ketotifen has been researched along with Muscle Contraction in 25 studies
Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
ketotifen : An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Using a new method for inducing IgE-mediated, systemic anaphylaxis in the rat both prednisolone and ketotifen had been shown previously to be effective in suppressing the bronchial anaphylaxis in vivo." | 3.67 | The effect of prednisolone and ketotifen on the antigen-induced bronchoconstriction and mediator release in rat isolated lungs. ( Ottenhof, M; Ufkes, JG; Van Rooij, HH, 1985) |
| " In an in vivo experiment, chronic administration of HQL-79 clearly reduced PGD2 contents and enhanced PGE2 contents in the lungs of repeatedly antigen-exposed guinea pigs." | 1.30 | Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antiasthmatic effects. ( Aritake, K; Hayashi, K; Hayashi, M; Hirotsu, I; Hizue, M; Kimura, Y; Matsushita, N; Mitsui, K; Nakajima, H; Takada, A; Tani, T, 1998) |
| "Ketotifen fumarate has been demonstrated to inhibit the noncholinergic contraction in guinea pig airways in vitro, but no attempt has been made to identify the receptor type." | 1.29 | Ketotifen modulates noncholinergic contraction in guinea pig airways in vitro by a prejunctional nonhistamine receptor. ( Demedts, MM; Pype, JL; Verleden, GM, 1994) |
| "Ketotifen is a tricyclic drug with a wide spectrum of pharmacological effects." | 1.29 | The actions of ketotifen on intestinal smooth muscles. ( Abu-Dalu, R; Hanani, M; Zhang, JM, 1996) |
| "Mequitazine was much less potent in antihistaminic action and slightly more potent in anticholinergic action than ketotifen." | 1.27 | [Antiallergic effects of mequitazine. 1. In vitro experiments]. ( Koda, A; Kohno, S; Masuki, S; Nagai, H; Ohata, K; Shida, T; Tatumi, H; Yamamura, H; Yanagihara, Y; Yoshida, Y, 1988) |
| "Azelastine is a phthalazinone derivative with a wide spectrum of pharmacological activities." | 1.27 | Inhibition of cysteinyl-leukotriene production by azelastine and its biological significance. ( Achterrath-Tuckermann, U; Luck, W; Peskar, BA; Simmet, T; Szelenyi, I, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (48.00) | 18.7374 |
| 1990's | 6 (24.00) | 18.2507 |
| 2000's | 3 (12.00) | 29.6817 |
| 2010's | 4 (16.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rychter, J | 1 |
| Ortega, O | 1 |
| Berdun, S | 1 |
| Arenas, C | 1 |
| Lopez, I | 1 |
| Espin, F | 1 |
| Vergara, P | 2 |
| Clavé, P | 1 |
| Min, Y | 1 |
| He, P | 1 |
| Wang, Q | 1 |
| Jin, X | 1 |
| Song, B | 1 |
| Li, L | 1 |
| Fitzgerald, JJ | 1 |
| Ustinova, E | 1 |
| Koronowski, KB | 1 |
| de Groat, WC | 1 |
| Pezzone, MA | 1 |
| Fernández-Blanco, JA | 2 |
| Hollenberg, MD | 1 |
| Martínez, V | 1 |
| Ishimura, M | 1 |
| Kataoka, S | 1 |
| Suda, M | 1 |
| Maeda, T | 1 |
| Hiyama, Y | 1 |
| Fukuda, T | 1 |
| Morimoto, Y | 1 |
| Iemura, R | 1 |
| Kawashima, T | 1 |
| Tsukamoto, G | 1 |
| Ito, K | 1 |
| Alvarez, RG | 1 |
| Arruzazabala, ML | 1 |
| de Lourdes Arruzazabala, M | 1 |
| González Alvarez, R | 2 |
| Lowe, DA | 1 |
| Richardson, BP | 1 |
| Verleden, GM | 1 |
| Pype, JL | 1 |
| Demedts, MM | 1 |
| Abu-Dalu, R | 1 |
| Zhang, JM | 1 |
