ketotifen has been researched along with Disease Models, Animal in 49 studies
Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
ketotifen : An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study, we compared the efficacy of KOB03 with modern drugs such as ketotifen and montelukast in an experimental mouse model of allergic rhinitis (AR)." | 7.79 | Comparison of the efficacy of KOB03, ketotifen, and montelukast in an experimental mouse model of allergic rhinitis. ( Jung, HW; Jung, JK; Park, YK, 2013) |
| "The use of a mast cell stabilizer, ketotifen, was effective in reducing the biomechanical and cellular manifestations of joint capsule fibrosis in a rabbit model of posttraumatic joint contracture." | 7.76 | The mast cell stabilizer ketotifen fumarate lessens contracture severity and myofibroblast hyperplasia: a study of a rabbit model of posttraumatic joint contractures. ( Befus, AD; Hart, DA; Hildebrand, KA; Monument, MJ; Salo, PT; Zhang, M, 2010) |
| " For the evaluation of itching, ovalbumin was used as an antigen instead of RW." | 7.75 | Cyclosporine A eye drops inhibit the early-phase reaction in a type-I allergic conjunctivitis model in mice. ( Katsuta, O; Nakamura, M; Oda, T; Shii, D; Shinomiya, K, 2009) |
| "To study the effects of ketotifen fumarate, olopatadine, and levocabastine on ocular active anaphylaxis in guinea pigs and on ocular immediate hypersensitivity in albino rats." | 7.73 | Effect of ketotifen fumarate, olopatadine, and levocabastine on ocular active anaphylaxis in the guinea pig and ocular immediate hypersensitivity in the albino rat. ( Schoch, C, 2005) |
| "The inhibitory effects of ketotifen, a histamine H1-receptor antagonist and mast cell stabilizer, were examined on a non-IgE experimental model of middle ear effusion." | 7.73 | Ketotifen induced inhibition of histamine release in a non-IgE model of middle ear effusion. ( Berger, G; Berger, R; Goldberg, A, 2006) |
| "The effects of ketotifen, a 'mast cell stabiliser,' on two models of experimental colitis were examined." | 7.68 | Ketotifen effectively prevents mucosal damage in experimental colitis. ( Eliakim, R; Karmeli, F; Okon, E; Rachmilewitz, D, 1992) |
| " Oral treatment with ketotifen, an inhibitor of mast cell degranulation, at a dose comparable to that recommended for man, was associated with a decrease in both mast cell degranulation and in skin fibrosis, suggesting the potential for its use in human scleroderma." | 7.68 | Ketotifen prevents skin fibrosis in the tight skin mouse. ( Harley, R; LeRoy, EC; Walker, M, 1990) |
| " The purpose of this study was to use a validated rabbit model to assess the effects on surgically-induced knee joint contractures of two combined pharmacological interventions: celecoxib (CXB) loaded on an implanted collagen membrane, and subcutaneously (SQ) injected ketotifen." | 3.96 | Reduction of arthrofibrosis utilizing a collagen membrane drug-eluting scaffold with celecoxib and subcutaneous injections with ketotifen. ( Abdel, MP; Berry, CE; Berry, DJ; Bolon, B; Carter, JM; Jay, AG; Limberg, AK; McLaury, AR; Morrey, ME; Salib, CG; Sanchez-Sotelo, J; Tibbo, ME; Turner, TW; van Wijnen, AJ, 2020) |
| " In the present study, we compared the efficacy of KOB03 with modern drugs such as ketotifen and montelukast in an experimental mouse model of allergic rhinitis (AR)." | 3.79 | Comparison of the efficacy of KOB03, ketotifen, and montelukast in an experimental mouse model of allergic rhinitis. ( Jung, HW; Jung, JK; Park, YK, 2013) |
