ketotifen has been researched along with Hay Fever in 35 studies
Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
ketotifen : An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The place of KETOTIFEN in the immunotherapy for atopic asthmatic patients (confirmed by cutaneous test and RAST) has been determined by a study conducted on 48 patients divided into two randomly selected parallel groups." | 9.06 | [Role of ketotifen in the immunotherapy of atopic asthmatics]. ( Haddad, G; Pacaud, D; Papeix, P; Steeg, LF; Tran, Q; Vincent, J, 1986) |
| " In this study, we looked at the changes in the number of sanguineous cells that ketotifen produces, especially in basophil cells, that could explain its prophylactic effects in bronchial hyperreactivity disclosed by exercise, as well as its relation to the variations in basal and total histamine in blood." | 7.68 | In vitro ketotifen protection in bronchial hyperreactivity. ( Córdoba, H; Fernández, M; Oehling, A; Santos, F, 1991) |
| "Ketotifen fumarate is a topical antiallergic combination mast-cell stabilizer and antihistamine indicated for the temporary prevention of ocular itching due to allergic conjunctivitis." | 5.10 | Comparison of ketotifen fumarate ophthalmic solution alone, desloratadine alone, and their combination for inhibition of the signs and symptoms of seasonal allergic rhinoconjunctivitis in the conjunctival allergen challenge model: a double-masked, placebo ( Crampton, HJ, 2003) |
| "The place of KETOTIFEN in the immunotherapy for atopic asthmatic patients (confirmed by cutaneous test and RAST) has been determined by a study conducted on 48 patients divided into two randomly selected parallel groups." | 5.06 | [Role of ketotifen in the immunotherapy of atopic asthmatics]. ( Haddad, G; Pacaud, D; Papeix, P; Steeg, LF; Tran, Q; Vincent, J, 1986) |
| "Ketotifen produced seizures in a 5-year-old boy with secondary generalized epilepsy (SGE) and allergic rhinitis." | 3.68 | Proconvulsant effect of ketotifen, a histamine H1 antagonist, confirmed by the use of d-chlorpheniramine with monitoring electroencephalography. ( Iinuma, K; Onodera, K; Sakurai, E; Watanabe, T; Yanai, K; Yokoyama, H, 1993) |
| " In this study, we looked at the changes in the number of sanguineous cells that ketotifen produces, especially in basophil cells, that could explain its prophylactic effects in bronchial hyperreactivity disclosed by exercise, as well as its relation to the variations in basal and total histamine in blood." | 3.68 | In vitro ketotifen protection in bronchial hyperreactivity. ( Córdoba, H; Fernández, M; Oehling, A; Santos, F, 1991) |
| "Twelve children with pollinosis or bronchial asthma were treated continuously, without interruption, for 6 months with ketotifen (2 mg per day)." | 3.67 | Growth hormone plasma levels in children treated for 6 months with ketotifen. ( Dolecek, R; Halatová, A; Janstová, V, 1984) |
| "Nine patients with Japanese cedar pollinosis who had no nasal or ocular symptoms were included in the present study, after obtaining informed consent in writing." | 2.72 | Effect of antihistamine eye drops on the conjunctival provocation test with Japanese cedar pollen allergen. ( Cheng, L; Dake, Y; Enomoto, K; Enomoto, T; Ikeda, H; Sakota, T; Shibano, A; Yajin, S; Yamanishi, E; Yoda, S, 2006) |
| "Ketotifen-treated eyes experienced significantly less ocular itching induced by CAC than nedocromil-treated eyes and those that received placebo at both the 5-minute and 12-hour posttreatment allergen challenges (all P < 0." | 2.71 | A placebo-controlled comparison of ketotifen fumarate and nedocromil sodium ophthalmic solutions for the prevention of ocular itching with the conjunctival allergen challenge model. ( Greiner, JV; Minno, G, 2003) |
| "025% ophthalmic solution, when dosed ocularly, offered protecdon against the nasal signs and symptoms of acute allergic rhinoconjunctival reaction as induced by the CAC model." | 2.70 | A comparison of the relative clinical efficacy of a single dose of ketotifen fumarate 0.025% ophthalmic solution versus placebo in inhibiting the signs and symptoms of allergic rhinoconjunctivitis as induced by the conjunctival allergen challenge model. ( Crampton, HJ, 2002) |
