ketotifen has been researched along with Reperfusion Injury in 8 studies
Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
ketotifen : An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mast cells were associated with intestinal ischemia-reperfusion injury, the study was to observe the influence of Ketotifen, Cromolyn Sdium(CS), and Compound 48/80(CP) on the survival rates on the third day after intestinal ischemia-reperfusion injury in rats." | 7.74 | Influence of Ketotifen, Cromolyn Sodium, and Compound 48/80 on the survival rates after intestinal ischemia reperfusion injury in rats. ( Gan, XL; Gao, WL; Hei, ZQ; Huang, PJ; Shen, N; Wei, J, 2008) |
| "Mast cells were associated with intestinal ischemia-reperfusion injury, the study was to observe the influence of Ketotifen, Cromolyn Sdium(CS), and Compound 48/80(CP) on the survival rates on the third day after intestinal ischemia-reperfusion injury in rats." | 3.74 | Influence of Ketotifen, Cromolyn Sodium, and Compound 48/80 on the survival rates after intestinal ischemia reperfusion injury in rats. ( Gan, XL; Gao, WL; Hei, ZQ; Huang, PJ; Shen, N; Wei, J, 2008) |
| "Treatment with cromolyn sodium or ketotifen markedly alleviated I/R-mediated kidney injury, whereas compound 48/80 further aggravated kidney injury." | 1.43 | Effect of Intervention in Mast Cell Function Before Reperfusion on Renal Ischemia-Reperfusion Injury in Rats. ( Liu, D; Luo, L; Tong, F, 2016) |
| "S)." | 1.40 | Effects of anti-histamine treatment on liver injury triggered by small intestinal ischemia reperfusion in rats. ( Gan, XL; Hei, ZQ; Huang, PJ; Liu, DZ; Liu, JP; Wang, YL, 2014) |
| "Pretreatment with ketotifen, a connective tissue mast cell stabilizer, prevented the formation of gastric mucosal lesions, the increases of gastric mucosal lipid peroxide content, xanthine oxidase and myeloperoxidase activities, and serum serotonin level; and the decreases of gastric mucosal nonprotein SH content, glutathione peroxidase activity, and blood flow found at 0." | 1.30 | Relationship between changes of active oxygen metabolism and blood flow and formation, progression, and recovery of lesions is gastric mucosa of rats with a single treatment of compound 48/80, a mast cell degranulator. ( Ishiguro, I; Kobayashi, T; Nishida, K; Ohta, Y, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, PJ | 2 |
| Gan, XL | 2 |
| Liu, JP | 1 |
| Liu, DZ | 1 |
| Wang, YL | 1 |
| Hei, ZQ | 2 |
| El-Shitany, NA | 1 |
| El-Desoky, K | 1 |
| Tong, F | 1 |
| Luo, L | 1 |
| Liu, D | 2 |
| Wei, J | 1 |
| Shen, N | 1 |
| Gao, WL | 1 |
| Huang, P | 1 |
| Gan, X | 1 |
| Zhang, R | 1 |
| Gao, W | 1 |
| Xia, Z | 1 |
| Hei, Z | 1 |
| Kalia, N | 1 |
| Brown, NJ | 1 |
| Wood, RF | 1 |
| Pockley, AG | 1 |
| Ohta, Y | 1 |
| Kobayashi, T | 1 |
| Nishida, K | 1 |
| Ishiguro, I | 1 |
| Vural, KM | 1 |
| Liao, H | 1 |
| Oz, MC | 1 |
| Pinsky, DJ | 1 |
8 other studies available for ketotifen and Reperfusion Injury
| Article | Year |
|---|---|
Effects of anti-histamine treatment on liver injury triggered by small intestinal ischemia reperfusion in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cell Degranulation; Histamine; Histamine | 2014 |
Cromoglycate, not ketotifen, ameliorated the injured effect of warm ischemia/reperfusion in rat liver: role of mast cell degranulation, oxidative stress, proinflammatory cytokine, and inducible nitric oxide synthase.
Topics: Animals; Biomarkers; Cell Degranulation; Cromolyn Sodium; Cytokines; Cytoprotection; Disease Models, | 2015 |
Effect of Intervention in Mast Cell Function Before Reperfusion on Renal Ischemia-Reperfusion Injury in Rats.
Topics: Animals; Anti-Allergic Agents; Cromolyn Sodium; Ketotifen; Kidney; Mast Cells; p-Methoxy-N-methylphe | 2016 |
Influence of Ketotifen, Cromolyn Sodium, and Compound 48/80 on the survival rates after intestinal ischemia reperfusion injury in rats.
Topics: Animals; Anti-Asthmatic Agents; Cromolyn Sodium; Histamine H1 Antagonists; Interleukin-10; Interleuk | 2008 |
Mast cells activation contribute to small intestinal ischemia reperfusion induced acute lung injury in rats.
Topics: Acute Lung Injury; Animals; Cromolyn Sodium; Histamine H1 Antagonists; Interleukin-8; Intestine, Sma | 2012 |
Ketotifen abrogates local and systemic consequences of rat intestinal ischemia-reperfusion injury.
Topics: Administration, Oral; Animals; Blood Pressure; Disease Models, Animal; Disease Progression; Heart Ra | 2005 |
Relationship between changes of active oxygen metabolism and blood flow and formation, progression, and recovery of lesions is gastric mucosa of rats with a single treatment of compound 48/80, a mast cell degranulator.
Topics: Animals; Cell Degranulation; Gastric Mucosa; Glutathione Peroxidase; Hexosamines; Ketotifen; Lipid P | 1997 |
Effects of mast cell membrane stabilizing agents in a rat lung ischemia-reperfusion model.
Topics: Analysis of Variance; Animals; Anti-Asthmatic Agents; Cell Membrane; Cromolyn Sodium; Cyclic GMP; Di | 2000 |