ketotifen has been researched along with Innate Inflammatory Response in 18 studies
Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
ketotifen : An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We aim to explore effects of Ketotifen on metabolic profiles, inflammation and oxidative stress." | 7.85 | Role of Ketotifen on metabolic profiles, inflammation and oxidative stress in diabetic rats. ( Chen, Q; Chen, Z; Cheng, X; Ge, S; Gu, X; Mu, L; Ni, L; Sun, H; Wang, J, 2017) |
| "To determine whether intestinal mast cells and capsaicin-sensitive afferent nerves are involved in the development and sequels of Nippostrongylus brasiliensis-induced intestinal inflammation in rats." | 7.70 | Development and sequels of intestinal inflammation in nematode-infected rats: role of mast cells and capsaicin-sensitive afferents. ( Bueno, L; Fioramonti, J; Garcia-Villar, R; Gay, J, 2000) |
| "Gingivitis is evidenced by inflammation of the free gingiva, and still reversible." | 6.87 | Ketotifen fumarate attenuates feline gingivitis related with gingival microenvironment modulation. ( Chen, X; Hou, S; Jia, H; Li, H; Liang, L; Liu, T; Qiu, Z; Sui, X; Sun, Y; Yuan, W; Zhao, X; Zhao, Z, 2018) |
| "The treatment with ketotifen prevented hypermotility and mast cell hyperplasia and diminished mucosal mast cell activity." | 5.33 | Mast cell stabilizer ketotifen [4-(1-methyl-4-piperidylidene)-4h-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one fumarate] prevents mucosal mast cell hyperplasia and intestinal dysmotility in experimental Trichinella spiralis inflammation in the rat. ( Porras, M; Serna, H; Vergara, P, 2006) |
| "It is clear that bronchial asthma is caused by chronic airway inflammation." | 5.29 | [The effect of ketotifen on the inflammation of bronchial mucosa in atopic asthmatics]. ( Hoshino, M, 1994) |
| "We aim to explore effects of Ketotifen on metabolic profiles, inflammation and oxidative stress." | 3.85 | Role of Ketotifen on metabolic profiles, inflammation and oxidative stress in diabetic rats. ( Chen, Q; Chen, Z; Cheng, X; Ge, S; Gu, X; Mu, L; Ni, L; Sun, H; Wang, J, 2017) |
| "To determine whether intestinal mast cells and capsaicin-sensitive afferent nerves are involved in the development and sequels of Nippostrongylus brasiliensis-induced intestinal inflammation in rats." | 3.70 | Development and sequels of intestinal inflammation in nematode-infected rats: role of mast cells and capsaicin-sensitive afferents. ( Bueno, L; Fioramonti, J; Garcia-Villar, R; Gay, J, 2000) |
| "The effects of free radical scavengers and the anti-inflammatory drug ketotifen on rabbit oesophagitis induced by acidified pepsin were studied." | 3.69 | Superoxide anions produced by inflammatory cells play an important part in the pathogenesis of acid and pepsin induced oesophagitis in rabbits. ( Alda, JO; Lanas, A; Naya, MJ; Ortego, J; Pereboom, D, 1997) |
| "Gingivitis is evidenced by inflammation of the free gingiva, and still reversible." | 2.87 | Ketotifen fumarate attenuates feline gingivitis related with gingival microenvironment modulation. ( Chen, X; Hou, S; Jia, H; Li, H; Liang, L; Liu, T; Qiu, Z; Sui, X; Sun, Y; Yuan, W; Zhao, X; Zhao, Z, 2018) |
| "Colitis was induced by administering mice with dextran sulfate sodium (DSS), in drinking water, or 2,4,6-trinitrobenzene sulfonic acid (TNBS), by intrarectal enema." | 1.46 | Genetic and Pharmacological Dissection of the Role of Spleen Tyrosine Kinase (Syk) in Intestinal Inflammation and Immune Dysfunction in Inflammatory Bowel Diseases. ( Baldelli, F; Biagioli, M; Carino, A; Cipriani, S; Costantino, G; Distrutti, E; Donini, A; Fiorucci, C; Fiorucci, S; Graziosi, L; Marchianò, S; Mencarelli, A, 2017) |
