ketotifen has been researched along with Hypersensitivity in 48 studies
Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
ketotifen : An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.
Hypersensitivity: Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketotifen is an orally active prophylactic agent for the management of bronchial asthma and allergic disorders." | 8.78 | Ketotifen. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in asthma and allergic disorders. ( Fitton, A; Goa, KL; Grant, SM; Sorkin, EM, 1990) |
| "The results of this study suggest that emedastine and ketotifen are not significantly different with respect to anti-itching efficacy in the CAC model of acute allergic conjunctivitis." | 5.10 | Randomized, double-masked, placebo-controlled comparison of the efficacy of emedastine difumarate 0.05% ophthalmic solution and ketotifen fumarate 0.025% ophthalmic solution in the human conjunctival allergen challenge model. ( Bensch, G; D'Arienzo, PA; Leonardi, A, 2002) |
| "1% Ketotifen ophthalmic preparation was evaluated in 11 cases of conjunctivitis due to Japanese cedar pollinoisis (three cases also associated with vernal catarrh)." | 5.05 | Therapeutic effects of a new, anti-allergic ophthalmic preparation. ( Arai, Y; Fujiwara, T; Kubota, A; Mikuni, I; Mizushima, N; Mochida, H; Togawa, K, 1982) |
| "Ketotifen is an orally active prophylactic agent for the management of bronchial asthma and allergic disorders." | 4.78 | Ketotifen. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in asthma and allergic disorders. ( Fitton, A; Goa, KL; Grant, SM; Sorkin, EM, 1990) |
| " By screening molecules related to arachidonic acid metabolism or pruritus, SA6541 was found to be a specific inhibitor of LTA(4) hydrolase." | 3.76 | Role of leukotriene B4 in 5-lipoxygenase metabolite- and allergy-induced itch-associated responses in mice. ( Aono, H; Enomoto, H; Inagaki, N; Mizutani, K; Murakami, T; Tsuboi, T; Tsuji, F, 2010) |
| "The effects of betotastine besilate (betotastine: TAU-284), a novel antiallergic drug, on homologous passive cutaneous anaphylaxis (PCA), mediator-induced cutaneous reaction, antigen-induced asthmatic responses and platelet-activating factor (PAF)-induced airway eosinophilia in several animal models, were compared to ketotifen." | 3.70 | Antiallergic action of betotastine besilate (TAU-284) in animal models: A comparison with ketotifen. ( Inagaki, N; Koda, A; Nagai, H; Ueno, M, 1998) |
| " When leukocytes from asthmatic patients sensitive to mite were stimulated with the allergen, epinastine inhibited histamine release with a concentration required for 50% inhibition (IC50) of 3 x 10(-5) mol/l and leukotriene C4 generation." | 3.69 | Comparison of anti-allergic activities of the histamine H1 receptor antagonists epinastine, ketotifen and oxatomide in human leukocytes. ( Mita, H; Shida, T, 1995) |
| "Eosinophilic cystitis is rare in children." | 2.41 | Eosinophilic cystitis. ( de Jong, TP; Nikkels, PG; Verhagen, PC, 2001) |
| "The reference anti-allergy drugs, such as the inhaled corticosteroids or the cromones, without anti H1 activity, inhibit this late pulmonary response." | 2.38 | Pharmacological treatment of allergies. ( De Vos, C, 1992) |
