ketotifen has been researched along with Malaria, Falciparum in 5 studies
Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
ketotifen : An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.
Malaria, Falciparum: Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketotifen is known to exhibit antimalarial activity in mouse and monkey malaria models." | 7.78 | Ketotifen is an antimalarial prodrug of norketotifen with blood schizonticidal and liver-stage efficacy. ( Auschwitz, J; Caridha, D; Dow, GS; Gardner, S; Grauer, K; Harris, E; Hickman, M; Kozar, MP; Lee, P; Leed, S; Li, Q; Melendez, V; Milner, E; Moon, J; Ngundam, F; O'Neil, M; Parriott, S; Potter, B; Pybus, B; Sciotti, R; Sousa, J; Tangteung, A, 2012) |
| " The findings indicate that - at least at the dosing regimen used in the present study and among children with acute, uncomplicated, P." | 6.71 | A randomized comparison of chloroquine and chloroquine plus ketotifen in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children. ( Sowunmi, A, 2003) |
| "The present in vivo study evaluates the potential use of ketotifen, a tricyclic antihistaminic drug, in treatment of Sudanese patients with uncomplicated Plasmodium falciparum malaria (19-38 years)." | 5.09 | Ketotifen in treatment of uncomplicated falciparum malaria. ( Elhag, ER; Ibrahim, AM; Mustafa, SE, 2000) |
| "Ketotifen is known to exhibit antimalarial activity in mouse and monkey malaria models." | 3.78 | Ketotifen is an antimalarial prodrug of norketotifen with blood schizonticidal and liver-stage efficacy. ( Auschwitz, J; Caridha, D; Dow, GS; Gardner, S; Grauer, K; Harris, E; Hickman, M; Kozar, MP; Lee, P; Leed, S; Li, Q; Melendez, V; Milner, E; Moon, J; Ngundam, F; O'Neil, M; Parriott, S; Potter, B; Pybus, B; Sciotti, R; Sousa, J; Tangteung, A, 2012) |
| " The findings indicate that - at least at the dosing regimen used in the present study and among children with acute, uncomplicated, P." | 2.71 | A randomized comparison of chloroquine and chloroquine plus ketotifen in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children. ( Sowunmi, A, 2003) |
| "Malaria is a deadly infectious disease in many tropical and subtropical countries." | 1.39 | A class of tricyclic compounds blocking malaria parasite oocyst development and transmission. ( Austin, CP; Deng, B; Dixit, S; Eastman, RT; Huang, R; Jiang, H; Johnson, RL; Lambert, LE; Long, C; Miura, K; Pattaradilokrat, S; Raj, DK; Su, XZ; Tanaka, TQ; Williamson, KC; Wu, Y; Yuan, J, 2013) |
| "Cyproheptadine and verapamil were not effective in reversing chloroquine resistance and probable drug toxicity was observed with these drugs in combination with chloroquine." | 1.29 | Reversal of Plasmodium falciparum resistance to chloroquine in Panamanian Aotus monkeys. ( Kyle, DE; Milhous, WK; Rossan, RN, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Milner, E | 1 |
| Sousa, J | 1 |
| Pybus, B | 1 |
| Auschwitz, J | 1 |
| Caridha, D | 1 |
| Gardner, S | 1 |
| Grauer, K | 1 |
| Harris, E | 1 |
| Hickman, M | 1 |
| Kozar, MP | 1 |
| Lee, P | 1 |
| Leed, S | 1 |
| Li, Q | 1 |
| Melendez, V | 1 |
| Moon, J | 1 |
| Ngundam, F | 1 |
| O'Neil, M | 1 |
| Parriott, S | 1 |
| Potter, B | 1 |
| Sciotti, R | 1 |
| Tangteung, A | 1 |
| Dow, GS | 1 |
| Eastman, RT | 1 |
| Pattaradilokrat, S | 1 |
| Raj, DK | 1 |
| Dixit, S | 1 |
| Deng, B | 1 |
| Miura, K | 1 |
| Yuan, J | 1 |
| Tanaka, TQ | 1 |
| Johnson, RL | 1 |
| Jiang, H | 1 |
| Huang, R | 1 |
| Williamson, KC | 1 |
| Lambert, LE | 1 |
| Long, C | 1 |
| Austin, CP | 1 |
| Wu, Y | 1 |
| Su, XZ | 1 |
| Sowunmi, A | 1 |
| Kyle, DE | 1 |
| Milhous, WK | 1 |
| Rossan, RN | 1 |
| Ibrahim, AM | 1 |
| Elhag, ER | 1 |
| Mustafa, SE | 1 |
2 trials available for ketotifen and Malaria, Falciparum
| Article | Year |
|---|---|
A randomized comparison of chloroquine and chloroquine plus ketotifen in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children.
Topics: Acute Disease; Administration, Oral; Amodiaquine; Analysis of Variance; Antimalarials; Child; Child, | 2003 |
Ketotifen in treatment of uncomplicated falciparum malaria.
Topics: Adult; Antimalarials; Body Weight; Chloroquine; Drug Monitoring; Drug Therapy, Combination; Follow-U | 2000 |
3 other studies available for ketotifen and Malaria, Falciparum
| Article | Year |
|---|---|
Ketotifen is an antimalarial prodrug of norketotifen with blood schizonticidal and liver-stage efficacy.
Topics: Animals; Antimalarials; Female; Humans; Inhibitory Concentration 50; Ketotifen; Liver; Malaria; Mala | 2012 |
A class of tricyclic compounds blocking malaria parasite oocyst development and transmission.
Topics: Animals; Anti-Allergic Agents; Antimalarials; ATP-Binding Cassette Transporters; Biological Transpor | 2013 |
Reversal of Plasmodium falciparum resistance to chloroquine in Panamanian Aotus monkeys.
Topics: Animals; Aotus trivirgatus; Calcium Channel Blockers; Chloroquine; Chlorpromazine; Cyproheptadine; D | 1993 |