ketotifen has been researched along with Anaphylactic Reaction in 34 studies
Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
ketotifen : An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To study the possible efficacy of ketotifen (K) in the treatment of idiopathic anaphylaxis (IA), K was administered in an open-label trial to six patients with IA who required corticosteroids at doses below which their disease could not be controlled." | 9.06 | Evaluation of ketotifen in corticosteroid-dependent idiopathic anaphylaxis. ( Dykewicz, MS; Harris, KE; Patterson, R; Wong, SS, 1990) |
| "The protective effect of ketotifen was examined by an open assessment trial in 261 asthmatics of variable types, a double blind trial comparing ketotifen and inert placebo in 189 asthmatics of extrinsic type including pure atopic asthma and asthma with atopic and infectious components (mixed type or combined type), and a double blind trial comparing ketotifen and disodium cromoglycate (DSCG) by double placebo technique in 132 asthmatics of a pure atopic type." | 9.05 | Clinical evaluation of a new orally active anti-anaphylactic compound: ketotifen (HC 20-511) in Japanese adult asthmatics. ( Kumagai, A; Muranaka, M; Shida, T; Takahashi, T; Tomioka, H, 1980) |
| "To study the effects of ketotifen fumarate, olopatadine, and levocabastine on ocular active anaphylaxis in guinea pigs and on ocular immediate hypersensitivity in albino rats." | 7.73 | Effect of ketotifen fumarate, olopatadine, and levocabastine on ocular active anaphylaxis in the guinea pig and ocular immediate hypersensitivity in the albino rat. ( Schoch, C, 2005) |
| "We present five patients, two with malignant idiopathic anaphylaxis and three with corticosteroid-dependent idiopathic anaphylaxis, who responded to the administration of ketotifen." | 7.69 | Malignant and corticosteroid-dependent idiopathic anaphylaxis: successful responses to ketotifen. ( Choy, AC; Fitzsimons, EJ; Harris, KE; Patterson, R, 1997) |
| "To assess the potential benefit of ketotifen in the treatment of patients with corticosteroid-dependent idiopathic anaphylaxis, ketotifen was administered in an open trial to nine patients with idiopathic anaphylaxis who required maintenance prednisone for control of their disease." | 7.68 | Efficacy of ketotifen in corticosteroid-dependent idiopathic anaphylaxis. ( Dykewicz, MS; Harris, KE; Patterson, R; Wong, S, 1991) |
| "In a multicentre, double-blind trial, the steroid sparing effect of a new anti-anaphylactic agent ketotifen was assessed against placebo in eighty-six steroid-dependent asthmatics." | 7.66 | A steroid sparing effect of ketotifen in steroid-dependent asthmatics. ( Lane, DJ, 1980) |
| "Azelastine is an orally effective and long-acting inhibitor of in vivo synthesis and/or release of leukotrienes." | 5.27 | Inhibition of leukotriene (SRS-A)-mediated acute lung anaphylaxis by azelastine in guinea pigs. ( Chand, N; Diamantis, W; Nolan, K; Perhach, JL; Sofia, RD, 1986) |
| "To study the possible efficacy of ketotifen (K) in the treatment of idiopathic anaphylaxis (IA), K was administered in an open-label trial to six patients with IA who required corticosteroids at doses below which their disease could not be controlled." | 5.06 | Evaluation of ketotifen in corticosteroid-dependent idiopathic anaphylaxis. ( Dykewicz, MS; Harris, KE; Patterson, R; Wong, SS, 1990) |
