ketotifen has been researched along with Chronic Illness in 26 studies
Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
ketotifen : An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The efficacy of Ketotifen was examined in the treatment of 113 infants between 6 and 36 months of age presenting with a history of cough and/or wheeze in a multicentre randomized placebo-controlled double-blind study." | 9.07 | A multicentre randomized placebo-controlled double-blind study on the efficacy of Ketotifen in infants with chronic cough or wheeze. ( Gibbeson, M; Harris, M; Harth, SC; Loh, RK; McKay, KO; Mellis, CM; Rhodes, L; Robertson, IF; Thong, YH; van Asperen, PP, 1992) |
| "Ketotifen, an orally active, prophylactic anti-asthmatic drug, was compared with placebo in a double-blind, three-month parallel-group trial in 20 children." | 9.05 | Ketotifen: a new drug for prophylaxis of asthma in children. ( Becker, AB; Gillespie, CA; Luciuk, GH; Simons, FE, 1982) |
| "A role for histamine in the pathogenesis of uremic pruritus was investigated in maintenance hemodialysis patients." | 7.68 | Elevated plasma histamine in chronic uremia. Effects of ketotifen on pruritus. ( Besarab, A; Burke, JF; Francos, GC; Gittlen, SD; Goyal, S; Kauh, YC; Schulman, ES, 1991) |
| "21 patients suffering from chronic urticaria were treated with Ketotifen (2 X 1 mg/d) for 4 weeks." | 7.67 | [Ketotifen treatment of chronic urticaria. An open study of therapeutically difficult courses]. ( Lässig, W; Taube, KM; Wozniak, KD, 1985) |
| "Ketotifen treatment provided significant relief of symptoms." | 6.70 | Levothyroxine versus ketotifen in the treatment of patients with chronic urticaria and thyroid autoimmunity. ( Akar, A; Calişkaner, Z; Karaayvaz, M; Ozangüç, N; Oztürk, S; Turan, M, 2002) |
| "Ketotifen is an anti-H-1 antihistamine with MC-stabilizing properties." | 5.29 | Ketotifen therapy in chronic graft-versus-host disease (cGVHD): effect on mast cells and fibroblasts. ( Levi-Schaffer, F; Nagler, A; Segal, V; Slavin, S, 1995) |
| "The efficacy of Ketotifen was examined in the treatment of 113 infants between 6 and 36 months of age presenting with a history of cough and/or wheeze in a multicentre randomized placebo-controlled double-blind study." | 5.07 | A multicentre randomized placebo-controlled double-blind study on the efficacy of Ketotifen in infants with chronic cough or wheeze. ( Gibbeson, M; Harris, M; Harth, SC; Loh, RK; McKay, KO; Mellis, CM; Rhodes, L; Robertson, IF; Thong, YH; van Asperen, PP, 1992) |
| "Ketotifen, an orally active, prophylactic anti-asthmatic drug, was compared with placebo in a double-blind, three-month parallel-group trial in 20 children." | 5.05 | Ketotifen: a new drug for prophylaxis of asthma in children. ( Becker, AB; Gillespie, CA; Luciuk, GH; Simons, FE, 1982) |
| "Using population-based, health care administrative data, children with possible asthma were identified as having one or more physician visits or hospitalizations for asthma or bronchitis diagnoses from January 1995 to December 1995, or, in the absence of asthma-like diagnoses, one or more prescriptions for asthma prophylaxis drugs or ketotifen concomitant with a beta-agonist, or two or more prescriptions for beta-agonists." | 3.72 | Identifying children with persistent asthma from health care administrative records. ( Becker, AB; Kozyrskyj, AL; Mustard, CA, 2004) |
