ketotifen has been researched along with Cirrhosis in 4 studies
Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
ketotifen : An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Oral treatment with ketotifen, an inhibitor of mast cell degranulation, at a dose comparable to that recommended for man, was associated with a decrease in both mast cell degranulation and in skin fibrosis, suggesting the potential for its use in human scleroderma." | 7.68 | Ketotifen prevents skin fibrosis in the tight skin mouse. ( Harley, R; LeRoy, EC; Walker, M, 1990) |
| "Treatment with ketotifen decreased tissue hydroxyproline levels, histological damage, and the stenosis index." | 5.32 | Ketotifen ameliorates development of fibrosis in alkali burns of the esophagus. ( Karaoglu, AO; Ozutemiz, O; Tuncyurek, M; Yenisey, C; Yukselen, V, 2004) |
| " Oral treatment with ketotifen, an inhibitor of mast cell degranulation, at a dose comparable to that recommended for man, was associated with a decrease in both mast cell degranulation and in skin fibrosis, suggesting the potential for its use in human scleroderma." | 3.68 | Ketotifen prevents skin fibrosis in the tight skin mouse. ( Harley, R; LeRoy, EC; Walker, M, 1990) |
| "Treatment with ketotifen decreased tissue hydroxyproline levels, histological damage, and the stenosis index." | 1.32 | Ketotifen ameliorates development of fibrosis in alkali burns of the esophagus. ( Karaoglu, AO; Ozutemiz, O; Tuncyurek, M; Yenisey, C; Yukselen, V, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Willems, M | 1 |
| Seβenhausen, P | 1 |
| Gies, I | 1 |
| Vloeberghs, V | 1 |
| Tournaye, H | 1 |
| Van Saen, D | 1 |
| Goossens, E | 1 |
| Monument, MJ | 1 |
| Hart, DA | 1 |
| Befus, AD | 1 |
| Salo, PT | 1 |
| Zhang, M | 1 |
| Hildebrand, KA | 1 |
| Yukselen, V | 1 |
| Karaoglu, AO | 1 |
| Ozutemiz, O | 1 |
| Yenisey, C | 1 |
| Tuncyurek, M | 1 |
| Walker, M | 1 |
| Harley, R | 1 |
| LeRoy, EC | 1 |
4 other studies available for ketotifen and Cirrhosis
| Article | Year |
|---|---|
Intratesticular xenografting of Klinefelter pre-pubertal testis tissue as potential model to study testicular fibrosis.
Topics: Animals; Female; Fibrosis; Humans; Ketotifen; Klinefelter Syndrome; Longitudinal Studies; Male; Mice | 2022 |
The mast cell stabilizer ketotifen reduces joint capsule fibrosis in a rabbit model of post-traumatic joint contractures.
Topics: Actins; Animals; Anti-Allergic Agents; Collagen Type I; Collagen Type III; Contracture; Fibrosis; Hi | 2012 |
Ketotifen ameliorates development of fibrosis in alkali burns of the esophagus.
Topics: Animals; Burns, Chemical; Esophageal Stenosis; Esophagus; Fibrosis; Histamine H1 Antagonists; Ketoti | 2004 |
Ketotifen prevents skin fibrosis in the tight skin mouse.
Topics: Animals; Disease Models, Animal; Fibrosis; Ketotifen; Mast Cells; Mice; Mice, Inbred C57BL; Sclerode | 1990 |