ketotifen has been researched along with Inflammation in 18 studies
Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
ketotifen : An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We aim to explore effects of Ketotifen on metabolic profiles, inflammation and oxidative stress." | 7.85 | Role of Ketotifen on metabolic profiles, inflammation and oxidative stress in diabetic rats. ( Chen, Q; Chen, Z; Cheng, X; Ge, S; Gu, X; Mu, L; Ni, L; Sun, H; Wang, J, 2017) |
| "To determine whether intestinal mast cells and capsaicin-sensitive afferent nerves are involved in the development and sequels of Nippostrongylus brasiliensis-induced intestinal inflammation in rats." | 7.70 | Development and sequels of intestinal inflammation in nematode-infected rats: role of mast cells and capsaicin-sensitive afferents. ( Bueno, L; Fioramonti, J; Garcia-Villar, R; Gay, J, 2000) |
| "Gingivitis is evidenced by inflammation of the free gingiva, and still reversible." | 6.87 | Ketotifen fumarate attenuates feline gingivitis related with gingival microenvironment modulation. ( Chen, X; Hou, S; Jia, H; Li, H; Liang, L; Liu, T; Qiu, Z; Sui, X; Sun, Y; Yuan, W; Zhao, X; Zhao, Z, 2018) |
| "The treatment with ketotifen prevented hypermotility and mast cell hyperplasia and diminished mucosal mast cell activity." | 5.33 | Mast cell stabilizer ketotifen [4-(1-methyl-4-piperidylidene)-4h-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one fumarate] prevents mucosal mast cell hyperplasia and intestinal dysmotility in experimental Trichinella spiralis inflammation in the rat. ( Porras, M; Serna, H; Vergara, P, 2006) |
| "It is clear that bronchial asthma is caused by chronic airway inflammation." | 5.29 | [The effect of ketotifen on the inflammation of bronchial mucosa in atopic asthmatics]. ( Hoshino, M, 1994) |
| "We aim to explore effects of Ketotifen on metabolic profiles, inflammation and oxidative stress." | 3.85 | Role of Ketotifen on metabolic profiles, inflammation and oxidative stress in diabetic rats. ( Chen, Q; Chen, Z; Cheng, X; Ge, S; Gu, X; Mu, L; Ni, L; Sun, H; Wang, J, 2017) |
| "To determine whether intestinal mast cells and capsaicin-sensitive afferent nerves are involved in the development and sequels of Nippostrongylus brasiliensis-induced intestinal inflammation in rats." | 3.70 | Development and sequels of intestinal inflammation in nematode-infected rats: role of mast cells and capsaicin-sensitive afferents. ( Bueno, L; Fioramonti, J; Garcia-Villar, R; Gay, J, 2000) |
| "The effects of free radical scavengers and the anti-inflammatory drug ketotifen on rabbit oesophagitis induced by acidified pepsin were studied." | 3.69 | Superoxide anions produced by inflammatory cells play an important part in the pathogenesis of acid and pepsin induced oesophagitis in rabbits. ( Alda, JO; Lanas, A; Naya, MJ; Ortego, J; Pereboom, D, 1997) |
| "Gingivitis is evidenced by inflammation of the free gingiva, and still reversible." | 2.87 | Ketotifen fumarate attenuates feline gingivitis related with gingival microenvironment modulation. ( Chen, X; Hou, S; Jia, H; Li, H; Liang, L; Liu, T; Qiu, Z; Sui, X; Sun, Y; Yuan, W; Zhao, X; Zhao, Z, 2018) |
| "Colitis was induced by administering mice with dextran sulfate sodium (DSS), in drinking water, or 2,4,6-trinitrobenzene sulfonic acid (TNBS), by intrarectal enema." | 1.46 | Genetic and Pharmacological Dissection of the Role of Spleen Tyrosine Kinase (Syk) in Intestinal Inflammation and Immune Dysfunction in Inflammatory Bowel Diseases. ( Baldelli, F; Biagioli, M; Carino, A; Cipriani, S; Costantino, G; Distrutti, E; Donini, A; Fiorucci, C; Fiorucci, S; Graziosi, L; Marchianò, S; Mencarelli, A, 2017) |