| "Atherosclerosis was produced in apolipoprotein E-deficient (Apoe(-/-)) mice with a Western diet." | 1.43 | Allergic lung inflammation promotes atherosclerosis in apolipoprotein E-deficient mice. ( Cheng, X; Fernandes, C; Huang, X; Levy, B; Liao, M; Libby, P; Liu, CL; Santos, MM; Shi, GP; Sukhova, GK; Wang, Y; Wu, G; Yang, C; Zhang, JY, 2016) |
| "Olopatadine hydrochloride (olopatadine) is an antiallergic drug with histamine H(1) receptor antagonistic activity." | 1.33 | Olopatadine suppresses the migration of THP-1 monocytes induced by S100A12 protein. ( Hasegawa, K; Kaneko, S; Kishimoto, K; Ohmori, K; Tamura, T, 2006) |
| "The treatment with ketotifen prevented hypermotility and mast cell hyperplasia and diminished mucosal mast cell activity." | 1.33 | Mast cell stabilizer ketotifen [4-(1-methyl-4-piperidylidene)-4h-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one fumarate] prevents mucosal mast cell hyperplasia and intestinal dysmotility in experimental Trichinella spiralis inflammation in the rat. ( Porras, M; Serna, H; Vergara, P, 2006) |
| "It is clear that bronchial asthma is caused by chronic airway inflammation." | 1.29 | [The effect of ketotifen on the inflammation of bronchial mucosa in atopic asthmatics]. ( Hoshino, M, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (22.22) | 18.2507 |
| 2000's | 8 (44.44) | 29.6817 |
| 2010's | 6 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Z | 1 |
| Sun, H | 1 |
| Wang, J | 1 |
| Ni, L | 1 |
| Gu, X | 1 |
| Ge, S | 1 |
| Chen, Q | 1 |
| Mu, L | 1 |
| Cheng, X | 2 |
| Biagioli, M | 1 |
| Mencarelli, A | 1 |
| Carino, A | 1 |
| Cipriani, S | 1 |
| Marchianò, S | 1 |
| Fiorucci, C | 1 |
| Donini, A | 1 |
| Graziosi, L | 1 |
| Baldelli, F | 1 |
| Distrutti, E | 1 |
| Costantino, G | 1 |
| Fiorucci, S | 1 |
| Yuan, W | 1 |
| Hou, S | 1 |
| Jia, H | 1 |
| Qiu, Z | 1 |
| Liu, T | 1 |
| Chen, X | 1 |
| Li, H | 1 |
| Sun, Y | 1 |
| Liang, L | 1 |
| Sui, X | 1 |
| Zhao, X | 1 |
| Zhao, Z | 1 |
| Zhang, A | 1 |
| Chi, X | 1 |
| Luo, G | 1 |
| Hei, Z | 1 |
| Xia, H | 1 |
| Luo, C | 1 |
| Wang, Y | 2 |
| Mao, X | 1 |
| Xia, Z | 1 |
| El-Haggar, SM | 1 |
| Farrag, WF | 1 |
| Kotkata, FA | 1 |
| Liu, CL | 1 |
| Liao, M | 1 |
| Santos, MM | 1 |
| Fernandes, C | 1 |
| Sukhova, GK | 1 |
| Zhang, JY | 1 |
| Yang, C | 1 |
| Huang, X | 1 |
| Levy, B | 1 |
| Libby, P | 1 |
| Wu, G | 1 |
| Shi, GP | 1 |
| Sánchez-Patán, F | 1 |
| Aller, MA | 1 |
| Cuellar, C | 1 |
| Rodero, M | 1 |
| Corcuera, MT | 1 |
| Nava, MP | 1 |
| Gómez, F | 1 |
| Blanco, MD | 1 |
| Guerrero, S | 1 |
| Anchuelo, R | 1 |
| Muñiz, E | 1 |
| Alonso, MJ | 1 |
| Teijón, JM | 1 |
| Arias, J | 1 |
| Wang, D | 1 |
| Liu, Y | 1 |
| She, R | 1 |
| Xu, J | 1 |
| Liu, L | 1 |
| Xiong, J | 1 |
| Yang, Y | 1 |
| Sun, Q | 1 |
| Peng, K | 1 |
| Frezzolini, A | 1 |
| De Pità, O | 1 |
| Cassano, N | 1 |
| D'Argento, V | 1 |
| Ferranti, G | 1 |
| Filotico, R | 1 |
| Vena, GA | 1 |
| Dugina, TN | 1 |
| Kiseleva, EV | 1 |
| Glusa, E | 1 |
| Strukova, SM | 1 |
| Kishimoto, K | 1 |
| Kaneko, S | 1 |
| Ohmori, K | 1 |
| Tamura, T | 1 |
| Hasegawa, K | 1 |
| Serna, H | 1 |
| Porras, M | 1 |
| Vergara, P | 1 |
| Hoshino, M | 2 |
| Naya, MJ | 1 |
| Pereboom, D | 1 |
| Ortego, J | 1 |
| Alda, JO | 1 |
| Lanas, A | 1 |
| Nakamura, Y | 1 |
| Shin, Z | 1 |
| Fukushima, Y | 1 |
| Gay, J | 1 |
| Fioramonti, J | 1 |
| Garcia-Villar, R | 1 |
| Bueno, L | 1 |
| Nevzorova, VA | 1 |
| Prosekova, EV | 1 |
| Gel'tser, BI | 1 |
| Luk'ianov, PA | 1 |
| Shestovskaia, TN | 1 |
| Maĭstrovskaia, IuV | 1 |
| Arzamastseva, AI | 1 |
| Snyman, JR | 1 |
| Sommers, DK | 1 |
| Gregorowski, MD | 1 |
| Boraine, H | 1 |
5 trials available for ketotifen and Innate Inflammatory Response
| Article | Year |
|---|---|
Ketotifen fumarate attenuates feline gingivitis related with gingival microenvironment modulation.