| "The protective effect of ketotifen was examined by an open assessment trial in 261 asthmatics of variable types, a double blind trial comparing ketotifen and inert placebo in 189 asthmatics of extrinsic type including pure atopic asthma and asthma with atopic and infectious components (mixed type or combined type), and a double blind trial comparing ketotifen and disodium cromoglycate (DSCG) by double placebo technique in 132 asthmatics of a pure atopic type." | 5.05 | Clinical evaluation of a new orally active anti-anaphylactic compound: ketotifen (HC 20-511) in Japanese adult asthmatics. ( Kumagai, A; Muranaka, M; Shida, T; Takahashi, T; Tomioka, H, 1980) |
| "To study the effects of ketotifen fumarate, olopatadine, and levocabastine on ocular active anaphylaxis in guinea pigs and on ocular immediate hypersensitivity in albino rats." | 3.73 | Effect of ketotifen fumarate, olopatadine, and levocabastine on ocular active anaphylaxis in the guinea pig and ocular immediate hypersensitivity in the albino rat. ( Schoch, C, 2005) |
| "We present five patients, two with malignant idiopathic anaphylaxis and three with corticosteroid-dependent idiopathic anaphylaxis, who responded to the administration of ketotifen." | 3.69 | Malignant and corticosteroid-dependent idiopathic anaphylaxis: successful responses to ketotifen. ( Choy, AC; Fitzsimons, EJ; Harris, KE; Patterson, R, 1997) |
| "To assess the potential benefit of ketotifen in the treatment of patients with corticosteroid-dependent idiopathic anaphylaxis, ketotifen was administered in an open trial to nine patients with idiopathic anaphylaxis who required maintenance prednisone for control of their disease." | 3.68 | Efficacy of ketotifen in corticosteroid-dependent idiopathic anaphylaxis. ( Dykewicz, MS; Harris, KE; Patterson, R; Wong, S, 1991) |
| "Effects of KB-2413 on experimental asthma and respiration were examined in comparison with ketotifen and chlorpheniramine in guinea pigs." | 3.67 | Antiasthmatic effect of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidaz ole difumarate (KB-2413), a new antiallergic. ( Fukuda, T; Ito, K; Saito, T, 1984) |
| "Ketotifen, a benzocycloheptathiophene, possesses asthma-prophylactic and antiallergic activities in a number of in vitro and in vivo systems: prevention of cutaneous and lung anaphylaxis in the rat and guinea pig; inhibition of dermal and bronchial antigen challenges in man; inhibition of mediator release from rat mast cells, human basophils, human neutrophils, and human and guinea pig chopped lung; reduction of human neutrophil activation induced by PAF-acether; functional antagonism of mediator effects in the guinea pig; blockade of H1-receptors and prevention and reversal of beta-adrenergic tachyphylaxis in the rat." | 3.67 | Immunologic and therapeutic aspects of ketotifen. ( Craps, LP, 1985) |
| "Using a new method for inducing IgE-mediated, systemic anaphylaxis in the rat both prednisolone and ketotifen had been shown previously to be effective in suppressing the bronchial anaphylaxis in vivo." | 3.67 | The effect of prednisolone and ketotifen on the antigen-induced bronchoconstriction and mediator release in rat isolated lungs. ( Ottenhof, M; Ufkes, JG; Van Rooij, HH, 1985) |
| "In a multicentre, double-blind trial, the steroid sparing effect of a new anti-anaphylactic agent ketotifen was assessed against placebo in eighty-six steroid-dependent asthmatics." | 3.66 | A steroid sparing effect of ketotifen in steroid-dependent asthmatics. ( Lane, DJ, 1980) |
| "Pretreatment with metyrapone accelerated both antigen-induced responses." | 1.29 | Effect of ZCR-2060, an antiallergic agent, on antigen-induced immediate- and late-phase increases in airway resistance in sensitized guinea pigs. ( Abe, T; Matsuda, K; Nagai, H; Omata, T; Segawa, Y; Yoshida, K, 1995) |
