ketotifen has been researched along with Malaria in 5 studies
Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
ketotifen : An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.
Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketotifen is known to exhibit antimalarial activity in mouse and monkey malaria models." | 7.78 | Ketotifen is an antimalarial prodrug of norketotifen with blood schizonticidal and liver-stage efficacy. ( Auschwitz, J; Caridha, D; Dow, GS; Gardner, S; Grauer, K; Harris, E; Hickman, M; Kozar, MP; Lee, P; Leed, S; Li, Q; Melendez, V; Milner, E; Moon, J; Ngundam, F; O'Neil, M; Parriott, S; Potter, B; Pybus, B; Sciotti, R; Sousa, J; Tangteung, A, 2012) |
| "Ketotifen is known to exhibit antimalarial activity in mouse and monkey malaria models." | 3.78 | Ketotifen is an antimalarial prodrug of norketotifen with blood schizonticidal and liver-stage efficacy. ( Auschwitz, J; Caridha, D; Dow, GS; Gardner, S; Grauer, K; Harris, E; Hickman, M; Kozar, MP; Lee, P; Leed, S; Li, Q; Melendez, V; Milner, E; Moon, J; Ngundam, F; O'Neil, M; Parriott, S; Potter, B; Pybus, B; Sciotti, R; Sousa, J; Tangteung, A, 2012) |
| "The effect on the morphology of Plasmodium yoelii of ketotifen treatment was different from that of chloroquine and other antimalarial drugs." | 3.68 | Effect of ketotifen on the ultrastructure of the erythrocytic stages of Plasmodium yoelii. ( Cao, HM; Pan, XQ, 1990) |
| "Malaria is a deadly infectious disease in many tropical and subtropical countries." | 1.39 | A class of tricyclic compounds blocking malaria parasite oocyst development and transmission. ( Austin, CP; Deng, B; Dixit, S; Eastman, RT; Huang, R; Jiang, H; Johnson, RL; Lambert, LE; Long, C; Miura, K; Pattaradilokrat, S; Raj, DK; Su, XZ; Tanaka, TQ; Williamson, KC; Wu, Y; Yuan, J, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Milner, E | 1 |
| Sousa, J | 1 |
| Pybus, B | 1 |
| Auschwitz, J | 1 |
| Caridha, D | 1 |
| Gardner, S | 1 |
| Grauer, K | 1 |
| Harris, E | 1 |
| Hickman, M | 1 |
| Kozar, MP | 1 |
| Lee, P | 1 |
| Leed, S | 1 |
| Li, Q | 1 |
| Melendez, V | 1 |
| Moon, J | 1 |
| Ngundam, F | 1 |
| O'Neil, M | 1 |
| Parriott, S | 1 |
| Potter, B | 1 |
| Sciotti, R | 1 |
| Tangteung, A | 1 |
| Dow, GS | 1 |
| Eastman, RT | 1 |
| Pattaradilokrat, S | 1 |
| Raj, DK | 1 |
| Dixit, S | 1 |
| Deng, B | 1 |
| Miura, K | 1 |
| Yuan, J | 1 |
| Tanaka, TQ | 1 |
| Johnson, RL | 1 |
| Jiang, H | 1 |
| Huang, R | 1 |
| Williamson, KC | 1 |
| Lambert, LE | 1 |
| Long, C | 1 |
| Austin, CP | 1 |
| Wu, Y | 1 |
| Su, XZ | 1 |
| Singh, N | 1 |
| Puri, SK | 1 |
| Cao, HM | 1 |
| Pan, XQ | 2 |
| Huang, WZ | 1 |
| Luo, MZ | 1 |
| Zhou, MX | 1 |
5 other studies available for ketotifen and Malaria
| Article | Year |
|---|---|
Ketotifen is an antimalarial prodrug of norketotifen with blood schizonticidal and liver-stage efficacy.
Topics: Animals; Antimalarials; Female; Humans; Inhibitory Concentration 50; Ketotifen; Liver; Malaria; Mala | 2012 |
A class of tricyclic compounds blocking malaria parasite oocyst development and transmission.
Topics: Animals; Anti-Allergic Agents; Antimalarials; ATP-Binding Cassette Transporters; Biological Transpor | 2013 |
Inhibition of the development of the hepatic stages of Plasmodium yoelii nigeriensis by antihistaminic agents.
Topics: Animals; Antimalarials; Cyproheptadine; Dose-Response Relationship, Drug; Female; Histamine H1 Antag | 1999 |
Effect of ketotifen on the ultrastructure of the erythrocytic stages of Plasmodium yoelii.
Topics: Animals; Disease Models, Animal; Erythrocytes; Ketotifen; Malaria; Mice; Plasmodium yoelii | 1990 |
[Study on the treatment of Plasmodium cynomolgi infections of the macaque with ketotifen].
Topics: Animals; Antimalarials; Drug Synergism; Ketotifen; Macaca mulatta; Malaria; Sulfadoxine | 1987 |