Page last updated: 2024-10-30

ketotifen and Mastocytosis

ketotifen has been researched along with Mastocytosis in 14 studies

Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
ketotifen : An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.

Mastocytosis: A rare neoplastic disorder characterized by a clonal proliferation of MAST CELLS, associated with KIT-D816 mutations, and accompanied by aberrant mast cell activation. The abnormal increase of MAST CELLS may occur in only the skin (MASTOCYTOSIS, CUTANEOUS), in extracutaneous tissues involving multiple organs (MASTOCYTOSIS, SYSTEMIC), or in solid tumors (MASTOCYTOMA).

Research Excerpts

ExcerptRelevanceReference
"To asses the efficacy of ketotifen (Zaditen; Sandoz Pharmaceuticals, Basel, Switzerland) for the treatment of pediatric mastocytosis, eight children who exhibited symptoms as a result of mastocytosis were enrolled in a 12-week, double-blind, placebo-controlled, crossover trial of ketotifen versus hydroxyzine (Atarax; Roerig, New York, N."9.06A double-blind, placebo-controlled, crossover trial of ketotifen versus hydroxyzine in the treatment of pediatric mastocytosis. ( Berkebile, C; Bradley, D; Kettelhut, BV; Metcalfe, DD, 1989)
"Treatment of four mastocytosis patients with the mast cell stabilising drugs, disodium cromoglycate and ketotifen failed to alter significantly the urinary excretion levels of histamine or N tau-methylimidazole acetic acid."7.67The effect of disodium cromoglycate and ketotifen on the excretion of histamine and N tau-methylimidazole acetic acid in urine of patients with mastocytosis. ( Greaves, MW; Mallet, AI; Norris, P; Rendell, NB; Wong, E, 1989)
"Mastocytosis is a disorder of mast cell proliferation that occurs in both cutaneous and systemic forms."5.30Heterogeneity of mast cells in mastocytosis and inhibitory effect of ketotifen and ranitidine on indolent systemic mastocytosis. ( Akimoto, S; Amano, H; Hashimoto, T; Kanbe, N; Kurimoto, F; Kurosawa, M; Miyachi, Y; Takeuchi, Y; Yamashita, T, 1997)
"To asses the efficacy of ketotifen (Zaditen; Sandoz Pharmaceuticals, Basel, Switzerland) for the treatment of pediatric mastocytosis, eight children who exhibited symptoms as a result of mastocytosis were enrolled in a 12-week, double-blind, placebo-controlled, crossover trial of ketotifen versus hydroxyzine (Atarax; Roerig, New York, N."5.06A double-blind, placebo-controlled, crossover trial of ketotifen versus hydroxyzine in the treatment of pediatric mastocytosis. ( Berkebile, C; Bradley, D; Kettelhut, BV; Metcalfe, DD, 1989)
"Treatment of four mastocytosis patients with the mast cell stabilising drugs, disodium cromoglycate and ketotifen failed to alter significantly the urinary excretion levels of histamine or N tau-methylimidazole acetic acid."3.67The effect of disodium cromoglycate and ketotifen on the excretion of histamine and N tau-methylimidazole acetic acid in urine of patients with mastocytosis. ( Greaves, MW; Mallet, AI; Norris, P; Rendell, NB; Wong, E, 1989)
"Mastocytosis is a disorder of mast cell proliferation that occurs in both cutaneous and systemic forms."1.30Heterogeneity of mast cells in mastocytosis and inhibitory effect of ketotifen and ranitidine on indolent systemic mastocytosis. ( Akimoto, S; Amano, H; Hashimoto, T; Kanbe, N; Kurimoto, F; Kurosawa, M; Miyachi, Y; Takeuchi, Y; Yamashita, T, 1997)
"Mucosal mastocytosis was first observed on day 26 postinfection and occurred only in the ileum of tapeworm-infected rats."1.30Hymenolepsis diminuta: mucosal mastocytosis and intestinal smooth muscle hypertrophy occur in tapeworm-infected rats. ( Bass, P; Dwinell, MB; Oaks, JA; Wise, RM, 1998)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19904 (28.57)18.7374
1990's8 (57.14)18.2507
2000's0 (0.00)29.6817
2010's2 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Asawa, A1
Simpson, KH1
Bonds, RS1
Homann, J1
Kolck, UW1
Ehnes, A1
Frieling, T1
Raithel, M1
Molderings, GJ1
de las Nieves, M1
Poveda, F1
Queipo de Llano, MP1
González-Hermoso, C1
Kurosawa, M1
Amano, H1
Kanbe, N1
Akimoto, S1
Takeuchi, Y1
Yamashita, T1
Hashimoto, T1
Kurimoto, F1
Miyachi, Y1
Dwinell, MB1
Wise, RM1
Bass, P1
Oaks, JA1
Mezei, P1
Bencsik, Z1
Vicze, B1
Simon, K1
István, L1
Pajor, L1
Kettelhut, BV2
Póvoa, P1
Ducla-Soares, J1
Fernandes, A1
Palma-Carlos, AG1
Graves, L1
Stechschulte, DJ1
Morris, DC1
Lukert, BP1
Ting, S1
Mallet, AI1
Norris, P1
Rendell, NB1
Wong, E1
Greaves, MW1
Berkebile, C1
Bradley, D1
Metcalfe, DD1
Kawano, Y1
Abe, H1
Yoshida, K1
Saitoh, F1
Kuramochi, M1
Ito, K1
Omae, T1
François, B1
Duprez, D1
Oomen, C1
Kint, A1
Clement, DL1

