ketotifen has been researched along with Itching in 31 studies
Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
ketotifen : An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aims to compare the efficiency of Pregabalin and Ketotifen in treatment of uremic pruritus in hemodialysis (HD) patients." | 9.51 | Comparison of Pregabalin and Ketotifen in treatment of uremic pruritus in hemodialysis patients. ( Aflatoonian, M; Azmandian, J; Khalili, M; Khoundabi, B; Mohammadi, S; Mohebbi, A; Mousavi, M; Parsimood, E; Seifi, M; Shamspour, N, 2022) |
| "We aimed to compare the clinical efficacy and ocular surface variables of olopatadine, ketotifen fumarate, epinastine, emedastine and fluorometholone acetate ophthalmic solutions in preventing the signs and symptoms of seasonal allergic conjunctivitis (SAC)." | 9.14 | Efficacy of olopatadine HCI 0.1%, ketotifen fumarate 0.025%, epinastine HCI 0.05%, emedastine 0.05% and fluorometholone acetate 0.1% ophthalmic solutions for seasonal allergic conjunctivitis: a placebo-controlled environmental trial. ( Akman, A; Akova, YA; Borazan, M; Erbek, SS; Karalezli, A; Kiyici, H, 2009) |
| "Based on potential contributions of mast cells to neurofibroma-associated itching, pain, and tenderness, the mast cell blocker ketotifen fumarate (Zaditen, Sandoz Pharmaceuticals Corp, Hanover, NJ) has been proposed as a treatment for these symptoms." | 9.07 | A controlled multiphase trial of ketotifen to minimize neurofibroma-associated pain and itching. ( Riccardi, VM, 1993) |
| "The effects of single doses of placebo, clemastine, ketotifen and prednisolone on chloroquine-induced pruritus were investigated in healthy black African volunteers using a visual analogue scale." | 9.06 | Effects of clemastine, ketotifen and prednisolone on chloroquine-induced pruritus. ( Abila, B; Ikueze, R, 1989) |
| " For the evaluation of itching, ovalbumin was used as an antigen instead of RW." | 7.75 | Cyclosporine A eye drops inhibit the early-phase reaction in a type-I allergic conjunctivitis model in mice. ( Katsuta, O; Nakamura, M; Oda, T; Shii, D; Shinomiya, K, 2009) |
| "In the search for natural compounds useful against pruritus, alpha,beta-amyrins, the pentacyclic triterpenes isolated from the resin of popular medicinal plant Protium heptaphyllum were examined on scratching behavior induced by dextran T40 and compound 48/80 in mice." | 7.72 | Pentacyclic triterpenoids, alpha,beta-amyrins, suppress the scratching behavior in a mouse model of pruritus. ( Almeida, FR; Chaves, MH; Cordeiro, WM; Lima-Junior, RC; Oliveira, FA; Rao, VS; Santos, FA; Silva, RM; Vieira-Júnior, GM, 2004) |
| "A role for histamine in the pathogenesis of uremic pruritus was investigated in maintenance hemodialysis patients." | 7.68 | Elevated plasma histamine in chronic uremia. Effects of ketotifen on pruritus. ( Besarab, A; Burke, JF; Francos, GC; Gittlen, SD; Goyal, S; Kauh, YC; Schulman, ES, 1991) |