| "The use of a mast cell stabilizer, ketotifen, was effective in reducing the biomechanical and cellular manifestations of joint capsule fibrosis in a rabbit model of posttraumatic joint contracture." | 3.76 | The mast cell stabilizer ketotifen fumarate lessens contracture severity and myofibroblast hyperplasia: a study of a rabbit model of posttraumatic joint contractures. ( Befus, AD; Hart, DA; Hildebrand, KA; Monument, MJ; Salo, PT; Zhang, M, 2010) |
| " For the evaluation of itching, ovalbumin was used as an antigen instead of RW." | 3.75 | Cyclosporine A eye drops inhibit the early-phase reaction in a type-I allergic conjunctivitis model in mice. ( Katsuta, O; Nakamura, M; Oda, T; Shii, D; Shinomiya, K, 2009) |
| "To study the effects of ketotifen fumarate, olopatadine, and levocabastine on ocular active anaphylaxis in guinea pigs and on ocular immediate hypersensitivity in albino rats." | 3.73 | Effect of ketotifen fumarate, olopatadine, and levocabastine on ocular active anaphylaxis in the guinea pig and ocular immediate hypersensitivity in the albino rat. ( Schoch, C, 2005) |
| "The inhibitory effects of ketotifen, a histamine H1-receptor antagonist and mast cell stabilizer, were examined on a non-IgE experimental model of middle ear effusion." | 3.73 | Ketotifen induced inhibition of histamine release in a non-IgE model of middle ear effusion. ( Berger, G; Berger, R; Goldberg, A, 2006) |
| " This research first proposed that alterations of mast cell histamine release, gastric acid back-diffusion and mucosal microvascular permeability are important in modulating gastric ulcer and hemorrhage in Salmonella typhi-infected rats." | 3.72 | Role of histamine and acid back-diffusion in modulation of gastric microvascular permeability and hemorrhagic ulcers in Salmonella typhimurium-infected rats. ( Hung, CR; Wang, PS, 2004) |
| "The effects of betotastine besilate (betotastine: TAU-284), a novel antiallergic drug, on homologous passive cutaneous anaphylaxis (PCA), mediator-induced cutaneous reaction, antigen-induced asthmatic responses and platelet-activating factor (PAF)-induced airway eosinophilia in several animal models, were compared to ketotifen." | 3.70 | Antiallergic action of betotastine besilate (TAU-284) in animal models: A comparison with ketotifen. ( Inagaki, N; Koda, A; Nagai, H; Ueno, M, 1998) |
| "The effects of ketotifen, a 'mast cell stabiliser,' on two models of experimental colitis were examined." | 3.68 | Ketotifen effectively prevents mucosal damage in experimental colitis. ( Eliakim, R; Karmeli, F; Okon, E; Rachmilewitz, D, 1992) |
| "The effect on the morphology of Plasmodium yoelii of ketotifen treatment was different from that of chloroquine and other antimalarial drugs." | 3.68 | Effect of ketotifen on the ultrastructure of the erythrocytic stages of Plasmodium yoelii. ( Cao, HM; Pan, XQ, 1990) |
| " Oral treatment with ketotifen, an inhibitor of mast cell degranulation, at a dose comparable to that recommended for man, was associated with a decrease in both mast cell degranulation and in skin fibrosis, suggesting the potential for its use in human scleroderma." | 3.68 | Ketotifen prevents skin fibrosis in the tight skin mouse. ( Harley, R; LeRoy, EC; Walker, M, 1990) |