| "Histamine release was not stimulated by AL-4943A at concentrations as high as 10 mM." | 1.29 | The in vitro and in vivo ocular pharmacology of olopatadine (AL-4943A), an effective anti-allergic/antihistaminic agent. ( Brady, MT; Gamache, DA; Graff, G; Lang, LS; Miller, ST; Parnell, D; Spellman, JM; Stephens, DJ; Weimer, LK; Yanni, JM, 1996) |
| "Azelastine is an orally effective and long-acting inhibitor of in vivo synthesis and/or release of leukotrienes." | 1.27 | Inhibition of leukotriene (SRS-A)-mediated acute lung anaphylaxis by azelastine in guinea pigs. ( Chand, N; Diamantis, W; Nolan, K; Perhach, JL; Sofia, RD, 1986) |
| "Ketotifen is a compound with strong anti-anaphylactic and anti-histaminic properties both in experimental mental animals and man." | 1.26 | Dissociation between the anti-anaphylactic and the anti-histaminic actions of ketotifen. ( Baggiolini, M; Martin, U, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (61.76) | 18.7374 |
| 1990's | 11 (32.35) | 18.2507 |
| 2000's | 1 (2.94) | 29.6817 |
| 2010's | 1 (2.94) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ross, WJ | 1 |
| Harrison, RG | 1 |
| Jolley, MR | 1 |
| Neville, MC | 1 |
| Todd, A | 1 |
| Verge, JP | 1 |
| Dawson, W | 2 |
| Sweatman, WJ | 2 |
| Buckle, DR | 2 |
| Rockell, CJ | 1 |
| Smith, H | 2 |
| Spicer, BA | 2 |
| Ho, CY | 1 |
| Hageman, WE | 1 |
| Persico, FJ | 1 |
| Evans, D | 1 |
| Cracknell, ME | 1 |
| Saunders, JC | 1 |
| Smith, CE | 1 |
| Williamson, WR | 1 |
| Outred, DJ | 1 |
| Asawa, A | 1 |
| Simpson, KH | 1 |
| Bonds, RS | 1 |
| Schoch, C | 1 |
| Martin, U | 1 |
| Baggiolini, M | 1 |
| Craps, L | 1 |
| Fukuda, T | 1 |
| Saito, T | 1 |
| Ito, K | 1 |
| Khandwala, A | 1 |
| Carlson, R | 1 |
| Dally-Meade, V | 1 |
| Donigi-Ruzza, D | 1 |
| Ufkes, JG | 2 |
| Ottenhof, M | 2 |
| Kumagai, A | 1 |
| Tomioka, H | 1 |
| Shida, T | 1 |
| Takahashi, T | 1 |
| Muranaka, M | 1 |
| Lane, DJ | 1 |
| Abe, T | 1 |
| Yoshida, K | 1 |
| Omata, T | 1 |
| Segawa, Y | 1 |
| Matsuda, K | 1 |
| Nagai, H | 2 |
| Ditto, AM | 1 |
| Harris, KE | 6 |
| Krasnick, J | 1 |
| Miller, MA | 1 |
| Patterson, R | 6 |
| Yanni, JM | 1 |
| Stephens, DJ | 1 |
| Miller, ST | 1 |
| Weimer, LK | 1 |
| Graff, G | 1 |
| Parnell, D | 1 |
| Lang, LS | 1 |
| Spellman, JM | 1 |
| Brady, MT | 1 |
| Gamache, DA | 1 |
| Watanabe, A | 1 |
| Tominaga, T | 1 |
| Shutoh, H | 1 |
| Hayashi, H | 1 |
| Tsuji, J | 1 |
| Koda, A | 1 |
| Kumazawa, Y | 1 |
| Shimada, H | 1 |
| Fitzsimons, EJ | 1 |
| Choy, AC | 1 |
| Chiang, CH | 1 |
| Chen, JL | 1 |
| Liu, YT | 1 |
| Wang, DP | 1 |
| Stoloff, RS | 1 |
| Orfan, N | 1 |
| Greenberger, PA | 1 |
| Grammer, LC | 1 |
| Wong, S | 2 |
| Dykewicz, MS | 3 |
| Adolphson, RL | 1 |
| Thueson, DO | 1 |
| Finkel, MP | 1 |
| Chestnut, JC | 1 |
| Conroy, MC | 1 |
| Wong, SS | 1 |
| Takeuchi, Y | 1 |
| Nishimura, Y | 1 |
| Yoshikawa, T | 1 |
| Kuriyama, J | 1 |
| Kimura, Y | 1 |
| Saiga, T | 1 |
| Konno-Amano, S | 1 |
| Hirao, T | 1 |
| Kohno, H | 1 |
| Mori, H | 1 |
| Sato, Y | 1 |
| Sekardi, L | 1 |
| Friedberg, KD | 1 |
| Wagner, W | 1 |
| Bahr, T | 1 |
| Schaper, U | 1 |
| Becker, K | 1 |
| Lueddeckens, G | 1 |
| Förster, W | 1 |
| Scheuch, DW | 1 |
| Grupe, R | 1 |
| Morris, EC | 1 |
| Chand, N | 1 |
| Nolan, K | 1 |
| Diamantis, W | 1 |
| Perhach, JL | 1 |
| Sofia, RD | 1 |
| Craps, LP | 1 |
| Van Rooij, HH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ketotifen as a Treatment for Vascular Leakage During Dengue Fever (KETODEN)[NCT02673840] | Phase 4 | 110 participants (Anticipated) | Interventional | 2015-03-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for ketotifen and Anaphylactic Reaction
| Article | Year |
|---|---|
[Ketotifen in the prevention of bronchial asthma. International therapeutic evaluation].