| " There were no significant differences in adverse events between groups." | 6.71 | Efficacy and safety of ketotifen fumarate 0.025% in the conjunctival antigen challenge model of ocular allergic conjunctivitis. ( Abelson, MB; Casey, R; Dubiner, H; Greiner, JV; Kapik, BM; Lonsdale, J; Mundorf, T; Parver, L; Shams, NB, 2003) |
| "This study aims to compare the efficiency of Pregabalin and Ketotifen in treatment of uremic pruritus in hemodialysis (HD) patients." | 5.51 | Comparison of Pregabalin and Ketotifen in treatment of uremic pruritus in hemodialysis patients. ( Aflatoonian, M; Azmandian, J; Khalili, M; Khoundabi, B; Mohammadi, S; Mohebbi, A; Mousavi, M; Parsimood, E; Seifi, M; Shamspour, N, 2022) |
| "We aimed to compare the clinical efficacy and ocular surface variables of olopatadine, ketotifen fumarate, epinastine, emedastine and fluorometholone acetate ophthalmic solutions in preventing the signs and symptoms of seasonal allergic conjunctivitis (SAC)." | 5.14 | Efficacy of olopatadine HCI 0.1%, ketotifen fumarate 0.025%, epinastine HCI 0.05%, emedastine 0.05% and fluorometholone acetate 0.1% ophthalmic solutions for seasonal allergic conjunctivitis: a placebo-controlled environmental trial. ( Akman, A; Akova, YA; Borazan, M; Erbek, SS; Karalezli, A; Kiyici, H, 2009) |
| "Ketotifen was safe and statistically effective in reducing ocular itching and hyperemia associated with allergic conjunctivitis." | 5.10 | Efficacy of ketotifen fumarate 0.025% ophthalmic solution compared with placebo in the conjunctival allergen challenge model. ( Abelson, MB; Chapin, MJ; Kapik, BM; Shams, NB, 2003) |
| "The results of this study suggest that emedastine and ketotifen are not significantly different with respect to anti-itching efficacy in the CAC model of acute allergic conjunctivitis." | 5.10 | Randomized, double-masked, placebo-controlled comparison of the efficacy of emedastine difumarate 0.05% ophthalmic solution and ketotifen fumarate 0.025% ophthalmic solution in the human conjunctival allergen challenge model. ( Bensch, G; D'Arienzo, PA; Leonardi, A, 2002) |
| "Based on potential contributions of mast cells to neurofibroma-associated itching, pain, and tenderness, the mast cell blocker ketotifen fumarate (Zaditen, Sandoz Pharmaceuticals Corp, Hanover, NJ) has been proposed as a treatment for these symptoms." | 5.07 | A controlled multiphase trial of ketotifen to minimize neurofibroma-associated pain and itching. ( Riccardi, VM, 1993) |
| "The effects of single doses of placebo, clemastine, ketotifen and prednisolone on chloroquine-induced pruritus were investigated in healthy black African volunteers using a visual analogue scale." | 5.06 | Effects of clemastine, ketotifen and prednisolone on chloroquine-induced pruritus. ( Abila, B; Ikueze, R, 1989) |
| " By screening molecules related to arachidonic acid metabolism or pruritus, SA6541 was found to be a specific inhibitor of LTA(4) hydrolase." | 3.76 | Role of leukotriene B4 in 5-lipoxygenase metabolite- and allergy-induced itch-associated responses in mice. ( Aono, H; Enomoto, H; Inagaki, N; Mizutani, K; Murakami, T; Tsuboi, T; Tsuji, F, 2010) |