| "Of these, 29 (33%) had eosinophilic esophagitis (EoE), and 10 (11%) had eosinophilic gastritis, gastroenteritis or enterocolitis." | 1.62 | Disease Course and Treatment Response of Eosinophilic Gastrointestinal Diseases in Children With Liver Transplantation: Long-Term Follow-Up. ( Arikan, C; Can, D; Doganay, L; Ozdogan, E, 2021) |
| "Atherosclerosis was produced in apolipoprotein E-deficient (Apoe(-/-)) mice with a Western diet." | 1.43 | Allergic lung inflammation promotes atherosclerosis in apolipoprotein E-deficient mice. ( Cheng, X; Fernandes, C; Huang, X; Levy, B; Liao, M; Libby, P; Liu, CL; Santos, MM; Shi, GP; Sukhova, GK; Wang, Y; Wu, G; Yang, C; Zhang, JY, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (52.08) | 18.7374 |
| 1990's | 13 (27.08) | 18.2507 |
| 2000's | 4 (8.33) | 29.6817 |
| 2010's | 4 (8.33) | 24.3611 |
| 2020's | 2 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Nishikawa, Y | 1 |
| Shindo, T | 1 |
| Ishii, K | 1 |
| Nakamura, H | 1 |
| Kon, T | 1 |
| Uno, H | 1 |
| Ho, CY | 1 |
| Hageman, WE | 1 |
| Persico, FJ | 1 |
| Iwasaki, N | 1 |
| Ohashi, T | 2 |
| Musoh, K | 1 |
| Nishino, H | 1 |
| Kado, N | 1 |
| Yasuda, S | 1 |
| Kato, H | 2 |
| Ito, Y | 2 |
| Ozdogan, E | 1 |
| Doganay, L | 1 |
| Can, D | 1 |
| Arikan, C | 1 |
| Abd Rani, NZ | 1 |
| Lam, KW | 1 |
| Jalil, J | 1 |
| Mohamad, HF | 1 |
| Mat Ali, MS | 1 |
| Husain, K | 1 |
| Liu, CL | 1 |
| Wang, Y | 1 |
| Liao, M | 1 |
| Santos, MM | 1 |
| Fernandes, C | 1 |
| Sukhova, GK | 1 |
| Zhang, JY | 1 |
| Cheng, X | 1 |
| Yang, C | 1 |
| Huang, X | 1 |
| Levy, B | 1 |
| Libby, P | 1 |
| Wu, G | 1 |
| Shi, GP | 1 |
| Tsuji, F | 1 |
| Aono, H | 1 |
| Tsuboi, T | 1 |
| Murakami, T | 1 |
| Enomoto, H | 1 |
| Mizutani, K | 1 |
| Inagaki, N | 3 |
| van Diest, SA | 1 |
| Stanisor, OI | 1 |
| de Jonge, WJ | 1 |
| Boeckxstaens, GE | 1 |
| van den Wijngaard, RM | 1 |
| Lee, CL | 1 |
| Hsu, SH | 1 |
| Jong, YJ | 1 |
| Hung, CH | 1 |
| Suen, JL | 1 |
| Feitosa, RF | 1 |
| Melcíades, GB | 1 |
| Assreuy, AM | 1 |
| Rocha, MF | 1 |
| Ribeiro, RA | 1 |
| Lima, AA | 1 |
| Dolecek, R | 1 |
| Dry, J | 2 |
| Pradalier, A | 1 |
| Mikuni, I | 2 |
| Davies, RJ | 1 |
| Moodley, I | 1 |
| DeShazo, RD | 1 |
| Levinson, AI | 1 |
| Dvorak, HF | 1 |
| Fuangtong, R | 1 |
| Ufkes, JG | 1 |
| Ottenhof, M | 1 |
| Sokolova, TS | 1 |
| Reviakina, VA | 1 |
| Partsalis, EM | 1 |
| Botvin'eva, VV | 1 |
| Zakhidov, IuV | 1 |
| von Wichert, P | 1 |
| Fujiwara, T | 1 |
| Togawa, K | 1 |
| Mochida, H | 1 |
| Arai, Y | 2 |
| Kubota, A | 1 |
| Mizushima, N | 1 |
| Nagai, H | 3 |
| Kawasaki, H | 1 |
| Takeda, H | 1 |
| Takaoka, Y | 1 |
| Shirouzu, K | 1 |
| Mita, H | 1 |
| Shida, T | 1 |
| Shiratori, Y | 1 |
| Takada, H | 1 |
| Hai, K | 1 |
| Kiriyama, H | 1 |
| Mawet, E | 1 |
| Komatsu, Y | 1 |
| Niwa, Y | 1 |
| Matsumura, M | 1 |
| Shiina, S | 1 |
| Kawase, T | 1 |
| Szczepanowska, A | 1 |
| Zbarańska, S | 1 |
| Kudlicka, A | 1 |
| Ueno, M | 1 |
| Koda, A | 2 |
| Akiyama, H | 1 |
| Sakushima, J | 1 |
| Taniuchi, S | 1 |
| Kanda, T | 1 |
| Yanagida, A | 1 |
| Kojima, T | 1 |
| Teshima, R | 1 |
| Kobayashi, Y | 1 |
| Goda, Y | 1 |
| Toyoda, M | 1 |
| Verhagen, PC | 1 |
| Nikkels, PG | 1 |
| de Jong, TP | 1 |
| D'Arienzo, PA | 1 |
| Leonardi, A | 1 |
| Bensch, G | 1 |
| De Vos, C | 1 |
| Nakagawa, T | 1 |
| Nakamura, T | 1 |
| Kuriyama, M | 1 |
| Ishihara, K | 1 |
| Matsumura, Y | 1 |
| Miyamoto, T | 1 |
| Makino, E | 1 |
| Takahashi, H | 1 |
| Azuma, H | 1 |