| "Atherosclerosis was produced in apolipoprotein E-deficient (Apoe(-/-)) mice with a Western diet." | 1.43 | Allergic lung inflammation promotes atherosclerosis in apolipoprotein E-deficient mice. ( Cheng, X; Fernandes, C; Huang, X; Levy, B; Liao, M; Libby, P; Liu, CL; Santos, MM; Shi, GP; Sukhova, GK; Wang, Y; Wu, G; Yang, C; Zhang, JY, 2016) |
| "Olopatadine hydrochloride (olopatadine) is an antiallergic drug with histamine H(1) receptor antagonistic activity." | 1.33 | Olopatadine suppresses the migration of THP-1 monocytes induced by S100A12 protein. ( Hasegawa, K; Kaneko, S; Kishimoto, K; Ohmori, K; Tamura, T, 2006) |
| "The treatment with ketotifen prevented hypermotility and mast cell hyperplasia and diminished mucosal mast cell activity." | 1.33 | Mast cell stabilizer ketotifen [4-(1-methyl-4-piperidylidene)-4h-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one fumarate] prevents mucosal mast cell hyperplasia and intestinal dysmotility in experimental Trichinella spiralis inflammation in the rat. ( Porras, M; Serna, H; Vergara, P, 2006) |
| "It is clear that bronchial asthma is caused by chronic airway inflammation." | 1.29 | [The effect of ketotifen on the inflammation of bronchial mucosa in atopic asthmatics]. ( Hoshino, M, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (22.22) | 18.2507 |
| 2000's | 8 (44.44) | 29.6817 |
| 2010's | 6 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Z | 1 |
| Sun, H | 1 |
| Wang, J | 1 |
| Ni, L | 1 |
| Gu, X | 1 |
| Ge, S | 1 |
| Chen, Q | 1 |
| Mu, L | 1 |
| Cheng, X | 2 |
| Biagioli, M | 1 |
| Mencarelli, A | 1 |
| Carino, A | 1 |
| Cipriani, S | 1 |
| Marchianò, S | 1 |
| Fiorucci, C | 1 |
| Donini, A | 1 |
| Graziosi, L | 1 |
| Baldelli, F | 1 |
| Distrutti, E | 1 |
| Costantino, G | 1 |
| Fiorucci, S | 1 |
| Yuan, W | 1 |
| Hou, S | 1 |
| Jia, H | 1 |
| Qiu, Z | 1 |
| Liu, T | 1 |
| Chen, X | 1 |
| Li, H | 1 |
| Sun, Y | 1 |
| Liang, L | 1 |
| Sui, X | 1 |
| Zhao, X | 1 |
| Zhao, Z | 1 |
| Zhang, A | 1 |
| Chi, X | 1 |
| Luo, G | 1 |
| Hei, Z | 1 |
| Xia, H | 1 |
| Luo, C | 1 |
| Wang, Y | 2 |
| Mao, X | 1 |
| Xia, Z | 1 |
| El-Haggar, SM | 1 |
| Farrag, WF | 1 |
| Kotkata, FA | 1 |
| Liu, CL | 1 |
| Liao, M | 1 |
| Santos, MM | 1 |
| Fernandes, C | 1 |
| Sukhova, GK | 1 |
| Zhang, JY | 1 |
| Yang, C | 1 |
| Huang, X | 1 |
| Levy, B | 1 |
| Libby, P | 1 |
| Wu, G | 1 |
| Shi, GP | 1 |
| Sánchez-Patán, F | 1 |
| Aller, MA | 1 |
| Cuellar, C | 1 |
| Rodero, M | 1 |
| Corcuera, MT | 1 |
| Nava, MP | 1 |
| Gómez, F | 1 |
| Blanco, MD | 1 |
| Guerrero, S | 1 |
| Anchuelo, R | 1 |
| Muñiz, E | 1 |
| Alonso, MJ | 1 |
| Teijón, JM | 1 |
| Arias, J | 1 |
| Wang, D | 1 |
| Liu, Y | 1 |
| She, R | 1 |
| Xu, J | 1 |
| Liu, L | 1 |
| Xiong, J | 1 |
| Yang, Y | 1 |
| Sun, Q | 1 |
| Peng, K | 1 |
| Frezzolini, A | 1 |
| De Pità, O | 1 |
| Cassano, N | 1 |
| D'Argento, V | 1 |
| Ferranti, G | 1 |
| Filotico, R | 1 |
| Vena, GA | 1 |
| Dugina, TN | 1 |
| Kiseleva, EV | 1 |
| Glusa, E | 1 |
| Strukova, SM | 1 |
| Kishimoto, K | 1 |
| Kaneko, S | 1 |
| Ohmori, K | 1 |
| Tamura, T | 1 |
| Hasegawa, K | 1 |
| Serna, H | 1 |
| Porras, M | 1 |
| Vergara, P | 1 |
| Hoshino, M | 2 |
| Naya, MJ | 1 |
| Pereboom, D | 1 |
| Ortego, J | 1 |
| Alda, JO | 1 |
| Lanas, A | 1 |
| Nakamura, Y | 1 |
| Shin, Z | 1 |
| Fukushima, Y | 1 |
| Gay, J | 1 |
| Fioramonti, J | 1 |
| Garcia-Villar, R | 1 |
| Bueno, L | 1 |
| Nevzorova, VA | 1 |
| Prosekova, EV | 1 |
| Gel'tser, BI | 1 |
| Luk'ianov, PA | 1 |
| Shestovskaia, TN | 1 |
| Maĭstrovskaia, IuV | 1 |
| Arzamastseva, AI | 1 |
| Snyman, JR | 1 |
| Sommers, DK | 1 |
| Gregorowski, MD | 1 |
| Boraine, H | 1 |
5 trials available for ketotifen and Inflammation
| Article | Year |
|---|---|
Ketotifen fumarate attenuates feline gingivitis related with gingival microenvironment modulation.