Topics: Adrenal Cortex Hormones; Adult; Anaphylaxis; Asthma; Bronchial Provocation Tests; Bronchodilator Age | 1981 |
Pharmacotherapy of allergic disease.
Topics: Adrenal Cortex Hormones; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adult; Aged; Anaphylax | 1987 |
3 trials available for ketotifen and Anaphylactic Reaction
| Article | Year |
|---|---|
[Ketotifen in the prevention of bronchial asthma. International therapeutic evaluation].
Topics: Adrenal Cortex Hormones; Adult; Anaphylaxis; Asthma; Bronchial Provocation Tests; Bronchodilator Age | 1981 |
Clinical evaluation of a new orally active anti-anaphylactic compound: ketotifen (HC 20-511) in Japanese adult asthmatics.
Topics: Adult; Anaphylaxis; Asthma; Basophils; Cromolyn Sodium; Double-Blind Method; Humans; Hypersensitivit | 1980 |
Evaluation of ketotifen in corticosteroid-dependent idiopathic anaphylaxis.
Topics: Adult; Anaphylaxis; Angioedema; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Ketotife | 1990 |
30 other studies available for ketotifen and Anaphylactic Reaction
| Article | Year |
|---|---|
Antianaphylactic agents. 1. 2-(Acylamino)oxazoles.
Topics: Anaphylaxis; Animals; Bronchial Spasm; Capillary Permeability; Female; Guinea Pigs; Humans; In Vitro | 1979 |
Studies on 1,2,3-triazoles. 13. (Piperazinylalkoxy) [1]benzopyrano[2,3-d]-1,2,3-triazol-9(1H)-ones with combined H1-antihistamine and mast cell stabilizing properties.
Topics: Anaphylaxis; Animals; Guinea Pigs; Histamine H1 Antagonists; Histamine Release; In Vitro Techniques; | 1986 |
Indolo[2,1-c][1,4]benzodiazepines: a new class of antiallergic agents.
Topics: Anaphylaxis; Animals; Benzodiazepines; Cromolyn Sodium; Guinea Pigs; Histamine H1 Antagonists; Hyper | 1986 |
Antianaphylactic benzophenones and related compounds.
Topics: Anaphylaxis; Animals; Benzophenones; Chemical Phenomena; Chemistry; Guinea Pigs; Humans; Lung; Male; | 1987 |
N-benzylpiperazino derivatives of 3-nitro-4-hydroxycoumarin with H1 antihistamine and mast cell stabilizing properties.
Topics: 4-Hydroxycoumarins; Anaphylaxis; Animals; Ascitic Fluid; Guinea Pigs; Histamine Antagonists; Histami | 1984 |
Ketotifen use in a patient with fire ant hypersensitivity and mast cell activation syndrome.
Topics: Adult; Anaphylaxis; Animals; Ant Venoms; Anti-Allergic Agents; Ants; Asthma; Erythema; Female; Hista | 2015 |
Effect of ketotifen fumarate, olopatadine, and levocabastine on ocular active anaphylaxis in the guinea pig and ocular immediate hypersensitivity in the albino rat.
Topics: Anaphylaxis; Animals; Capillary Permeability; Conjunctivitis, Allergic; Dibenzoxepins; Disease Model | 2005 |
Dissociation between the anti-anaphylactic and the anti-histaminic actions of ketotifen.
Topics: Airway Resistance; Anaphylaxis; Animals; Antigens; Clemastine; Female; Histamine H1 Antagonists; Ket | 1981 |
Antiasthmatic effect of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidaz ole difumarate (KB-2413), a new antiallergic.
Topics: Airway Resistance; Anaphylaxis; Animals; Asthma; Benzimidazoles; Chlorpheniramine; Guinea Pigs; Hist | 1984 |
In vitro and in vivo activity profile of RHC 2851: a new orally effective antiallergic agent.
Topics: Anaphylaxis; Animals; Basophils; Carrageenan; Cromolyn Sodium; Edema; Guinea Pigs; Histamine Release | 1983 |
Characterization of various antiallergic agents using a new method for inducing systemic anaphylaxis in the rat.
Topics: Anaphylaxis; Animals; Blood Pressure; Bronchodilator Agents; Chromones; Cromolyn Sodium; Disease Mod | 1984 |
A steroid sparing effect of ketotifen in steroid-dependent asthmatics.