| "A study was made of the effect of ketotifen on the concentration of leukotriene B4, prostacyclin and thromboxane A2 in the liquid of bronchoalveolar lavage and on external respiration and cellular immunity during 4 weeks of the treatment of patients with infection-dependent bronchial asthma and chronic obstructive bronchitis." | 3.68 | [Effect of ketotifen on the eicosanoid system, immunoreactivity and bronchial patency in patients with obstructive pulmonary diseases]. ( Blazhko, VI; Bondar', TN; Efimov, VV; Liashenko, MM; Voeĭkova, LS, 1991) |
| "A role for histamine in the pathogenesis of uremic pruritus was investigated in maintenance hemodialysis patients." | 3.68 | Elevated plasma histamine in chronic uremia. Effects of ketotifen on pruritus. ( Besarab, A; Burke, JF; Francos, GC; Gittlen, SD; Goyal, S; Kauh, YC; Schulman, ES, 1991) |
| "To treat children suffering from the nephrotic syndrome, use was made of the membrano-stabilizing agents: zaditen that also has an antiallergic action; dimephosphon, a membrano-stabilizer and immunomodulator." | 3.68 | [The first experience of using membranotropic agents in the treatment of the nephrotic syndrome]. ( Ignatova, MS; Katysheva, OV; Kopyleva, SD; Moskaleva, ES, 1991) |
| "21 patients suffering from chronic urticaria were treated with Ketotifen (2 X 1 mg/d) for 4 weeks." | 3.67 | [Ketotifen treatment of chronic urticaria. An open study of therapeutically difficult courses]. ( Lässig, W; Taube, KM; Wozniak, KD, 1985) |
| "Ketotifen treatment provided significant relief of symptoms." | 2.70 | Levothyroxine versus ketotifen in the treatment of patients with chronic urticaria and thyroid autoimmunity. ( Akar, A; Calişkaner, Z; Karaayvaz, M; Ozangüç, N; Oztürk, S; Turan, M, 2002) |
| "Eosinophilic cystitis is rare in children." | 2.41 | Eosinophilic cystitis. ( de Jong, TP; Nikkels, PG; Verhagen, PC, 2001) |
| "Atherosclerosis was produced in apolipoprotein E-deficient (Apoe(-/-)) mice with a Western diet." | 1.43 | Allergic lung inflammation promotes atherosclerosis in apolipoprotein E-deficient mice. ( Cheng, X; Fernandes, C; Huang, X; Levy, B; Liao, M; Libby, P; Liu, CL; Santos, MM; Shi, GP; Sukhova, GK; Wang, Y; Wu, G; Yang, C; Zhang, JY, 2016) |
| "Ketotifen is an anti-H-1 antihistamine with MC-stabilizing properties." | 1.29 | Ketotifen therapy in chronic graft-versus-host disease (cGVHD): effect on mast cells and fibroblasts. ( Levi-Schaffer, F; Nagler, A; Segal, V; Slavin, S, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (42.31) | 18.7374 |
| 1990's | 8 (30.77) | 18.2507 |
| 2000's | 3 (11.54) | 29.6817 |
| 2010's | 4 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sokol, KC | 1 |
| Amar, NK | 1 |
| Starkey, J | 1 |
| Grant, JA | 1 |
| Singh, S | 1 |
| Arthur, S | 1 |
| Talukder, J | 1 |
| Palaniappan, B | 1 |
| Coon, S | 1 |
| Sundaram, U | 1 |
| Liu, CL | 1 |
| Wang, Y | 1 |
| Liao, M | 1 |
| Santos, MM | 1 |
| Fernandes, C | 1 |
| Sukhova, GK | 1 |
| Zhang, JY | 1 |
| Cheng, X | 1 |
| Yang, C | 1 |
| Huang, X | 1 |
| Levy, B | 1 |
| Libby, P | 1 |
| Wu, G | 1 |
| Shi, GP | 1 |
| Smets, K | 1 |
| Werbrouck, J | 1 |
| Goossens, A | 1 |
| Gilissen, L | 1 |
| Karaayvaz, M | 1 |
| Calişkaner, Z | 1 |
