ketotifen and Mastocytosis
ketotifen has been researched along with Mastocytosis in 14 studies
Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
ketotifen : An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.
Mastocytosis: A rare neoplastic disorder characterized by a clonal proliferation of MAST CELLS, associated with KIT-D816 mutations, and accompanied by aberrant mast cell activation. The abnormal increase of MAST CELLS may occur in only the skin (MASTOCYTOSIS, CUTANEOUS), in extracutaneous tissues involving multiple organs (MASTOCYTOSIS, SYSTEMIC), or in solid tumors (MASTOCYTOMA).
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"To asses the efficacy of ketotifen (Zaditen; Sandoz Pharmaceuticals, Basel, Switzerland) for the treatment of pediatric mastocytosis, eight children who exhibited symptoms as a result of mastocytosis were enrolled in a 12-week, double-blind, placebo-controlled, crossover trial of ketotifen versus hydroxyzine (Atarax; Roerig, New York, N." | 9.06 | A double-blind, placebo-controlled, crossover trial of ketotifen versus hydroxyzine in the treatment of pediatric mastocytosis. ( Berkebile, C; Bradley, D; Kettelhut, BV; Metcalfe, DD, 1989) |
"Treatment of four mastocytosis patients with the mast cell stabilising drugs, disodium cromoglycate and ketotifen failed to alter significantly the urinary excretion levels of histamine or N tau-methylimidazole acetic acid." | 7.67 | The effect of disodium cromoglycate and ketotifen on the excretion of histamine and N tau-methylimidazole acetic acid in urine of patients with mastocytosis. ( Greaves, MW; Mallet, AI; Norris, P; Rendell, NB; Wong, E, 1989) |
"Mastocytosis is a disorder of mast cell proliferation that occurs in both cutaneous and systemic forms." | 5.30 | Heterogeneity of mast cells in mastocytosis and inhibitory effect of ketotifen and ranitidine on indolent systemic mastocytosis. ( Akimoto, S; Amano, H; Hashimoto, T; Kanbe, N; Kurimoto, F; Kurosawa, M; Miyachi, Y; Takeuchi, Y; Yamashita, T, 1997) |
"To asses the efficacy of ketotifen (Zaditen; Sandoz Pharmaceuticals, Basel, Switzerland) for the treatment of pediatric mastocytosis, eight children who exhibited symptoms as a result of mastocytosis were enrolled in a 12-week, double-blind, placebo-controlled, crossover trial of ketotifen versus hydroxyzine (Atarax; Roerig, New York, N." | 5.06 | A double-blind, placebo-controlled, crossover trial of ketotifen versus hydroxyzine in the treatment of pediatric mastocytosis. ( Berkebile, C; Bradley, D; Kettelhut, BV; Metcalfe, DD, 1989) |
"Treatment of four mastocytosis patients with the mast cell stabilising drugs, disodium cromoglycate and ketotifen failed to alter significantly the urinary excretion levels of histamine or N tau-methylimidazole acetic acid." | 3.67 | The effect of disodium cromoglycate and ketotifen on the excretion of histamine and N tau-methylimidazole acetic acid in urine of patients with mastocytosis. ( Greaves, MW; Mallet, AI; Norris, P; Rendell, NB; Wong, E, 1989) |
"Mastocytosis is a disorder of mast cell proliferation that occurs in both cutaneous and systemic forms." | 1.30 | Heterogeneity of mast cells in mastocytosis and inhibitory effect of ketotifen and ranitidine on indolent systemic mastocytosis. ( Akimoto, S; Amano, H; Hashimoto, T; Kanbe, N; Kurimoto, F; Kurosawa, M; Miyachi, Y; Takeuchi, Y; Yamashita, T, 1997) |
"Mucosal mastocytosis was first observed on day 26 postinfection and occurred only in the ileum of tapeworm-infected rats." | 1.30 | Hymenolepsis diminuta: mucosal mastocytosis and intestinal smooth muscle hypertrophy occur in tapeworm-infected rats. ( Bass, P; Dwinell, MB; Oaks, JA; Wise, RM, 1998) |
Research
Studies (14)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 4 (28.57) | 18.7374 |
1990's | 8 (57.14) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 2 (14.29) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Asawa, A | 1 |
Simpson, KH | 1 |
Bonds, RS | 1 |