| "In this review of the current treatment of seasonal allergic rhinitis, the clinical studies that compare these four new second-generation H1-receptor antagonists are discussed." | 2.38 | H1-receptor antagonist treatment of seasonal allergic rhinitis. ( Kaiser, HB, 1990) |
| "CD14+ cells prepared from patients with pollinosis to Japanese cedar pollen were stimulated with specific allergen extracted from Japanese cedar pollen (Cry j 1) in the presence of azelastine (AZE), ketotifen (KET), fexofenadine (FEX) and oxatomide (OXA) for 6 days." | 1.37 | Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro. ( Asano, K; Furuta, A; Hirano, K; Shoji, N; Suzaki, H, 2011) |
| " Second-generation antihistamines have become increasingly popular because of their comparable efficacy and lower incidence of adverse effects relative to their first-generation counterparts, and the safety and efficacy of this drug class are established in the adult population." | 1.35 | Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast. ( Moeller, ML; Nahata, MC; Phan, H, 2009) |
| "Japanese cedar pollinosis is a typical allergic disease and has recently become a big social problem." | 1.28 | [Platelet-activating factor in Japanese cedar pollinosis]. ( Ishihara, K; Kuriyama, M; Matsumura, Y; Miyamoto, T; Nakamura, T, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (48.57) | 18.7374 |
| 1990's | 11 (31.43) | 18.2507 |
| 2000's | 6 (17.14) | 29.6817 |
| 2010's | 1 (2.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Phan, H | 1 |
| Moeller, ML | 1 |
| Nahata, MC | 1 |
| Shoji, N | 1 |
| Asano, K | 1 |
| Furuta, A | 1 |
| Hirano, K | 1 |
| Suzaki, H | 1 |
| Crampton, HJ | 2 |
| Greiner, JV | 1 |
| Minno, G | 1 |
| Dake, Y | 1 |
| Enomoto, T | 1 |
| Cheng, L | 1 |
| Enomoto, K | 1 |
| Shibano, A | 1 |
| Ikeda, H | 1 |
| Yoda, S | 1 |
| Yajin, S | 1 |
| Sakota, T | 1 |
| Yamanishi, E | 1 |
| Tsunematsu, M | 1 |
| Yamaji, T | 1 |
| Kozutsumi, D | 1 |
| Murakami, R | 1 |
| Kimura, S | 1 |
| Kino, K | 1 |
| Debelić, M | 1 |
| Schiess, W | 1 |
| Mikuni, I | 2 |
| Moretti, AM | 1 |
| Marano, R | 1 |
| van Cauwenberge, PB | 1 |
| Wheatley, D | 1 |
| Sato, K | 1 |
| Togawa, K | 1 |
| Mizushima, N | 1 |
| Sokolova, TS | 1 |
| Reviakina, VA | 1 |
| Partsalis, EM | 1 |
| Botvin'eva, VV | 1 |
| Zakhidov, IuV | 1 |
| Dolecek, R | 1 |
| Janstová, V | 1 |
| Halatová, A | 1 |
| Warner, JO | 1 |
| Goldsworthy, SJ | 1 |
| Graff-Lonnevig, V | 1 |
| Langrick, AF | 1 |
| Wallace, MG | 1 |
| Naito, K | 1 |
| Senoh, Y | 1 |
| Ishihara, M | 1 |
| Takeda, N | 1 |
| Ibata, K | 1 |
| Yokoyama, N | 1 |
| Iwata, S | 1 |
| Naclerio, RM | 2 |
| Yokoyama, H | 1 |
| Iinuma, K | 1 |
| Yanai, K | 1 |
| Watanabe, T | 1 |
| Sakurai, E | 1 |
| Onodera, K | 1 |
| Fernández, M | 1 |
| Córdoba, H | 1 |
| Santos, F | 1 |
| Oehling, A | 1 |
| Majchel, AM | 1 |
| Proud, D | 1 |
| Kagey-Sobotka, A | 1 |
| Lichtenstein, LM | 1 |
| Albegger, K | 1 |
| Bittera, I | 1 |
| Kadocsa, E | 1 |
| Gyurkovits, K | 1 |
| Kaiser, HB | 1 |
| Ferrannini, A | 1 |
| Bilancia, R | 1 |
| Mariani, F | 1 |
| Iacobelli, A | 1 |
| Tripodi, D | 1 |
| Torchia, SL | 1 |
| Nakamura, T | 1 |
| Ishihara, K | 1 |
| Kuriyama, M | 1 |
| Miyamoto, T | 1 |
| Matsumura, Y | 1 |
| Kaiser, C | 1 |
| Bernáldez, R | 1 |
| Moñux, A | 1 |
| Calatayud, J | 1 |
| Morris, EC | 1 |
| Farri, A | 1 |
| Lucisano, S | 1 |
| Mora, P | 1 |
| Cantani, A | 1 |
| Bellioni, P | 1 |
| Businco, E | 1 |
| Benincori, N | 1 |
| Haddad, G | 1 |
| Pacaud, D | 1 |
| Papeix, P | 1 |
| Tran, Q | 1 |
| Vincent, J | 1 |
| Steeg, LF | 1 |
| Zawisza, E | 1 |
| Blinowski, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effectiveness of Montelukast Versus Intranasal Fluticasone Propionate in the Management of Allergic Rhinitis Among Children 02 to 05 Years of Age[NCT04957927] | Phase 4 | 60 participants (Anticipated) | Interventional | 2020-12-12 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for ketotifen and Hay Fever
| Article | Year |
|---|---|
Eye itching in ophthalmology and its treatment.
