ketotifen has been researched along with Atopic Hypersensitivity in 24 studies
Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
ketotifen : An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The therapeutic effects of inhaled disodium cromoglycate (DSCG) and orally administered ketotifen were compared in thirty atopic asthmatics aged 15-34 years during a 22-week double-blind parallel group study." | 9.05 | A double-blind comparison of ketotifen and disodium cromoglycate in atopic adult asthmatics. ( Sears, MR, 1983) |
| "The protective effect of ketotifen was examined by an open assessment trial in 261 asthmatics of variable types, a double blind trial comparing ketotifen and inert placebo in 189 asthmatics of extrinsic type including pure atopic asthma and asthma with atopic and infectious components (mixed type or combined type), and a double blind trial comparing ketotifen and disodium cromoglycate (DSCG) by double placebo technique in 132 asthmatics of a pure atopic type." | 9.05 | Clinical evaluation of a new orally active anti-anaphylactic compound: ketotifen (HC 20-511) in Japanese adult asthmatics. ( Kumagai, A; Muranaka, M; Shida, T; Takahashi, T; Tomioka, H, 1980) |
| "Plasma histamine and serum neutrophil chemotactic activity (S-NCA) were measured in ten atopic asthmatic patients on four separate occasions after allergen bronchial provocation testing (BPT)." | 9.05 | Circulating histamine and neutrophil chemotactic activity during allergen-induced asthma: the effect of inhaled antihistamines and anti-allergic compounds. ( Cundell, DR; Davies, RJ; Moodley, I; Morgan, DJ; Sheinman, BD; Smart, W, 1985) |
| "Three hundred seventy-four patients with asthma were entered into a year-long, double-blind, double-placebo controlled study comparing the prophylactic effect of ketotifen (229 patients), theophylline (73 patients), and placebo (72 patients)." | 9.05 | A multicenter trial of the prophylactic effect of ketotifen, theophylline, and placebo in atopic asthma. ( Buckley, CE; Bukantz, SC; Chodosh, S; Cohen, BM; Dobken, JH; Moss, BA; Rappaport, I; Rosenthal, RR; Sheffer, AL; Tinkelman, DG, 1985) |
| "Published pharmacokinetic data on ketotifen are sparse, although it is a commonly used prophylactic agent in various allergic disorders in adults and children." | 6.68 | Ketotifen pharmacokinetics in children with atopic perennial asthma. ( Ludden, TM; McFadyen, ML; Miller, R, 1997) |
| "The therapeutic effects of inhaled disodium cromoglycate (DSCG) and orally administered ketotifen were compared in thirty atopic asthmatics aged 15-34 years during a 22-week double-blind parallel group study." | 5.05 | A double-blind comparison of ketotifen and disodium cromoglycate in atopic adult asthmatics. ( Sears, MR, 1983) |
| "The protective effect of ketotifen was examined by an open assessment trial in 261 asthmatics of variable types, a double blind trial comparing ketotifen and inert placebo in 189 asthmatics of extrinsic type including pure atopic asthma and asthma with atopic and infectious components (mixed type or combined type), and a double blind trial comparing ketotifen and disodium cromoglycate (DSCG) by double placebo technique in 132 asthmatics of a pure atopic type." | 5.05 | Clinical evaluation of a new orally active anti-anaphylactic compound: ketotifen (HC 20-511) in Japanese adult asthmatics. ( Kumagai, A; Muranaka, M; Shida, T; Takahashi, T; Tomioka, H, 1980) |