Homann, J | 1 |
Kolck, UW | 1 |
Ehnes, A | 1 |
Frieling, T | 1 |
Raithel, M | 1 |
Molderings, GJ | 1 |
de las Nieves, M | 1 |
Poveda, F | 1 |
Queipo de Llano, MP | 1 |
González-Hermoso, C | 1 |
Kurosawa, M | 1 |
Amano, H | 1 |
Kanbe, N | 1 |
Akimoto, S | 1 |
Takeuchi, Y | 1 |
Yamashita, T | 1 |
Hashimoto, T | 1 |
Kurimoto, F | 1 |
Miyachi, Y | 1 |
Dwinell, MB | 1 |
Wise, RM | 1 |
Bass, P | 1 |
Oaks, JA | 1 |
Mezei, P | 1 |
Bencsik, Z | 1 |
Vicze, B | 1 |
Simon, K | 1 |
István, L | 1 |
Pajor, L | 1 |
Kettelhut, BV | 2 |
Póvoa, P | 1 |
Ducla-Soares, J | 1 |
Fernandes, A | 1 |
Palma-Carlos, AG | 1 |
Graves, L | 1 |
Stechschulte, DJ | 1 |
Morris, DC | 1 |
Lukert, BP | 1 |
Ting, S | 1 |
Mallet, AI | 1 |
Norris, P | 1 |
Rendell, NB | 1 |
Wong, E | 1 |
Greaves, MW | 1 |
Berkebile, C | 1 |
Bradley, D | 1 |
Metcalfe, DD | 1 |
Kawano, Y | 1 |
Abe, H | 1 |
Yoshida, K | 1 |
Saitoh, F | 1 |
Kuramochi, M | 1 |
Ito, K | 1 |
Omae, T | 1 |
François, B | 1 |
Duprez, D | 1 |
Oomen, C | 1 |
Kint, A | 1 |
Clement, DL | 1 |
Reviews
1 review available for ketotifen and Mastocytosis
Article | Year |
---|---|
[Systemic mastocytosis--definition of an internal disease].
Topics: Algorithms; Apoptosis; Ascorbic Acid; Biopsy; Bone Marrow; Codon; Combined Modality Therapy; Cromoly | 2010 |
Trials
1 trial available for ketotifen and Mastocytosis
Article | Year |
---|---|
A double-blind, placebo-controlled, crossover trial of ketotifen versus hydroxyzine in the treatment of pediatric mastocytosis.
Topics: Child; Child, Preschool; Clinical Trials as Topic; Double-Blind Method; Female; Histamine; Humans; H | 1989 |
Other Studies
12 other studies available for ketotifen and Mastocytosis
Article | Year |
---|---|
Ketotifen use in a patient with fire ant hypersensitivity and mast cell activation syndrome.
Topics: Adult; Anaphylaxis; Animals; Ant Venoms; Anti-Allergic Agents; Ants; Asthma; Erythema; Female; Hista | 2015 |
[System mastocytosis: presentation of a case evolving into myelofibrosis and no response to interferon alfa 2b].
Topics: Bone Marrow; Cerebral Hemorrhage; Combined Modality Therapy; Fatal Outcome; Female; Histamine Antago | 1997 |
Heterogeneity of mast cells in mastocytosis and inhibitory effect of ketotifen and ranitidine on indolent systemic mastocytosis.
Topics: Adult; Biopsy; Chymases; Dinoprostone; Histamine; Humans; Infant; Ketotifen; Leukotrienes; Male; Mas | 1997 |
Hymenolepsis diminuta: mucosal mastocytosis and intestinal smooth muscle hypertrophy occur in tapeworm-infected rats.
Topics: Animals; Cell Count; Electromyography; Gastrointestinal Motility; Histamine H1 Antagonists; Hymenole | 1998 |
[Two cases of malignant and benign systemic mastocytosis].
Topics: Adult; Bone Marrow; Ethylenediamines; Fatal Outcome; Female; Femur; Histamine H1 Antagonists; Humans | 1999 |
Ketotifen in systemic mastocytosis--a response.
Topics: Adult; Child; Humans; Ketotifen; Mastocytosis | 1991 |
A case of systemic mastocytosis; therapeutic efficacy of ketotifen.
Topics: Aged; Humans; Ketotifen; Male; Mastocytosis | 1991 |
Inhibition of mediator release in systemic mastocytosis is associated with reversal of bone changes.
Topics: Bone and Bones; Bone Resorption; Calcitriol; Histamine; Humans; Ketotifen; Male; Mast Cells; Mastocy | 1990 |
Ketotifen and systemic mastocytosis.
Topics: Adult; Humans; Ketotifen; Male; Mastocytosis | 1990 |
The effect of disodium cromoglycate and ketotifen on the excretion of histamine and N tau-methylimidazole acetic acid in urine of patients with mastocytosis.
Topics: Adult; Cromolyn Sodium; Female; Histamine; Humans; Imidazoles; Ketotifen; Male; Mastocytosis; Middle | 1989 |
[A case of systemic mastocytosis with flushing, palpitation and dyspnea].
Topics: Chlorpheniramine; Cimetidine; Diagnosis, Differential; Drug Therapy, Combination; Dyspnea; Histamine | 1987 |
Hypotensive attacks due to systemic mastocytosis.
Topics: Humans; Hypotension; Ketotifen; Male; Mastocytosis; Middle Aged | 1987 |