Topics: Animals; B-Lymphocytes; Cat Diseases; Cats; Cytokines; Female; Gene Expression Regulation; Gingiviti | 2018 |
Effect of ketotifen in obese patients with type 2 diabetes mellitus.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Drug Interactions; Drug Therapy, Combination; Female; Huma | 2015 |
Evaluation of inflammatory parameters in physical urticarias and effects of an anti-inflammatory/antiallergic treatment.
Topics: Adolescent; Adult; Anti-Allergic Agents; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion Mole | 2002 |
Effects of ketotifen on symptoms and on bronchial mucosa in patients with atopic asthma.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Anti-Allergic Agents; Antigens, CD; Antineoplastic Comb | 1997 |
Effect of cetirizine, ketotifen and chlorpheniramine on the dynamics of the cutaneous hypersensitivity reaction: a comparative study.
Topics: Basophils; Cetirizine; Chlorpheniramine; Dermatitis, Contact; Double-Blind Method; Eosinophils; Hist | 1992 |
13 other studies available for ketotifen and Innate Inflammatory Response
| Article | Year |
|---|---|
Role of Ketotifen on metabolic profiles, inflammation and oxidative stress in diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Inflammation; Insulin; Insulin | 2017 |
Genetic and Pharmacological Dissection of the Role of Spleen Tyrosine Kinase (Syk) in Intestinal Inflammation and Immune Dysfunction in Inflammatory Bowel Diseases.
Topics: Adaptor Proteins, Signal Transducing; Adult; Animals; Antipruritics; Colitis; Cytokines; Disease Mod | 2017 |
Mast cell stabilization alleviates acute lung injury after orthotopic autologous liver transplantation in rats by downregulating inflammation.
Topics: Acute Lung Injury; Animals; Cromolyn Sodium; Disease Models, Animal; Down-Regulation; Inflammation; | 2013 |
Allergic lung inflammation promotes atherosclerosis in apolipoprotein E-deficient mice.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Budesonide; Chronic Disease; Disease Progression; Gluco | 2016 |
Mast cell inhibition by ketotifen reduces splanchnic inflammatory response in a portal hypertension model in rats.
Topics: Animals; Anti-Allergic Agents; Enzyme-Linked Immunosorbent Assay; Hypertension, Portal; Inflammation | 2008 |
Reduced mucosal injury of SPF chickens by mast cell stabilization after infection with very virulent infectious bursal disease virus.
Topics: Animals; Antigens, Viral; Birnaviridae Infections; Bursa of Fabricius; Cell Count; Chickens; Histami | 2009 |
Activation of mast cells induced by agonists of proteinase-activated receptors under normal conditions and during acute inflammation in rats.
Topics: Acute Disease; Animals; beta-N-Acetylhexosaminidases; Cell Degranulation; Dose-Response Relationship | 2003 |
Olopatadine suppresses the migration of THP-1 monocytes induced by S100A12 protein.
Topics: Aminopyridines; Cell Culture Techniques; Cell Movement; Dibenzoxepins; Gene Expression Regulation; H | 2006 |
Mast cell stabilizer ketotifen [4-(1-methyl-4-piperidylidene)-4h-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one fumarate] prevents mucosal mast cell hyperplasia and intestinal dysmotility in experimental Trichinella spiralis inflammation in the rat.
Topics: Animals; Cell Count; Cell Size; Cholecystokinin; Chymases; Cyclooxygenase 2; Gastrointestinal Motili | 2006 |
[The effect of ketotifen on the inflammation of bronchial mucosa in atopic asthmatics].
Topics: Adult; Asthma; Bronchi; Eosinophils; Female; Humans; Inflammation; Ketotifen; Male; Mucous Membrane; | 1994 |
Superoxide anions produced by inflammatory cells play an important part in the pathogenesis of acid and pepsin induced oesophagitis in rabbits.
Topics: Animals; Anions; Catalase; Cells, Cultured; Esophagitis; Esophagus; Flow Cytometry; Fluorescent Anti | 1997 |
Development and sequels of intestinal inflammation in nematode-infected rats: role of mast cells and capsaicin-sensitive afferents.
Topics: Animals; Capsaicin; Cell Count; Inflammation; Intestine, Small; Ketotifen; Mast Cells; Neurons, Affe | 2000 |
[Changes in biochemical inflammation markers in evaluation of the effectiveness of basic chemotherapy in bronchial asthma].
Topics: Adolescent; Adult; Age Factors; Androstadienes; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Ast | 2001 |