Topics: Cell Degranulation; Humans; Ketotifen; Male; Mast Cells; Middle Aged; Remission Induction; Scleroder | 1990 |