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ketotifen and Plasmodium falciparum Malaria

ketotifen has been researched along with Plasmodium falciparum Malaria in 5 studies

Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
ketotifen : An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.

Research Excerpts

ExcerptRelevanceReference
"Ketotifen is known to exhibit antimalarial activity in mouse and monkey malaria models."7.78Ketotifen is an antimalarial prodrug of norketotifen with blood schizonticidal and liver-stage efficacy. ( Auschwitz, J; Caridha, D; Dow, GS; Gardner, S; Grauer, K; Harris, E; Hickman, M; Kozar, MP; Lee, P; Leed, S; Li, Q; Melendez, V; Milner, E; Moon, J; Ngundam, F; O'Neil, M; Parriott, S; Potter, B; Pybus, B; Sciotti, R; Sousa, J; Tangteung, A, 2012)
" The findings indicate that - at least at the dosing regimen used in the present study and among children with acute, uncomplicated, P."6.71A randomized comparison of chloroquine and chloroquine plus ketotifen in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children. ( Sowunmi, A, 2003)
"The present in vivo study evaluates the potential use of ketotifen, a tricyclic antihistaminic drug, in treatment of Sudanese patients with uncomplicated Plasmodium falciparum malaria (19-38 years)."5.09Ketotifen in treatment of uncomplicated falciparum malaria. ( Elhag, ER; Ibrahim, AM; Mustafa, SE, 2000)
"Ketotifen is known to exhibit antimalarial activity in mouse and monkey malaria models."3.78Ketotifen is an antimalarial prodrug of norketotifen with blood schizonticidal and liver-stage efficacy. ( Auschwitz, J; Caridha, D; Dow, GS; Gardner, S; Grauer, K; Harris, E; Hickman, M; Kozar, MP; Lee, P; Leed, S; Li, Q; Melendez, V; Milner, E; Moon, J; Ngundam, F; O'Neil, M; Parriott, S; Potter, B; Pybus, B; Sciotti, R; Sousa, J; Tangteung, A, 2012)
" The findings indicate that - at least at the dosing regimen used in the present study and among children with acute, uncomplicated, P."2.71A randomized comparison of chloroquine and chloroquine plus ketotifen in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children. ( Sowunmi, A, 2003)
"Malaria is a deadly infectious disease in many tropical and subtropical countries."1.39A class of tricyclic compounds blocking malaria parasite oocyst development and transmission. ( Austin, CP; Deng, B; Dixit, S; Eastman, RT; Huang, R; Jiang, H; Johnson, RL; Lambert, LE; Long, C; Miura, K; Pattaradilokrat, S; Raj, DK; Su, XZ; Tanaka, TQ; Williamson, KC; Wu, Y; Yuan, J, 2013)
"Cyproheptadine and verapamil were not effective in reversing chloroquine resistance and probable drug toxicity was observed with these drugs in combination with chloroquine."1.29Reversal of Plasmodium falciparum resistance to chloroquine in Panamanian Aotus monkeys. ( Kyle, DE; Milhous, WK; Rossan, RN, 1993)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's2 (40.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Milner, E1
Sousa, J1
Pybus, B1
Auschwitz, J1
Caridha, D1
Gardner, S1
Grauer, K1
Harris, E1
Hickman, M1
Kozar, MP1
Lee, P1
Leed, S1
Li, Q1
Melendez, V1
Moon, J1
Ngundam, F1
O'Neil, M1
Parriott, S1
Potter, B1
Sciotti, R1
Tangteung, A1
Dow, GS1
Eastman, RT1
Pattaradilokrat, S1
Raj, DK1
Dixit, S1
Deng, B1
Miura, K1
Yuan, J1
Tanaka, TQ1
Johnson, RL1
Jiang, H1
Huang, R1
Williamson, KC1
Lambert, LE1
Long, C1
Austin, CP1
Wu, Y1
Su, XZ1
Sowunmi, A1
Kyle, DE1
Milhous, WK1
Rossan, RN1
Ibrahim, AM1
Elhag, ER1
Mustafa, SE1

Trials

2 trials available for ketotifen and Plasmodium falciparum Malaria

ArticleYear
A randomized comparison of chloroquine and chloroquine plus ketotifen in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children.
    Annals of tropical medicine and parasitology, 2003, Volume: 97, Issue:2

    Topics: Acute Disease; Administration, Oral; Amodiaquine; Analysis of Variance; Antimalarials; Child; Child,

2003
Ketotifen in treatment of uncomplicated falciparum malaria.
    Saudi medical journal, 2000, Volume: 21, Issue:3

    Topics: Adult; Antimalarials; Body Weight; Chloroquine; Drug Monitoring; Drug Therapy, Combination; Follow-U

2000

Other Studies

3 other studies available for ketotifen and Plasmodium falciparum Malaria

ArticleYear
Ketotifen is an antimalarial prodrug of norketotifen with blood schizonticidal and liver-stage efficacy.
    European journal of drug metabolism and pharmacokinetics, 2012, Volume: 37, Issue:1

    Topics: Animals; Antimalarials; Female; Humans; Inhibitory Concentration 50; Ketotifen; Liver; Malaria; Mala

2012
A class of tricyclic compounds blocking malaria parasite oocyst development and transmission.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:1

    Topics: Animals; Anti-Allergic Agents; Antimalarials; ATP-Binding Cassette Transporters; Biological Transpor

2013
Reversal of Plasmodium falciparum resistance to chloroquine in Panamanian Aotus monkeys.
    The American journal of tropical medicine and hygiene, 1993, Volume: 48, Issue:1

    Topics: Animals; Aotus trivirgatus; Calcium Channel Blockers; Chloroquine; Chlorpromazine; Cyproheptadine; D

1993
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