ketotifen has been researched along with Bronchial Spasm in 18 studies
Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
ketotifen : An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.
Bronchial Spasm: Spasmodic contraction of the smooth muscle of the bronchi.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Eight asthmatic patients completed a 12-week, double-blind, placebo controlled study to assess the efficacy of ketotifen, 1 mg twice daily, in the inhibition of bronchoconstriction induced by isocapnic hyperventilation (IH)." | 9.06 | Does regular treatment with ketotifen inhibit bronchoconstriction induced by isocapnic hyperventilation? ( Biggs, BA; Ferguson, RJ; Grant, IW; Rafferty, P; Tweeddale, PM, 1987) |
| "Eighteen children with perennial bronchial asthma with an average age of 9." | 6.66 | The effect of ketotifen on bronchial hyperreactivity in childhood asthma. ( Graff-Lonnevig, V; Hedlin, G, 1985) |
| "Eight asthmatic patients completed a 12-week, double-blind, placebo controlled study to assess the efficacy of ketotifen, 1 mg twice daily, in the inhibition of bronchoconstriction induced by isocapnic hyperventilation (IH)." | 5.06 | Does regular treatment with ketotifen inhibit bronchoconstriction induced by isocapnic hyperventilation? ( Biggs, BA; Ferguson, RJ; Grant, IW; Rafferty, P; Tweeddale, PM, 1987) |
| " Histamine and acetylcholine were used to guinea pigs to establish bronchospasm model." | 3.77 | Phytopharmacological evaluation and anti-asthmatic activity of Ficus religiosa leaves. ( Acharya, N; Acharya, S; Jasani, N; Kapoor, M; Kumar, V, 2011) |
| " Some of them displayed good inhibition of both histamine-induced bronchospasm in the anesthetized guinea pig at 10 micrograms/kg by the intravenous route and of passive cutaneous anaphylaxis in the rat at 10 mg/kg by the oral route." | 3.67 | New antihistaminic theophylline or theobromine derivatives. ( Beranger, S; Désiles, JP; Pascal, JC; Pinhas, H; Poizot, A, 1985) |
| "New 1-(2-pyridinyl)piperazine derivatives were synthesized and tested as inhibitors of the reaginic passive cutaneous anaphylaxis in the rat (PCA), of the histamine-induced bronchospasm in the guinea pig, and of the rat mesenteric mast cell degranulation induced by compound 48/80." | 3.67 | 1-(2-pyridinyl)piperazine derivatives with antianaphylactic, antibronchospastic, and mast cell stabilizing activities. ( Catto, A; Cazzulani, P; Leonardi, A; Motta, G; Nardi, D; Tajana, A, 1987) |
| "The mechanism of action of ketotifen in the prevention of bronchial asthma is discussed, the pathogenesis of the disease itself being taken as a starting point." | 3.67 | Ketotifen: current views on its mechanism of action and their therapeutic implications. ( Craps, LP; Ney, UM, 1984) |
| "Ketotifen, a benzocycloheptathiophene, possesses asthma-prophylactic and antiallergic activities in a number of in vitro and in vivo systems: prevention of cutaneous and lung anaphylaxis in the rat and guinea pig; inhibition of dermal and bronchial antigen challenges in man; inhibition of mediator release from rat mast cells, human basophils, human neutrophils, and human and guinea pig chopped lung; reduction of human neutrophil activation induced by PAF-acether; functional antagonism of mediator effects in the guinea pig; blockade of H1-receptors and prevention and reversal of beta-adrenergic tachyphylaxis in the rat." | 3.67 | Immunologic and therapeutic aspects of ketotifen. ( Craps, LP, 1985) |
| "Ketotifen administered prior to aspirin offered protection against bronchoconstriction in 13 of 14 patients with aspirin-sensitive asthma." | 3.66 | Inhibition by ketotifen of idiosyncratic reactions to aspirin. ( Czerniawska-Mysik, G; Kuklinski, P; Serwonska, M; Szczeklik, A, 1980) |
| "Eighteen children with perennial bronchial asthma with an average age of 9." | 2.66 | The effect of ketotifen on bronchial hyperreactivity in childhood asthma. ( Graff-Lonnevig, V; Hedlin, G, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (94.44) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ross, WJ | 1 |
| Harrison, RG | 1 |
| Jolley, MR | 1 |
| Neville, MC | 1 |
| Todd, A | 1 |
| Verge, JP | 1 |
| Dawson, W | 1 |
| Sweatman, WJ | 1 |
| Pascal, JC | 1 |
| Beranger, S | 1 |
| Pinhas, H | 1 |
| Poizot, A | 1 |
| Désiles, JP | 1 |
| Catto, A | 1 |
| Motta, G | 1 |
| Tajana, A | 1 |
| Cazzulani, P | 1 |
| Nardi, D | 1 |
| Leonardi, A | 1 |
| Kapoor, M | 1 |
| Jasani, N | 1 |
| Acharya, N | 1 |
| Acharya, S | 1 |
| Kumar, V | 1 |
| Szczeklik, A | 2 |
| Czerniawska-Mysik, G | 2 |
| Serwonska, M | 2 |
| Kuklinski, P | 2 |
| Craps, LP | 2 |
| Ney, UM | 1 |
| Fischer, JF | 1 |
| Meister, W | 1 |
| Mohorn, M | 1 |
| Rozniecki, J | 1 |
| Górski, P | 1 |
| Szmidt, M | 1 |
| Grzelewska-Rzymowska, I | 1 |
| Girard, JP | 1 |
| Arnoux, B | 1 |
| Denjean, A | 1 |
| Benveniste, J | 1 |
| Chung, KF | 1 |
| Minette, P | 1 |
| McCusker, M | 1 |
| Barnes, PJ | 1 |
| Rafferty, P | 1 |
| Tweeddale, PM | 1 |
| Ferguson, RJ | 1 |
| Biggs, BA | 1 |
| Grant, IW | 1 |
| Tjwa, MK | 1 |
| Smeets, J | 1 |
| Maesen, F | 1 |
| Tamura, G | 1 |
| Mue, S | 1 |
| Takishima, T | 1 |
| Graff-Lonnevig, V | 1 |
| Hedlin, G | 1 |
| Popa, V | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ketotifen as a Treatment for Vascular Leakage During Dengue Fever (KETODEN)[NCT02673840] | Phase 4 | 110 participants (Anticipated) | Interventional | 2015-03-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 trials available for ketotifen and Bronchial Spasm
| Article | Year |
|---|---|
Ketotifen inhibits the cutaneous but not the airway responses to platelet-activating factor in man.