| "Plasma histamine and serum neutrophil chemotactic activity (S-NCA) were measured in ten atopic asthmatic patients on four separate occasions after allergen bronchial provocation testing (BPT)." | 5.05 | Circulating histamine and neutrophil chemotactic activity during allergen-induced asthma: the effect of inhaled antihistamines and anti-allergic compounds. ( Cundell, DR; Davies, RJ; Moodley, I; Morgan, DJ; Sheinman, BD; Smart, W, 1985) |
| "Three hundred seventy-four patients with asthma were entered into a year-long, double-blind, double-placebo controlled study comparing the prophylactic effect of ketotifen (229 patients), theophylline (73 patients), and placebo (72 patients)." | 5.05 | A multicenter trial of the prophylactic effect of ketotifen, theophylline, and placebo in atopic asthma. ( Buckley, CE; Bukantz, SC; Chodosh, S; Cohen, BM; Dobken, JH; Moss, BA; Rappaport, I; Rosenthal, RR; Sheffer, AL; Tinkelman, DG, 1985) |
| "To treat children suffering from the nephrotic syndrome, use was made of the membrano-stabilizing agents: zaditen that also has an antiallergic action; dimephosphon, a membrano-stabilizer and immunomodulator." | 3.68 | [The first experience of using membranotropic agents in the treatment of the nephrotic syndrome]. ( Ignatova, MS; Katysheva, OV; Kopyleva, SD; Moskaleva, ES, 1991) |
| "Published pharmacokinetic data on ketotifen are sparse, although it is a commonly used prophylactic agent in various allergic disorders in adults and children." | 2.68 | Ketotifen pharmacokinetics in children with atopic perennial asthma. ( Ludden, TM; McFadyen, ML; Miller, R, 1997) |
| " Allergen (Southern Grass Mix) was administered intradermally 2 h after last drug dosage and the surface areas of the immediate wheal-and-flare-reactions were measured 15 min later." | 2.67 | Effect of enalapril on allergen-induced cutaneous hypersensitivity reaction. ( Snyman, JR; Sommers, DK, 1991) |
| "Ketotifen was significantly more potent in the inhibition of both histamine (P less than 0." | 2.65 | A comparison of the in vivo effects of ketotifen, clemastine, chlorpheniramine and sodium cromoglycate on histamine and allergen induced weals in human skin. ( Davies, RJ; Meyrick Thomas, RH; Moodley, I; Phillips, MJ, 1983) |
| "Hexapeptide 95/220 inhibited immediate hypersensitivity reactions such as passive cutaneous anaphylaxis (PCA) and mast cell degranulation in rats, antigen-induced bronchoconstriction in actively sensitized guinea pigs in dose dependent manner like DSCG." | 1.31 | Antiallergic/antiasthmatic effect of novel antiallergic hexapeptide-95/220 in various experimental models. ( Gupta, PP; Khare, SK; Kundu, B; Nath, A; Shukla, M; Singh, R, 2001) |
| "Ketotifen was used as a reference drug." | 1.29 | The effect of a novel thromboxane A2 (TXA2) receptor antagonist (S-1452) on the antigen-induced bronchoconstriction and airway hyperresponsiveness in guinea pigs. ( Arimura, A; Iwama, T; Koda, A; Nagai, H; Sakurai, T; Yoshitake, K, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (54.17) | 18.7374 |
| 1990's | 6 (25.00) | 18.2507 |
| 2000's | 4 (16.67) | 29.6817 |
| 2010's | 1 (4.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Miyagawa, N | 1 |
| Iwasaki, H | 1 |
| Kato, T | 1 |
| Tanaka, M | 1 |
| Shibata, T | 1 |
| Wakitani, K | 1 |
| Yoshihara, S | 1 |
| Ono, M | 1 |
| Yamada, Y | 1 |
| Fukuda, H | 1 |
| Abe, T | 1 |
| Arisaka, O | 1 |
| Pressler, A | 1 |
| Grosber, M | 1 |
| Halle, M | 1 |
| Ring, J | 1 |
| Brockow, K | 1 |
| Seropian, E | 1 |
| Filip, V | 1 |
| Iamandescu, I | 1 |
| Phillips, MJ | 1 |
| Meyrick Thomas, RH | 1 |
| Moodley, I | 2 |
| Davies, RJ | 2 |