Reviews

1 review available for ketotifen and Mastocytosis

ArticleYear
[Systemic mastocytosis--definition of an internal disease].
    Medizinische Klinik (Munich, Germany : 1983), 2010, Volume: 105, Issue:8

    Topics: Algorithms; Apoptosis; Ascorbic Acid; Biopsy; Bone Marrow; Codon; Combined Modality Therapy; Cromoly

2010

Trials

1 trial available for ketotifen and Mastocytosis

ArticleYear
A double-blind, placebo-controlled, crossover trial of ketotifen versus hydroxyzine in the treatment of pediatric mastocytosis.
    The Journal of allergy and clinical immunology, 1989, Volume: 83, Issue:5

    Topics: Child; Child, Preschool; Clinical Trials as Topic; Double-Blind Method; Female; Histamine; Humans; H

1989

Other Studies

12 other studies available for ketotifen and Mastocytosis

ArticleYear
Ketotifen use in a patient with fire ant hypersensitivity and mast cell activation syndrome.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2015, Volume: 114, Issue:6

    Topics: Adult; Anaphylaxis; Animals; Ant Venoms; Anti-Allergic Agents; Ants; Asthma; Erythema; Female; Hista

2015
[System mastocytosis: presentation of a case evolving into myelofibrosis and no response to interferon alfa 2b].
    Sangre, 1997, Volume: 42, Issue:5

    Topics: Bone Marrow; Cerebral Hemorrhage; Combined Modality Therapy; Fatal Outcome; Female; Histamine Antago

1997
Heterogeneity of mast cells in mastocytosis and inhibitory effect of ketotifen and ranitidine on indolent systemic mastocytosis.
    The Journal of allergy and clinical immunology, 1997, Volume: 100, Issue:6 Pt 2

    Topics: Adult; Biopsy; Chymases; Dinoprostone; Histamine; Humans; Infant; Ketotifen; Leukotrienes; Male; Mas

1997
Hymenolepsis diminuta: mucosal mastocytosis and intestinal smooth muscle hypertrophy occur in tapeworm-infected rats.
    Experimental parasitology, 1998, Volume: 89, Issue:1

    Topics: Animals; Cell Count; Electromyography; Gastrointestinal Motility; Histamine H1 Antagonists; Hymenole

1998
[Two cases of malignant and benign systemic mastocytosis].
    Orvosi hetilap, 1999, Oct-10, Volume: 140, Issue:41

    Topics: Adult; Bone Marrow; Ethylenediamines; Fatal Outcome; Female; Femur; Histamine H1 Antagonists; Humans

1999
Ketotifen in systemic mastocytosis--a response.
    The Journal of allergy and clinical immunology, 1991, Volume: 87, Issue:2

    Topics: Adult; Child; Humans; Ketotifen; Mastocytosis

1991
A case of systemic mastocytosis; therapeutic efficacy of ketotifen.
    Journal of internal medicine, 1991, Volume: 229, Issue:5

    Topics: Aged; Humans; Ketotifen; Male; Mastocytosis

1991
Inhibition of mediator release in systemic mastocytosis is associated with reversal of bone changes.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1990, Volume: 5, Issue:11

    Topics: Bone and Bones; Bone Resorption; Calcitriol; Histamine; Humans; Ketotifen; Male; Mast Cells; Mastocy

1990
Ketotifen and systemic mastocytosis.
    The Journal of allergy and clinical immunology, 1990, Volume: 85, Issue:4

    Topics: Adult; Humans; Ketotifen; Male; Mastocytosis

1990
The effect of disodium cromoglycate and ketotifen on the excretion of histamine and N tau-methylimidazole acetic acid in urine of patients with mastocytosis.
    British journal of clinical pharmacology, 1989, Volume: 27, Issue:1

    Topics: Adult; Cromolyn Sodium; Female; Histamine; Humans; Imidazoles; Ketotifen; Male; Mastocytosis; Middle

1989
[A case of systemic mastocytosis with flushing, palpitation and dyspnea].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1987, Volume: 76, Issue:12

    Topics: Chlorpheniramine; Cimetidine; Diagnosis, Differential; Drug Therapy, Combination; Dyspnea; Histamine

1987
Hypotensive attacks due to systemic mastocytosis.
    Acta clinica Belgica, 1987, Volume: 42, Issue:1

    Topics: Humans; Hypotension; Ketotifen; Male; Mastocytosis; Middle Aged

1987
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