Page last updated: 2024-10-30

ketotifen and Epilepsy

ketotifen has been researched along with Epilepsy in 3 studies

Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
ketotifen : An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research Excerpts

ExcerptRelevanceReference
"Clinical reports have shown that some antihistamines, such as ketotifen, occasionally produced seizures, especially in pre-school age children or young patients with epilepsy."7.78The effect of antihistamines on seizures induced by increasing-current electroshocks: ketotifen, but not olopatadine, promotes the seizures in infant rats. ( Kanda, T; Takizawa, F; Tamura, T; Yamada, K, 2012)
"Clinical reports have shown that some antihistamines, such as ketotifen, occasionally produced seizures, especially in pre-school age children or young patients with epilepsy."3.78The effect of antihistamines on seizures induced by increasing-current electroshocks: ketotifen, but not olopatadine, promotes the seizures in infant rats. ( Kanda, T; Takizawa, F; Tamura, T; Yamada, K, 2012)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yamada, K1
Takizawa, F1
Tamura, T1
Kanda, T1
Yokoyama, H1
Hirose, M1
Uematsu, M1
Haginoya, K1
Iinuma, K1
Kimura, S1
Fujii, Y1
Tanaka, T1
Harada, C1
Hirai, T1
Kamei, C1

Other Studies

3 other studies available for ketotifen and Epilepsy

ArticleYear
The effect of antihistamines on seizures induced by increasing-current electroshocks: ketotifen, but not olopatadine, promotes the seizures in infant rats.
    Biological & pharmaceutical bulletin, 2012, Volume: 35, Issue:5

    Topics: Age Factors; Animals; Anti-Allergic Agents; Brain; Caffeine; Central Nervous System Stimulants; Dibe

2012
Ketotifen overdose in infancy associated with development of epilepsy and mild mental retardation.
    Pediatrics international : official journal of the Japan Pediatric Society, 2012, Volume: 54, Issue:6

    Topics: Dermatitis, Atopic; Drug Overdose; Epilepsy; Histamine H1 Antagonists; Humans; Infant; Intellectual

2012
Epileptogenic activity induced by histamine H(1) antagonists in amygdala-kindled rats.
    Brain research, 2003, Nov-21, Volume: 991, Issue:1-2

    Topics: Amygdala; Animals; Cetirizine; Diphenhydramine; Electroencephalography; Epilepsy; Histamine H1 Antag

2003