| Hanani, M | 1 |
| Tanaka, Y | 1 |
| Masai, E | 1 |
| Yashima, T | 1 |
| Furukawa, M | 1 |
| Kobayashi, T | 1 |
| Takehana, Y | 1 |
| Shinagawa, K | 1 |
| Tsuyuki, S | 1 |
| Tokutake, Y | 1 |
| Sato, M | 1 |
| Momose, D | 1 |
| Matsushita, N | 1 |
| Aritake, K | 1 |
| Takada, A | 1 |
| Hizue, M | 1 |
| Hayashi, K | 1 |
| Mitsui, K | 1 |
| Hayashi, M | 1 |
| Hirotsu, I | 1 |
| Kimura, Y | 1 |
| Tani, T | 1 |
| Nakajima, H | 1 |
| Takizawa, T | 1 |
| Matsumoto, J | 1 |
| Tohma, T | 1 |
| Kanke, T | 1 |
| Wada, Y | 1 |
| Nagao, M | 1 |
| Inagaki, N | 2 |
| Nagai, H | 4 |
| Zhang, MQ | 1 |
| Timmerman, H | 1 |
| Hashimoto, T | 1 |
| Nakano, Y | 1 |
| Yamashita, M | 1 |
| Fang, YI | 1 |
| Ohata, H | 1 |
| Momose, K | 1 |
| Makino, E | 1 |
| Ohashi, T | 1 |
| Takahashi, H | 1 |
| Kato, H | 1 |
| Ito, Y | 1 |
| Koda, A | 3 |
| Azuma, H | 1 |
| Kohno, S | 1 |
| Yamamura, H | 1 |
| Ohata, K | 1 |
| Yanagihara, Y | 1 |
| Shida, T | 1 |
| Masuki, S | 1 |
| Yoshida, Y | 1 |
| Tatumi, H | 1 |
| Kamikawa, Y | 1 |
| Achterrath-Tuckermann, U | 1 |
| Simmet, T | 1 |
| Luck, W | 1 |
| Szelenyi, I | 1 |
| Peskar, BA | 1 |
| Wilhelms, OH | 1 |
| Yamada, H | 1 |
| Goto, S | 1 |
| Loftus, BG | 1 |
| Price, JF | 1 |
| Heaton, R | 1 |
| Costello, JF | 1 |
| Ottenhof, M | 1 |
| Ufkes, JG | 1 |
| Van Rooij, HH | 1 |
| Arruzazabala Valmaña, ML | 1 |
25 other studies available for ketotifen and Muscle Contraction
| Article | Year |
|---|---|
Mast cell degranulation inhibits motor patterns of human ileum and sigmoid colon in vitro: relevance for postoperative ileus.
Topics: Adult; Aged; Aged, 80 and over; Cell Degranulation; Colon, Sigmoid; Female; Humans; Ileum; Ileus; In | 2015 |
The effects of the c-kit blocker glivec on the contractile response of urinary bladder.
Topics: Animals; Atropine; Benzamides; Female; Histamine H1 Antagonists; Imatinib Mesylate; Interstitial Cel | 2011 |
Evidence for the role of mast cells in colon-bladder cross organ sensitization.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Female; Ketotifen; Mast Cells; Membrane Transport M | 2013 |
PAR-2-mediated control of barrier function and motility differs between early and late phases of postinfectious gut dysfunction in the rat.
Topics: Animals; Gastroenteritis; Gastrointestinal Motility; Gastrointestinal Tract; Ketotifen; Male; Mast C | 2013 |
Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetates; Acetylcholine; Albuter | 2006 |
Effect of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)-benzimida zole difumarate (KB-2413), a new antiallergic, on chemical mediators.
Topics: Acetylcholine; Airway Resistance; Animals; Benzimidazoles; Bradykinin; Capillary Permeability; Guine | 1984 |
Further studies on the effects of ketotifen on guinea pig ileum.
Topics: Acetylcholine; Animals; Barium; Barium Compounds; Chlorides; Cromolyn Sodium; Dinoprost; Electric St | 1983 |
Protective effects of ketotifen on guinea pig trachea.
Topics: Acetylcholine; Animals; Barium; Barium Compounds; Chlorides; Dinoprost; Electric Stimulation; Guinea | 1984 |
Effects of cyproheptadine, ketotifen and sodium nitroprusside on mechanical activity and calcium uptake in guinea pig taenia coli in vitro.