| "Joint contractures are well known to hand surgeons because they limit function of our patients." | 2.49 | Posttraumatic elbow joint contractures: defining pathologic capsular mechanisms and potential future treatment paradigms. ( Hildebrand, KA, 2013) |
| "Colitis was induced by administering mice with dextran sulfate sodium (DSS), in drinking water, or 2,4,6-trinitrobenzene sulfonic acid (TNBS), by intrarectal enema." | 1.46 | Genetic and Pharmacological Dissection of the Role of Spleen Tyrosine Kinase (Syk) in Intestinal Inflammation and Immune Dysfunction in Inflammatory Bowel Diseases. ( Baldelli, F; Biagioli, M; Carino, A; Cipriani, S; Costantino, G; Distrutti, E; Donini, A; Fiorucci, C; Fiorucci, S; Graziosi, L; Marchianò, S; Mencarelli, A, 2017) |
| " Airway eosinophilia in repeatedly antigen-exposed guinea pigs was suppressed by chronic administration of HQL-79 for 2 weeks." | 1.30 | Pharmacological studies on the novel antiallergic drug HQL-79: I. Antiallergic and antiasthmatic effects in various experimental models. ( Aritake, K; Hayashi, K; Hayashi, M; Hirotsu, I; Hizue, M; Kimura, Y; Matsushita, N; Mitsui, K; Nakajima, H; Takada, A; Tani, T, 1998) |
| "Cyproheptadine and verapamil were not effective in reversing chloroquine resistance and probable drug toxicity was observed with these drugs in combination with chloroquine." | 1.29 | Reversal of Plasmodium falciparum resistance to chloroquine in Panamanian Aotus monkeys. ( Kyle, DE; Milhous, WK; Rossan, RN, 1993) |
| "Ketotifen is an anti-allergic agent that was recently shown to prevent experimental gastric and colonic mucosal injury." | 1.29 | Ketotifen is protective against indomethacin-induced intestinal ulceration in the rat. ( Dinari, G; Karmeli, F; Marcus, H; Weizen, T; Zahavi, I, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (4.08) | 18.7374 |
| 1990's | 13 (26.53) | 18.2507 |
| 2000's | 18 (36.73) | 29.6817 |
| 2010's | 13 (26.53) | 24.3611 |
| 2020's | 3 (6.12) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Kimura, H | 1 |
| Yoneya, Y | 1 |
| Mikawa, S | 1 |
| Kaji, N | 1 |
| Ito, H | 1 |
| Tsuchida, Y | 1 |
| Komatsu, H | 1 |
| Murata, T | 1 |
| Ozaki, H | 1 |
| Uchida, R | 1 |
| Nishida, K | 1 |
| Hori, M | 1 |
| Limberg, AK | 1 |
| Tibbo, ME | 1 |
| Salib, CG | 1 |
| McLaury, AR | 1 |
| Turner, TW | 1 |
| Berry, CE | 1 |
| Jay, AG | 1 |
| Carter, JM | 1 |
| Bolon, B | 1 |
| Berry, DJ | 1 |
| Morrey, ME | 1 |
| Sanchez-Sotelo, J | 1 |
| van Wijnen, AJ | 1 |
| Abdel, MP | 1 |
| Morrison, J | 1 |
| Rathore, APS | 1 |
| Mantri, CK | 1 |
| Aman, SAB | 1 |
| Nishida, A | 1 |
| St John, AL | 1 |
| Biagioli, M | 1 |
| Mencarelli, A | 1 |
| Carino, A | 1 |
| Cipriani, S | 1 |
| Marchianò, S | 1 |
| Fiorucci, C | 1 |
| Donini, A | 1 |
| Graziosi, L | 1 |
| Baldelli, F | 1 |
| Distrutti, E | 1 |
| Costantino, G | 1 |
| Fiorucci, S | 1 |
| Jung, HW | 1 |
| Jung, JK | 1 |
| Park, YK | 1 |
| Nabe, T | 1 |
| Kijitani, Y | 1 |
| Kitagawa, Y | 1 |
| Sakano, E | 1 |
| Ueno, T | 1 |
| Fujii, M | 1 |
| Nakao, S | 1 |
| Sakai, M | 1 |
| Takai, S | 1 |
| Hildebrand, KA | 2 |
| Zhang, A | 1 |
| Chi, X | 1 |
| Luo, G | 1 |
| Hei, Z | 1 |
| Xia, H | 1 |
| Luo, C | 1 |
| Wang, Y | 1 |
| Mao, X | 1 |
| Xia, Z | 1 |
| Li, H | 1 |
| Zhao, LF | 1 |
| Hao, YQ | 1 |
| Han, DW | 1 |
| Acikgoz, A | 1 |
| Asci, R | 1 |