Topics: Conjunctiva; Cromolyn Sodium; Dermatitis; Eczema; Edema; Emotions; Eye; Histamine; Histamine H1 Anta | 1984 |
Ketotifen in childhood allergic disease.
Topics: Aging; Airway Obstruction; Animals; Asthma; Asthma, Exercise-Induced; Body Weight; Bronchial Provoca | 1982 |
[The symptomatic therapy of allergic rhinitis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cromolyn Sodium; Glucocorticoids; Histamine Antagonists; Hu | 1990 |
[Comparative study of ketotiphen and oxatomide (repeated skin- and nasal provocation)].
Topics: Adolescent; Child; Drug Evaluation; Female; Histamine H1 Antagonists; Humans; Ketotifen; Male; Nasal | 1990 |
H1-receptor antagonist treatment of seasonal allergic rhinitis.
Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Cetirizine; Chlorpheniramine; Clemastine; Cyprohep | 1990 |
[Allergic rhinopathy: diagnosis and current therapy].
Topics: Adolescent; Adult; Aged; Child; Cromolyn Sodium; Desensitization, Immunologic; Female; Humans; Immun | 1990 |
Pharmacotherapy of allergic disease.
Topics: Adrenal Cortex Hormones; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adult; Aged; Anaphylax | 1987 |
15 trials available for ketotifen and Hay Fever
| Article | Year |
|---|---|
A comparison of the relative clinical efficacy of a single dose of ketotifen fumarate 0.025% ophthalmic solution versus placebo in inhibiting the signs and symptoms of allergic rhinoconjunctivitis as induced by the conjunctival allergen challenge model.
Topics: Adult; Aged; Allergens; Anti-Allergic Agents; Conjunctivitis, Allergic; Double-Blind Method; Female; | 2002 |
Comparison of ketotifen fumarate ophthalmic solution alone, desloratadine alone, and their combination for inhibition of the signs and symptoms of seasonal allergic rhinoconjunctivitis in the conjunctival allergen challenge model: a double-masked, placebo
Topics: Adolescent; Adult; Aged; Allergens; Anti-Allergic Agents; Child; Conjunctivitis, Allergic; Double-Bl | 2003 |
A placebo-controlled comparison of ketotifen fumarate and nedocromil sodium ophthalmic solutions for the prevention of ocular itching with the conjunctival allergen challenge model.
Topics: Adolescent; Adult; Aged; Allergens; Anti-Allergic Agents; Child; Conjunctivitis, Allergic; Double-Bl | 2003 |
Effect of antihistamine eye drops on the conjunctival provocation test with Japanese cedar pollen allergen.
Topics: Adult; Allergens; Antigens, Plant; Conjunctivitis, Allergic; Cryptomeria; Dose-Response Relationship | 2006 |
[Influence of ketotifen on IgE-mediated cutaneous test reactions (author's transl)].
Topics: Adolescent; Child; Female; Histamine H1 Antagonists; Humans; Immunoglobulin E; Ketotifen; Male; Rhin | 1981 |
Ketotifen in hay fever and allergic rhinitis.
Topics: Adolescent; Adult; Aged; Chlorpheniramine; Clinical Trials as Topic; Double-Blind Method; Female; Hu | 1984 |
Ketotifen in childhood allergic disease.
Topics: Aging; Airway Obstruction; Animals; Asthma; Asthma, Exercise-Induced; Body Weight; Bronchial Provoca | 1982 |
[Ketotifen in the prophylactic treatment of children with pollen asthma during flowering time].
Topics: Asthma; Child; Female; Humans; Ketotifen; Male; Rhinitis, Allergic, Seasonal | 1982 |
A new approach to the treatment of seasonal allergic rhinitis.
Topics: Adolescent; Adult; Chlorpheniramine; Female; Humans; Ketotifen; Male; Middle Aged; Rhinitis, Allergi | 1982 |
The effect of antihistamines on the immediate allergic response: a comparative review.