Topics: Adult; Aged; Anaphylaxis; Asthma; Cromolyn Sodium; Double-Blind Method; Female; Humans; Ketotifen; M | 1980 |
Effect of ZCR-2060, an antiallergic agent, on antigen-induced immediate- and late-phase increases in airway resistance in sensitized guinea pigs.
Topics: Airway Resistance; Anaphylaxis; Animals; Benzoates; Bronchi; Cetirizine; Female; Guinea Pigs; Ketoti | 1995 |
Idiopathic anaphylaxis: a series of 335 cases.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anaphylaxis; Anti-Allergic Agents; Anti-Asthmatic Agents | 1996 |
The in vitro and in vivo ocular pharmacology of olopatadine (AL-4943A), an effective anti-allergic/antihistaminic agent.
Topics: Administration, Topical; Anaphylaxis; Animals; Anti-Allergic Agents; Capillary Permeability; Conjunc | 1996 |
Effect of TYB-2285 on lung anaphylaxis in actively sensitized rats.
Topics: Anaphylaxis; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antigens; B | 1997 |
Malignant and corticosteroid-dependent idiopathic anaphylaxis: successful responses to ketotifen.
Topics: Adrenal Cortex Hormones; Adult; Anaphylaxis; Anti-Allergic Agents; Dose-Response Relationship, Drug; | 1997 |
Therapeutic effect and pharmacokinetics of ketotifen transdermal delivery system.
Topics: Adhesives; Administration, Cutaneous; Anaphylaxis; Animals; Anti-Allergic Agents; Chromatography, Hi | 1998 |
Malignant idiopathic anaphylaxis: three additional cases and extended evaluation.
Topics: Adrenal Cortex Hormones; Adult; Aged; Anaphylaxis; Drug Therapy, Combination; Evaluation Studies as | 1992 |
Efficacy of ketotifen in corticosteroid-dependent idiopathic anaphylaxis.
Topics: Adult; Aged; Anaphylaxis; Dose-Response Relationship, Drug; Female; Humans; Ketotifen; Male; Middle | 1991 |
CI-949: a new, potential antiallergy compound inhibits antigen-induced allergic reactions in guinea-pigs in vitro and in vivo.
Topics: Anaphylaxis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens; Cromolyn Sodium; Guinea Pig | 1990 |
Malignant idiopathic anaphylaxis.
Topics: Acute Disease; Adult; Anaphylaxis; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fema | 1990 |
[A comparison between Chinese blended medicine "shoseiryuto", tranilast and ketotifen on the anti-allergic action in the guinea pigs].
Topics: Acetylcholine; Anaphylaxis; Animals; Female; Guinea Pigs; Histamine Antagonists; Ketotifen; Medicine | 1985 |
Passive air-pouch anaphylaxis in rats. II. Pharmacological characterization.
Topics: Adult; Air; Anaphylaxis; Animals; Capillary Permeability; Chromones; Cromolyn Sodium; Dexamethasone; | 1989 |
Inhibition of immunological histamine release from guinea pig lungs and other organs by mepyramine, ketotifen, and picumast in vivo.
Topics: Aminopyridines; Anaphylaxis; Animals; Coumarins; Female; Guinea Pigs; Histamine; Histamine H1 Antago | 1989 |
Exercise-induced allergic syndromes on the increase.
Topics: Adolescent; Adult; Albuterol; Anaphylaxis; Asthma; Asthma, Exercise-Induced; Beclomethasone; Exercis | 1989 |
Influence of inhibitors of the eicosanoid metabolism, and of eicosanoids- and PAF-acether antagonists on mortality and some biochemical parameters of three shock models.
Topics: Anaphylaxis; Animals; Aspirin; Diterpenes; Fatty Acids, Unsaturated; Female; Ginkgolides; Imidazoles | 1989 |
Inhibition of leukotriene (SRS-A)-mediated acute lung anaphylaxis by azelastine in guinea pigs.
Topics: Anaphylaxis; Animals; Atropine; Chromones; Cromolyn Sodium; Guinea Pigs; Indomethacin; Ketotifen; Ma | 1986 |
Immunologic and therapeutic aspects of ketotifen.
Topics: Anaphylaxis; Animals; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Heart Rate; Humans; Isop | 1985 |
The effect of prednisolone and ketotifen on the antigen-induced bronchoconstriction and mediator release in rat isolated lungs.
Topics: Anaphylaxis; Animals; Bronchi; Female; Histamine; In Vitro Techniques; Ketotifen; Lung; Muscle Contr | 1985 |