Topics: Animals; B-Lymphocytes; Cat Diseases; Cats; Cytokines; Female; Gene Expression Regulation; Gingiviti | 2018 |
Effect of ketotifen in obese patients with type 2 diabetes mellitus.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Drug Interactions; Drug Therapy, Combination; Female; Huma | 2015 |
Evaluation of inflammatory parameters in physical urticarias and effects of an anti-inflammatory/antiallergic treatment.
Topics: Adolescent; Adult; Anti-Allergic Agents; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion Mole | 2002 |
Effects of ketotifen on symptoms and on bronchial mucosa in patients with atopic asthma.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Anti-Allergic Agents; Antigens, CD; Antineoplastic Comb | 1997 |
Effect of cetirizine, ketotifen and chlorpheniramine on the dynamics of the cutaneous hypersensitivity reaction: a comparative study.
Topics: Basophils; Cetirizine; Chlorpheniramine; Dermatitis, Contact; Double-Blind Method; Eosinophils; Hist | 1992 |
13 other studies available for ketotifen and Inflammation
| Article | Year |
|---|---|
Role of Ketotifen on metabolic profiles, inflammation and oxidative stress in diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Inflammation; Insulin; Insulin | 2017 |
Genetic and Pharmacological Dissection of the Role of Spleen Tyrosine Kinase (Syk) in Intestinal Inflammation and Immune Dysfunction in Inflammatory Bowel Diseases.
Topics: Adaptor Proteins, Signal Transducing; Adult; Animals; Antipruritics; Colitis; Cytokines; Disease Mod | 2017 |
Mast cell stabilization alleviates acute lung injury after orthotopic autologous liver transplantation in rats by downregulating inflammation.
Topics: Acute Lung Injury; Animals; Cromolyn Sodium; Disease Models, Animal; Down-Regulation; Inflammation; | 2013 |
Allergic lung inflammation promotes atherosclerosis in apolipoprotein E-deficient mice.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Budesonide; Chronic Disease; Disease Progression; Gluco | 2016 |
Mast cell inhibition by ketotifen reduces splanchnic inflammatory response in a portal hypertension model in rats.
Topics: Animals; Anti-Allergic Agents; Enzyme-Linked Immunosorbent Assay; Hypertension, Portal; Inflammation | 2008 |
Reduced mucosal injury of SPF chickens by mast cell stabilization after infection with very virulent infectious bursal disease virus.
Topics: Animals; Antigens, Viral; Birnaviridae Infections; Bursa of Fabricius; Cell Count; Chickens; Histami | 2009 |
Activation of mast cells induced by agonists of proteinase-activated receptors under normal conditions and during acute inflammation in rats.
Topics: Acute Disease; Animals; beta-N-Acetylhexosaminidases; Cell Degranulation; Dose-Response Relationship | 2003 |
Olopatadine suppresses the migration of THP-1 monocytes induced by S100A12 protein.
Topics: Aminopyridines; Cell Culture Techniques; Cell Movement; Dibenzoxepins; Gene Expression Regulation; H | 2006 |
Mast cell stabilizer ketotifen [4-(1-methyl-4-piperidylidene)-4h-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one fumarate] prevents mucosal mast cell hyperplasia and intestinal dysmotility in experimental Trichinella spiralis inflammation in the rat.
Topics: Animals; Cell Count; Cell Size; Cholecystokinin; Chymases; Cyclooxygenase 2; Gastrointestinal Motili | 2006 |
[The effect of ketotifen on the inflammation of bronchial mucosa in atopic asthmatics].
Topics: Adult; Asthma; Bronchi; Eosinophils; Female; Humans; Inflammation; Ketotifen; Male; Mucous Membrane; | 1994 |
Superoxide anions produced by inflammatory cells play an important part in the pathogenesis of acid and pepsin induced oesophagitis in rabbits.
Topics: Animals; Anions; Catalase; Cells, Cultured; Esophagitis; Esophagus; Flow Cytometry; Fluorescent Anti | 1997 |
Development and sequels of intestinal inflammation in nematode-infected rats: role of mast cells and capsaicin-sensitive afferents.
Topics: Animals; Capsaicin; Cell Count; Inflammation; Intestine, Small; Ketotifen; Mast Cells; Neurons, Affe | 2000 |
[Changes in biochemical inflammation markers in evaluation of the effectiveness of basic chemotherapy in bronchial asthma].
Topics: Adolescent; Adult; Age Factors; Androstadienes; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Ast | 2001 |