Topics: Capillary Permeability; Cetirizine; Cyproheptadine; Diphenhydramine; Double-Blind Method; Histamine | 1993 |
Ketotifen reduces sneezing but not histamine release following nasal challenge with antigen.
Topics: Adult; Antigens; Double-Blind Method; Histamine Release; Humans; Ketotifen; Nasal Provocation Tests; | 1990 |
[Inhibition by ketotifen of specific skin wheal reaction in atopic subjects].
Topics: Adult; Cromolyn Sodium; Female; Humans; Ketotifen; Male; Rhinitis, Allergic, Seasonal; Skin Tests; T | 1990 |
[Ketotifen in allergic rhinitis].
Topics: Adolescent; Adult; Clemastine; Double-Blind Method; Drug Tolerance; Female; Humans; Ketotifen; Male; | 1989 |
[Role of ketotifen in the immunotherapy of atopic asthmatics].
Topics: Adolescent; Adult; Animals; Asthma; Child; Child, Preschool; Desensitization, Immunologic; Dust; Fem | 1986 |
[Zaditen (ketotifen) in the treatment of hay fever and vasomotor rhinitis].
Topics: Adult; Clinical Trials as Topic; Female; Humans; Ketotifen; Male; Rhinitis, Allergic, Seasonal; Rhin | 1985 |
14 other studies available for ketotifen and Hay Fever
| Article | Year |
|---|---|
Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast.
Topics: Acetates; Administration, Oral; Adult; Anti-Allergic Agents; Anti-Asthmatic Agents; Astemizole; Ceti | 2009 |
Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro.
Topics: Adult; Antigens, Plant; Cell Proliferation; Chemokine CCL17; Chemokine CCL22; Chlorpheniramine; Extr | 2011 |
Establishment of an allergic rhinitis model in mice for the evaluation of nasal symptoms.
Topics: Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Antigens; Cryptomeria; Dexamethasone; Disea | 2007 |
[Preventive effect of ketotifen in allergic rhinitis caused by grasses].
Topics: Adolescent; Adult; Child; Drug Evaluation; Female; Humans; Ketotifen; Male; Middle Aged; Poaceae; Rh | 1984 |
Mast cell stabilizing agents in nasal allergy.
Topics: Adrenal Cortex Hormones; Cell Membrane Permeability; Cromolyn Sodium; Cyclic AMP; Cytoplasmic Granul | 1984 |
A quantitative tear fluids determination of therapeutic efficacy for allergic conjunctivitis.
Topics: Adult; Child; Conjunctivitis; Female; Humans; Ketotifen; Male; Refractometry; Rhinitis, Allergic, Se | 1984 |
[Clinical study of the preventive action of ketotifen in children with allergic diseases].
Topics: Asthma; Child; Child, Preschool; Dermatitis, Atopic; Eczema; Humans; Hypersensitivity; Infant; Ketot | 1983 |
Growth hormone plasma levels in children treated for 6 months with ketotifen.
Topics: Adolescent; Asthma; Blood Glucose; Body Height; Body Weight; Child; Female; Glucose Tolerance Test; | 1984 |
Seasonal variations of nasal resistance in allergic rhinitis and environmental pollen counts. III: Efficacy of antiallergic agents.
Topics: Administration, Topical; Airway Obstruction; Airway Resistance; Circadian Rhythm; Environment; Human | 1994 |
Proconvulsant effect of ketotifen, a histamine H1 antagonist, confirmed by the use of d-chlorpheniramine with monitoring electroencephalography.
Topics: Child, Preschool; Chlorpheniramine; Dopamine; Electroencephalography; Epilepsies, Partial; Epinephri | 1993 |
In vitro ketotifen protection in bronchial hyperreactivity.
Topics: Adolescent; Adult; Animals; Asthma, Exercise-Induced; Basophil Degranulation Test; Basophils; Bronch | 1991 |
[Platelet-activating factor in Japanese cedar pollinosis].
Topics: Adult; Female; Humans; Ketotifen; Male; Middle Aged; Platelet Activating Factor; Pollen; Rhinitis, A | 1990 |
[Rhinitis pathology: our experience with ketotifen].
Topics: Child; Child, Preschool; Drug Evaluation; Female; Humans; Ketotifen; Male; Rhinitis, Allergic, Seaso | 1987 |
[Therapy of allergic rhinitis in childhood].
Topics: Asthma; Beclomethasone; Child; Cromolyn Sodium; Desensitization, Immunologic; Humans; Ketotifen; Rhi | 1987 |