| " For the evaluation of itching, ovalbumin was used as an antigen instead of RW." | 3.75 | Cyclosporine A eye drops inhibit the early-phase reaction in a type-I allergic conjunctivitis model in mice. ( Katsuta, O; Nakamura, M; Oda, T; Shii, D; Shinomiya, K, 2009) |
| "In the search for natural compounds useful against pruritus, alpha,beta-amyrins, the pentacyclic triterpenes isolated from the resin of popular medicinal plant Protium heptaphyllum were examined on scratching behavior induced by dextran T40 and compound 48/80 in mice." | 3.72 | Pentacyclic triterpenoids, alpha,beta-amyrins, suppress the scratching behavior in a mouse model of pruritus. ( Almeida, FR; Chaves, MH; Cordeiro, WM; Lima-Junior, RC; Oliveira, FA; Rao, VS; Santos, FA; Silva, RM; Vieira-Júnior, GM, 2004) |
| "A role for histamine in the pathogenesis of uremic pruritus was investigated in maintenance hemodialysis patients." | 3.68 | Elevated plasma histamine in chronic uremia. Effects of ketotifen on pruritus. ( Besarab, A; Burke, JF; Francos, GC; Gittlen, SD; Goyal, S; Kauh, YC; Schulman, ES, 1991) |
| "Nine patients with Japanese cedar pollinosis who had no nasal or ocular symptoms were included in the present study, after obtaining informed consent in writing." | 2.72 | Effect of antihistamine eye drops on the conjunctival provocation test with Japanese cedar pollen allergen. ( Cheng, L; Dake, Y; Enomoto, K; Enomoto, T; Ikeda, H; Sakota, T; Shibano, A; Yajin, S; Yamanishi, E; Yoda, S, 2006) |
| " There were no significant differences in adverse events between groups." | 2.71 | Efficacy and safety of ketotifen fumarate 0.025% in the conjunctival antigen challenge model of ocular allergic conjunctivitis. ( Abelson, MB; Casey, R; Dubiner, H; Greiner, JV; Kapik, BM; Lonsdale, J; Mundorf, T; Parver, L; Shams, NB, 2003) |
| " No drug-related systemic adverse events were reported, and ocular adverse events were comparable to placebo." | 2.71 | Efficacy and safety of single- and multiple-dose ketotifen fumarate 0.025% ophthalmic solution in a pediatric population. ( Abelson, MB; Crampton, HJ; Ferzola, NJ; McWhirter, CL, 2004) |
| "Chloroquine (CQ) is a widely used antimalarial drug that causes pruritus in humans and mice." | 1.42 | Characterization and Validation of a Canine Pruritic Model. ( Aberg, GA; Arulnesan, N; Bolger, GT; Ciofalo, VB; Pucaj, K, 2015) |
| "Pretreatment with ketotifen, a histamine H1 receptor antagonist, and capsaicin inhibited LPA-induced ISRs." | 1.32 | Itch-scratch responses induced by lysophosphatidic acid in mice. ( Hashimoto, T; Momose, K; Ohata, H, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.45) | 18.7374 |
| 1990's | 4 (12.90) | 18.2507 |
| 2000's | 17 (54.84) | 29.6817 |
| 2010's | 7 (22.58) | 24.3611 |
| 2020's | 1 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Shamspour, N | 1 |
| Aflatoonian, M | 1 |
| Khalili, M | 1 |