| Sears, MR | 1 |
| de Kozak, Y | 1 |
| Sakai, J | 1 |
| Sainte-Laudy, J | 1 |
| Faure, JP | 1 |
| Benveniste, J | 1 |
| Esau, S | 1 |
| del Carpio, J | 1 |
| Martin, JG | 1 |
| Sokolova, TS | 1 |
| Botvin'eva, VV | 1 |
| Zhukovskiĭ, AM | 1 |
| Zakhidov, IuV | 1 |
| Reviakina, VA | 1 |
| Kumagai, A | 1 |
| Tomioka, H | 1 |
| Shida, T | 1 |
| Takahashi, T | 1 |
| Muranaka, M | 1 |
| Warner, JO | 1 |
| Goldsworthy, SJ | 1 |
| Nagai, H | 1 |
| Arimura, A | 1 |
| Yoshitake, K | 1 |
| Iwama, T | 1 |
| Sakurai, T | 1 |
| Koda, A | 1 |
| Ditto, AM | 1 |
| Harris, KE | 1 |
| Krasnick, J | 1 |
| Miller, MA | 1 |
| Patterson, R | 1 |
| McFadyen, ML | 1 |
| Miller, R | 1 |
| Ludden, TM | 1 |
| González Silva, M | 1 |
| Botero Flores, L | 1 |
| Knol, K | 1 |
| Singh, R | 1 |
| Nath, A | 1 |
| Gupta, PP | 1 |
| Shukla, M | 1 |
| Khare, SK | 1 |
| Kundu, B | 1 |
| Snyman, JR | 1 |
| Sommers, DK | 1 |
| Ignatova, MS | 1 |
| Moskaleva, ES | 1 |
| Kopyleva, SD | 1 |
| Katysheva, OV | 1 |
| Wang, SS | 1 |
| Wang, SR | 1 |
| Chiang, BN | 1 |
| Moniaci, D | 1 |
| Mozzati, M | 1 |
| Albera, G | 1 |
| Parabita, SF | 1 |
| Re, G | 1 |
| Morgan, DJ | 1 |
| Cundell, DR | 1 |
| Sheinman, BD | 1 |
| Smart, W | 1 |
| Morris, EC | 1 |
| Tinkelman, DG | 1 |
| Moss, BA | 1 |
| Bukantz, SC | 1 |
| Sheffer, AL | 1 |
| Dobken, JH | 1 |
| Chodosh, S | 1 |
| Cohen, BM | 1 |
| Rosenthal, RR | 1 |
| Rappaport, I | 1 |
| Buckley, CE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Double-blind, Placebo-controlled, Cross-over Trial of Ketotifen in Children and Adolescents With Functional Dyspepsia in Association With Duodenal Eosinophilia[NCT02484248] | Phase 3 | 40 participants (Anticipated) | Interventional | 2015-08-31 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for ketotifen and Atopic Hypersensitivity
| Article | Year |
|---|---|
Ketotifen in childhood allergic disease.
Topics: Aging; Airway Obstruction; Animals; Asthma; Asthma, Exercise-Induced; Body Weight; Bronchial Provoca | 1982 |
Clinical use of antihistamines in infants and children at risk of asthma development.
Topics: Asthma; Cetirizine; Child, Preschool; Clinical Trials as Topic; Histamine H1 Antagonists; Humans; Hy | 2000 |
Pharmacotherapy of allergic disease.
Topics: Adrenal Cortex Hormones; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adult; Aged; Anaphylax | 1987 |
11 trials available for ketotifen and Atopic Hypersensitivity
| Article | Year |
|---|---|
Early intervention with suplatast tosilate for prophylaxis of pediatric atopic asthma: a pilot study.
Topics: Allergens; Animals; Anti-Allergic Agents; Arylsulfonates; Asthma; Chemoprevention; Dermatitis, Atopi | 2009 |
A comparison of the in vivo effects of ketotifen, clemastine, chlorpheniramine and sodium cromoglycate on histamine and allergen induced weals in human skin.
Topics: Allergens; Chlorpheniramine; Clemastine; Clinical Trials as Topic; Cromolyn Sodium; Dose-Response Re | 1983 |
A double-blind comparison of ketotifen and disodium cromoglycate in atopic adult asthmatics.
Topics: Administration, Oral; Adolescent; Adult; Asthma; Clinical Trials as Topic; Cromolyn Sodium; Double-B | 1983 |
A comparison of the effects of ketotifen and clemastine on cutaneous and airway reactivity to histamine and allergen in atopic asthmatic subjects.
Topics: Adult; Airway Resistance; Allergens; Bronchial Provocation Tests; Clemastine; Female; Histamine; Hum | 1984 |
Clinical evaluation of a new orally active anti-anaphylactic compound: ketotifen (HC 20-511) in Japanese adult asthmatics.