| Aydin, O | 1 |
| Çavuş, H | 1 |
| Donmez, G | 1 |
| Buyukalpelli, R | 1 |
| Staats, KA | 1 |
| Schönefeldt, S | 1 |
| Van Helleputte, L | 1 |
| Van Rillaer, M | 1 |
| Lampi, Y | 1 |
| Dooley, J | 1 |
| Van Den Bosch, L | 1 |
| Liston, A | 1 |
| El-Shitany, NA | 1 |
| El-Desoky, K | 1 |
| Sanchez-Patan, F | 1 |
| Anchuelo, R | 1 |
| Vara, E | 1 |
| Garcia, C | 1 |
| Saavedra, Y | 1 |
| Vergara, P | 1 |
| Cuellar, C | 1 |
| Rodero, M | 1 |
| Aller, MA | 1 |
| Arias, J | 1 |
| Takahashi, Y | 1 |
| Kagawa, Y | 1 |
| Izawa, K | 1 |
| Ono, R | 1 |
| Akagi, M | 1 |
| Kamei, C | 3 |
| Shii, D | 1 |
| Oda, T | 2 |
| Shinomiya, K | 1 |
| Katsuta, O | 1 |
| Nakamura, M | 1 |
| Monument, MJ | 1 |
| Hart, DA | 1 |
| Befus, AD | 1 |
| Salo, PT | 1 |
| Zhang, M | 1 |
| Fitzgerald, JJ | 1 |
| Ustinova, E | 1 |
| Koronowski, KB | 1 |
| de Groat, WC | 1 |
| Pezzone, MA | 1 |
| Kato, M | 1 |
| Kurose, T | 1 |
| Miyaji, S | 1 |
| Ruh, J | 2 |
| Schmidt, E | 2 |
| Gebhard, MM | 1 |
| Klar, E | 1 |
| Glaser, F | 1 |
| Herfarth, C | 1 |
| Hashimoto, T | 1 |
| Igarashi, A | 1 |
| Hoshina, F | 1 |
| Yamada, M | 1 |
| Toyoda, Y | 1 |
| Notsu, Y | 1 |
| Kohno, S | 1 |
| Hung, CR | 1 |
| Wang, PS | 1 |
| Schoch, C | 1 |
| Kalia, N | 1 |
| Brown, NJ | 1 |
| Wood, RF | 1 |
| Pockley, AG | 1 |
| Berger, G | 1 |
| Berger, R | 1 |
| Goldberg, A | 1 |
| Tsumuro, T | 1 |
| Alejandra Hossen, M | 1 |
| Kishi, Y | 1 |
| Fujii, Y | 1 |
| Tsunematsu, M | 1 |
| Yamaji, T | 1 |
| Kozutsumi, D | 1 |
| Murakami, R | 1 |
| Kimura, S | 1 |
| Kino, K | 1 |
| Sanchis-Merino, ME | 1 |
| Montero, JA | 1 |
| Ruiz-Moreno, JM | 1 |
| Rodriguez, AE | 1 |
| Pastor, S | 1 |
| Santone, DJ | 1 |
| Shahani, R | 1 |
| Rubin, BB | 1 |
| Romaschin, AD | 1 |
| Lindsay, TF | 1 |
| Werner-Klein, M | 1 |
| Göggel, R | 1 |
| Westhof, A | 1 |
| Erb, KJ | 1 |
| DeShazo, RD | 1 |
| Levinson, AI | 1 |
| Dvorak, HF | 1 |
| Ufkes, JG | 1 |
| Ottenhof, M | 1 |
| Nagai, H | 2 |
| Iwama, T | 1 |
| Mori, H | 1 |
| Nishida, H | 1 |
| Takatsu, K | 1 |
| Iikura, Y | 1 |
| Kovarik, J | 1 |
| Kuntz, L | 1 |
| Ryffel, B | 1 |
| Borel, JF | 1 |
| Kyle, DE | 1 |
| Milhous, WK | 1 |
| Rossan, RN | 1 |
| Zahavi, I | 1 |
| Weizen, T | 1 |
| Marcus, H | 1 |
| Karmeli, F | 4 |
| Dinari, G | 1 |
| Stalnikowicz, R | 1 |
| Rachmilewitz, D | 3 |
| Okon, E | 2 |
| Ueno, M | 1 |
| Inagaki, N | 1 |
| Koda, A | 1 |
| Matsushita, N | 1 |
| Hizue, M | 1 |
| Aritake, K | 1 |
| Hayashi, K | 1 |
| Takada, A | 1 |
| Mitsui, K | 1 |
| Hayashi, M | 1 |
| Hirotsu, I | 1 |
| Kimura, Y | 1 |
| Tani, T | 1 |
| Nakajima, H | 1 |
| Vural, KM | 1 |
| Liao, H | 1 |
| Oz, MC | 1 |
| Pinsky, DJ | 1 |
| Sugimoto, Y | 1 |
| Kawamoto, E | 1 |
| Chen, Z | 1 |
| Vogel, F | 1 |
| Togashi, Y | 1 |
| Umeuchi, H | 1 |
| Okano, K | 1 |
| Ando, N | 1 |
| Yoshizawa, Y | 1 |
| Honda, T | 1 |
| Kawamura, K | 1 |
| Endoh, T | 1 |
| Utsumi, J | 1 |
| Kamei, J | 1 |
| Tanaka, T | 1 |
| Nagase, H | 1 |
| Eliakim, R | 1 |
| Tarayre, JP | 1 |
| Aliaga, M | 1 |
| Barbara, M | 1 |
| Tisseyre, N | 1 |
| Vieu, S | 1 |
| Tisne-Versailles, J | 1 |
| Cao, HM | 1 |
| Pan, XQ | 1 |
| Walker, M | 1 |
| Harley, R | 1 |
| LeRoy, EC | 1 |
1 review available for ketotifen and Disease Models, Animal
| Article | Year |
|---|---|
Posttraumatic elbow joint contractures: defining pathologic capsular mechanisms and potential future treatment paradigms.