| Seifi, M | 1 |
| Mousavi, M | 1 |
| Azmandian, J | 1 |
| Mohammadi, S | 1 |
| Khoundabi, B | 1 |
| Parsimood, E | 1 |
| Mohebbi, A | 1 |
| Ben-Eli, H | 1 |
| Solomon, A | 1 |
| Nabe, T | 1 |
| Kijitani, Y | 1 |
| Kitagawa, Y | 1 |
| Sakano, E | 1 |
| Ueno, T | 1 |
| Fujii, M | 1 |
| Nakao, S | 1 |
| Sakai, M | 1 |
| Takai, S | 1 |
| Asawa, A | 1 |
| Simpson, KH | 1 |
| Bonds, RS | 1 |
| Aberg, GA | 1 |
| Arulnesan, N | 1 |
| Bolger, GT | 1 |
| Ciofalo, VB | 1 |
| Pucaj, K | 1 |
| Borazan, M | 1 |
| Karalezli, A | 1 |
| Akova, YA | 1 |
| Akman, A | 1 |
| Kiyici, H | 1 |
| Erbek, SS | 1 |
| Shii, D | 1 |
| Oda, T | 2 |
| Shinomiya, K | 1 |
| Katsuta, O | 1 |
| Nakamura, M | 1 |
| Tsuji, F | 1 |
| Aono, H | 1 |
| Tsuboi, T | 1 |
| Murakami, T | 1 |
| Enomoto, H | 1 |
| Mizutani, K | 1 |
| Inagaki, N | 2 |
| Gruber, R | 1 |
| Vassilaki, I | 1 |
| Zelger, B | 1 |
| Abelson, MB | 3 |
| Chapin, MJ | 1 |
| Kapik, BM | 2 |
| Shams, NB | 2 |
| Kato, M | 1 |
| Kurose, T | 1 |
| Miyaji, S | 1 |
| Umeuchi, H | 2 |
| Togashi, Y | 2 |
| Honda, T | 2 |
| Nakao, K | 1 |
| Okano, K | 2 |
| Tanaka, T | 2 |
| Nagase, H | 2 |
| Greiner, JV | 1 |
| Mundorf, T | 1 |
| Dubiner, H | 1 |
| Lonsdale, J | 1 |
| Casey, R | 1 |
| Parver, L | 1 |
| Hashimoto, T | 2 |
| Igarashi, A | 1 |
| Hoshina, F | 1 |
| Yamada, M | 1 |
| Toyoda, Y | 1 |
| Notsu, Y | 1 |
| Kohno, S | 1 |
| Ohata, H | 1 |
| Momose, K | 1 |
| Oliveira, FA | 1 |
| Lima-Junior, RC | 1 |
| Cordeiro, WM | 1 |
| Vieira-Júnior, GM | 1 |
| Chaves, MH | 1 |
| Almeida, FR | 1 |
| Silva, RM | 1 |
| Santos, FA | 1 |
| Rao, VS | 1 |
| Ferzola, NJ | 1 |
| McWhirter, CL | 1 |
| Crampton, HJ | 1 |
| Avunduk, AM | 1 |
| Tekelioglu, Y | 1 |
| Turk, A | 1 |
| Akyol, N | 1 |
| Jiang, S | 1 |
| Tsumuro, T | 1 |
| Takubo, M | 1 |
| Fujii, Y | 1 |
| Kamei, C | 1 |
| Dake, Y | 1 |
| Enomoto, T | 1 |
| Cheng, L | 1 |
| Enomoto, K | 1 |
| Shibano, A | 1 |
| Ikeda, H | 1 |
| Yoda, S | 1 |
| Yajin, S | 1 |
| Sakota, T | 1 |
| Yamanishi, E | 1 |
| Kim, HJ | 1 |
| Kim, H | 1 |
| Han, ES | 1 |
| Park, SM | 1 |
| Koh, JY | 1 |
| Kim, KM | 1 |
| Noh, MS | 1 |
| Kim, JJ | 1 |
| Lee, CH | 1 |
| Mikuni, I | 1 |
| Riccardi, VM | 1 |
| Meyer, LJ | 1 |
| Takizawa, T | 1 |
| Matsumoto, J | 1 |
| Tohma, T | 1 |
| Kanke, T | 1 |
| Wada, Y | 1 |
| Nagao, M | 1 |
| Nagai, H | 1 |
| Zhang, MQ | 1 |
| Timmerman, H | 1 |
| Ando, N | 1 |
| Yoshizawa, Y | 1 |
| Kawamura, K | 1 |
| Endoh, T | 1 |
| Utsumi, J | 1 |
| Kamei, J | 1 |
| D'Arienzo, PA | 1 |
| Leonardi, A | 1 |
| Bensch, G | 1 |
| Tercedor, J | 1 |
| López-Hernández, B | 1 |
| Ródenas, JM | 1 |
| Herranz, MT | 1 |
| Serrano-Ortega, S | 1 |
| Francos, GC | 1 |
| Kauh, YC | 1 |
| Gittlen, SD | 1 |
| Schulman, ES | 1 |
| Besarab, A | 1 |
| Goyal, S | 1 |
| Burke, JF | 1 |
| Abila, B | 1 |
| Ikueze, R | 1 |
3 reviews available for ketotifen and Itching
| Article | Year |
|---|---|
Topical antihistamines, mast cell stabilizers, and dual-action agents in ocular allergy: current trends.
