ketotifen has been researched along with Rhinitis, Allergic, Nonseasonal in 23 studies
Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
ketotifen : An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study, we compared the efficacy of KOB03 with modern drugs such as ketotifen and montelukast in an experimental mouse model of allergic rhinitis (AR)." | 7.79 | Comparison of the efficacy of KOB03, ketotifen, and montelukast in an experimental mouse model of allergic rhinitis. ( Jung, HW; Jung, JK; Park, YK, 2013) |
| " In this study, we looked at the changes in the number of sanguineous cells that ketotifen produces, especially in basophil cells, that could explain its prophylactic effects in bronchial hyperreactivity disclosed by exercise, as well as its relation to the variations in basal and total histamine in blood." | 7.68 | In vitro ketotifen protection in bronchial hyperreactivity. ( Córdoba, H; Fernández, M; Oehling, A; Santos, F, 1991) |
| "In 2 clinical studies we tested the efficacy of ketotifen in allergic rhinitis and allergic bronchial asthma." | 5.06 | [Experience with ketotifen in respiratory tract diseases]. ( Jäger, L; Mohorn, M; Wenz, W, 1986) |
| " In the present study, we compared the efficacy of KOB03 with modern drugs such as ketotifen and montelukast in an experimental mouse model of allergic rhinitis (AR)." | 3.79 | Comparison of the efficacy of KOB03, ketotifen, and montelukast in an experimental mouse model of allergic rhinitis. ( Jung, HW; Jung, JK; Park, YK, 2013) |
| " In this study, we looked at the changes in the number of sanguineous cells that ketotifen produces, especially in basophil cells, that could explain its prophylactic effects in bronchial hyperreactivity disclosed by exercise, as well as its relation to the variations in basal and total histamine in blood." | 3.68 | In vitro ketotifen protection in bronchial hyperreactivity. ( Córdoba, H; Fernández, M; Oehling, A; Santos, F, 1991) |
| " Rhinitis symptoms score (parent-rated), clinical evaluation of symptoms (investigator-rated) and adverse event profiles during the treatment period." | 2.71 | Perennial rhinitis in the under 4s: a difficult problem to treat safely and effectively? A comparison of intranasal fluticasone propionate and ketotifen in the treatment of 2-4-year-old children with perennial rhinitis. ( Fokkens, WJ; Scadding, GK, 2004) |
| "Cetirizine was significantly more effective at reducing the mean rhinorrhea score compared with oxatomide for both weeks 8 and 12 (P < 0." | 2.70 | The comparison of the efficacy and safety of cetirizine, oxatomide, ketotifen, and a placebo for the treatment of childhood perennial allergic rhinitis. ( Hsieh, JC; Lai, DS; Lee, HS; Lin, KL; Lue, KH, 2002) |
| "025% ophthalmic solution, when dosed ocularly, offered protecdon against the nasal signs and symptoms of acute allergic rhinoconjunctival reaction as induced by the CAC model." | 2.70 | A comparison of the relative clinical efficacy of a single dose of ketotifen fumarate 0.025% ophthalmic solution versus placebo in inhibiting the signs and symptoms of allergic rhinoconjunctivitis as induced by the conjunctival allergen challenge model. ( Crampton, HJ, 2002) |
| "Ketotifen treatment was associated with reversal of the histopathology and enzyme changes in every case." | 2.67 | The histological and histochemical effects of ketotifen in allergic rhinitis. ( Ibrahim, TE; Inaam, PK; Mohammed, MH; Talaat, MA, 1991) |