Topics: Animals; Contracture; Disease Models, Animal; Elbow Injuries; Elbow Joint; Humans; Joint Capsule; Ke | 2013 |
48 other studies available for ketotifen and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
A new zinc chelator, IPZ-010 ameliorates postoperative ileus.
Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Antigens, CD; Antigens, Differentiation, | 2020 |
Reduction of arthrofibrosis utilizing a collagen membrane drug-eluting scaffold with celecoxib and subcutaneous injections with ketotifen.
Topics: Animals; Celecoxib; Contracture; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Drug Delivery | 2020 |
Transcriptional Profiling Confirms the Therapeutic Effects of Mast Cell Stabilization in a Dengue Disease Model.
Topics: Animals; Anti-Allergic Agents; Dengue; Dengue Virus; Disease Models, Animal; Gene Expression Profili | 2017 |
Genetic and Pharmacological Dissection of the Role of Spleen Tyrosine Kinase (Syk) in Intestinal Inflammation and Immune Dysfunction in Inflammatory Bowel Diseases.
Topics: Adaptor Proteins, Signal Transducing; Adult; Animals; Antipruritics; Colitis; Cytokines; Disease Mod | 2017 |
Comparison of the efficacy of KOB03, ketotifen, and montelukast in an experimental mouse model of allergic rhinitis.
Topics: Acetates; Animals; Anti-Allergic Agents; Antigens; Cyclopropanes; Cytokines; Disease Models, Animal; | 2013 |
Involvement of chymase in allergic conjunctivitis of guinea pigs.
Topics: Allergens; Animals; Chymases; Conjunctivitis, Allergic; Disease Models, Animal; Enzyme Inhibitors; G | 2013 |
Mast cell stabilization alleviates acute lung injury after orthotopic autologous liver transplantation in rats by downregulating inflammation.
Topics: Acute Lung Injury; Animals; Cromolyn Sodium; Disease Models, Animal; Down-Regulation; Inflammation; | 2013 |
[Effects of antihistamine treatment on immune function in rats with experimental hepatitis].
Topics: Animals; Ascorbic Acid; Disease Models, Animal; Hepatitis; Histamine Antagonists; Interferon-gamma; | 2013 |
The role of ketotifen in the prevention of testicular damage in rats with experimental unilateral undescended testes.
Topics: Animals; Animals, Newborn; Cell Proliferation; Cryptorchidism; Disease Models, Animal; Ketotifen; Ma | 2014 |
C-kit is important for SOD1(G93A) mouse survival independent of mast cells.
Topics: Action Potentials; Age Factors; Amyotrophic Lateral Sclerosis; Animals; Cell Survival; Disease Model | 2015 |
Cromoglycate, not ketotifen, ameliorated the injured effect of warm ischemia/reperfusion in rat liver: role of mast cell degranulation, oxidative stress, proinflammatory cytokine, and inducible nitric oxide synthase.
Topics: Animals; Biomarkers; Cell Degranulation; Cromolyn Sodium; Cytokines; Cytoprotection; Disease Models, | 2015 |
Prophylaxis with ketotifen in rats with portal hypertension: involvement of mast cell and eicosanoids.