Topics: Administration, Ophthalmic; Anti-Allergic Agents; Benzazepines; Conjunctivitis, Allergic; Cromolyn S | 2018 |
Concomitant juvenile xanthogranuloma and cutaneous mastocytosis in a 3-year-old Swedish girl: case report and review of the literature.
Topics: Adrenal Cortex Hormones; Biopsy; Child, Preschool; Dimethindene; Female; Histamine H1 Antagonists; H | 2011 |
Eye itching in ophthalmology and its treatment.
Topics: Conjunctiva; Cromolyn Sodium; Dermatitis; Eczema; Edema; Emotions; Eye; Histamine; Histamine H1 Anta | 1984 |
10 trials available for ketotifen and Itching
| Article | Year |
|---|---|
Comparison of Pregabalin and Ketotifen in treatment of uremic pruritus in hemodialysis patients.
Topics: Humans; Ketotifen; Pregabalin; Pruritus; Quality of Life; Renal Dialysis; Uremia | 2022 |
Efficacy of olopatadine HCI 0.1%, ketotifen fumarate 0.025%, epinastine HCI 0.05%, emedastine 0.05% and fluorometholone acetate 0.1% ophthalmic solutions for seasonal allergic conjunctivitis: a placebo-controlled environmental trial.
Topics: Adolescent; Adult; Anti-Allergic Agents; Benzimidazoles; Child; Conjunctival Diseases; Conjunctiviti | 2009 |
Efficacy of ketotifen fumarate 0.025% ophthalmic solution compared with placebo in the conjunctival allergen challenge model.
Topics: Adult; Aged; Allergens; Anti-Allergic Agents; Conjunctiva; Conjunctivitis, Allergic; Double-Blind Me | 2003 |
Efficacy and safety of ketotifen fumarate 0.025% in the conjunctival antigen challenge model of ocular allergic conjunctivitis.
Topics: Adult; Aged; Allergens; Anti-Allergic Agents; Antigens; Conjunctiva; Conjunctivitis, Allergic; Doubl | 2003 |
Efficacy and safety of single- and multiple-dose ketotifen fumarate 0.025% ophthalmic solution in a pediatric population.
Topics: Adolescent; Anti-Allergic Agents; Child; Conjunctivitis, Allergic; Dose-Response Relationship, Drug; | 2004 |
Comparison of the effects of ketotifen fumarate 0.025% and olopatadine HCl 0.1% ophthalmic solutions in seasonal allergic conjunctivities: a 30-day, randomized, double-masked, artificial tear substitute-controlled trial.
Topics: Adolescent; Adult; Anti-Allergic Agents; Cell Adhesion Molecules; Conjunctiva; Conjunctivitis, Aller | 2005 |
Effect of antihistamine eye drops on the conjunctival provocation test with Japanese cedar pollen allergen.
Topics: Adult; Allergens; Antigens, Plant; Conjunctivitis, Allergic; Cryptomeria; Dose-Response Relationship | 2006 |
A controlled multiphase trial of ketotifen to minimize neurofibroma-associated pain and itching.
Topics: Adult; Double-Blind Method; Female; Follow-Up Studies; Humans; Ketotifen; Male; Neurofibroma; Pain; | 1993 |
Randomized, double-masked, placebo-controlled comparison of the efficacy of emedastine difumarate 0.05% ophthalmic solution and ketotifen fumarate 0.025% ophthalmic solution in the human conjunctival allergen challenge model.
Topics: Allergens; Anti-Allergic Agents; Benzimidazoles; Conjunctivitis; Double-Blind Method; Eye Color; Fem | 2002 |
Effects of clemastine, ketotifen and prednisolone on chloroquine-induced pruritus.