| " Second-generation antihistamines have become increasingly popular because of their comparable efficacy and lower incidence of adverse effects relative to their first-generation counterparts, and the safety and efficacy of this drug class are established in the adult population." | 1.35 | Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast. ( Moeller, ML; Nahata, MC; Phan, H, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (39.13) | 18.7374 |
| 1990's | 7 (30.43) | 18.2507 |
| 2000's | 6 (26.09) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jung, HW | 1 |
| Jung, JK | 1 |
| Park, YK | 1 |
| Takahashi, Y | 1 |
| Kagawa, Y | 1 |
| Izawa, K | 1 |
| Ono, R | 1 |
| Akagi, M | 1 |
| Kamei, C | 2 |
| Phan, H | 1 |
| Moeller, ML | 1 |
| Nahata, MC | 1 |
| Lai, DS | 1 |
| Lue, KH | 1 |
| Hsieh, JC | 1 |
| Lin, KL | 1 |
| Lee, HS | 1 |
| Crampton, HJ | 1 |
| Fokkens, WJ | 1 |
| Scadding, GK | 1 |
| van Cauwenberge, PB | 1 |
| Wheatley, D | 1 |
| Okuda, M | 1 |
| Phillips, MJ | 1 |
| Ollier, S | 1 |
| Davies, RJ | 1 |
| Donato, L | 1 |
| Kuhn, P | 1 |
| Cerveau, C | 1 |
| Charles, X | 1 |
| Chognot, D | 1 |
| Ohkawa, C | 1 |
| Ukai, K | 1 |
| Miyahara, Y | 1 |
| Takeuchi, K | 1 |
| Sakakura, Y | 1 |
| Sugimoto, Y | 1 |
| Kawamoto, E | 1 |
| Chen, Z | 1 |
| Fernández, M | 1 |
| Córdoba, H | 1 |
| Santos, F | 1 |
| Oehling, A | 1 |
| Albegger, K | 1 |
| Talaat, MA | 1 |
| Inaam, PK | 1 |
| Mohammed, MH | 1 |
| Ibrahim, TE | 1 |
| Tripodi, D | 1 |
| Torchia, SL | 1 |
| Gianotti, A | 1 |
| Franconieri, N | 1 |
| Kohno, H | 1 |
| Seyama, Y | 1 |
| Yamashita, S | 1 |
| Akasu, M | 1 |
| Inoue, H | 1 |
| Morris, EC | 1 |
| Wenz, W | 1 |
| Mohorn, M | 1 |
| Jäger, L | 1 |
| Cantani, A | 1 |
| Bellioni, P | 1 |
| Businco, E | 1 |
| Benincori, N | 1 |
| Purello D'Ambrosio, F | 1 |
| Cascio, F | 1 |
| Orlando, F | 1 |
| Niosi, G | 1 |
| Tigano, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effectiveness of Montelukast Versus Intranasal Fluticasone Propionate in the Management of Allergic Rhinitis Among Children 02 to 05 Years of Age[NCT04957927] | Phase 4 | 60 participants (Anticipated) | Interventional | 2020-12-12 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for ketotifen and Rhinitis, Allergic, Nonseasonal
| Article | Year |
|---|---|
[Antiallergy drugs and respiratory diseases in children].
Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Anti-Asthmatic Agents; Asthma; Child; Child, Preschoo | 1999 |
[The symptomatic therapy of allergic rhinitis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cromolyn Sodium; Glucocorticoids; Histamine Antagonists; Hu | 1990 |
[Allergic rhinopathy: diagnosis and current therapy].
Topics: Adolescent; Adult; Aged; Child; Cromolyn Sodium; Desensitization, Immunologic; Female; Humans; Immun | 1990 |
Pharmacotherapy of allergic disease.
Topics: Adrenal Cortex Hormones; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adult; Aged; Anaphylax | 1987 |
7 trials available for ketotifen and Rhinitis, Allergic, Nonseasonal
| Article | Year |
|---|---|
The comparison of the efficacy and safety of cetirizine, oxatomide, ketotifen, and a placebo for the treatment of childhood perennial allergic rhinitis.
Topics: Allergens; Animals; Anti-Allergic Agents; Blood Proteins; Cetirizine; Child; Conjunctivitis, Allergi | 2002 |
A comparison of the relative clinical efficacy of a single dose of ketotifen fumarate 0.025% ophthalmic solution versus placebo in inhibiting the signs and symptoms of allergic rhinoconjunctivitis as induced by the conjunctival allergen challenge model.
Topics: Adult; Aged; Allergens; Anti-Allergic Agents; Conjunctivitis, Allergic; Double-Blind Method; Female; | 2002 |
Perennial rhinitis in the under 4s: a difficult problem to treat safely and effectively? A comparison of intranasal fluticasone propionate and ketotifen in the treatment of 2-4-year-old children with perennial rhinitis.