Topics: Animals; Anti-Inflammatory Agents; Cell Movement; Chymases; Disease Models, Animal; Eicosanoids; Hyp | 2008 |
Effect of histamine H4 receptor antagonist on allergic rhinitis in mice.
Topics: Administration, Intranasal; Administration, Oral; Animals; Disease Models, Animal; Female; Histamine | 2009 |
Cyclosporine A eye drops inhibit the early-phase reaction in a type-I allergic conjunctivitis model in mice.
Topics: Administration, Topical; Ambrosia; Animals; Anti-Allergic Agents; Betamethasone; Capillary Permeabil | 2009 |
The mast cell stabilizer ketotifen fumarate lessens contracture severity and myofibroblast hyperplasia: a study of a rabbit model of posttraumatic joint contractures.
Topics: Animals; Anti-Inflammatory Agents; Contracture; Disease Models, Animal; Fibroblasts; Hyperplasia; Im | 2010 |
Evidence for the role of mast cells in colon-bladder cross organ sensitization.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Female; Ketotifen; Mast Cells; Membrane Transport M | 2013 |
The role of platelet activating factor and the efficacy of apafant ophthalmic solution in experimental allergic conjunctivitis.
Topics: Animals; Antigens; Azepines; Capillary Permeability; Conjunctivitis, Allergic; Disease Models, Anima | 2003 |
[Effect of mast cell activation on microcirculation of intestinal mucosa in inflamed small intestine of the rat].
Topics: Animals; Blood Flow Velocity; Crohn Disease; Disease Models, Animal; Histamine H1 Antagonists; Hista | 1998 |
Effects of nonsteroidal anti-inflammatory drugs on experimental allergic conjunctivitis in Guinea pigs.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens; Benzophenones; | 2003 |
Role of histamine and acid back-diffusion in modulation of gastric microvascular permeability and hemorrhagic ulcers in Salmonella typhimurium-infected rats.
Topics: Amine Oxidase (Copper-Containing); Animals; Capillary Permeability; Diphenhydramine; Disease Models, | 2004 |
Effect of ketotifen fumarate, olopatadine, and levocabastine on ocular active anaphylaxis in the guinea pig and ocular immediate hypersensitivity in the albino rat.
Topics: Anaphylaxis; Animals; Capillary Permeability; Conjunctivitis, Allergic; Dibenzoxepins; Disease Model | 2005 |
Ketotifen abrogates local and systemic consequences of rat intestinal ischemia-reperfusion injury.
Topics: Administration, Oral; Animals; Blood Pressure; Disease Models, Animal; Disease Progression; Heart Ra | 2005 |
Ketotifen induced inhibition of histamine release in a non-IgE model of middle ear effusion.
Topics: Animals; Cell Degranulation; Disease Models, Animal; Histamine H1 Antagonists; Histamine Release; Ke | 2006 |
Nasal congestion model in Brown Norway rats and the effects of some H1-antagonists.
Topics: Animals; Chlorpheniramine; Dibenzazepines; Disease Models, Animal; Histamine; Histamine H1 Antagonis | 2006 |
Establishment of an allergic rhinitis model in mice for the evaluation of nasal symptoms.
Topics: Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Antigens; Cryptomeria; Dexamethasone; Disea | 2007 |
Comparative efficacy of topical antihistamines in an animal model of early phase allergic conjunctivitis.
Topics: Animals; Anti-Allergic Agents; Benzimidazoles; Coloring Agents; Conjunctivitis, Allergic; Dibenzoxep | 2008 |
Mast cell stabilization improves cardiac contractile function following hemorrhagic shock and resuscitation.
Topics: Animals; beta-N-Acetylhexosaminidases; Blood Pressure; Cell Degranulation; Cromolyn Sodium; Disease | 2008 |
Development and characterisation of a novel and rapid lung eosinophil influx model in the rat.
Topics: Alum Compounds; Aminopyridines; Animals; Anti-Inflammatory Agents; Asthma; Benzamides; Bronchoalveol | 2008 |
The late phase skin reaction: paradigm or epiphenomena?