| Deeva, TF | 1 |
| Cheburkin, AA | 1 |
| Chistiakov, GM | 1 |
| Basova, EN | 1 |
| Tsvetkova, EI | 1 |
| Kliubina, AO | 1 |
| Sviatkina, OB | 1 |
| Grant, SM | 1 |
| Goa, KL | 1 |
| Fitton, A | 1 |
| Sorkin, EM | 1 |
| Chand, N | 2 |
| Pillar, J | 1 |
| Diamantis, W | 2 |
| Sofia, RD | 2 |
| Yamada, N | 1 |
| Takahashi, K | 1 |
| Endoh, K | 1 |
| Jamieson, DM | 1 |
| Guill, MF | 1 |
| Wray, BB | 1 |
| May, JR | 1 |
| Kay, AB | 1 |
| Pipkorn, U | 1 |
| Morley, J | 1 |
| Page, CP | 1 |
| Mazzoni, L | 1 |
| Sanjar, S | 1 |
| Sirenko, OI | 1 |
| Tsuketti, AD | 1 |
| Gridneva, NN | 1 |
| Bryntsova, SS | 1 |
| Chmielewska, D | 1 |
| Zawadzka, A | 1 |
| Harrison, JE | 1 |
| Rooney, SM | 1 |
| Dal Negro, RW | 1 |
| Turco, P | 1 |
| Zoccatelli, O | 1 |
| Trevisan, F | 1 |
| Pomari, C | 1 |
| Lesbros, D | 1 |
| Loftus, BG | 1 |
| Price, JF | 1 |
| Heaton, R | 1 |
| Costello, JF | 1 |
7 reviews available for ketotifen and Hypersensitivity
| Article | Year |
|---|---|
Eye itching in ophthalmology and its treatment.
Topics: Conjunctiva; Cromolyn Sodium; Dermatitis; Eczema; Edema; Emotions; Eye; Histamine; Histamine H1 Anta | 1984 |
Antiallergic compounds.
Topics: Adrenal Cortex Hormones; Allergens; Animals; Aspirin; Bronchodilator Agents; Cromolyn Sodium; Histam | 1982 |
Eosinophilic cystitis.
Topics: Adolescent; Anti-Allergic Agents; Child; Child, Preschool; Chronic Disease; Cystitis; Enuresis; Eosi | 2001 |
Pharmacological treatment of allergies.
Topics: Animals; Cetirizine; Drug Evaluation; Drug Evaluation, Preclinical; Guinea Pigs; Histamine H1 Antago | 1992 |
Ketotifen. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in asthma and allergic disorders.
Topics: Asthma; Bronchi; Humans; Hypersensitivity; Ketotifen; Platelet Activating Factor | 1990 |
Metabisulfite sensitivity: case report and literature review.
Topics: Adult; Asthma; Female; Food Additives; Histamine Release; Humans; Hypersensitivity; Immunoglobulin E | 1985 |
Pharmacological influence of antiallergic medication on in vivo allergen testing.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Allergens; Cromolyn Sodium; Glucocorticoids; Hi | 1988 |
4 trials available for ketotifen and Hypersensitivity
| Article | Year |
|---|---|
A clinical trial of ketotifen in Thai asthmatics.
Topics: Adolescent; Adult; Asthma; Clinical Trials as Topic; Female; Humans; Hypersensitivity; Ketotifen; Ma | 1983 |
Therapeutic effects of a new, anti-allergic ophthalmic preparation.
Topics: Animals; Clinical Trials as Topic; Conjunctivitis; Humans; Hypersensitivity; Ketotifen; Ointments; P | 1982 |
Randomized, double-masked, placebo-controlled comparison of the efficacy of emedastine difumarate 0.05% ophthalmic solution and ketotifen fumarate 0.025% ophthalmic solution in the human conjunctival allergen challenge model.
Topics: Allergens; Anti-Allergic Agents; Benzimidazoles; Conjunctivitis; Double-Blind Method; Eye Color; Fem | 2002 |
[Zaditen in the treatment of children with allergies].
Topics: Adolescent; Child; Child, Preschool; Clinical Trials as Topic; Female; Humans; Hypersensitivity; Inf | 1986 |
37 other studies available for ketotifen and Hypersensitivity
| Article | Year |
|---|---|
Acrylamide derivatives as antiallergic agents. 2. Synthesis and structure-activity relationships of N-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acryl amides.
