ketotifen has been researched along with Colitis in 8 studies
Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
ketotifen : An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.
Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of the present study is to clarify the relative importance of mast cells in the progression of acetic acid-induced colitis in mice." | 7.69 | Evaluation of the role of mast cells in the progression of acetic acid-induced colitis in mice. ( Eto, T; Higa, A; Ishikawa, N; Nawa, Y, 1996) |
| "The effects of ketotifen, a 'mast cell stabiliser,' on two models of experimental colitis were examined." | 7.68 | Ketotifen effectively prevents mucosal damage in experimental colitis. ( Eliakim, R; Karmeli, F; Okon, E; Rachmilewitz, D, 1992) |
| "Ketotifen pretreatment significantly decreased the macroscopic damage and the increase in colonic weight." | 5.29 | Ketotifen ameliorates capsaicin-augmented acetic acid-induced colitis. ( Eliakim, R; Karmeli, F; Okon, E; Rachmilewitz, D, 1995) |
| " The aim of the present study is to clarify the relative importance of mast cells in the progression of acetic acid-induced colitis in mice." | 3.69 | Evaluation of the role of mast cells in the progression of acetic acid-induced colitis in mice. ( Eto, T; Higa, A; Ishikawa, N; Nawa, Y, 1996) |
| "The effects of ketotifen, a 'mast cell stabiliser,' on two models of experimental colitis were examined." | 3.68 | Ketotifen effectively prevents mucosal damage in experimental colitis. ( Eliakim, R; Karmeli, F; Okon, E; Rachmilewitz, D, 1992) |
| "Colitis was induced by administering mice with dextran sulfate sodium (DSS), in drinking water, or 2,4,6-trinitrobenzene sulfonic acid (TNBS), by intrarectal enema." | 1.46 | Genetic and Pharmacological Dissection of the Role of Spleen Tyrosine Kinase (Syk) in Intestinal Inflammation and Immune Dysfunction in Inflammatory Bowel Diseases. ( Baldelli, F; Biagioli, M; Carino, A; Cipriani, S; Costantino, G; Distrutti, E; Donini, A; Fiorucci, C; Fiorucci, S; Graziosi, L; Marchianò, S; Mencarelli, A, 2017) |
| "A rare association between autism and microscopic eosinophilic colitis in 2 children is reported through retrospective chart review." | 1.36 | Childhood autism and eosinophilic colitis. ( Chen, B; El-Matary, W; Girgis, S, 2010) |
| "Colitis was induced by 4% DSS in drinking water, in rats pretreated with L-NAME or aminoguanidine." | 1.34 | Modulatory effect of nitric oxide on mast cells during induction of dextran sulfate sodium colitis. ( Guarner, F; Malagelada, JR; Medina, C; Mourelle, M; Salas, A; Videla, S; Vilaseca, J, 2007) |
| "Ketotifen pretreatment significantly decreased the macroscopic damage and the increase in colonic weight." | 1.29 | Ketotifen ameliorates capsaicin-augmented acetic acid-induced colitis. ( Eliakim, R; Karmeli, F; Okon, E; Rachmilewitz, D, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Biagioli, M | 1 |
| Mencarelli, A | 1 |
| Carino, A | 1 |
| Cipriani, S | 1 |
| Marchianò, S | 1 |
| Fiorucci, C | 1 |
| Donini, A | 1 |
| Graziosi, L | 1 |
| Baldelli, F | 1 |
| Distrutti, E | 1 |
| Costantino, G | 1 |
| Fiorucci, S | 1 |
| Chen, B | 1 |
| Girgis, S | 1 |
| El-Matary, W | 1 |
| Fitzgerald, JJ | 1 |
| Ustinova, E | 1 |
| Koronowski, KB | 1 |
| de Groat, WC | 1 |
| Pezzone, MA | 1 |
| Videla, S | 1 |
| Vilaseca, J | 1 |
| Medina, C | 1 |
| Mourelle, M | 1 |
| Guarner, F | 1 |
| Salas, A | 1 |
| Malagelada, JR | 1 |
| Eliakim, R | 2 |
| Karmeli, F | 2 |
| Okon, E | 2 |
| Rachmilewitz, D | 2 |
| Higa, A | 1 |
| Ishikawa, N | 1 |
| Eto, T | 1 |
| Nawa, Y | 1 |
| Katsinelos, P | 1 |
| Pilpilidis, I | 1 |
| Xiarchos, P | 1 |
| Christodoulou, K | 1 |
| Papagiannis, A | 1 |
| Tsolkas, P | 1 |
| Capelidis, P | 1 |
| Vasiliadis, I | 1 |
8 other studies available for ketotifen and Colitis
| Article | Year |
|---|---|
Genetic and Pharmacological Dissection of the Role of Spleen Tyrosine Kinase (Syk) in Intestinal Inflammation and Immune Dysfunction in Inflammatory Bowel Diseases.
Topics: Adaptor Proteins, Signal Transducing; Adult; Animals; Antipruritics; Colitis; Cytokines; Disease Mod | 2017 |
Childhood autism and eosinophilic colitis.
Topics: Autistic Disorder; Child; Colitis; Diagnosis, Differential; Eosinophilia; Histamine H1 Antagonists; | 2010 |
Evidence for the role of mast cells in colon-bladder cross organ sensitization.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Female; Ketotifen; Mast Cells; Membrane Transport M | 2013 |
Modulatory effect of nitric oxide on mast cells during induction of dextran sulfate sodium colitis.
Topics: Animals; Colitis; Dextran Sulfate; Guanidines; Intestinal Mucosa; Ketotifen; Male; Mast Cells; NG-Ni | 2007 |
Ketotifen ameliorates capsaicin-augmented acetic acid-induced colitis.
Topics: Acetates; Acetic Acid; Amino Acid Oxidoreductases; Animals; Capsaicin; Colitis; Colon; Intestinal Mu | 1995 |
Evaluation of the role of mast cells in the progression of acetic acid-induced colitis in mice.
Topics: Acetic Acid; Animals; Colitis; Intestinal Mucosa; Ketotifen; Male; Mast Cells; Mice; Mice, Inbred St | 1996 |
Oral administration of ketotifen in a patient with eosinophilic colitis and severe osteoporosis.
Topics: Administration, Oral; Aged; Anti-Allergic Agents; Colitis; Eosinophilia; Female; Humans; Ketotifen; | 2002 |
Ketotifen effectively prevents mucosal damage in experimental colitis.
Topics: Acetates; Acetic Acid; Animals; Colitis; Colon; Disease Models, Animal; Intestinal Mucosa; Ketotifen | 1992 |