Topics: Adrenal Cortex Hormones; Animals; Arthus Reaction; Chemotaxis, Leukocyte; Dermatitis, Atopic; Diseas | 1983 |
Characterization of various antiallergic agents using a new method for inducing systemic anaphylaxis in the rat.
Topics: Anaphylaxis; Animals; Blood Pressure; Bronchodilator Agents; Chromones; Cromolyn Sodium; Disease Mod | 1984 |
Increase in respiratory resistance after exercise in conscious guinea pigs. As a model for exercise-induced asthma.
Topics: Airway Resistance; Animals; Asthma, Exercise-Induced; Bronchoalveolar Lavage Fluid; Disease Models, | 1995 |
The viable motheaten (mev) mouse--a new model for arthritis.
Topics: Animals; Arthritis, Rheumatoid; Cyclosporine; Dexamethasone; Disease Models, Animal; Foot; Ketotifen | 1994 |
Reversal of Plasmodium falciparum resistance to chloroquine in Panamanian Aotus monkeys.
Topics: Animals; Aotus trivirgatus; Calcium Channel Blockers; Chloroquine; Chlorpromazine; Cyproheptadine; D | 1993 |
Ketotifen is protective against indomethacin-induced intestinal ulceration in the rat.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Disease Models | 1996 |
Effect of colchicine and bisacodyl on rat intestinal transit and nitric oxide synthase activity.
Topics: Animals; Bisacodyl; Colchicine; Disease Models, Animal; Gastrointestinal Agents; Gastrointestinal Tr | 1997 |
Sulphydryl blocker induced small intestinal inflammation in rats: a new model mimicking Crohn's disease.
Topics: Acetophenones; Animals; Antioxidants; Crohn Disease; Cyclic N-Oxides; Disease Models, Animal; Enteri | 1997 |
Antiallergic action of betotastine besilate (TAU-284) in animal models: A comparison with ketotifen.
Topics: Animals; Anti-Allergic Agents; Asthma; Bronchoconstriction; Disease Models, Animal; Eosinophilia; Eo | 1998 |
Pharmacological studies on the novel antiallergic drug HQL-79: I. Antiallergic and antiasthmatic effects in various experimental models.
Topics: Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Antigens; Bronchoconstriction; Capillary Perme | 1998 |
Effects of mast cell membrane stabilizing agents in a rat lung ischemia-reperfusion model.
Topics: Analysis of Variance; Animals; Anti-Asthmatic Agents; Cell Membrane; Cromolyn Sodium; Cyclic GMP; Di | 2000 |
A new model of allergic rhinitis in rats by topical sensitization and evaluation of H(1)-receptor antagonists.
Topics: Allergens; Animals; Anti-Allergic Agents; Astemizole; Chlorpheniramine; Dibenzazepines; Disease Mode | 2000 |
In vivo assessment of villous microcirculation in the rat small intestine in indomethacin-induced inflammation: role of mast-cell stabilizer Ketotifen.
Topics: Animals; Anti-Allergic Agents; Anti-Inflammatory Agents, Non-Steroidal; Arterioles; Blood Flow Veloc | 2000 |
Antipruritic activity of the kappa-opioid receptor agonist, TRK-820.
Topics: Animals; Antipruritics; Chlorpheniramine; Disease Models, Animal; Histamine; Histamine H1 Antagonist | 2002 |
Ketotifen effectively prevents mucosal damage in experimental colitis.
Topics: Acetates; Acetic Acid; Animals; Colitis; Colon; Disease Models, Animal; Intestinal Mucosa; Ketotifen | 1992 |
Model of bronchial allergic inflammation in the brown Norway rat. Pharmacological modulation.
Topics: Albuterol; Animals; Bronchitis; Dexamethasone; Disease Models, Animal; Ketotifen; Male; Ovalbumin; R | 1992 |
Effect of ketotifen on the ultrastructure of the erythrocytic stages of Plasmodium yoelii.
Topics: Animals; Disease Models, Animal; Erythrocytes; Ketotifen; Malaria; Mice; Plasmodium yoelii | 1990 |
Ketotifen prevents skin fibrosis in the tight skin mouse.
Topics: Animals; Disease Models, Animal; Fibrosis; Ketotifen; Mast Cells; Mice; Mice, Inbred C57BL; Sclerode | 1990 |