Topics: Adult; Analysis of Variance; Black People; Chloroquine; Clemastine; Humans; Ketotifen; Male; Prednis | 1989 |
18 other studies available for ketotifen and Itching
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Involvement of chymase in allergic conjunctivitis of guinea pigs.
Topics: Allergens; Animals; Chymases; Conjunctivitis, Allergic; Disease Models, Animal; Enzyme Inhibitors; G | 2013 |
Ketotifen use in a patient with fire ant hypersensitivity and mast cell activation syndrome.
Topics: Adult; Anaphylaxis; Animals; Ant Venoms; Anti-Allergic Agents; Ants; Asthma; Erythema; Female; Hista | 2015 |
Characterization and Validation of a Canine Pruritic Model.
Topics: Animals; Antimalarials; Antipruritics; Chloroquine; Cross-Over Studies; Dog Diseases; Dogs; Dose-Res | 2015 |
Cyclosporine A eye drops inhibit the early-phase reaction in a type-I allergic conjunctivitis model in mice.
Topics: Administration, Topical; Ambrosia; Animals; Anti-Allergic Agents; Betamethasone; Capillary Permeabil | 2009 |
Role of leukotriene B4 in 5-lipoxygenase metabolite- and allergy-induced itch-associated responses in mice.
Topics: Animals; Arachidonic Acid; Behavior, Animal; Capillary Permeability; Epoxide Hydrolases; Histamine H | 2010 |
The role of platelet activating factor and the efficacy of apafant ophthalmic solution in experimental allergic conjunctivitis.
Topics: Animals; Antigens; Azepines; Capillary Permeability; Conjunctivitis, Allergic; Disease Models, Anima | 2003 |
Involvement of central mu-opioid system in the scratching behavior in mice, and the suppression of it by the activation of kappa-opioid system.
Topics: Animals; Antipruritics; Behavior, Animal; Injections, Intraventricular; Injections, Subcutaneous; Ke | 2003 |
Effects of nonsteroidal anti-inflammatory drugs on experimental allergic conjunctivitis in Guinea pigs.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens; Benzophenones; | 2003 |
Itch-scratch responses induced by lysophosphatidic acid in mice.
Topics: Amides; Animals; Antipruritics; Capsaicin; Injections, Intradermal; Intracellular Signaling Peptides | 2004 |
Pentacyclic triterpenoids, alpha,beta-amyrins, suppress the scratching behavior in a mouse model of pruritus.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Cell Degranulation; Cyproheptadine; Dextrans; Endorph | 2004 |
Antipruritic and antierythema effects of ascomycete Bulgaria inquinans extract in ICR Mice.
Topics: Administration, Oral; Animals; Ascomycota; Behavior, Animal; Capillary Permeability; Complex Mixture | 2005 |
Characterizations of sphingosylphosphorylcholine-induced scratching responses in ICR mice using naltrexon, capsaicin, ketotifen and Y-27632.
Topics: Amides; Animals; Antipruritics; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Injec | 2008 |
Drug therapy for neurofibromatosis?
Topics: Humans; Ketotifen; Neurofibromatosis 1; Pruritus | 1993 |
VUF-K-8788, a periphery-selective histamine H1 antagonist with anti-pruritic activities.
Topics: Animals; Anti-Allergic Agents; Behavior, Animal; Benzimidazoles; Capillary Permeability; Guinea Pigs | 2001 |
Antipruritic activity of the kappa-opioid receptor agonist, TRK-820.
Topics: Animals; Antipruritics; Chlorpheniramine; Disease Models, Animal; Histamine; Histamine H1 Antagonist | 2002 |
Erythropoietin therapy for uremic pruritus.
Topics: Erythropoietin; Humans; Ketotifen; Pruritus; Uremia | 1992 |
Elevated plasma histamine in chronic uremia. Effects of ketotifen on pruritus.
Topics: Chronic Disease; Histamine; Humans; Ketotifen; Mast Cells; Pilot Projects; Pruritus; Renal Dialysis; | 1991 |