Topics: Animals; Calcium; Colon; Cyproheptadine; Ferricyanides; Guinea Pigs; Ketotifen; Muscle Contraction; | 1980 |
Ketotifen modulates noncholinergic contraction in guinea pig airways in vitro by a prejunctional nonhistamine receptor.
Topics: Adrenergic Fibers; Animals; Cholinergic Fibers; Dose-Response Relationship, Drug; Electric Stimulati | 1994 |
The actions of ketotifen on intestinal smooth muscles.
Topics: Animals; Colon; Electric Stimulation; Female; Guinea Pigs; Ileum; Ketotifen; Male; Mice; Mice, Inbre | 1996 |
[Antiallergic effects of a novel compound, SWR-00151].
Topics: Animals; Anti-Allergic Agents; Asthma; Bronchoconstriction; Cells, Cultured; Depression, Chemical; D | 1997 |
Pharmacological characterization of a novel long-acting histamine H1 receptor antagonist, KAA-276.
Topics: Administration, Inhalation; Administration, Oral; Animals; Azocines; Benzimidazoles; Bronchoconstric | 1998 |
Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antiasthmatic effects.
Topics: Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Antigens; Capillary Permeability; Dibenzazepin | 1998 |
VUF-K-8788, a periphery-selective histamine H1 antagonist with anti-pruritic activities.
Topics: Animals; Anti-Allergic Agents; Behavior, Animal; Benzimidazoles; Capillary Permeability; Guinea Pigs | 2001 |
Role of Rho-associated protein kinase and histamine in lysophosphatidic acid-induced airway hyperresponsiveness in guinea pigs.
Topics: Acetylcholine; Amides; Animals; Bronchial Hyperreactivity; Enzyme Inhibitors; Guinea Pigs; Histamine | 2002 |
Potent inhibitory activity of HSR-6071, a new antiallergic agent, on passive cutaneous anaphylaxis (PCA).
Topics: Aminopyridines; Animals; Antigens; Ascaris; Azoles; Calcimycin; Cromolyn Sodium; Dinitrophenols; Gui | 1990 |
[Antiallergic effects of mequitazine. 1. In vitro experiments].
Topics: Acetylcholine; Animals; Bronchi; Guinea Pigs; Histamine H1 Antagonists; Histamine Release; In Vitro | 1988 |
Inhibitory effect of anti-allergic drugs on cholinergic and non-cholinergic neurotransmissions of guinea pig bronchial muscle in vitro.
Topics: Acetylcholine; Animals; Bronchi; Cholinergic Fibers; Cromolyn Sodium; Electric Stimulation; Guinea P | 1989 |
Inhibition of cysteinyl-leukotriene production by azelastine and its biological significance.
Topics: Animals; Antigens; Arachidonic Acid; Arachidonic Acids; Bronchi; Guinea Pigs; Histamine H1 Antagonis | 1988 |
Antagonism of picumast and ketotifen against histamine, acetylcholine, LTC4, slow-reacting substance of anaphylaxis and barium chloride in the guinea pig ileum bioassay.
Topics: Acetylcholine; Animals; Barium; Barium Compounds; Chlorides; Coumarins; Drug Evaluation, Preclinical | 1987 |
Reduction of antigen-induced contraction of sensitized guinea-pig tracheal smooth muscle in vitro by calmodulin inhibitors.
Topics: Animals; Antigens; Calmodulin; Chlorpromazine; Female; Guinea Pigs; Histamine; Imidazoles; Immunizat | 1985 |
Effects of ketotifen on in vitro bronchoconstriction.
Topics: Acetylcholine; Animals; Antigens; Bronchi; Guinea Pigs; Histamine; Humans; Hypersensitivity; Ketotif | 1985 |
The effect of prednisolone and ketotifen on the antigen-induced bronchoconstriction and mediator release in rat isolated lungs.
Topics: Anaphylaxis; Animals; Bronchi; Female; Histamine; In Vitro Techniques; Ketotifen; Lung; Muscle Contr | 1985 |
Pharmacological characterization of ketotifen effects on guinea pig ileum.
Topics: Acetylcholine; Animals; Electric Stimulation; Female; Guinea Pigs; Ileum; In Vitro Techniques; Ketot | 1985 |