Topics: Adult; Anaphylaxis; Asthma; Basophils; Cromolyn Sodium; Double-Blind Method; Humans; Hypersensitivit | 1980 |
Ketotifen in childhood allergic disease.
Topics: Aging; Airway Obstruction; Animals; Asthma; Asthma, Exercise-Induced; Body Weight; Bronchial Provoca | 1982 |
Ketotifen pharmacokinetics in children with atopic perennial asthma.
Topics: Anti-Allergic Agents; Asthma; Child; Child, Preschool; Double-Blind Method; Humans; Hypersensitivity | 1997 |
Effect of enalapril on allergen-induced cutaneous hypersensitivity reaction.
Topics: Administration, Oral; Adult; Allergens; Enalapril; Female; Humans; Hypersensitivity, Immediate; Indo | 1991 |
Suppressive effects of oral ketotifen on skin responses to histamine, codeine, and allergen skin tests.
Topics: Administration, Oral; Adult; Allergens; Codeine; Dose-Response Relationship, Immunologic; Erythema; | 1985 |
Circulating histamine and neutrophil chemotactic activity during allergen-induced asthma: the effect of inhaled antihistamines and anti-allergic compounds.
Topics: Adult; Allergens; Asthma; Bronchial Provocation Tests; Chemotaxis, Leukocyte; Clemastine; Cromolyn S | 1985 |
A multicenter trial of the prophylactic effect of ketotifen, theophylline, and placebo in atopic asthma.
Topics: Adolescent; Asthma; Clinical Trials as Topic; Female; Humans; Hypersensitivity, Immediate; Ketotifen | 1985 |
11 other studies available for ketotifen and Atopic Hypersensitivity
| Article | Year |
|---|---|
Two pharmacological phases in antigen-induced immediate airway response in rats.
Topics: Administration, Inhalation; Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Agonists; Albutero | 2008 |
Failure of omalizumab and successful control with ketotifen in a patient with vibratory angio-oedema.
Topics: Adult; Angioedema; Anti-Allergic Agents; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal, Humaniz | 2013 |
Mast cell mediators in asthma. Clinical uses of the inhibitors.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Asthma; Child; Child, Preschool; Cromolyn Sodium; Cytopl | 1981 |
Pharmacological modulation of IgE-dependent mast cell degranulation in experimental autoimmune uveoretinitis.
Topics: Animals; Anti-Inflammatory Agents; Autoimmune Diseases; Cromolyn Sodium; Hypersensitivity, Immediate | 1983 |
[Immunologic indices in evaluation of the effectiveness of treatment of atopic bronchial asthma in children].
Topics: Asthma; Child; Child, Preschool; Desensitization, Immunologic; Humans; Hypersensitivity, Immediate; | 1983 |
The effect of a novel thromboxane A2 (TXA2) receptor antagonist (S-1452) on the antigen-induced bronchoconstriction and airway hyperresponsiveness in guinea pigs.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Benzenea | 1993 |
Idiopathic anaphylaxis: a series of 335 cases.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anaphylaxis; Anti-Allergic Agents; Anti-Asthmatic Agents | 1996 |
[Agranulocytosis induced by ketotifen].
Topics: Adult; Agranulocytosis; Anti-Allergic Agents; Anti-Asthmatic Agents; Asthma; Female; Humans; Hyperse | 1997 |
Antiallergic/antiasthmatic effect of novel antiallergic hexapeptide-95/220 in various experimental models.
Topics: Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Bronchoconstriction; Cetirizine; Cromolyn Sodi | 2001 |
[The first experience of using membranotropic agents in the treatment of the nephrotic syndrome].
Topics: Adjuvants, Immunologic; Child; Chronic Disease; Cromolyn Sodium; Drug Evaluation; Drug Therapy, Comb | 1991 |
[Pharmacologic prevention of allergic complications caused by local anesthesia in odontostomatology].
Topics: Adrenal Cortex Hormones; Anesthetics, Local; Cromolyn Sodium; Drug Hypersensitivity; Histamine Antag | 1989 |