Topics: Adult; Aerosols; Blood Cell Count; Bronchial Provocation Tests; Bronchial Spasm; Double-Blind Method | 1988 |
Does regular treatment with ketotifen inhibit bronchoconstriction induced by isocapnic hyperventilation?
Topics: Adult; Asthma; Bronchial Spasm; Clinical Trials as Topic; Double-Blind Method; Female; Forced Expira | 1987 |
Ketotifen and methacholine-induced bronchospasm.
Topics: Adolescent; Adult; Bronchial Spasm; Clinical Trials as Topic; Double-Blind Method; Female; Forced Ex | 1986 |
Protective effects of ketotifen on allergen-induced bronchoconstriction and skin weal.
Topics: Adult; Allergens; Bronchial Provocation Tests; Bronchial Spasm; Dermatitis, Contact; Female; Humans; | 1986 |
The effect of ketotifen on bronchial hyperreactivity in childhood asthma.
Topics: Adolescent; Asthma; Bronchial Spasm; Child; Female; Humans; Ketotifen; Male; Methacholine Chloride; | 1985 |
13 other studies available for ketotifen and Bronchial Spasm
| Article | Year |
|---|---|
Antianaphylactic agents. 1. 2-(Acylamino)oxazoles.
Topics: Anaphylaxis; Animals; Bronchial Spasm; Capillary Permeability; Female; Guinea Pigs; Humans; In Vitro | 1979 |
New antihistaminic theophylline or theobromine derivatives.
Topics: Acetylcholine; Animals; Bronchial Spasm; Guinea Pigs; Histamine; Histamine H1 Antagonists; Male; Pas | 1985 |
1-(2-pyridinyl)piperazine derivatives with antianaphylactic, antibronchospastic, and mast cell stabilizing activities.
Topics: Animals; Bronchial Spasm; Female; Guinea Pigs; Histamine; Histamine H1 Antagonists; Humans; Indicato | 1987 |
Phytopharmacological evaluation and anti-asthmatic activity of Ficus religiosa leaves.
Topics: Acetylcholine; Aminophylline; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Asthma; Bronchia | 2011 |
Inhibition by ketotifen of idiosyncratic reactions to aspirin.
Topics: Adult; Aspirin; Asthma; Bronchi; Bronchial Spasm; Drug Hypersensitivity; Female; Histamine H1 Antago | 1980 |
Ketotifen: current views on its mechanism of action and their therapeutic implications.
Topics: Animals; Asthma; Bronchial Spasm; Guinea Pigs; Histamine Release; Humans; In Vitro Techniques; Ketot | 1984 |
[Rational asthma drug therapy].
Topics: Aminophylline; Anti-Bacterial Agents; Asthma; Bronchial Spasm; Cromolyn Sodium; Desensitization, Imm | 1983 |
[Comparative evaluation of the effectiveness of sodium cromoglycate and ketotifen in bronchial asthma and their effect on blood histamine and polymyxin-induced bronchial spasm].
Topics: Asthma; Bronchial Spasm; Cromolyn Sodium; Female; Histamine; Humans; Ketotifen; Male; Polymyxin B | 1983 |
Ketotifen and bronchial hyperreactivity in asthmatic patients.
Topics: Acetylcholine; Adult; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Female; Forced Expirator | 1981 |
Inhibition of idiosyncratic reactions to aspirin by ketotifen.
Topics: Adult; Aspirin; Asthma; Bronchial Spasm; Drug Hypersensitivity; Humans; Ketotifen; Piperidines; Thio | 1980 |
Effect of PAF-acether in non-human primates.
Topics: Airway Resistance; Animals; Asthma; Bronchial Spasm; Constriction, Pathologic; Cromolyn Sodium; Keto | 1988 |
Immunologic and therapeutic aspects of ketotifen.
Topics: Anaphylaxis; Animals; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Heart Rate; Humans; Isop | 1985 |
Clemastine and ketotifen in allergen-induced bronchoconstriction: is the current evidence conflicting?
Topics: Allergens; Bronchial Spasm; Clemastine; Humans; Ketotifen; Pyrrolidines | 1985 |