| Turan, M | 1 |
| Akar, A | 1 |
| Oztürk, S | 1 |
| Ozangüç, N | 1 |
| Kozyrskyj, AL | 1 |
| Mustard, CA | 1 |
| Becker, AB | 2 |
| Simons, FE | 1 |
| Luciuk, GH | 1 |
| Gillespie, CA | 1 |
| Split, W | 1 |
| Szmidt, M | 1 |
| Prusiński, A | 1 |
| Rozniecki, J | 1 |
| Karaulov, AV | 1 |
| Sil'vestrov, VP | 1 |
| Martsinovskiĭ, VIu | 1 |
| Bulycheva, NA | 1 |
| Likov, VF | 1 |
| Petrov, D | 1 |
| Stoeva, N | 1 |
| Camarasa, JG | 1 |
| Moragas, JM | 1 |
| Nagler, A | 1 |
| Segal, V | 1 |
| Slavin, S | 1 |
| Levi-Schaffer, F | 1 |
| Egan, CA | 1 |
| Rallis, TM | 1 |
| Taşkapan, O | 1 |
| Harmanyeri, Y | 1 |
| Verhagen, PC | 1 |
| Nikkels, PG | 1 |
| de Jong, TP | 1 |
| van Asperen, PP | 1 |
| McKay, KO | 1 |
| Mellis, CM | 1 |
| Loh, RK | 1 |
| Harth, SC | 1 |
| Thong, YH | 1 |
| Harris, M | 1 |
| Robertson, IF | 1 |
| Gibbeson, M | 1 |
| Rhodes, L | 1 |
| Efimov, VV | 1 |
| Blazhko, VI | 1 |
| Liashenko, MM | 1 |
| Voeĭkova, LS | 1 |
| Bondar', TN | 1 |
| Francos, GC | 1 |
| Kauh, YC | 1 |
| Gittlen, SD | 1 |
| Schulman, ES | 1 |
| Besarab, A | 1 |
| Goyal, S | 1 |
| Burke, JF | 1 |
| Ignatova, MS | 1 |
| Moskaleva, ES | 1 |
| Kopyleva, SD | 1 |
| Katysheva, OV | 1 |
| Magnussen, H | 2 |
| Kamide, R | 1 |
| Niimura, M | 1 |
| Ueda, H | 1 |
| Imamura, S | 1 |
| Yamamoto, S | 1 |
| Yoshida, H | 1 |
| Kukita, A | 1 |
| Lipets, ME | 1 |
| Lopatko, VN | 1 |
| Guillot, B | 1 |
| Meynadier, J | 1 |
| Sergeev, IuV | 1 |
| Potekaev, NS | 1 |
| Taube, KM | 1 |
| Wozniak, KD | 1 |
| Lässig, W | 1 |
2 reviews available for ketotifen and Chronic Illness
| Article | Year |
|---|---|
Eosinophilic cystitis.
Topics: Adolescent; Anti-Allergic Agents; Child; Child, Preschool; Chronic Disease; Cystitis; Enuresis; Eosi | 2001 |
[Hypersensitivity of the respiratory tract: determination, occurrence and clinical significance].
Topics: Adrenal Cortex Hormones; Allergens; Asthma; Bronchitis; Chronic Disease; Humans; Ketotifen; Nedocrom | 1990 |
4 trials available for ketotifen and Chronic Illness
| Article | Year |
|---|---|
Levothyroxine versus ketotifen in the treatment of patients with chronic urticaria and thyroid autoimmunity.
Topics: Adult; Anti-Allergic Agents; Autoantibodies; Chronic Disease; Female; Humans; Iodide Peroxidase; Ket | 2002 |
Ketotifen: a new drug for prophylaxis of asthma in children.
Topics: Acute Disease; Asthma; Blood Pressure; Body Weight; Child; Chronic Disease; Clinical Trials as Topic | 1982 |
A multicentre randomized placebo-controlled double-blind study on the efficacy of Ketotifen in infants with chronic cough or wheeze.
Topics: Child, Preschool; Chronic Disease; Cough; Double-Blind Method; Female; Humans; Infant; Ketotifen; Ma | 1992 |
Clinical evaluation of ketotifen for chronic urticaria: multicenter double-blind comparative study with clemastine.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Chronic Disease; Clemastine; Clinical Trials as T | 1989 |
20 other studies available for ketotifen and Chronic Illness
| Article | Year |
|---|---|
Ketotifen in the management of chronic urticaria: resurrection of an old drug.
Topics: Anti-Allergic Agents; Chronic Disease; Humans; Ketotifen; Urticaria | 2013 |
Mast cell regulation of Na-glutamine co-transporters B0AT1 in villus and SN2 in crypt cells during chronic intestinal inflammation.