Topics: Acrylamides; Animals; Chemical Phenomena; Chemistry; Guinea Pigs; Histamine Antagonists; Histamine R | 1989 |
Indolo[2,1-c][1,4]benzodiazepines: a new class of antiallergic agents.
Topics: Anaphylaxis; Animals; Benzodiazepines; Cromolyn Sodium; Guinea Pigs; Histamine H1 Antagonists; Hyper | 1986 |
Amphoteric drugs. 3. Synthesis and antiallergic activity of 3-[(5,11-dihydro[1]benzoxepino[4,3-b]pyridin-11- ylidene)piperidino]propionic acid derivatives and related compounds.
Topics: Animals; Capillary Permeability; Central Nervous System; Guinea Pigs; Histamine Antagonists; Hyperse | 1995 |
Disease Course and Treatment Response of Eosinophilic Gastrointestinal Diseases in Children With Liver Transplantation: Long-Term Follow-Up.
Topics: Age Factors; Anti-Allergic Agents; Biliary Atresia; Budesonide; Child; Child, Preschool; Cholestasis | 2021 |
Mechanistic Studies of the Antiallergic Activity of
Topics: Animals; Anti-Allergic Agents; Biomarkers; Cell Line, Tumor; Chromatography, High Pressure Liquid; G | 2021 |
Allergic lung inflammation promotes atherosclerosis in apolipoprotein E-deficient mice.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Budesonide; Chronic Disease; Disease Progression; Gluco | 2016 |
Role of leukotriene B4 in 5-lipoxygenase metabolite- and allergy-induced itch-associated responses in mice.
Topics: Animals; Arachidonic Acid; Behavior, Animal; Capillary Permeability; Epoxide Hydrolases; Histamine H | 2010 |
Visceral hypersensitivity in IBS: from bench to bedside.
Topics: Abdominal Pain; Animals; Histamine H1 Antagonists; Humans; Hypersensitivity; Irritable Bowel Syndrom | 2011 |
Inhibition of histamine H1 receptor activity modulates proinflammatory cytokine production of dendritic cells through c-Rel activity.
Topics: Adoptive Transfer; Animals; Dendritic Cells; Drug Inverse Agonism; Female; Gene Expression Regulatio | 2013 |
The pharmacological profile of ovalbumin-induced paw oedema in rats.
Topics: Animals; Anti-Allergic Agents; Azepines; Chlorpromazine; Dopamine Antagonists; Dose-Response Relatio | 2002 |
Ketotifen in the treatment of diabetics with various allergic conditions.
Topics: Biguanides; Blood; Diabetes Complications; Diabetes Mellitus; Drug Interactions; Female; Glucose Tol | 1981 |
[Current data on anti-allergy drugs].
Topics: Cromolyn Sodium; Glucocorticoids; Histamine H1 Antagonists; Humans; Hypersensitivity; Ketotifen; The | 1982 |
The late phase skin reaction: paradigm or epiphenomena?
Topics: Adrenal Cortex Hormones; Animals; Arthus Reaction; Chemotaxis, Leukocyte; Dermatitis, Atopic; Diseas | 1983 |
Characterization of various antiallergic agents using a new method for inducing systemic anaphylaxis in the rat.
Topics: Anaphylaxis; Animals; Blood Pressure; Bronchodilator Agents; Chromones; Cromolyn Sodium; Disease Mod | 1984 |
[Clinical study of the preventive action of ketotifen in children with allergic diseases].
Topics: Asthma; Child; Child, Preschool; Dermatitis, Atopic; Eczema; Humans; Hypersensitivity; Infant; Ketot | 1983 |
Ketotifen, an anti-allergic drug. Pharmacological figures anc clinical experience.
Topics: Asthma; Cromolyn Sodium; Humans; Hypersensitivity; Ketotifen; Piperidines; Thiophenes | 1980 |
The effect of a TXA2 receptor antagonist ON-579 on experimental allergic reactions.
Topics: Aerosols; Airway Resistance; Animals; Antigens; Arthus Reaction; Bronchoalveolar Lavage Fluid; Conca | 1995 |
Inhibition of Fc gamma R- and CR-mediated human neutrophil chemiluminescent responses by anti-allergic and anti-histaminergic drugs.
Topics: Clemastine; Humans; Hypersensitivity; Ketotifen; Luminescent Measurements; Neutrophils; Receptors, I | 1995 |
Comparison of anti-allergic activities of the histamine H1 receptor antagonists epinastine, ketotifen and oxatomide in human leukocytes.
