ketotifen has been researched along with Colitis, Mucous in 8 studies
Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
ketotifen : An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the study was to investigate the clinical efficacy and safety of ketotifen for the treatment of irritable bowel syndrome with diarrhea (IBS-D)." | 9.34 | Clinical efficacy and safety of ketotifen in treating irritable bowel syndrome with diarrhea. ( Gu, W; Wang, J; Wang, X; Wang, Y; Yang, J; Zhou, H, 2020) |
| "The aim of the study was to investigate the clinical efficacy and safety of ketotifen for the treatment of irritable bowel syndrome with diarrhea (IBS-D)." | 5.34 | Clinical efficacy and safety of ketotifen in treating irritable bowel syndrome with diarrhea. ( Gu, W; Wang, J; Wang, X; Wang, Y; Yang, J; Zhou, H, 2020) |
| "The therapeutic potential of long-term ketotifen in irritable bowel syndrome and postoperative ileus is currently under investigation." | 3.79 | Word of caution before implementing ketotifen for gastrointestinal transit improvement. ( de Haan, JJ; Reisinger, KW; Schreinemacher, MH, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, H | 1 |
| Zhang, W | 1 |
| Ma, F | 1 |
| Zhang, X | 1 |
| Wang, Y | 2 |
| Wang, J | 2 |
| Zhou, H | 1 |
| Gu, W | 1 |
| Wang, X | 1 |
| Yang, J | 1 |
| Reisinger, KW | 1 |
| de Haan, JJ | 1 |
| Schreinemacher, MH | 1 |
| Klooker, TK | 1 |
| Braak, B | 1 |
| Koopman, KE | 1 |
| Welting, O | 1 |
| Wouters, MM | 1 |
| van der Heide, S | 1 |
| Schemann, M | 1 |
| Bischoff, SC | 1 |
| van den Wijngaard, RM | 2 |
| Boeckxstaens, GE | 2 |
| O'Sullivan, M | 1 |
| Ford, AC | 1 |
| Talley, NJ | 1 |
| van Diest, SA | 1 |
| Stanisor, OI | 1 |
| de Jonge, WJ | 1 |
| Sebastián Domingo, JJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Double-blind, Placebo-controlled, Cross-over Trial of Ketotifen in Children and Adolescents With Functional Dyspepsia in Association With Duodenal Eosinophilia[NCT02484248] | Phase 3 | 40 participants (Anticipated) | Interventional | 2015-08-31 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for ketotifen and Colitis, Mucous
| Article | Year |
|---|---|
IBS in 2010: advances in pathophysiology, diagnosis and treatment.
Topics: Central Nervous System; Colonoscopy; Gastrointestinal Agents; Humans; Intestinal Diseases; Irritable | 2011 |
2 trials available for ketotifen and Colitis, Mucous
| Article | Year |
|---|---|
Clinical efficacy and safety of ketotifen in treating irritable bowel syndrome with diarrhea.
Topics: Adult; Diarrhea; Female; Gastrointestinal Agents; Humans; Intestinal Mucosa; Irritable Bowel Syndrom | 2020 |
The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome.
Topics: Adult; Aged; Cell Count; Double-Blind Method; Elasticity; Female; Histamine H1 Antagonists; Histamin | 2010 |
5 other studies available for ketotifen and Colitis, Mucous
| Article | Year |
|---|---|
Abdominal Massage Improves the Symptoms of Irritable Bowel Syndrome by Regulating Mast Cells via the Trypase-PAR2-PKC
Topics: Animals; Humans; Irritable Bowel Syndrome; Ketotifen; Male; Massage; Mast Cells; Protein Kinase C-ep | 2022 |
Word of caution before implementing ketotifen for gastrointestinal transit improvement.
Topics: Animals; Dose-Response Relationship, Drug; Gastric Emptying; Gastrointestinal Transit; Ileus; Irrita | 2013 |
Therapeutic potential of ketotifen in irritable bowel syndrome (IBS) may involve changes in mast cells at sites beyond the rectum.
Topics: Histamine H1 Antagonists; Humans; Intestines; Irritable Bowel Syndrome; Ketotifen; Mast Cells | 2011 |
Visceral hypersensitivity in IBS: from bench to bedside.
Topics: Abdominal Pain; Animals; Histamine H1 Antagonists; Humans; Hypersensitivity; Irritable Bowel Syndrom | 2011 |
[The irritable bowel syndrome, should not be considered a functional disorder?].
Topics: Abdominal Pain; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Translocation; Causality | 2013 |