Topics: Amino Acid Transport Systems, Neutral; Animals; beta-N-Acetylhexosaminidases; Biological Transport; | 2015 |
Allergic lung inflammation promotes atherosclerosis in apolipoprotein E-deficient mice.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Budesonide; Chronic Disease; Disease Progression; Gluco | 2016 |
Sensitization from ketotifen fumarate in eye drops presenting as chronic conjunctivitis.
Topics: Adult; Anti-Allergic Agents; Chronic Disease; Conjunctivitis, Allergic; Female; Humans; Ketotifen; P | 2017 |
Identifying children with persistent asthma from health care administrative records.
Topics: Adolescent; Adrenergic beta-Agonists; Anti-Allergic Agents; Asthma; Bronchitis; Canada; Child; Child | 2004 |
Ketotifen in the treatment of chronic cluster headache.
Topics: Adult; Chronic Disease; Cluster Headache; Drug Administration Schedule; Histamine Release; Humans; K | 1984 |
[Analysis of immunocompetent cell subpopulations in chronic bronchitis patients during the use of different immunomodulating preparations].
Topics: Adjuvants, Immunologic; Adolescent; Adult; B-Lymphocytes; Bronchitis; Chronic Disease; Concanavalin | 1984 |
[Effect of Zaditen in patients with atopic bronchial asthma at Sandanski health resort].
Topics: Adolescent; Adult; Asthma; Bulgaria; Chronic Disease; Climate; Drug Evaluation; Drug Therapy, Combin | 1984 |
[Chronic urticaria. Treatment with ketotifen].
Topics: Administration, Oral; Adolescent; Adult; Aged; Child; Chronic Disease; Female; Humans; Ketotifen; Ma | 1982 |
Ketotifen therapy in chronic graft-versus-host disease (cGVHD): effect on mast cells and fibroblasts.
Topics: 3T3 Cells; Adolescent; Adult; Animals; Cell Division; Child; Child, Preschool; Chronic Disease; Dino | 1995 |
Treatment of chronic urticaria with ketotifen.
Topics: Adult; Chronic Disease; Female; Histamine H1 Antagonists; Humans; Ketotifen; Urticaria | 1997 |
Ketotifen and chronic urticaria.
Topics: Anti-Allergic Agents; Antipruritics; Autoimmune Diseases; Child; Chronic Disease; Histamine H1 Antag | 1998 |
[Effect of ketotifen on the eicosanoid system, immunoreactivity and bronchial patency in patients with obstructive pulmonary diseases].
Topics: Adult; Asthma; Bronchi; Bronchitis; Bronchoalveolar Lavage Fluid; Chronic Disease; Eicosanoids; Epop | 1991 |
Elevated plasma histamine in chronic uremia. Effects of ketotifen on pruritus.
Topics: Chronic Disease; Histamine; Humans; Ketotifen; Mast Cells; Pilot Projects; Pruritus; Renal Dialysis; | 1991 |
[The first experience of using membranotropic agents in the treatment of the nephrotic syndrome].
Topics: Adjuvants, Immunologic; Child; Chronic Disease; Cromolyn Sodium; Drug Evaluation; Drug Therapy, Comb | 1991 |
[The use of zaditen in the combined treatment of allergic skin diseases in children].
Topics: Adolescent; Child; Child, Preschool; Chronic Disease; Combined Modality Therapy; Dermatitis, Atopic; | 1989 |
[Treatment of chronic urticaria with ketotifen].
Topics: Adolescent; Adult; Aged; Child; Chronic Disease; Female; Histamine H1 Antagonists; Humans; Ketotifen | 1986 |
[Clinical effectiveness and prospects for using zaditen (ketotifen) in the therapy of allergic dermatoses].
Topics: Adolescent; Adult; Aged; Chronic Disease; Dermatitis, Atopic; Drug Evaluation; Eczema; Female; Human | 1987 |
[Treatment of chronic bronchial asthma].
Topics: Asthma; Chronic Disease; Cromolyn Sodium; Glucocorticoids; Humans; Ketotifen; Male; Nifedipine; Para | 1985 |
[Ketotifen treatment of chronic urticaria. An open study of therapeutically difficult courses].
Topics: Adolescent; Adult; Child; Chronic Disease; Female; Humans; Ketotifen; Male; Middle Aged; Urticaria | 1985 |