Topics: Asthma; Calcimycin; Dibenzazepines; Histamine H1 Antagonists; Humans; Hypersensitivity; Imidazoles; | 1995 |
Effect of anti-allergic agents on chemotaxis of neutrophils by stimulation of chemotactic factor released from hepatocytes exposed to ethanol.
Topics: Adult; Animals; Antibodies; Cells, Cultured; Chemokines; Chemotactic Factors; Chemotaxis, Leukocyte; | 1994 |
Ketotifen in the treatment of changes of the upper part of digestive tract in allergic children.
Topics: Adolescent; Anti-Allergic Agents; Child; Child, Preschool; Endoscopy; Female; Gastrointestinal Disea | 1995 |
Antiallergic action of betotastine besilate (TAU-284) in animal models: A comparison with ketotifen.
Topics: Animals; Anti-Allergic Agents; Asthma; Bronchoconstriction; Disease Models, Animal; Eosinophilia; Eo | 1998 |
Antiallergic effect of apple polyphenols on the allergic model mouse.
Topics: Animals; Anti-Allergic Agents; Dose-Response Relationship, Drug; Ear, External; Edema; Enzyme-Linked | 2000 |
[Chemical mediators and anti-mediator drugs].
Topics: Asthma; Chemotactic Factors, Eosinophil; Cromolyn Sodium; Cytokines; Depression, Chemical; Histamine | 1991 |
Platelet-activating factor (PAF) in allergic diseases: inhibitory effects of anti-allergic drugs, ketotifen and three kampo medicines on PAF production.
Topics: Adult; Cromolyn Sodium; Histamine H1 Antagonists; Humans; Hypersensitivity; Ketotifen; Male; Medicin | 1991 |
Inhibitory effect of HSR-6071, a new anti-allergic agent, on experimental asthma in rats and guinea-pigs.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminopyridines; Animals; Asthma; Azoles; Bronchi; Cromolyn Sodi | 1990 |
[Manifestations of pseudo-allergy in different diseases in children].
Topics: Adjuvants, Immunologic; Adolescent; Angioedema; Child; Child, Preschool; Dermatitis, Atopic; Diagnos | 1990 |
Inhibition of IgE-mediated allergic histamine release from rat peritoneal mast cells by azelastine and selected antiallergic drugs.
Topics: Animals; Astemizole; Benzimidazoles; Diphenhydramine; Histamine Release; Hypersensitivity; Immunoglo | 1985 |
[Inhibitory effect on the release of mediators from rat peritoneal exudate cells and the antagonistic effect against mediators of MY-5116 and other anti-allergic agents].
Topics: Animals; Bradykinin; Chromones; Cromolyn Sodium; Female; Guinea Pigs; Histamine H1 Antagonists; Hype | 1986 |
The mode of action of anti-allergic drugs.
Topics: Adrenergic beta-Agonists; Animals; Cromolyn Sodium; Humans; Hypersensitivity; Ketotifen; Mast Cells; | 1987 |
[Antiallergic drugs].
Topics: Cromolyn Sodium; Glucocorticoids; Histamine H1 Antagonists; Humans; Hypersensitivity; Ketotifen; Sym | 1988 |
Effects of ketotifen upon responses to platelet activating factor: a basis for asthma prophylaxis.
Topics: Albuterol; Asthma; Cromolyn Sodium; Humans; Hypersensitivity; Injections, Intravenous; Ketotifen; Lu | 1986 |
[Use of euphylline and zaditen in the treatment of obstructive syndrome in children with allergic diathesis under ambulatory care].
Topics: Ambulatory Care; Aminophylline; Disease Susceptibility; Humans; Hypersensitivity; Infant; Infant Foo | 1988 |
Inhibition of passive cutaneous anaphylaxis (PCA) by azelastine: dissociation of its antiallergic activities from antihistaminic and antiserotonin properties.
Topics: Animals; Antigens; Astemizole; Benzimidazoles; Histamine Antagonists; Hypersensitivity; Ketotifen; M | 1985 |
Prevention of bronchial hyperreactivity in atopic asthmatics during the period of maximal allergenic risk: a six-month study.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Child; Forced Expiratory Volume; Humans; Hyp | 1986 |
[Ketotifen in the prevention of bronchial asthma of allergic origin in children].
Topics: Adolescent; Asthma; Child; Child, Preschool; Female; Humans; Hypersensitivity; Ketotifen; Male | 1986 |
Effects of ketotifen on in vitro bronchoconstriction.
Topics: Acetylcholine; Animals; Antigens; Bronchi; Guinea Pigs; Histamine; Humans; Hypersensitivity; Ketotif | 1985 |