Page last updated: 2024-10-30

ketotifen and Neoplasms

ketotifen has been researched along with Neoplasms in 3 studies

Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
ketotifen : An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
" In addition, characterization of the UGT1A locus and genetic studies directed at understanding the role of bilirubin glucuronidation and the biochemical basis of the clinical symptoms found in unconjugated hyperbilirubinemia have uncovered the structural gene polymorphisms associated with Crigler-Najjar's and Gilbert's syndrome."4.80Human UDP-glucuronosyltransferases: metabolism, expression, and disease. ( Strassburg, CP; Tukey, RH, 2000)
"Exosomes released from cancer cells support metastasis and growth of recipient cells and increase their resistance to chemotherapy."1.48Inhibition of exosome release by ketotifen enhances sensitivity of cancer cells to doxorubicin. ( Alawadhi, H; El-Awady, R; Harati, R; Khan, FM; Saleh, E; Zimmermann, WH, 2018)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (66.67)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tukey, RH1
Strassburg, CP1
Khan, FM1
Saleh, E1
Alawadhi, H1
Harati, R1
Zimmermann, WH1
El-Awady, R1
Briasoulis, E1
Karavasilis, V1
Pavlidis, N1

Reviews

1 review available for ketotifen and Neoplasms

ArticleYear
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
    Annual review of pharmacology and toxicology, 2000, Volume: 40

    Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia;

2000

Trials

1 trial available for ketotifen and Neoplasms

ArticleYear
Successful rechallenge with taxanes following prophylactic ketotifen in patients who had developed severe hypersensitivity reactions.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2000, Volume: 11, Issue:7

    Topics: Adult; Aged; Anti-Allergic Agents; Antineoplastic Agents, Phytogenic; Docetaxel; Drug Hypersensitivi

2000

Other Studies

1 other study available for ketotifen and Neoplasms

ArticleYear
Inhibition of exosome release by ketotifen enhances sensitivity of cancer cells to doxorubicin.
    Cancer biology & therapy, 2018, 01-02, Volume: 19, Issue:1

    Topics: Antibiotics, Antineoplastic; Doxorubicin; Drug Resistance, Neoplasm; Exosomes; HeLa Cells; Humans; K

2018