Topics: Administration, Intranasal; Administration, Oral; Adrenal Cortex Hormones; Androstadienes; Anti-Alle | 2004 |
Ketotifen in hay fever and allergic rhinitis.
Topics: Adolescent; Adult; Aged; Chlorpheniramine; Clinical Trials as Topic; Double-Blind Method; Female; Hu | 1984 |
Clinical investigation of ketotifen in perennial allergic rhinitis: a double-blind comparative study of ketotifen and clemastine fumarate.
Topics: Clemastine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Follow- | 1984 |
The histological and histochemical effects of ketotifen in allergic rhinitis.
Topics: Acid Phosphatase; Adult; Biopsy; Drug Evaluation; Female; Humans; Ketotifen; Male; Nasal Mucosa; Rhi | 1991 |
[Experience with ketotifen in respiratory tract diseases].
Topics: Asthma; Clinical Trials as Topic; Double-Blind Method; Humans; Ketotifen; Rhinitis, Allergic, Perenn | 1986 |
12 other studies available for ketotifen and Rhinitis, Allergic, Nonseasonal
| Article | Year |
|---|---|
Comparison of the efficacy of KOB03, ketotifen, and montelukast in an experimental mouse model of allergic rhinitis.
Topics: Acetates; Animals; Anti-Allergic Agents; Antigens; Cyclopropanes; Cytokines; Disease Models, Animal; | 2013 |
Effect of histamine H4 receptor antagonist on allergic rhinitis in mice.
Topics: Administration, Intranasal; Administration, Oral; Animals; Disease Models, Animal; Female; Histamine | 2009 |
Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast.
Topics: Acetates; Administration, Oral; Adult; Anti-Allergic Agents; Anti-Asthmatic Agents; Astemizole; Ceti | 2009 |
Mast cell stabilizing agents in nasal allergy.
Topics: Adrenal Cortex Hormones; Cell Membrane Permeability; Cromolyn Sodium; Cyclic AMP; Cytoplasmic Granul | 1984 |
Use of anterior rhinometry in nasal provocation challenges with allergen and evaluation of the effects of ketotifen, clemastine and sodium cromoglycate on these responses.
Topics: Adolescent; Adult; Clemastine; Cromolyn Sodium; Female; Humans; Ketotifen; Male; Middle Aged; Piperi | 1980 |
Histamine H1 receptor and reactivity of the nasal mucosa in sensitized guinea pigs.
Topics: Administration, Oral; Animals; Ascaris; Dose-Response Relationship, Drug; Guinea Pigs; Histamine H1 | 1999 |
A new model of allergic rhinitis in rats by topical sensitization and evaluation of H(1)-receptor antagonists.
Topics: Allergens; Animals; Anti-Allergic Agents; Astemizole; Chlorpheniramine; Dibenzazepines; Disease Mode | 2000 |
In vitro ketotifen protection in bronchial hyperreactivity.
Topics: Adolescent; Adult; Animals; Asthma, Exercise-Induced; Basophil Degranulation Test; Basophils; Bronch | 1991 |
[Ketotifen and polysomnography in patients with allergic rhinitis].
Topics: Adult; Electrocardiography; Electroencephalography; Electromyography; Electrooculography; Humans; Ke | 1990 |
[Effects of cepharanthine on experimental nasal allergy].
Topics: Alkaloids; Animals; Azo Compounds; Benzylisoquinolines; Glucuronidase; Histamine H1 Antagonists; Ket | 1986 |
[Therapy of allergic rhinitis in childhood].
Topics: Asthma; Beclomethasone; Child; Cromolyn Sodium; Desensitization, Immunologic; Humans; Ketotifen; Rhi | 1987 |
[Hyposensitivity therapy in perennial allergic rhinitis from Dermatophagoides pteronyssinus: effect of combination with ketotifen].
Topics: Adolescent; Adult; Child; Desensitization, Immunologic; Female; Humans; Ketotifen; Male; Middle Aged | 1987 |